Sylvain Peuget

In recent years, scientists have discovered that the composition of the intestinal flora can influence several diseases, including cancer. Several studies have shown that the bacteria found in the intestines of cancer patients differ from the flora of healthy individuals. In addition, it has been shown that specific bacteria, such as Helicobacter pylori, can be carcinogenic. However, the exact molecular mechanisms for how bacteria influence cancer development are still not clear. In this research project, we want to understand how bacteria that have a connection to the origin of tumors can affect our defense against cancer. The most important barrier against cancer in our body is the tumor suppressor gene called p53. Our hypothesis is that certain bacteria can prevent p53 from working properly, which enables cancer development. Therefore, we will study which of the bacteria's molecular systems are involved and how they affect the human cells, so that cancer develops. Understanding which molecules are affected will help us find new opportunities for treatment. Despite all the knowledge we have gained about colorectal cancer and the advances made in treatment, it is still a deadly disease. There is therefore a need for new treatment methods to help patients. By understanding the relationship between gut bacteria and cancer, we want to find new opportunities for cancer treatments that can target the tumor but also the "bad" bacteria. In addition, we also hope to find new markers to identify which treatment is best suited for a particular patient.