Tom Erkers

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About me

We focus on exploring the biology behind blood cancers, aiming to uncover new treatment opportunities. Through functional precision medicine methods and in-depth molecular profiling, we strive to identify therapies tailored to each individual patient

Articles

Journal article: CANCER RESEARCH. 2024;84(6):706
Advancing radiotherapy strategies for high-risk rhabdomyosarcoma: Unveiling BCLxL inhibition as a potent sensitizer to radiotherapy
Park SSW; Struyf N; Erkers T; Lehmann S; Meister MT; Drost J; Holstege FC; Herold N; Ostling P; Stenman J; Kallioniemi O; Henter J-I; Seashore-Ludlow B; Karlsson K
Journal article: BLOOD CANCER DISCOVERY. 2024;5(2_Supplement):p30
Abstract P30: Therapeutic activation of pre-B-cell receptor signaling in high-risk pediatric ALL: exploiting TCF3 and MYC-linked vulnerabilities
Leo IR; Post F; Struyf N; Qi X; Aswad L; Nguyen TT; Tamai M; Akahane K; Pokrovskaja-Tamm K; Erkers T; Inukai T; Lehtiö J; Jafari R
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Struyf N; Osterroos A; Vesterlund M; Arnroth C; James T; Sunandar S; Mermelekas G; Bohlin A; Hamberg Levedahl K; Bengtzen S; Jafari R; Orre LM; Lehtio J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B; Erkers T
Article: SCIENTIFIC REPORTS. 2024;14(1):4000
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
Bwanika HC; Leo IR; Struyf N; Talanti A; Aswad L; Konnur A; Bjoerklund A-C; Heyman M; Rassidakis G; Erkers T; Seashore-Ludlow B; Jafari R; Pokrovskaja Tamm K
Journal article: BLOOD. 2023;142:5015
Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia
Xian X; Sandhu V; Eide CA; Kurtz SE; Malani D; Erkers T; Kallioniemi O; Tyner JW; Bhatt S
Journal article: CANCER RESEARCH. 2023;83(7):6612
Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia
Erkers T; Struyf N; James T; Marabita F; Vesterlund M; Vu N; Arnroth C; Osterroos A; Bohlin A; Bengtzen S; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Article: NPJ PRECISION ONCOLOGY. 2023;7(1):32
Prediction model for drug response of acute myeloid leukemia patients
Trac QT; Pawitan Y; Mou T; Erkers T; Ostling P; Bohlin A; Osterroos A; Vesterlund M; Jafari R; Siavelis I; Backvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtio J; Lehmann S; Kallioniemi O; Vu TN
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial
Jadersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzen S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Ostling P; Schinazi RF; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis GZ; Hoglund M; Henter J-I; Herold N
Journal article: HEMASPHERE. 2022;6:442-443
P543: TARGETING SAMHD1 WITH HYDROXYUREA IN FIRST‐LINE CYTARABINE‐BASED THERAPY OF NEWLY DIAGNOSED ACUTE MYELOID LEUKAEMIA: RESULTS FROM THE HEAT‐AML TRIAL
Jädersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzén S; Bohlin A; Arnroth C; Erkers T; Seashore‐Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Östling P; Schinazi R; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis G; Höglund M; Henter J; Herold N
Article: NATURE COMMUNICATIONS. 2022;13(1):1691
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines
Leo IR; Aswad L; Stahl M; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi RN; Gracia-Villacampa E; Ostling P; Kallioniemi OP; Tamm KP; Siavelis I; Lehtio J; Vesterlund M; Jafari R
Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:960329
Immunoregulatory effects of RGMb in gut inflammation.
Pérez-Cruz M; Iliopoulou BP; Hsu K; Wu H-H; Erkers T; Swaminathan K; Tang S-W; Bader CS; Kambham N; Xie B; Dekruyff RH; Freeman GJ; Meyer E
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
Mou T; Pawitan Y; Stahl M; Vesterlund M; Deng W; Jafari R; Bohlin A; Osterroos A; Siavelis L; Backvall H; Erkers T; Kiviluoto S; Seashore-Ludlow B; Ostling P; Orre LM; Kallioniemi O; Lehmann S; Lehtio J; Trung NV
Article: BLOOD. 2020;135(11):814-825
High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity
Erkers T; Xie BJ; Kenyon LJ; Smith B; Rieck M; Jensen KP; Ji X; Basina M; Strober S; Negrin RS; Maecker HT; Meyer EH
Article: BLOOD ADVANCES. 2019;3(21):3419-3431
Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation.
Iliopoulou BP; Hsu K; Pérez-Cruz M; Tang S-W; Pang WW; Erkers T; Kambham N; Freeman GJ; Dekruyff RH; Meyer EH
Article: JCI INSIGHT. 2017;2(20):92865
T cells expressing chimeric antigen receptor promote immune tolerance.
Pierini A; Iliopoulou BP; Peiris H; Pérez-Cruz M; Baker J; Hsu K; Gu X; Zheng P-P; Erkers T; Tang S-W; Strober W; Alvarez M; Ring A; Velardi A; Negrin RS; Kim SK; Meyer EH
Article: SCIENTIFIC REPORTS. 2017;7(1):6123
MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation
Solders M; Gorchs L; Erkers T; Lundell A-C; Nava S; Gidlof S; Tiblad E; Magalhaes I; Kaipe H
Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):82.20
Control of alloreactivity using transient expression of a monoclonal antibody directed chimeric antigen receptor in conventional and regulatory T cells
Pierini A; Iliopoulou B; Peiris H; Perez-Cruz M; Baker J; Hsu K; Strober W; Zheng PP; Erkers T; Alvarez M; Ring A; Velardi A; Negrin RS; Kim S; Meyer E
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2017;101(3):623-632
Frontline Science: Placenta-derived decidual stromal cells alter IL-2R expression and signaling in alloantigen-activated T cells
Erkers T; Solders M; Verleng L; Bergstroem C; Stikvoort A; Rane L; Nava S; Ringden O; Kaipe H
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1861
Mucosal-associated invariant T cells Display a Poor reconstitution and altered Phenotype after allogeneic hematopoietic stem cell Transplantation
Solders M; Erkers T; Gorchs L; Poiret T; Remberger M; Magalhaes I; Kaipe H
Article: STEM CELLS AND DEVELOPMENT. 2015;24(12):1471-1482
Immunogenicity of Decidual Stromal Cells in an Epidermolysis Bullosa Patient and in Allogeneic Hematopoietic Stem Cell Transplantation Patients
Kaipe H; Carlson L-M; Erkers T; Nava S; Mollden P; Gustafsson B; Qian H; Li X; Hashimoto T; Sadeghi B; Alheim M; Ringden O
Article: STEM CELLS AND DEVELOPMENT. 2015;24(2):253-263
Treatment of Severe Chronic Graft-Versus-Host Disease with Decidual Stromal Cells and Tracing with ¹¹¹Indium Radiolabeling
Erkers T; Kaipe H; Nava S; Mollden P; Gustafsson B; Axelsson R; Ringden O
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2014;20(9):1418-1425
Low CD34 Dose Is Associated with Poor Survival after Reduced-Intensity Conditioning Allogeneic Transplantation for Acute Myeloid Leukemia and Myelodygplastic Syndrome
Torlen J; Ringden O; Le Rademacher J; Batiwalla M; Chen J; Erkers T; Ho V; Kebriaei P; Keever-Taylor C; Kindwall-Keller T; Lazarus HM; Laughlin MJ; Lill M; O'Brien T; Perales M-A; Rocha V; Savani BN; Szwajcer D; Valcarcel D; Eapen M
Article: THE ANALYST. 2013;138(21):6573-6581
Capture and separation of biomolecules using magnetic beads in a simple microfluidic channel without an external flow device.
Wang J; Morabito K; Erkers T; Tripathi A
Article: STEM CELLS AND DEVELOPMENT. 2013;22(19):2596-2605
Decidual Stromal Cells Promote Regulatory T Cells and Suppress Alloreactivity in a Cell Contact-Dependent Manner
Erkers T; Nava S; Yosef J; Ringden O; Kaipe H
Article: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):153-162
A prospective randomized toxicity study to compare reduced-intensity and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation
Ringden O; Erkers T; Aschan J; Garming-Legert K; Le Blanc K; Hagglund H; Omazic B; Svenberg P; Dahllof G; Mattsson J; Ljungman P; Remberger M
Article: STEM CELLS. 2013;31(3):592-601
Fetal Membrane Cells for Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease
Ringden O; Erkers T; Nava S; Uzunel M; Iwarsson E; Conrad R; Westgren M; Mattsson J; Kaipe H
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;167(3):543-555
Stromal cells from term fetal membrane are highly suppressive in allogeneic settings in vitro
Karlsson H; Erkers T; Nava S; Ruhm S; Westgren M; Ringden O
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All other publications

Preprint: BIORXIV. 2024
Pathway activation model for personalized prediction of drug synergy
Trac QT; Huang Y; Erkers T; Östling P; Bohlin A; Österroos A; Vesterlund M; Jafari R; Siavelis I; Bäckvall H; Kiviluoto S; Orre LM; Rantalainen M; Lehtiö J; Lehmann S; Kallioniemi O; Pawitan Y; Vu TN
Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):413-436
Novel precision medicine approaches and treatment strategies in hematological malignancies
Rosenquist R; Bernard E; Erkers T; Scott DW; Itzykson R; Rousselot P; Soulier J; Hutchings M; Ostling P; Cavelier L; Fioretos T; Smedby KE
Preprint: RESEARCH SQUARE. 2023
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Erkers T; Struyf N; Arnroth C; Vesterlund M; James T; Sunandar S; Bohlin A; Hamberg-Levedahl K; Bengtzén S; Jafari R; Orre L; Lehtiö J; Lehmann S; Ostling P; Kallioniemi O; Seashore-Ludlow B
Conference publication: BLOOD. 2022;140:6299
Data-Driven Molecular Hallmarks of Acute Myeloid Leukemia: Biological, Prognostic and Therapeutic Implications
Erkers T; Marabita F; Struyf N; Vesterlund M; James T; Arnroth C; Bohlin A; Bengtzen S; Osterroos A; Stahl M; Jafari R; Orre L; Pawitan Y; Seashore-Ludlow B; Lehtio J; Lehmann S; Ostling P; Kallioniemi O
Conference publication: BLOOD. 2022;140:6290
Comparison of Data from Fresh and Frozen AML Samples for Functional Drug Testing
Struyf N; Arnroth C; Sunandar S; Bohlin A; Bengtzen S; Lehmann S; Kallioniemi O; Ostling P; Seashore-Ludlow B; Erkers T
Preprint: RESEARCH SQUARE. 2021
Multi-omics molecular phenotyping of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilities
Stahl M; Aswad L; Leo I; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi R; Gracia-Villacampa E; Östling P; Kalloniemi O; Tamm KP; Siavelis I; Lehtiö J; Vesterlund M; Jafari R
Meeting abstract: BLOOD. 2019;134:4641
High-Throughput Functional Ex-Vivo Drug Testing and Multi-Omics Profiling in Patients with Acute Myeloid Leukemia
Erkers T; Seashore-Ludlow B; Struyf N; Marabita F; James T; Malani D; Vesterlund M; Stalhl M; Pawitan Y; Lehmann S; Ostling P; Lehtio J; Kallioniemi O
Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s290
A Proinflammatory Invariant Natural Killer T Cell Phenotypic State Associates with Human Graft-Versus-Host Disease Onset
Xie BJ; Erkers T; Kenyon L; Rieck M; Basina M; Jensen K; Strober S; Negrin RS; Maecker HT; Meyer EH
Meeting abstract: BLOOD. 2018;132:2111
A Proinflammatory Invariant Natural Killer T Cells Phenotypic State Associates with Human Graft-Versus-Host Disease Onset and Response
Erkers T; Xei B; Kenyon L; Rieck M; Basina M; Jensen K; Strober S; Negrin RS; Maecker HT; Meyer EH
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2018;24(3):s324
Bone Morphogenetic Protein Signaling Pathway Modulation by Blocking Anti-Repulsive Guidance Molecule B Antibody Promotes Tolerance in Graft-Versus-Host Disease
Cruz MP; Hsu K; Iliopoulou BP; Erkers T; Pang W; Dekruyff RH; Freeman GJ; Meyer E
Review: STEM CELLS INTERNATIONAL. 2017;2017:5738371-17
Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy
Erkers T; Stikvoort A; Uhlin M
Meeting abstract: BLOOD. 2016;128(22):3355
The Use of Monoclonal Antibody Directed Chimeric Antigen Receptors to Facilitate Conventional T Cell and Treg Control of GvHD and Tissue Tolerance in Murine Models
Pierini A; Iliopoulou B; Peiris H; Cruz MP; Baker J; Hsu K; Strober W; Zheng P-P; Erkers T; Ring A; Velardi A; Negrin RS; Kim S; Meyer E
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2016;22(3):S48
Placenta-Derived Decidual Stromal Cells for Treatment of Severe Acute Graft-Versus-Host Disease
Ringden O; Solders M; Baygan A; Remberger M; Erkers T; Nava S; Gustavsson B; Winiarski J; Westgren M; Sadeghi B; Mattsson J; Kaipe H
Thesis / dissertation: 2016
Immunoregulatory effects of placenta-derived decidual stromal cells
Erkers, Tom
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(2):S149
Placenta-Derived Decidual Stromal Cells for Graft-Versus-Host Disease, Hemorrhaging, and Toxicity after Allogeneic Hematopoietic Stem Cell Transplantation
Ringden O; Solders M; Erkers T; Nava S; Mollden P; Khoein B; Baygan A; Aronsson-Kurttila W; Mohmand S; Remberger M; Westgren M; Mattsson J; Sadeghi B; Kaipe H
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(2):S349-S350
Decidual Stromal Cells As Treatment for Acute Graft Versus Host Disease
Solders M; Erkers T; Remberger M; Nava S; Mollden P; Mattsson J; Kaipe H; Ringden O
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(2):S147
Immunological Effects of Decidual Stromal Cell Treatment in Patients with Severe Chronic Graft-Versus-Host Disease
Erkers T; Kaipe H; Nava S; Mollden P; Gustafsson B; Axelsson R; Ringden O
Review: BONE MARROW TRANSPLANTATION. 2014;49(6):737-743
Stromal cells-are they really useful for GVHD?
Kaipe H; Erkers T; Sadeghi B; Ringden O
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2013;19(2):S141-S142
Fetal Membrane Cells for Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease
Ringden O; Erkers T; Nava S; Uzunel M; Iwarsson E; Conrad R; Westgren M; Mattsson J; Kaipe H
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2012;18(2):S335
A PROSPECTIVE RANDOMIZED STUDY COMPARING REDUCED-INTENSITY CONDITIONING AND MYELOABLATIVE CONDITIONING IN PATIENTS WITH MYELOID LEUKEMIA UNDERGOING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Ringden O; Erkers T; Aschan J; Le Blanc K; Hagglund H; Omazic B; Svenberg P; Ljungman P; Mattsson J; Remberger M
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2012;18(2):S264
STROMAL CELLS ISOLATED FROM TERM FETAL MEMBRANE GREATLY SUPPRESS ALLOANTIGEN-STIMULATED IMMUNE CELLS IN VITRO
Erkers T; Nava S; Ruhm S; Westgren M; Ringden O; Karlsson H
Conference publication: BONE MARROW TRANSPLANTATION. 2012;47:S416
A prospective randomised study comparing reduced-intensity conditioning and myeloablative conditioning in patients with myeloid leukaemia undergoing allogeneic haematopoietic stem cell transplantation
Ringden O; Erkers T; Aschan J; Le Blanc K; Hagglund H; Omazic B; Svenberg P; Ljungman P; Mattsson J; Remberger M
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Employments

Assistant Professor, Department of Oncology-Pathology, Karolinska Institutet, 2020-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2016

Visiting research fellowships

Postdoc, Stanford University School of Medicine, 2016-2018

About me

Articles

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Employments

Degrees and Education

Visiting research fellowships

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