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About me

I obtained my doctoral degree from Department of Medicine Huddinge, Karolinska Institutet (KI) in 2013. Following my two year postdoc  I joined the  Department of Laboratory Medicine as Assistant Professor in 2015, where my research focuses  on multi-omics system biology approach to understand the disease control mechanism in a group of HIV-1 positive individuals who control viral replication without any therapy called Elite Controller.

Education

March 2014- May 2015

Post-Doctoral Fellow, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden 

June 2013-March 2014

Post-Doctoral Reserach Scientist, St. John's Research Institute, Bangalore, India

2009 – 2013

Ph.D. in Medical Sciences, Karolinska Institutet, Stockholm, Sweden 

Thesis title: Translational genomics of HIV-1 subtype C in India: Molecular phylogeny and drug resistance

2005-2007                    

M.Sc Microbiology, Bangalore University Bangalore, India                                                        

Research description

The aim my research team is through translational research integrating multi-omics techniques and clinical data to understand the disease control mechanism in a group of HIV-1 positive individuals, who control viral replication and restrained progression to immunodeficiency, without any antiretroviral therapy for a longer duration of time (Elite controllers). 

In a systemic approach, we apply the molecular data-first approach (using genomics, transcriptomics, proteomics, and metabolomics) classifies persistent genetic variants or expression patterns to reduce host influenced heterogeneity followed by the phenotypic profiling, virological and immunological characterizations of the disease control mechanisms. This understanding of the unique gene expression and immunological characteristics of EC will predict a frame of reference for what may be required in clinical intervention strategies to induce immune control of HIV-1 and the future development of functional HIV-cure.

For more information visit: https://ki.se/en/labmed/research-group-ujjwal-neogi

Teaching portfolio

Teaching assignments under the Biomedical Laboratory Science program

Academic honours, awards and prizes

 

FELLOWSHIPS

2016

Jonas Söderquist’s Stipendium for Experimental Virology and Immunology Research-2016 for research in development of high-throughput techniques to quantify HIV-1 latent reservoir.

2012

AIDS International Training and Research Program (AITRP) fellowship, sponsored by National Institute of Health (NIH), US for training at Albert Einstein College of Medical Science, NY.

GRANTS

1.1. Ongoing 

01/2018-12/2021 Swedish Research Council (Startup grant- 2017-01330)

A multi-omics system biology approach to identify disease control mechanisms in HIV-1 positive Elite Controllers and the importance for HIV-cure

Role: Principal Investigator

11/2017-10/2021 Karolinska Institutet Doctoral Student Funding (KID2016-0022)

Characterization of HIV-1 persistence and dynamics in the latent viral reservoir

Role: Co-Investigator

11/2016-10/2018 Harald and Greta Jeansson Foundation (JS2016-0185)

Mechanisms of HIV-1 persistence and latency: Implications for a cure

Role: Principal Investigator

01/2017-12/2019 Stockholm County Council, ALF-Project Funding Medicine (Ref#20160074)

Clinical and translational studies of virus-host interactions for optimization of HIV treatment and possible cure of HIV

Role: Co-Investigator

07/2016-06/2020  US National Institute of Health (R01 GM118012-01)

Reverse transcriptase multi-class drug resistance and rilpivirine susceptibility in diverse HIV-1 Subtypes

Role: Site-PI

http://grantome.com/grant/NIH/R01-GM118012-01A1

03/2016-02/2020 Karolinska Institutet Doctoral Student Funding (KID2015-154)

High throughput system biology approach to identify resistance mechanisms against protease inhibitors in South African HIV-1C

Role: Principal Investigator

01/2016-07/2017  Swedish Physicians Against AIDS Foundation (Fob2015-009)

Viral genome wide association study to understand the mechanism of protease inhibitor failure

Role: Principal Investigator

01/2016-12/2018 Swedish Research Council  (2015-05914) 

Development of a molecular surveillance phylogeographic tool to track HIV transmission networks in Bangladesh

Role: Co-Investigator

06/2015-05/2019 Karolinska Institutet Doctoral Student Funding (KID2014-114)

Role of viral evolution for HIV-1 subtype C fitness, host-reactivity and therapeutic response

Role: Co-Investigator

Documents

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