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About me

  • Studied medicine at University of Uppsala, specialist in internal medicine and cardiology.
  • Clinical positions at Departments of Medicine at the following University Hospitals belonging to Karolinska Institutet (KI); Serafimer Hospital, Danderyd Hospital and Karolinska University Hospital, Solna.
  • Professor of Cardiovascular Epidemiology at KI, Department of Environmental Medicine since 1994 and in parallel senior consultant at Department of Cardiology, Karolinska University Hospital, Solna.
  • Over the years main supervisor to 12 and co-supervisor to 23 Ph.D students who have defended their theses.
  • Currently co-supervising 4 Ph.D students.
  • Received Tore Andersson´s prize in epidemiology in 2007 for outstanding acievements within cardiovascular epidemiological research.
  • Editor-in-Chief for Journal of Internal Medicine (IF 7,98), 2006 on.
  • Published 487 articles (see Pub Med FAIRE U).
  • About 41 200 citations and H-index 89 (Web of Science, Febr 2018).

Research description

Over the years our research group has been focused on studying inflammatory biomarkers and causally related mechanisms behind atherosclerosis and risks for cardiovascular disease. We perform both analyses of genetic variants and biomarkers applying various techniques and epidemiological/statistical models. We have several broad international collaborations with centres in USA ( Harvard), UK (Cambridge, Oxford, London) and Italy (Milan) regarding genetics of cardiovascular disease, gene-environmental interactions and biomarkers. We utilize several own , unique and well examined clinical/epidemiological materials as 60 year old men and women ( n=4232) followed for 18 years; Stockholm Heart Epidemiology Program (SHEEP) (n = 3982), a case-control study of myocardial infarction followed for 20 years for recurrences and death  among cases and first time MI among controls; IMPROVE, an EU-based cohort study from 6 European centres on subjects with > 3 risk factors (n=3700) regarding prediction of cardiovascular risk and atherosclerosis progression, now followed for 10 years. We also collaborate with the Swedish Twin Registry (TwinGene)(n=12 000); AMORIS, a database of 800 000 subjects  previously screened for risk factors and SCAPIS (the Swedish Cardio Pulmonary Bioimaging Study), a prospective study on 30 000 subjcets, 55 – 70 years old, from 6 Swedish university centres exploring causal mechanisms and biomarkers behind plaque rupture and cardiovascular risk.

 

Five selected publications

Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism.
de Faire U, Su J, Hua X, Frostegård A, Halldin M, Hellenius M, et al
J. Autoimmun. 2010 Mar;34(2):73-9

Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility.
Vergeer M, Boekholdt S, Sandhu M, Ricketts S, Wareham N, Brown M, et al
Circulation 2010 Aug;122(5):470-7

Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events: results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study.
Baldassarre D, Hamsten A, Veglia F, de Faire U, Humphries S, Smit A, et al
J. Am. Coll. Cardiol. 2012 Oct;60(16):1489-99

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women.
Marklund M, Leander K, Vikström M, Laguzzi F, Gigante B, Sjögren P, et al
Circulation 2015 Aug;132(7):586-94

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors.
Leander K, Mälarstig A, Van't Hooft F, Hyde C, Hellénius M, Troutt J, et al
Circulation 2016 Mar;133(13):1230-9

 

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