Toyonori Sakata

Publications
CV
Public outreach and news

Articles

Article: CURRENT BIOLOGY. 2025;35(6):1353-1363.e5
A common molecular mechanism underlying Cornelia de Lange and CHOPS syndromes
Sakata T; Tei S; Izumi K; Krantz ID; Bando M; Shirahige K
Journal article: METHODS IN MOLECULAR BIOLOGY. 2025;2856:63-70
Micro-C Analysis Workflow Using Pairtools and Juicer.
Sakata T
Article: MOLECULAR CELL. 2024;84(5):867-882.e5
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils
Jeppsson K; Pradhan B; Sutani T; Sakata T; Igarashi MU; Berta DG; Kanno T; Nakato R; Shirahige K; Kim E; Bjorkegren C
Article: HUMAN GENETICS. 2024;143(3):437-453
Biallelic variants in GTF3C5, a regulator of RNA polymerase III-mediated transcription, cause a multisystem developmental disorder.
Iwata-Otsubo A; Skraban CM; Yoshimura A; Sakata T; Alves CAP; Fiordaliso SK; Kuroda Y; Vengoechea J; Grochowsky A; Ernste P; Lulis L; Nesbitt A; Tayoun AA; Gray C; Towne MC; Radtke K; Normand EA; Rhodes L; Seiler C; Shirahige K; Izumi K
Article: NATURE COMMUNICATIONS. 2023;14(1):5647
Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors
Nakato R; Sakata T; Wang J; Nagai LAE; Nagaoka Y; Oba GM; Bando M; Shirahige K
Article: SCIENCE ADVANCES. 2022;8(23):eabn7063
Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
Jeppsson K; Sakata T; Nakato R; Milanova S; Shirahige K; Bjorkegren C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(35):e2025647118
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Miyata K; Imai Y; Hori S; Nishio M; Loo TM; Okada R; Yang L; Nakadai T; Maruyama R; Fujii R; Ueda K; Jiang L; Zheng H; Toyokuni S; Sakata T; Shirahige K; Kojima R; Nakayama M; Oshima M; Nagayama S; Seimiya H; Hirota T; Saya H; Hara E; Takahashi A
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(4):440-450
Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis.
Tsuchiya H; Ota M; Sumitomo S; Ishigaki K; Suzuki A; Sakata T; Tsuchida Y; Inui H; Hirose J; Kochi Y; Kadono Y; Shirahige K; Tanaka S; Yamamoto K; Fujio K
Article: METHODS. 2021;187:44-53
Methods for ChIP-seq analysis: A practical workflow and advanced applications.
Nakato R; Sakata T
Article: PLOS GENETICS. 2020;16(9):e1009048
Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
Fujiwara Y; Horisawa-Takada Y; Inoue E; Tani N; Shibuya H; Fujimura S; Kariyazono R; Sakata T; Ohta K; Araki K; Okada Y; Ishiguro K-I
Article: CANCER DISCOVERY. 2020;10(6):836-853
Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes
Ochi Y; Kon A; Sakata T; Nakagawa MM; Nakazawa N; Kakuta M; Kataoka K; Koseki H; Nakayama M; Morishita D; Tsuruyama T; Saiki R; Yoda A; Okuda R; Yoshizato T; Yoshida K; Shiozawa Y; Nannya Y; Kotani S; Kogure Y; Kakiuchi N; Nishimura T; Makishima H; Malcovati L; Yokoyama A; Takeuchi K; Sugihara E; Sato T-A; Sanada M; Takaori-Kondo A; Cazzola M; Kengaku M; Miyano S; Shirahige K; Suzuki HI; Ogawa S
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1515:257-271
ChIP-seq Analysis of Condensin Complex in Cultured Mammalian Cells.
Sakata T; Shirahige K; Sutani T
Article: NATURE COMMUNICATIONS. 2015;6:7815
Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.
Sutani T; Sakata T; Nakato R; Masuda K; Ishibashi M; Yamashita D; Suzuki Y; Hirano T; Bando M; Shirahige K

Employments

Research Specialist, Department of Cell and Molecular Biology, Karolinska Institutet, 2024-
Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024

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