Stig Linder

About me
Publications
Public outreach and news

About me

Stig Linder was appointed adjunct professor at KI in 1999 and became full professor in 2015. His research aims at developing new cancer drugs; for example, Stig Linder’s research group has developed a simple blood test for tumour cell death in collaboration with a biotech company.

Articles

Article: NPJ PRECISION ONCOLOGY. 2024;8(1):53
Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer.
Lindahl G; Fjellander S; Selvaraj K; Vildeval M; Ali Z; Almter R; Erkstam A; Rodriguez GV; Abrahamsson A; Kersley ÅR; Fahlgren A; Kjølhede P; Linder S; Dabrosin C; Jensen L
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1055067
The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
Corno C; D'Arcy P; Bagnoli M; Paolini B; Costantino M; Carenini N; Corna E; Alberti P; Mezzanzanica D; Colombo D; Linder S; Arrighetti N; Perego P
Article: FRONTIERS IN ONCOLOGY. 2022;12:852980
Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
Gubat J; Selvaraju K; Sjoestrand L; Kumar Singh D; Turkina MV; Schmierer B; Sabatier P; Zubarev RA; Linder S; D'Arcy P
Article: BIOCHEMICAL PHARMACOLOGY. 2022;197:114900
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells
Colombo D; Gatti L; Sjostrand L; Carenini N; Costantino M; Corna E; Arrighetti N; Zuccolo M; De Cesare M; Linder S; D'Arcy P; Perego P
Article: BIOMOLECULES. 2021;11(9):1339
Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System
Selvaraju K; Lotfi K; Gubat J; Miquel M; Nilsson A; Hill J; Jensen LD; Linder S; D'Arcy P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4750
Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
Zhang X; Shetty M; Clemente V; Linder S; Bazzaro M
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(24):15075-15093
Dienone Compounds: Targets and Pharmacological Responses
Bazzaro M; Linder S
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2020;889:173709
Identification of proteasome inhibitors using analysis of gene expression profiles
Mofers A; Selvaraju K; Gubat J; D 'Arcy P; Linder S
Article: INVESTIGATIONAL NEW DRUGS. 2020;38(5):1448-1453
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
Rowinsky EK; Paner A; Berdeja JG; Paba-Prada C; Venugopal P; Porkka K; Gullbo J; Linder S; Loskog A; Richardson PG; Landgren O
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(13):E4757-4757
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
Pellegrini P; Selvaraju K; Faustini E; Mofers A; Zhang X; Ternerot J; Schubert A; Linder S; D'Arcy P
Article: TOXICON. 2020;175:49-56
Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours
Sousa ML; Ribeiro T; Vasconcelos V; Linder S; Urbatzka R
Article: PLOS ONE. 2019;14(10):e0223807
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
Mofers A; Perego P; Selvaraju K; Gatti L; Gullbo J; Linder S; D'Arcy P
Article: ONCOTARGET. 2019;10(51):5372-5382
A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation.
Karlsson H; Senkowski W; Fryknäs M; Mansoori S; Linder S; Gullbo J; Larsson R; Nygren P
Article: SCIENTIFIC REPORTS. 2019;9(1):9841
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Article: BIOCHIMIE. 2019;162:46-54
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Zhang X; Selvaraju K; Saei AA; D'Arcy P; Zubarev RA; Arner ESJ; Linder S
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019;2019:1659468-11
Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment
Zhang X; Espinosa B; Saei AA; D'Arcy P; Zubarev RA; Linder S
Article: CANCER LETTERS. 2019;448:70-83
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation
Hillert E-K; Brnjic S; Zhang X; Mazurkiewicz M; Saei AA; Mofers A; Selvaraj K; Zubarev R; Linder S; D'Arcy P
Article: FRONTIERS IN ONCOLOGY. 2019;9:224
Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation
Sousa ML; Preto M; Vasconcelos V; Linder S; Urbatzka R
Article: BIOCHEMICAL PHARMACOLOGY. 2018;156:291-301
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and Check for mitochondrial damage
Zhang X; Pellegrini P; Saei AA; Hillert E-K; Mazurkiewicz M; Olofsson MH; Zubarev RA; D'Arcy P; Linder S
Article: CANCER CELL INTERNATIONAL. 2018;18:147
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini P; Serviss JT; Lundback T; Bancaro N; Mazurkiewicz M; Kolosenko I; Yu D; Haraldsson M; D'Arcy P; Linder S; De Milito A
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Tresaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzen H-SM; Orwar O; Ostman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arner ESJ
Article: PLOS ONE. 2017;12(12):e0188817
Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
Ribeiro T; Lemos F; Preto M; Azevedo J; Sousa ML; Leao PN; Campos A; Linder S; Vitorino R; Vasconcelos V; Urbatzka R
Article: ONCOTARGET. 2017;8(52):90225-90237
MYC is downregulated by a mitochondrial checkpoint mechanism
Zhang X; Mofers A; Hydbring P; Olofsson MH; Guo J; Linder S; D'Arcy P
Article: ONCOTARGET. 2017;8(13):21115-21127
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
Mazurkiewicz M; Hillert E-K; Wang X; Pellegrini P; Olofsson MH; Selvaraju K; D'Arcy P; Linder S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):djw236-14
Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ma R; Karthik G-M; Lovrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: SCIENTIFIC REPORTS. 2016;6:38343
Iron chelators target both proliferating and quiescent cancer cells
Fryknas M; Zhang X; Bremberg U; Senkowski W; Olofsson MH; Brandt P; Persson I; D'Arcy P; Gullbo J; Nygren P; Schughart LK; Linder S; Larsson R
Article: BLOOD CANCER JOURNAL. 2016;6(11):e492
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
Paulus A; Akhtar S; Caulfield TR; Samuel K; Yousaf H; Bashir Y; Paulus SM; Tran D; Hudec R; Cogen D; Jiang J; Edenfield B; Novak A; Ansell SM; Witzig T; Martin P; Coleman M; Roy V; Ailawadhi S; Chitta K; Linder S; Chanan-Khan A
Article: CANCER RESEARCH. 2016;76(15):4525-4534
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors
Shukla N; Somwar R; Smith RS; Ambati S; Munoz S; Merchant M; D'Arcy P; Wang X; Kobos R; Antczak C; Bhinder B; Shum D; Radu C; Yang G; Taylor BS; Ng CKY; Weigelt B; Khodos I; de Stanchina E; Reis-Filho JS; Ouerfelli O; Linder S; Djaballah H; Ladanyi M
Article: EJNMMI RESEARCH. 2016;6(1):58
Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
Cheng Q; Wallberg H; Grafstrom J; Lu L; Thorell J-O; Olofsson MH; Linder S; Johansson K; Tegnebratt T; Arner ESJ; Stone-Elander S; Ahlzen H-SM; Stahl S
Article: SCIENTIFIC REPORTS. 2016;6:26979
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Wang X; Mazurkiewicz M; Hillert E-K; Olofsson MH; Pierrou S; Hillertz P; Gullbo J; Selvaraju K; Paulus A; Akhtar S; Bossler F; Khan AC; Linder S; D'Arcy P
Article: LAKARTIDNINGEN. 2015;112:DSAR
[Handling of misconduct in Swedish research must be improved. More strict investigative procedures, tougher punishments and withdrawals are required].
Linder S
Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2015;86(5):1036-1048
Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15
Wang X; D'Arcy P; Caulfield TR; Paulus A; Chitta K; Mohanty C; Gullbo J; Chanan-Khan A; Linder S
Article: NUTRIENTS. 2015;7(6):4978-4994
Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
Brodin O; Eksborg S; Wallenberg M; Asker-Hagelberg C; Larsen EH; Mohlkert D; Lenneby-Helleday C; Jacobsson H; Linder S; Misra S; Bjornstedt M
Article: MOLECULAR CANCER THERAPEUTICS. 2015;14(6):1504-1516
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Senkowski W; Zhang X; Olofsson MH; Isacson R; Hoglund U; Gustafsson M; Nygren P; Linder S; Larsson R; Fryknas M
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(3):377-390
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstroom macroglobulinaemia tumour cells
Chitta K; Paulus A; Akhtar S; Blake MKK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):e51-e61
Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
Kolosenko I; Fryknas M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbacker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grander D; Linder S; Tamm KP; De Milito A
Article: ANTIOXIDANTS & REDOX SIGNALING. 2014;21(17):2271-2285
Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
Brnjic S; Mazurkiewicz M; Fryknas M; Sun C; Zhang X; Larsson R; D'Arcy P; Linder S
Article: PLOS ONE. 2014;9(10):e108839
Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
Sun C; Roboti P; Puumalainen M-R; Fryknas M; Wang X; D'Arcy P; Hult M; High S; Linder S; Swanton E
Article: CLINICAL CANCER RESEARCH. 2014;20(15):3908-3914
Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets
D'Arcy P; Linder S
Article: MOLECULAR PHARMACOLOGY. 2014;85(6):932-945
The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death
Wang X; Stafford W; Mazurkiewicz M; Fryknas M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arner ESJ; D'Arcy P; Linder S
Article: AUTOPHAGY. 2014;10(4):562-571
Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine
Pellegrini P; Strambi A; Zipoli C; Hagg-Olofsson M; Buoncervello M; Linder S; De Milito A
Article: LIVER INTERNATIONAL. 2014;34(3):367-378
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts
Thulin P; Nordahl G; Gry M; Yimer G; Aklillu E; Makonnen E; Aderaye G; Lindquist L; Mattsson CM; Ekblom B; Antoine DJ; Park BK; Linder S; Harrill AH; Watkins PB; Glinghammar B; Schuppe-Koistinen I
Article: RSC MEDICINAL CHEMISTRY. 2014;5(3):376-385
Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
Haglund C; Mohanty C; Fryknas M; D'Arcy P; Larsson R; Linder S; Rickardson L
Article: BLOOD. 2014;123(5):706-716
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
Tian Z; D'Arcy P; Wang X; Ray A; Tai Y-T; Hu Y; Carrasco RD; Richardson P; Linder S; Chauhan D; Anderson KC
Article: NATURE COMMUNICATIONS. 2014;5:3295
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Zhang X; Fryknas M; Hernlund E; Fayad W; De Milito A; Olofsson MH; Gogvadze V; Dang L; Pahlman S; Schughart LAK; Rickardson L; Darcy P; Gullbo J; Nygren P; Larsson R; Linder S
Article: AUTOPHAGY. 2014;10(1):57-69
Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter
Aftab O; Fryknas M; Zhang X; De Milito A; Hammerling U; Linder S; Larsson R; Gustafsson MG
Article: BREAST. 2013;22(5):643-649
Identification of intermediate risk breast cancer patients with1-3 positive lymph nodes and excellent survival after tamoxifen as only systemic adjuvant therapy by use of markers of proliferation and apoptosis
Linderholm BK; Linder S; Arnesson L-G; Stal O
Article: BMC CANCER. 2013;13:374
Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
Fryknas M; Gullbo J; Wang X; Rickardson L; Jarvius M; Wickstrom M; Hassan S; Andersson C; Gustafsson M; Westman G; Nygren P; Linder S; Larsson R
Article: STEM CELLS. 2013;31(8):1715-1725
Alterations in the Cellular Immune Compartment of Patients Treated with Third-Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation
Jitschin R; Mougiakakos D; Von Bahr L; Voelkl S; Moll G; Ringden O; Kiessling R; Linder S; Le Blanc K
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2013;62(8):1359-1368
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.
Sarhan D; Wennerberg E; D'Arcy P; Gurajada D; Linder S; Lundqvist A
Article: INVESTIGATIONAL NEW DRUGS. 2013;31(3):587-598
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
Felth J; Lesiak-Mieczkowska K; D'Arcy P; Haglund C; Gullbo J; Larsson R; Linder S; Bohlin L; Fryknas M; Rickardson L
Article: VIROLOGY. 2013;440(1):41-50
Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells
Li R; Sharma BN; Linder S; Gutteberg TJ; Hirsch HH; Rinaldo CH
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(3):2562-2573
Site-specifically ¹¹C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death
Cheng Q; Lu L; Grafstrom J; Olofsson MH; Thorell J-O; Samen E; Johansson K; Ahlzen H-S; Linder S; Arner ESJ; Stone-Elander S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;431(2):117-123
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells
Jarvius M; Fryknas M; D'Arcy P; Sun C; Rickardson L; Gullbo J; Haglund C; Nygren P; Linder S; Larsson R
Article: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2013;13(2):356-363
A Natural Anticancer Agent Thaspine Targets Human Topoisomerase IB
Castelli S; Katkar P; Vassallo O; Falconi M; Linder S; Desideri A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(36):30664-30676
Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress
Marino ML; Pellegrini P; Di Lernia G; Djavaheri-Mergny M; Brnjic S; Zhang X; Hagg M; Linder S; Fais S; Codogno P; De Milito A
Article: PLOS ONE. 2012;7(8):e42151
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.
Cheng Q; Lu L; Grafström J; Olofsson MH; Thorell J-O; Samén E; Johansson K; Ahlzén H-S; Stone-Elander S; Linder S; Arnér ESJ; Sel-tag Imaging Project
Article: BIOCHEMICAL JOURNAL. 2012;442(3):639-648
Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response
McKibbin C; Mares A; Piacenti M; Williams H; Roboti P; Puumalainen M; Callan AC; Lesiak-Mieczkowska K; Linder S; Harant H; High S; Flitsch SL; Whitehead RC; Swanton E
Article: EUROPEAN JOURNAL OF CANCER. 2012;48(3):396-406
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Hernlund E; Olofsson MH; Fayad W; Fryknas M; Lesiak-Mieczkowska K; Zhang X; Brnjic S; Schmidt V; D'Arcy P; Sjoblom T; De Milito A; Larsson R; Linder S
Article: CANCER SCIENCE. 2011;102(12):2206-2213
Novel activity of acriflavine against colorectal cancer tumor cells
Hassan S; Laryea D; Mahteme H; Felth J; Fryknas M; Fayad W; Linder S; Rickardson L; Gullbo J; Graf W; Pahlman L; Glimelius B; Larsson R; Nygren P
Article: NATURE MEDICINE. 2011;17(12):1636-U150
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy P; Brnjic S; Olofsson MH; Fryknäs M; Lindsten K; De Cesare M; Perego P; Sadeghi B; Hassan M; Larsson R; Linder S
Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2011;78(4):547-557
Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties
Fayad W; Rickardson L; Haglund C; Olofsson MH; D'Arcy P; Larsson R; Linder S; Fryknas M
Article: BIOCHEMICAL PHARMACOLOGY. 2011;82(2):139-147
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment
Gullbo J; Fryknas M; Rickardson L; Darcy P; Hagg M; Wickstrom M; Hassan S; Westman G; Brnjic S; Nygren P; Linder S; Larsson R
Article: EUROPEAN JOURNAL OF CANCER. 2011;47(1):131-137
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer
De Petris L; Branden E; Herrmann R; Sanchez BC; Koyi H; Linderholm B; Lewensohn R; Linder S; Lehtio J
Article: PHYTOMEDICINE. 2010;17(10):789-793
Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus
Bhutani KK; Paul AT; Fayad W; Linder S
Article: INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY. 2010;48(3):258-264
Screening of natural products for therapeutic activity against solid tumors
El-Menshawi BS; Fayad W; Mahmoud K; El-Hallouty SM; El-Manawaty M; Olofsson MH; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(10):2450-2455
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model
Fayad W; Brnjic S; Berglind D; Blixt S; Shoshan MC; Berndtsson M; Olofsson MH; Linder S
Article: PLOS ONE. 2009;4(10):e7238
Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters
Fayad W; Fryknas M; Brnjic S; Olofsson MH; Larsson R; Linder S
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(12):1607-1613
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation
Hernlund E; Kutuk O; Basaga H; Linder S; Panaretakis T; Shoshan M
Article: JOURNAL OF CHEMICAL BIOLOGY. 2009;2(2):81-87
Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.
Berndtsson M; Hernlund E; Shoshan MC; Linder S
Article: CANCER BIOMARKERS. 2009;5(3):117-125
Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker
Olofsson MH; Cummings J; Fayad W; Brnjic S; Herrmann R; Berndtsson M; Hodgkinson C; Dean E; Odedra R; Wilkinson RW; Mundt KE; Busk M; Dive C; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(6):1463-1469
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system
Berndtsson M; Beaujouin M; Rickardson L; Havelka AM; Larsson R; Westman J; Liaudet-Coopman E; Linder S
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2009;43(2):98-103
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines
Ullen A; Schwarz S; Lennartsson L; Kalkner K-M; Sandstrom P; Costa F; Lennernas B; Linder S; Nilsson S
Article: ANTICANCER RESEARCH. 2009;29(1):11-18
Utilization of a Right-handed Coiled-coil Protein from Archaebacterium Staphylothermus marinus as a Carrier for Cisplatin
Eriksson M; Hassan S; Larsson R; Linder S; Ramqvist T; Lovborg H; Vikinge T; Figgemeier E; Muller J; Stetefeld J; Dalianis T; Ozbek S
Article: BMC CHEMICAL BIOLOGY. 2008;8:2
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.
Olofsson MH; Havelka AM; Brnjic S; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):476-483
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
Hernlund E; Ihrlund LS; Khan O; Ates YO; Linder S; Panaretakis T; Shoshan MC
Article: LABORATORY INVESTIGATION. 2008;88(3):256-263
The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity
Ueno T; Elmberger G; Weaver TE; Toi M; Linder S
Article: JOURNAL OF BIOMOLECULAR SCREENING. 2008;13(1):1-8
Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids
Herrmann R; Fayad W; Schwarz S; Berndtsson M; Linder S
Article: LUNG CANCER. 2007;56(3):399-404
The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival
Ulukaya E; Yilmaztepe A; Akgoz S; Linder S; Karadag M
Article: CLINICAL CANCER RESEARCH. 2007;13(11):3198-3206
Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
Olofsson MH; Ueno T; Pan Y; Xu R; Cai F; van der Kuip H; Muerdter TE; Sonnenberg M; Aulitzk WE; Schwarz S; Andersson E; Shoshan MC; Havelka AM; Toi M; Linder S
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(4):1440-1450
Large-scale proteomics analysis of human ovarian cancer for biomarkers
Bengtsson S; Krogh M; Szigyarto CA-K; Uhlen M; Schedvins K; Silfversward C; Linder S; Auer G; Alaiya A; James P
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(1):175-180
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
Berndtsson M; Hagg M; Panaretakis T; Havelka AM; Shoshan MC; Linder S
Article: JOURNAL OF VIROLOGY. 2006;80(16):8279-8282
Loss of cell membrane integrity in Puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin
Klingstroem J; Hardestam J; Stoltz M; Zuber B; Lundkvist A; Linder S; Ahlm C
Article: BRITISH JOURNAL OF CANCER. 2006;94(11):1592-1598
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles
Kramer G; Schwarz S; Hagg M; Havelka AM; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589
Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1
Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: RADIATION ONCOLOGY. 2006;1:4
Is translational research compatible with preclinical publication strategies?
Linder S; Shoshan MC
Article: FEBS LETTERS. 2005;579(14):3090-3094
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis
Berndtsson M; Konishi Y; Bonni A; Hägg M; Shoshan M; Linder S; Havelka AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(1):192-197
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
Erdal H; Berndtsson M; Castro J; Brunk U; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(2):397-405
A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer
Takada M; Kataoka A; Toi M; Bando H; Toyama K; Horiguchi S; Ueno T; Linder S; Saji S; Hayashi Y; Funata N; Kinoshita J; Murakami S; Ohono S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(16):16178-16184
Processing of pulmonary surfactant protein B by napsin and cathepsin H
Ueno T; Linder S; Na CL; Rice WR; Johansson J; Weaver TE
Article: MOLECULAR CANCER THERAPEUTICS. 2004;3(4):489-497
Induction of endoplasmic reticulum stress by ellipticine plant alkaloids
Hägg M; Berndtsson M; Mandic A; Zhou R; Shoshan MC; Linder S
Article: CANCER RESEARCH. 2004;64(5):1751-1756
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
Kramer G; Erdal H; Mertens HJMM; Nap M; Mauermann J; Steiner G; Marberger M; Bivén K; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line
Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: APOPTOSIS. 2003;8(3):263-268
A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera
Bivén K; Erdal H; Hägg M; Ueno T; Zhou R; Lynch M; Rowley B; Wood J; Zhang C; Toi M; Shoshan MC; Linder S
Article: BRITISH JOURNAL OF CANCER. 2003;88(8):1229-1233
Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma
Ueno T; Linder S; Elmberger G
Article: EUROPEAN UROLOGY. 2003;43(4):362-368
Low IL-1α a expression in bladder cancer tissue and survival
Seddighzadeh M; Larsson P; Ulfgren AC; Onelöv E; Berggren P; Tribukait B; Torstensson A; Norming U; Wijkström H; Linder S; Steineck G
Article: EUROPEAN JOURNAL OF CANCER. 2003;39(6):769-774
Measurement of an apoptotic product in the sera of breast cancer patients
Ueno T; Toi M; Bivén K; Bando H; Ogawa T; Linder S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9100-9106
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
Mandic A; Hansson J; Linder S; Shoshan MC
Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259
A novel high-through-put assay for screening of pro-apoptotic drugs
Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;99(5):721-726
Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms
Seddighzadeh M; Steineck G; Larsson P; Wijkström H; Norming U; Onelöv E; Linder S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(9):3003-3013
Calpain-mediated bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis
Mandic A; Viktorsson K; Strandberg L; Heiden T; Hansson J; Linder S; Shoshan MC
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;98(6):895-899
Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles
Alaiya AA; Franzén B; Hagman A; Dysvik B; Roblick UJ; Becker S; Moberger B; Auer G; Linder S
Article: ANTICANCER RESEARCH. 2001;21(4B):2861-2865
Prognostic importance of the uPA/PAI-1 complex in breast cancer
Sten-Linder M; Seddighzadeh M; Engel G; Rutqvist LE; Linder S; Skoog L; Wiman B
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(11):3684-3691
Cisplatin induces the proapoptotic conformation of Bak in a ΔMEKK1-dependent manner
Mandic A; Viktorsson K; Molin M; Akusjärvi G; Eguchi H; Hayashi SI; Toi M; Hansson J; Linder S; Shoshan MC
Article: GENES CHROMOSOMES & CANCER. 2001;31(2):107-116
Haplotype analysis and age estimation of the 113insR CDKN2A founder mutation in Swedish melanoma families
Hashemi J; Bendahl PO; Sandberg T; Platz A; Linder S; Stierner U; Olsson H; Ingvar C; Hansson J; Borg A
Article: BRITISH JOURNAL OF CANCER. 2001;84(3):329-334
Low interleukin-1α messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma
Seddighzadeh M; Steineck G; Jansson O; Larsson P; Wijkström H; Adolfsson J; Portwood N; Hansson J; Linder S
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2001;58(2):307-311
Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry
Alaiya AA; Oppermann M; Langridge J; Roblick U; Egevad L; Brändstedt S; Hellström M; Linder S; Bergman T; Jörnvall H; Auer G
Article: ANTICANCER RESEARCH. 2001;21(1B):509-512
Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx
Nordemar S; Kronenwett U; Auer G; Högmo A; Lindholm J; Edström S; Tryggvasson K; Linder S; Munck-Wikland E
Article: APOPTOSIS. 2000;5(4):355-367
Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin
Viktorsson K; Heiden T; Molin M; Akusjärvi G; Linder S; Shoshan MC
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;86(5):731-736
Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns
Alaiya AA; Franzén B; Hagman A; Silfverswärd C; Moberger B; Linder S; Auer G
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2000;92(9):758A-7759
Re:: Biologic and biochemical analyses of p16^INK4a mutations from primary tumors
Hansson J; Hashemi J; Linder S; Platz A
Article: ELECTROPHORESIS. 2000;21(3):679-686
Identification of gel-separated tumor marker proteins by mass spectrometry
Bergman AC; Benjamin T; Alaiya A; Waltham M; Sakaguchi K; Franzén B; Linder S; Bergman T; Auer G; Appella E; Wirth PJ; Jörnvall H
Article: CELLULAR ONCOLOGY. 2000;21(1):1-9
Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma
Alaiya A; Roblick U; Egevad L; Carlsson A; Franzén B; Volz D; Huwendiek S; Linder S; Auer G
Article: FEBS LETTERS. 1999;462(1-2):129-134
Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas
Chuman Y; Bergman AC; Ueno T; Saito S; Sakaguchi K; Alaiya AA; Franzén B; Bergman T; Arnott D; Auer G; Appella E; Jörnvall H; Linder S
Article: ANTICANCER RESEARCH. 1999;19(4C):3409-3414
Angiostatin fragments in urine from patients with malignant disease
Sten-Linder M; Linder C; Strander H; Munck-Wikland E; Wersäll P; Linder S; Wiman B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 1999;55(3):467-471
Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts
Bergman AC; Alaiya AA; Wendler W; Binetruy B; Shoshan M; Sakaguchi K; Bergman T; Kronenwett U; Auer G; Appella E; Jörnvall H; Linder S
Article: MELANOMA RESEARCH. 1999;9(1):21-30
Melanoma development in relation to nonfunctional p16/INK4A protein and dysplastic naevus syndrome in Swedish melanoma kindreds
Hashemi J; Linder S; Platz A; Hansson J
Article: CLINICAL & EXPERIMENTAL METASTASIS. 1999;17(8):649-654
ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation
Seddighzadeh M; Zhou JN; Kronenwett U; Shoshan MC; Auer G; Sten-Linder M; Wiman B; Linder S
Article: SOMATIC CELL AND MOLECULAR GENETICS. 1998;24(6):327-339
Analysis of mechanisms and frequency of CDKN2A/B gene loss during progression of RAS-transformed rat embryo fibroblast clones
Zhou JN; Hashemi J; Helou K; Zhang A; Röhme D; Zetterberg A; Levan G; Linder S
Article: JOURNAL OF VIROLOGY. 1998;72(10):8358-8361
Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments
Molin M; Shoshan MC; Öhman-Forslund K; Linder S; Akusjärvi G
Article: INTERNATIONAL JOURNAL OF CANCER. 1998;78(1):95-99
Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
Zhou ZJ; Wang JM; Han XL; Zhou JN; Linder S
Article: ELECTROPHORESIS. 1998;19(10):1808-1810
Rapid isolation of phage displayed antibodies to β-actin eluted from two-dimensional electrophoresis gel
Zhou JN; Linder S; Franzén B; Auer G; Hochstrasser DF; Persson MAA
Article: MOLECULAR CANCER RESEARCH. 1998;9(7):565-573
Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop
Ljungdahl S; Linder S; Franzén B; Binétruy B; Auer G; Shoshan MC
Article: ANTICANCER RESEARCH. 1998;18(3B):2063-2068
Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma
Linder C; Linder S; Munck-Wikland E; Strander H
Article: MOLECULAR CARCINOGENESIS. 1998;21(4):234-243
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway
Zhou JN; Ljungdahl S; Shoshan MC; Swedenborg J; Linder S
Article: BRITISH JOURNAL OF CANCER. 1998;77(6):941-945
Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma
Linder C; Byström P; Engel G; Auer G; Aspenblad U; Strander H; Linder S
Article: ANGIOGENESIS. 1998;2(4):365-372
Evaluation of tissue and serum VEGF in patients with head and neck carcinoma.
Linder C; Linder S; Munck-Wikland E; Auer G; Aspenblad U; Strander H
Article: INTERNATIONAL JOURNAL OF CANCER. 1997;73(5):678-682
Phenotypic analysis of ovarian carcinoma: Polypeptide expression in benign, borderline and malignant tumors
Alaiya AA; Franzen B; Fujioka K; Moberger B; Schedvins K; Silversvard C; Linder S; Auer G
Article: FEBS LETTERS. 1997;417(1):17-20
Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen
Bergman AC; Linder C; Sakaguchi K; StenLinder M; Alaiya AA; Franzen B; Shoshan MC; Bergman T; Wiman B; Auer G; Appella E; Jornvall H; Linder S
Article: FEBS JOURNAL. 1997;249(3):648-656
Signal transduction in fibroblasts stably transformed by [Val12]Ras - The activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated
Ljungdahl S; Linder S; Sollerbrant K; Svensson C; Shoshan MC
Article: GENES CHROMOSOMES & CANCER. 1997;20(1):82-89
Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines
Zhou JN; Ljungdahl S; Rohme D; Levan G; Shoshan MC; Linder S
Article: ANTICANCER RESEARCH. 1997;17(4A):2347-2352
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line
Fokstuen T; Rabo YB; Zhou JN; Karlson J; Platz A; Shoshan MC; Hansson J; Linder S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1997;89(10):697-702
Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma
Platz A; Hansson J; ManssonBrahme E; Lagerlof B; Linder S; Lundqvist E; Sevigny P; Inganas M; Ringborg U
Article: BREAST CANCER RESEARCH AND TREATMENT. 1997;42(3):207-213
Distribution of stromelysin-3 mRNA transcripts and microvessels in human breast carcinomas
Linder C; Engel G; Auer G; Strander H; Linder S
Article: BRITISH JOURNAL OF CANCER. 1997;76(1):54-59
Prognostic significance of Ki-67 antigen and p53 protein expression in pancreatic duct carcinoma: A study of the monoclonal antibodies MIB-1 and DO-7 in formalin-fixed paraffin-embedded tumour material
Linder S; Parrado C; Falkmer UG; Blasjo M; Sundelin P; vonRosen A
Article: ANTI-CANCER DRUGS. 1997;8(1):62-66
Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B
Ljungdahl S; Shoshan NC; Linder S
Article: BRITISH JOURNAL OF CANCER. 1996;74(10):1632-1638
Analysis of polypeptide expression in benign and malignant human breast lesions: Down-regulation of cytokeratins
Franzen B; Linder S; Alaiya AA; Eriksson E; Uruy K; Hirano T; Okuzawa K; Auer G
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;69(5):408-414
Assessment of homogeneity in polypeptide expression in breast carcinomas shows widely variable expression in highly malignant tumors
Franzen B; Auer G; Alaiya AA; Eriksson E; Uryu K; Hirano T; Okuzawa K; Kato H; Linder S
Article: ANTICANCER RESEARCH. 1996;16(4A):1931-1935
Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines
Zhou JN; Linder S
Article: ANTI-CANCER DRUGS. 1996;7(4):422-429
Inhibition of tumor cell growth by monoterpenes in vitro: Evidence of a Ras-independent mechanism of action
Karlson J; BorgKarlson AK; Unelius R; Shoshan MC; Wilking N; Ringborg U; Linder S
Article: ONCOLOGY REPORTS. 1996;3(3):443-445
Tissue factor mRNA expression in breast carcinoma cells
Zhou JN; StenLinder M; Linder S
Article: JOURNAL OF VIROLOGY. 1996;70(5):3093-3097
A short peptide fluted from the H-2K(b) molecule of a polyomavirus positive tumor corresponds to polyomavirus large T antigen peptide at amino acids 578 to 585 and induces polyomavirus-specific immunity
Berke Z; Palmer S; Bergman T; Wester D; Svedmyr J; Linder S; Jornvall H; Dalianis T
Article: BRITISH JOURNAL OF CANCER. 1996;73(7):909-913
Expression of tropomyosin isoforms in benign and malignant human breast lesions
Franzen B; Linder S; Uryu K; Alaiya AA; Hirano T; Kato H; Auer G
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;65(6):821-826
Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light
Rabo YB; Shoshan MC; Linder S; Hansson J
Article: CELLULAR SIGNALLING. 1996;8(3):191-195
H-89 inhibits collagenase induction by phorbol ester through a mechanism that does not involve protein kinase A
Shoshan MC; Ljungdahl S; Linder S
Article: ANTI-CANCER DRUGS. 1995;6(5):657-668
APOPTOSIS AND C-JUN INDUCTION BY CISPLATIN IN A HUMAN-MELANOMA CELL-LINE AND A DRUG-RESISTANT DAUGHTER CELL-LINE
ZHAO R; RABO YB; EGYHAZI S; ANDERSSON A; EDGREN MR; LINDER S; HANSSON J
Article: ONCOLOGY REPORTS. 1995;2(2):303-306
DIFFERENTIAL-EFFECTS OF FIBROBLAST COCULTURE ON MCF-7 AND MDA-231 BREAST-CARCINOMA CELL INVASION THROUGH MATRIGEL
POPOWICZ P; ENGEL G; WILKING N; LINDER S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(3):663-668
EFFECT OF ADENOVIRUS-2 EARLY REGION-4 PRODUCTS ON E1-TRANSFORMATION
OHMAN K; NORDQVIST K; LINDER S; AKUSJARVI G
Article: NUCLEIC ACIDS RESEARCH. 1995;23(4):588-594
THE DNA-BINDING DOMAINS OF THE YEAST GAL4 AND HUMAN C-JUN TRANSCRIPTION FACTORS INTERACT THROUGH THE ZINC-FINGER AND BZIP MOTIFS
SOLLERBRANT K; AKUSJARVI G; LINDER S; SVENSSON C
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Corrigendum: FRONTIERS IN ONCOLOGY. 2023;13:1228436
Antiproliferative effects of the natural oxadiazine Nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation (vol 9, 224, 2029)
Sousa ML; Preto M; Vasconcelos V; Linder S; Urbatzka R
Review: CANCERS. 2020;12(4):E902-902
Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers
Zhang X; Linder S; Bazzaro M
Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):17501
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (vol 9, 9841, 2019)
Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(1):E229-229
Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
Emmings E; Mullany S; Chang Z; Landen CNJ; Linder S; Bazzaro M
Review: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2018;81(3):427-441
Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group
Perego P; Hempel G; Linder S; Bradshaw TD; Larsen AK; Peters GJ; Phillips RM
Review: CANCER AND METASTASIS REVIEWS. 2017;36(4):635-653
Proteasome-associated deubiquitinases and cancer
Mofers A; Pellegrini P; Linder S; D'Arcy P
Review: TRENDS IN CANCER. 2016;2(11):657-663
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Zhang X; De Milito A; Demiroglu-Zergeroglu A; Gullbo J; D'Arcy P; Linder S
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(11):27313-27326
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Zhang X; de Milito A; Olofsson MH; Gullbo J; D'Arcy P; Linder S
Review: DRUG RESISTANCE UPDATES. 2015;21-22:20-29
Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?
Selvaraju K; Mazurkiewicz M; Wang X; Gullbo J; Linder S; D'Arcy P
Review: PHARMACOLOGY & THERAPEUTICS. 2015;147:32-54
Deubiquitinase inhibition as a cancer therapeutic strategy
D'Arcy P; Wang X; Linder S
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2012;44(11):1729-1738
Proteasome deubiquitinases as novel targets for cancer therapy
D'Arcy P; Linder S
Letter: LIVER INTERNATIONAL. 2012;32(2):347-348
Determination of cell death modes using circulating biomarkers
Linder S; Herrmann R
Letter: JOURNAL OF HEPATOLOGY. 2011;55(6):1467
Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - The need for correct terminology
Linder S
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):182
Induction of acute apoptosis by cisplatin is not associated with damage to nuclear DNA and is likely to be an "off-target effect"
Linder S; Olofsson M; Fayad W; Shoshan MC
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):47
Identification of CB3, a novel inhibitor of the ubiquitin-proteasome system
Haglund C; Fryknas M; Larsson R; Linder S; Rickardson L
Review: MOLECULAR BIOSYSTEMS. 2010;6(5):767-774
Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis
Brnjic S; Olofsson MH; Havelka AM; Linder S
Review: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 2010;10(3):353-359
Utilization of cytokeratin-based biomarkers for pharmacodynamic studies
Linder S; Olofsson MH; Herrmann R; Ulukaya E
Review: BIOMARKERS IN MEDICINE. 2009;3(1):47-54
Serum efficacy biomarkers for oncology
Linder S; Alaiya A
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2008;4(3):273-280
Target specificity and off-target effects as determinants of cancer drug efficacy
Shoshan MC; Linder S
Review: MINI-REVIEWS IN MEDICINAL CHEMISTRY. 2007;7(10):1035-1039
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: Is acute apoptosis an "off-target" effect?
Havelka AM; Berndtsson M; Olofsson MH; Shoshan MC; Linder S
Letter: CANCER RESEARCH. 2007;67(6):2899
Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor
Linder S; Shoshan MC; Gupta RS
Review: TUMOR BIOLOGY. 2007;28(4):189-195
Cytokeratin markers come of age
Linder S
Review: EXPERT OPINION ON DRUG DISCOVERY. 2006;1(6):585-594
Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses
Shoshan MC; Havelka AM; Neumann F; Linder S
Published conference paper: BIOMEDICINE & PHARMACOTHERAPY. 2005;59:S359-S362
Detection of epithelial cell death in the body by cytokeratin 18 measurement
Ueno T; Toi M; Linder S
Review: JOURNAL OF PROTEOME RESEARCH. 2005;4(4):1213-1222
Clinical cancer proteomics: Promises and pitfalls
Alaiya A; Al-Mohanna M; Linder S
Review: DRUG RESISTANCE UPDATES. 2005;8(4):199-204
Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy
Linder S; Shoshan MC
Review: CANCER LETTERS. 2004;214(1):1-9
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker
Linder S; Havelka AM; Ueno T; Shoshan MC
Published conference paper: ELECTROPHORESIS. 2000;21(13):2737-2743
Inhibition of extracellular signal-regulated kinase1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression
Seddighzadeh M; Linder S; Shoshan MC; Auer G; Alaiya AA
Letter: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2000;92(9):758-760
Re: biologic and biochemical analyses of p16(INK4a) mutations from primary tumors.
Hansson J; Hashemi J; Linder S; Platz A
Review: ELECTROPHORESIS. 2000;21(6):1210-1217
Cancer proteomics: From identification of novel markers to creation of artificial learning models for tumor classification
Alaiya AA; Franzén B; Auer G; Linder S
Published conference paper: ELECTROPHORESIS. 1999;20(4-5):1039-1046
Two-dimensional gel analysis of protein expression in ovarian tumors shows a low degree of intratumoral heterogeneity
Alaiya AA; Franzén B; Moberger B; Silfverswärd C; Linder S; Auer G
Published conference paper: ELECTROPHORESIS. 1997;18(3-4):582-587
Analysis of polypeptide expression in benign and malignant human breast lesions
Franzen B; Linder S; Alaiya AA; Eriksson E; Fujioka K; Bergman AC; Jornvall H; Auer G
Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 1996;24(2):71-96
The metastatic phenotype-prognostic implications
Lindblom A; Linder S
Published conference paper: ELECTROPHORESIS. 1995;16(7):1087-1089
SAMPLE PREPARATION OF HUMAN TUMORS PRIOR TO 2-DIMENSIONAL ELECTROPHORESIS OF PROTEINS
FRANZEN B; HIRANO T; OKUZAWA K; URYU K; ALAIYA AA; LINDER S; AUER G
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