Sylvain Peuget

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About me

Dr. Sylvain Peuget is Assistant Professor at the Department of Microbiology,
Tumor and Cell Biology (MTC). His research is focused on the molecular
function of the tumor suppressor p53, its role during inflammation and its
regulation by the human microbiota. He defended his PhD in 2012 at the Cancer
Research Center of Marseille (INSERM/CNRS/Aix-Marseille University, France)
on the role of the p53 co-factor TP53INP1 during the pancreatic
carcinogenesis, and performed his postodoctoral research in Galina
Selivanova’s group at the Karolinska Institute on the molecular mechanism
of action of p53-reactivating compounds.

Articles

Article: BRITISH JOURNAL OF CANCER. 2022;127(11):2060-2071
Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
Zhou X; Santos GS; Zhan Y; Oliveira MMS; Rezaei S; Singh M; Peuget S; Westerberg LS; Johnsen JI; Selivanova G
Article: MOLECULAR CANCER THERAPEUTICS. 2022;21(10):1524-1534
Decreased DNA Damage and Improved p53 Specificity of RITA Analogs
Zhan Y; Zhou X; Peuget S; Singh M; Peyser BD; Fan Z; Selivanova G
Article: ONCOGENE. 2022;41(15):2173-2186
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization
Aschtgen M-S; Fragkoulis K; Sanz G; Normark S; Selivanova G; Henriques-Normark B; Peuget S
Article: BREAST CANCER RESEARCH. 2020;22(1):80
Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: SCIENTIFIC REPORTS. 2020;10(1):1049
Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
Zhu J; Singh M; Selivanova G; Peuget S
Article: CELL DEATH AND DISEASE. 2019;10(11):845
RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity
Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
Article: SCIENTIFIC REPORTS. 2019;9(1):2379
Prediction of response to anti-cancer drugs becomes robust via network integration of molecular data
Franco M; Jeggari A; Peuget S; Bottger F; Selivanova G; Alexeyenko A
Article: CANCER CELL. 2014;26(6):863-879
Copy Number Gain of hsa-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers
Chaluvally-Raghavan P; Zhang F; Pradeep S; Hamilton MP; Zhao X; Rupaimoole R; Moss T; Lu Y; Yu S; Pecot CV; Aure MR; Peuget S; Rodriguez-Aguayo C; Han H-D; Zhang D; Venkatanarayan A; Krohn M; Kristensen VN; Gagea M; Ram P; Liu W; Lopez-Berestein G; Lorenzi PL; Borresen-Dale A-L; Chin K; Gray J; Dusetti NJ; McGuire SE; Flores ER; Sood AK; Mills GB
Article: MOLECULAR & CELLULAR ONCOLOGY. 2014;1(3):e964044
Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53.
Bonacci T; Peuget S; Soubeyran P; Iovanna J; Dusetti NJ
Article: CELL DEATH AND DIFFERENTIATION. 2014;21(7):1107-1118
Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation
Peuget S; Bonacci T; Soubeyran P; Iovanna J; Dusetti NJ
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(6):1996-2004
Oxidative Stress Induced by Inactivation of TP53INP1 Cooperates with KrasG12D to Initiate and Promote Pancreatic Carcinogenesis in the Murine Pancreas
Al Saati T; Clerc P; Hanoun N; Peuget S; Lulka H; Gigoux V; Capilla F; Beluchon B; Couvelard A; Selves J; Buscail L; Carrier A; Dusetti N; Dufresne M
Article: RESULTS IN IMMUNOLOGY. 2013;3:51-56
Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients.
Saadi H; Seillier M; Sandi MJ; Peuget S; Kellenberger C; Gravis G; Dusetti NJ; Iovanna JL; Rocchi P; Amri M; Carrier A
Article: CELL DEATH AND DIFFERENTIATION. 2012;19(9):1525-1535
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death
Seillier M; Peuget S; Gayet O; Gauthier C; N'Guessan P; Monte M; Carrier A; Iovanna JL; Dusetti NJ
Article: ONCOGENE. 2011;30(27):3049-3061
TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression
Seux M; Peuget S; Montero MP; Siret C; Rigot V; Clerc P; Gigoux V; Pellegrino E; Pouyet L; N'Guessan P; Garcia S; Dufresne M; Iovanna JL; Carrier A; Andre F; Dusetti NJ

All other publications

Review: NATURE REVIEWS CANCER. 2024;24(3):192-215
Translating p53-based therapies for cancer into the clinic
Peuget S; Zhou X; Selivanova G
Editorial comment: CANCER DISCOVERY. 2023;13(5):1043-1045
MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation
Peuget S; Selivanova G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs
Zhan Y; Zhou X; Peuget S; Singh M; Peyser BD; Fan Z; Selivanova G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Decreased DNA Damage and Improved p53 Specificity of RITA Analogs
Zhan Y; Zhou X; Peuget S; Singh M; Peyser BD; Fan Z; Selivanova G
Editorial comment: CANCERS. 2021;13(19):4850
p53-Dependent Repression: DREAM or Reality?
Peuget S; Selivanova G
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(7):586-599
Inhibition of p53 inhibitors: progress, challenges and perspectives
Sanz G; Singh M; Peuget S; Selivanova G
Preprint: BIORXIV. 2018
Robust and clinically relevant prediction of response to anti-cancer drugs via network integration of molecular profiles
Franco M; Jeggari A; Peuget S; Böttger F; Selivanova G; Alexeyenko A
Book chapter: ANTIOXIDANT ENZYME. 2012;p.
Antioxidant Role of p53 and of Its Target TP53INP1
Seillier M; Peuget S; Dusetti NJ; Carrier A

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