Teresa Mortera Blanco

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About me

Teresa Mortera-Blanco is an MEng, MSc, PhD, who works as a Senior Research
Specialist and Biobank Manager at the Center for Hematology and Regenerative
Medicine (HERM) in Eva Hellström-Lindberg laboratory.
She took her undergraduate studies at Bath University (UK) where she obtained
a Masters degree in Chemical Engineering and afterwards moved to Nottingham
University (UK) where she received a Masters in Science in Applied
Biomolecular Technology. She then took her PhD in Chemical Engineering from
Imperial College London (UK) and joined the group at the Karolinska
Institutet in 2012.

Research

Her current research is focused on the isolation and functional
characterisation of stem cells from low risk MDS and specialises in 3D
culture systems, multi-colour flow cytometry and leukemic stem cell
biology.

Articles

Article: JOURNAL OF INTERNAL MEDICINE. 2024;296(1):53-67
Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS-M) prediction in myelodysplastic syndromes
Creignou M; Bernard E; Gasparini A; Tranberg A; Todisco G; Moura PL; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Lorenz F; Rasmussen B; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Elena C; Ferrari J; Galli A; Pozzi S; Malcovati L; Edgren G; Crowther MJ; Jaedersten M; Papaemmanuil E; Hellstroem-Lindberg E
Article: BLOOD. 2024;143(11):953-966
Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation
Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Hoegstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellstroem-Lindberg E; Woll PS; Jacobsen SEW
Article: CANCER RESEARCH. 2024;84(2):211-225
Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts
Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267
Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Todisco G; Creignou M; Bernard E; Bjorklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Larsson SV; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellstroem-Lindberg E
Journal article: HEMASPHERE. 2023;7(Suppl):e22964a1
P713: EXPLORING CLONAL COMPETITION THROUGH 12‐YEAR FOLLOW‐UP OF AN MDS‐RS PATIENT WITH DUAL SF3B1 MUTATIONS
Moura P; Hofman I; Nannya Y; Aliouat A; Mortera‐Blanco T; Yoshizato T; Saiki R; Nakagawa M; Björklund A; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir E; Woll P; Jacobsen SE; Ogawa S; Lindberg EH
Journal article: LEUKEMIA RESEARCH. 2023;128:107256
UNDERSTANDING CMML BIOLOGY BY INTEGRATIVE ANALYSIS OF EXOME SEQUENCING, RNA SEQUENCING, AND METHYLOME IN A LARGE PATIENT COHORT
Kynning MK; Nannya Y; Todisco G; Yoshizato T; Tesi B; Mortera-Blanco T; Bjorklund A-C; Bruck O; Ohyashiki K; Ishikawa T; Ochi Y; Haferlach T; Mustjoki S; Hellstrom-Lindberg E; Ogawa S; Ungerstedt J
Journal article: LEUKEMIA RESEARCH. 2023;128:107119
EARLY TRANSFUSION PATTERNS PREDICT OUTCOMES INDEPENDENTLY OF IPSS-M SCORE IN MYELODYSPLASTIC SYNDROMES
Creignou M; Bernard E; Crowther M; Tranberg A; Todisco G; Moura P; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Lorenz F; Rasmussen B; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Edgren G; Jadersten M; Papaemmanuil E; Hellstrom-Lindberg E
Journal article: LEUKEMIA RESEARCH. 2023;128:107135
ACCELERATED RNA SPLICING DYNAMICS DURING ERYTHROID DIFFERENTIATION AMPLIFY MIS-SPLICING IN SF3B1-MUTANT MDS-RS
Moura P; Mortera-Blanco T; Hofman I; Todisco G; Kretzschmar W; Bjorklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellstrom-Lindberg E
Article: BLOOD ADVANCES. 2022;6(10):2992-3005
Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs
Asimomitis G; G. Deslaurnes A; Kotini AG; Bernard E; Esposito D; Olszewska M; Spyrou N; Ossa JA; Mortera-Blanco T; Koche R; Malcovati L; Ogawa S; Cazzola M; Aaronson SA; Hellstro-Lindberg E; Papaemmanuil E; Nannya Y; Papapetrou EP
Article: NATURE CELL BIOLOGY. 2022;24(3):299-306
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome
Guzzi N; Muthukumar S; Ciesla M; Todisco G; Ngoc PCT; Madej M; Munita R; Fazio S; Ekstrom S; Mortera-Blanco T; Jansson M; Nannya Y; Cazzola M; Ogawa S; Malcovati L; Hellstrom-Lindberg E; Dimitriou M; Bellodi C
Journal article: BLOOD. 2021;138:146
Integrative Analysis of Primary SF3B1 ^mt Ring Sideroblasts Provides Fundamental Insights into MDS-RS Pathogenesis and Dyserythropoiesis
Moura PL; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar WW; Barbosa I; Bjorklund A-C; Walldin G; Jansson M; Yoshizato T; Woll PS; Jacobsen SEW; Lindberg EH
Journal article: LEUKEMIA RESEARCH. 2021;108:106679.9
O13 Topic: AS01-Diagnosis/AS01c-Molecular aberrations (cytogenetic, genetic, gene expression) WHOLE TRANSCRIPTOME ANALYSIS IDENTIFIES DISTINCT GENE EXPRESSION PROFILES BETWEEN SF3B1MUT AND SF3B1WT MYELODYSPLASTIC SYNDROME WITH RING SIDEROBLASTS
Todisco G; Creignou M; Bernard E; Björklund A-C; Moura P; Jansson M; Barbosa I; Chang D; Venckute S; Walldin G; Tesi B; Mortera-Blanco T; Papaemmanuil E; Hellström-Lindberg E
Article: LEUKEMIA. 2020;34(1):271-282
A three-dimensional in vitro model of erythropoiesis recapitulates erythroid failure in myelodysplastic syndromes
Elvarsdottir EM; Mortera-Blanco T; Dimitriou M; Bouderlique T; Jansson M; Hofman IJF; Conte S; Karimi M; Sander B; Douagi I; Woll PS; Hellstrom-Lindberg E
Article: BLOOD. 2017;130(7):881-890
SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E
Article: ONCOTARGET. 2016;7(45):72685-72698
Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality
Dimitriou M; Woll PS; Mortera-Blanco T; Karimi M; Wedge DC; Doolittle H; Douagi I; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;171(4):478-490
Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
Conte S; Katayama S; Vesterlund L; Karimi M; Dimitriou M; Jansson M; Mortera-Blanco T; Unneberg P; Papaemmanuil E; Sander B; Skoog T; Campbell P; Walfridsson J; Kere J; Hellstrom-Lindberg E
Article: CANCER CELL. 2014;25(6):794-808
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Journal article: BLOOD. 2013;122(21):4195
Diverse Genetic Lesions In Myelodysplastic Syndromes Originate Exclusively In Rare MDS Stem Cells
Woll P; Kjällquist U; Chowdhury O; Erlandsson R; Doolittle H; Ngara M; Anderson K; Giannoulatou E; Taylor S; Deng Q; Mead AJ; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Josefsen D; Kvalheim G; Göhring G; Schlegelberger B; Tobiasson M; Holm MS; Hokland P; Fenaux P; Nerlov C; Dybedal I; Nilsson L; Sandberg R; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Article: LEUKEMIA. 2013;27(4):889-896
The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts
Nikpour M; Scharenberg C; Liu A; Conte S; Karimi M; Mortera-Blanco T; Giai V; Fernandez-Mercado M; Papaemmanuil E; Hogstrand K; Jansson M; Vedin I; Wainscoat JS; Campbell P; Cazzola M; Boultwood J; Grandien A; Hellstrom-Lindberg E
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(62):3654
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
Mortera-Blanco T; Rende M; Macedo H; Farah S; Bismarck A; Mantalaris A; Panoskaltsis N
Article: BIOMATERIALS. 2011;32(35):9263-9270
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds
Mortera-Blanco T; Mantalaris A; Bismarck A; Aqel N; Panoskaltsis N
Article: BIOMATERIALS. 2010;31(8):2243-2251
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia
Blanco TM; Mantalaris A; Bismarck A; Panoskaltsis N
Journal article: BLOOD. 2009;114(22):503
Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold.
Mortera-Blanco T; Mantalaris A; Bismarck A; Panoskaltsis N
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All other publications

Preprint: BIORXIV. 2023
Erythroid differentiation intensifies RNA mis-splicing inSF3B1-mutant myelodysplastic syndromes with ring sideroblasts
Moura P; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar W; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellström-Lindberg E
Conference publication: BLOOD. 2022;140:6898-6899
Long-Term Clonal Inversion in an MDS-RS Case with Dual SF3B1 Mutations
Moura PL; Hofman IJF; Nannya Y; Aliouat A; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Bjorklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellstrom-Lindberg E
Meeting abstract: BLOOD. 2022;140:6968-6970
Transfusion Patterns during Early Follow-up Predict Overall Survival Independently of IPSS-M in Patients with Myelodysplastic Syndromes
Creignou M; Bernard E; Crowther M; Tranberg A; Ejerblad E; Nilsson L; Garelius H; Antunovic P; Rasmussen BEH; Lorenz F; Todisco G; Walldin G; Mortera-Blanco T; Jansson M; Tobiasson M; Edgren G; Jadersten M; Papaemmanuil E; Hellstrom-Lindberg E
Letter: BLOOD ADVANCES. 2022;6(16):4705-4709
The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS
Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jadersten M; Hellstrom-Lindberg E
Meeting abstract: BLOOD. 2021;138:147
Isogenic MDS-RS Patient-Derived iPSCs Define the Mis-Spliced Transcript Repertoire and Chromatin Landscape of SF3B1-Mutant Hematopoietic Stem/Progenitor Cells
Simomitis GA; Deslauriers AG; Kotini AG; Bernard E; Esposito D; Olszewska M; Spyrou N; Ossa JA; Mortera-Blanco T; Koche R; Aaronson S; Hellstrom-Lindberg E; Papaemmanuil E; Papapetrou EP
Meeting abstract: BLOOD. 2021;138:3695
Whole Transcriptome Analysis Identifies Distinct Gene Expression Profiles between SF3B1mut and SF3B1 wt Myelodysplastic Syndrome with Ring Sideroblasts
Todisco G; Creignou M; Bernard E; Björklund A-C; Moura PL; Jansson M; Chang D; Venckute S; Walldin G; Malcovati L; Tesi B; Mortera-Blanco T; Barbosa I; Papaemmanuil E; Lindberg EH
Conference publication: LEUKEMIA RESEARCH. 2021;108:S10-S11
WHOLE TRANSCRIPTOME ANALYSIS IDENTIFIES DISTINCT GENE EXPRESSION PROFILES BETWEEN SF3B1MUT AND SF3B1WT MYELODYSPLASTIC SYNDROME WITH RING SIDEROBLASTS
Todisco G; Creignou M; Bernard E; Bjorklund A-C; Moura P; Jansson M; Barbosa I; Chang D; Venckute S; Walldin G; Tesi B; Mortera-Blanco T; Papaemmanuil E; Hellstrom-Lindberg E
Conference publication: BLOOD. 2019;134:2993
Identification of an Expanded Immature Cell Population in Human Bone Marrow during Erythroid Responses to ESA Treatment
Hofman IJF; Mortera-Blanco T; Larsson SV; Jacobsen SEW; Woll PS; Dimitriou M; Lindberg EH
Review: WORLD JOURNAL OF STEM CELLS. 2019;11(8):476-490
Bone marrow microenvironment: The guardian of leukemia stem cells
Houshmand M; Blanco TM; Circosta P; Yazdi N; Kazemi A; Saglio G; Zarif MN
Conference publication: HAEMATOLOGICA. 2016;101:159
SF3B1 MUTATIONS IN MDS-RS ARISE IN MULTIPOTENT HEMOPOETIC STEM CELLS
Mortera-Blanco T; Dimitriou M; Woll PS; Elvarsdottir E; Karimi M; Conte S; Jansson M; Douagi I; Papaemmanuil E; Jacobsen SE; Hellstrom-Lindberg E
Conference publication: HAEMATOLOGICA. 2016;101:69
A CULTURE MODEL MIMICKING THE BM-NICHE ALLOWS FOR STUDYING THE DYSREGULATED ERYTHROPOIESIS OF SF3B1 MUTATED MYELODYSPLASTIC SYNDROME WITH RINGED SIDEROBLASTS
Elvarsdottir EM; Mortera-Blanco T; Dimitriou M; Conte S; Sander B; Jansson M; Douagi I; Jacobsen SE; Hellstrom-Lindberg E
Book chapter: COMPREHENSIVE BIOTECHNOLOGY. 2016;p. 225-235
5.17 Tissue Engineering of Normal and Abnormal Bone Marrow☆
Mortera-Blanco T; Rende M; Panoskaltsis N; Mantalaris A
Conference publication: LEUKEMIA RESEARCH. 2015;39:S36
CHARACTERIZATION OF THE HEMATOPOIETIC STEM AND PROGENITOR CELL HIERARCHY IN MYELODYSPLASTIC SYNDROMES PATIENTS WITH MONOSOMY 7 AS THE SOLE CYTOGENETIC ABNORMALITY
Dimitriou M; Mortera-Blanco T; Woll PS; Karimi M; Doolittle H; Wedge DC; Papaemmanuil E; Jacobsen SE; Hellstrom-Lindberg E
Corrigendum: CANCER CELL. 2015;27(4):603-605
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Conference publication: BLOOD. 2014;124(21):3490
Characterization of the Hematopoietic Stem and Progenitor Cell Hierarchy in Myelodysplastic Syndromes Patients with Monosomy 7 As the Sole Cytogenetic Abnormality
Dimitriou M; Mortera-Blanco T; Woll PS; Karimi M; Doolittle H; Jacobsen SEW; Hellstrom-Lindberg E
Corrigendum: CANCER CELL. 2014;25(6):861
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Meeting abstract: BLOOD. 2013;122(21):2408
Erythropoiesis In SF3B1 Mutated RARS Is Disrupted During Terminal Erythroid Maturation
Conte S; Vesterlund L; Katayama S; Karimi M; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbell PJ; Kere J; Unneberg P; Hellstroem-Lindberg E
Meeting abstract: LEUKEMIA RESEARCH. 2013;37:S24-S25
Aberrant splicing during erythroid differentiation in SF3B1 mutated sideroblastic anemia
Conte S; Vesterlund L; Katayama S; Karimi M; Unneberg P; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbell P; Kere J; Hellstrom-Lindberg E
Conference publication: HAEMATOLOGICA. 2013;98:73-74
ABERRANT SPLICING DURING ERYTHROID DIFFERENTIATION IN SF3B1 MUTATED SIDEROBLASTIC
Conte S; Vesterlund L; Katayama S; Karimi M; Unneberg P; Papaemmanuil E; Jansson M; Mortera-Blanco T; Dimitriou M; Sander B; Skoog T; Campbells P; Kere J; Hellstrom-Lindberg E
Meeting abstract: BLOOD. 2012;120(21):276
Physiologic Erythropoiesis with Enhanced Globin Switching and Endogenous Cytokine Production in a Long-Term Serum-free in Vitro human Bone Marrow Biomimicry
Rende M; Fauzi I; Mortera-Blanco T; da Costa Medeiros JM; Mantalaris A; Panoskaltsis N
Book chapter: COMPREHENSIVE BIOTECHNOLOGY. 2011;p. 331-340
5.26 Tissue Engineering of Normal and Abnormal Bone Marrow
Mortera-Blanco T; Panoskaltsis N; Mantalaris A
Review: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2009;6(32):209-232
Stem cell bioprocessing: fundamentals and principles
Placzek MR; Chung I-M; Macedo HM; Ismail S; Blanco TM; Lim M; Cha JM; Fauzi I; Kang Y; Yeo DCL; Ma CYJ; Polak JM; Panoskaltsis N; Mantalaris A
Conference publication: BLOOD. 2009;114(22):208
Long-Term in Vitro Cytokine-Free and Serum-Free Culture of Human Cord Blood Mononuclear Cells in a Three-Dimensional Scaffold
Mortera-Blanco T; Mantalaris A; Bismarck A; Panoskaltsis N
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Employments

Senior Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2022-
Senior Research Specialist, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2024-2025

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