Tobias Kammann
Affiliated to Research
E-mail: tobias.kammann@ki.se
Visiting address: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postal address: H7 Medicin, Huddinge, H7 CIM Sandberg, 171 77 Stockholm
About me
I enjoy exploring the human immune system. In my research, I study human tissue-resident T cells and want to understand how T cells mediate homeostasis in their environment, eliminate threats, improve tolerance, and repair damage.
Currently, I characterize mucosal effector-memory CD4 T cells resident in the human gastrointestinal barrier.
In my PhD at the Center for Infectious Medicine, I uncovered the diversity of mucosal-associated invariant T (MAIT) cells across the human body to understand their role in tissue homeostasis and immune defence. During the COVID-19 pandemic, I joined the Karolinska's efforts to better understand how the human immune system responds to the disease.
Before I joined Karolinska Institutet, I trained as a paramedic, then studied biochemistry at the Friedrich Schiller University in Jena, Germany, with a focus on liver dysfunction and sepsis research.
Articles
- Article: SCIENCE IMMUNOLOGY. 2025;10(109):eadq4881Niessl J; Mueller TR; Constantz C; Cai C; Nilsen V; Ballesteros OR; Adamo S; Kammann T; Mouchtaridi E; Gao Y; Akhirunnesa M; Raineri EJM; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Stellaccio T; Brownlie D; Ringqvist E; Flodstrom-Tullberg M; Llewellyn-Lacey S; Tibbitt C; Hammer Q; Michaelsson J; Price DA; Mjosberg J; Marquardt N; Sandberg JK; Sekine T; Jorns C; Buggert M
- Article: GENES AND IMMUNITY. 2025;26(1):70-74Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
- Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
- Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgard J; Maleki KT; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Bjorkstrom NK; Klingstrom J; Ljunggren H-G; Aleman S; Buggert M; Stralin K; Sandberg JK
- Article: CELL DEATH & DISEASE. 2023;14(4):275Hoff J; Xiong L; Kammann T; Neugebauer S; Micheel JM; Gassler N; Bauer M; Press AT
- Article: IMMUNITY. 2022;55(9):1732-1746.e5Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
- Article: MOLECULAR MEDICINE. 2022;28(1):54Boulouis C; Kammann T; Cuapio A; Parrot T; Gao Y; Mouchtaridi E; Wullimann D; Lange J; Chen P; Akber M; Ballesteros OR; Muvva JR; Smith CIE; Vesterbacka J; Kieri O; Nowak P; Bergman P; Buggert M; Ljunggren H-G; Aleman S; Sandberg JK
- Journal article: JOURNAL OF IMMUNOLOGY. 2022;208(1):169.16Kammann T; Parrot T; Boulouis C; Buggert M; Leeansyah E; Sandberg JK
- Article: MOLECULAR MEDICINE. 2022;28(1):20Cuapio A; Boulouis C; Filipovic I; Wullimann D; Kammann T; Parrot T; Chen P; Akber M; Gao Y; Hammer Q; Strunz B; Potti AP; Ballesteros OR; Lange J; Muvva JR; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; Osterborg A; Smith CIE; Bogdanovic G; Muschiol S; Hellgren F; Lore K; Sobkowiak MJ; Gabarrini G; Healy K; Chen MS; Alici E; Bjorkstrom NK; Buggert M; Ljungman P; Sandberg JK; Aleman S; Ljunggren H-G
- Article: METABOLITES. 2021;11(12):821Kammann T; Hoff J; Yildirim I; Shkodra B; Mueller T; Weber C; Graeler MH; Maus UA; Paton JC; Singer M; Traeger A; Schubert US; Bauer M; Press AT
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
- Article: CELL. 2020;183(1):158-168.e14Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
- Journal article: RESEARCH. 2019;2019:9854593Mishriki S; Fattah ARA; Kammann T; Sahu RP; Geng F; Puri IK
- Article: BIOMETALS. 2018;31(4):605-616Fattah ARA; Mishriki S; Kammann T; Sahu RP; Geng F; Puri IK
- Article: BIOMATERIALS SCIENCE. 2018;6(3):683-694Fattah ARA; Mishriki S; Kammann T; Sahu RP; Geng F; Puri IK
All other publications
- Thesis / dissertation: KAROLINSKA INSTITUTET. 2024Kammann T
- Preprint: MEDRXIV. 2020Parrot T; Gorin J-B; Ponzetta A; Maleki K; Kammann T; Emgârd J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; the Karolinska COVID-19 Study Group; Folkesson E; Rooyackers O; Eriksson L; Norrby-Teglund A; Ljunggren H-G; Björkström N; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg J
- Preprint: BIORXIV. 2020Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann D; Kammann T; Emgård J; Parrot T; Folkesson E; Rooyackers O; Eriksson L; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström N; Sandberg J; Price D; Ljunggren H-G; Aleman S; Buggert M; Karolinska COVID-19 Study Group
Grants
- Charting the human tissue terrain of regulatory T cell immunity and memory against respiratory virusesSwedish Society for Medical Research7 July 2025 - 7 July 2028Regulatory T (Treg) cells are specialized immune cells that are essential for balancing the activity of the immune system. In human tissues, Treg cells not only suppress exacerbated immune activity and thereby prevent self-harm but also aid in repair, a role that appears especially crucial in the respiratory system where diseases like COVID-19 can cause severe organ damage. However, our knowledge on how Treg cells contribute to immune memory, tissue repair and protection from viral disease is mostly limited to animal models. In collaboration with Columbia University, New York, USA, and Karolinska Institutet, Stockholm, Sweden, this project seeks to explore how human tissue-resident Treg cells contribute to protection against respiratory viruses. Our research will use mucosal and lymphoid tissues from human organ donors to examine memory Treg cells that respond specifically to viral antigens. We will profile antiviral Treg cell characteristics on an epigenetic, transcriptomic, and functional level and further apply cutting-edge technology to map and track individual Treg populations within human lymphoid tissues to deepen our understanding on how Treg cells establish antiviral immune memory and support adaptive immune responses. Together, this research aims to chart the terrain of antiviral Treg cells in human tissues and offers insights that could lead to targeted therapies enhancing resilience against respiratory tract infections.
- Swedish Research Council1 July 2025 - 30 June 2028Regulatory T (Treg) cells are specialized immune cells that are essential for balancing the activity of the immune system. In human tissues, Treg cells not only suppress exacerbated immune activity but also aid in repair, a role that appears especially crucial in the respiratory system where diseases like COVID-19 can cause severe organ damage. However, our knowledge on how Treg cells contribute to immune memory, tissue repair and protection from viral disease is mostly limited to animal models.In collaboration with Columbia University, New York, USA, and Karolinska Institutet, Stockholm, Sweden, this project seeks to explore how human tissue-resident Treg cells contribute to protection against respiratory viruses. Our research will use mucosal and lymphoid tissues from human organ donors to examine memory Treg cells that respond specifically to viral antigens. We will profile antiviral Treg cell characteristics on an epigenetic, transcriptomic, and functional level and further apply cutting-edge technology to map and track individual Treg populations within human lymphoid tissues to deepen our understanding on how Treg cells establish antiviral memory and support adaptive immune responses.Together, this research aims to chart the terrain of antiviral Treg cells in human tissues and offers insights that could lead to novel Treg cell-targeting therapies enhancing resilience against respiratory tract infections.
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2025-2027
- Postdoctoral Researcher, Department of Medicine Solna, Karolinska Institutet, 2025-2025
- Postdoctoral Researcher, Department of Medicine Huddinge, Karolinska Institutet, 2024-2025
- Doctoral Researcher (PhD candidate), Human tissue-resident T cell immunology, Department of Medicine Huddinge, Karolinska Institutet, 2020-2024