Stig Linder

About me
Publications
Public outreach and news

About me

Stig Linder was appointed adjunct professor at KI in 1999 and became full professor in 2015. His research aims at developing new cancer drugs
for example, Stig Linder’s research group has developed a simple blood test for tumour cell death in collaboration with a biotech company.

Articles

Article: NPJ PRECISION ONCOLOGY. 2024;8(1):53

Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer.

Lindahl G; Fjellander S; Selvaraj K; Vildeval M; Ali Z; Almter R; Erkstam A; Rodriguez GV; Abrahamsson A; Kersley ÅR; Fahlgren A; Kjølhede P; Linder S; Dabrosin C; Jensen L
Article: BIOCHEMICAL PHARMACOLOGY. 2022;197:114900

Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells

Colombo D; Gatti L; Sjostrand L; Carenini N; Costantino M; Corna E; Arrighetti N; Zuccolo M; De Cesare M; Linder S; D'Arcy P; Perego P
Article: FRONTIERS IN ONCOLOGY. 2022;12:852980

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

Gubat J; Selvaraju K; Sjoestrand L; Kumar Singh D; Turkina MV; Schmierer B; Sabatier P; Zubarev RA; Linder S; D'Arcy P
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1055067

The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis

Corno C; D'Arcy P; Bagnoli M; Paolini B; Costantino M; Carenini N; Corna E; Alberti P; Mezzanzanica D; Colombo D; Linder S; Arrighetti N; Perego P
Article: BIOMOLECULES. 2021;11(9):1339

Sensitivity of Acute Myelocytic Leukemia Cells to the Dienone Compound VLX1570 Is Associated with Inhibition of the Ubiquitin-Proteasome System

Selvaraju K; Lotfi K; Gubat J; Miquel M; Nilsson A; Hill J; Jensen LD; Linder S; D'Arcy P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4750

Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries

Zhang X; Shetty M; Clemente V; Linder S; Bazzaro M
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(24):15075-15093

Dienone Compounds: Targets and Pharmacological Responses

Bazzaro M; Linder S
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2020;889:173709

Identification of proteasome inhibitors using analysis of gene expression profiles

Mofers A; Selvaraju K; Gubat J; D 'Arcy P; Linder S
Article: INVESTIGATIONAL NEW DRUGS. 2020;38(5):1448-1453

Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma

Rowinsky EK; Paner A; Berdeja JG; Paba-Prada C; Venugopal P; Porkka K; Gullbo J; Linder S; Loskog A; Richardson PG; Landgren O
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(13):E4757-4757

Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570

Pellegrini P; Selvaraju K; Faustini E; Mofers A; Zhang X; Ternerot J; Schubert A; Linder S; D'Arcy P
Article: TOXICON. 2020;175:49-56

Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours

Sousa ML; Ribeiro T; Vasconcelos V; Linder S; Urbatzka R
Article: ONCOTARGET. 2019;10(51):5372-5382

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation.

Karlsson H; Senkowski W; Fryknäs M; Mansoori S; Linder S; Gullbo J; Larsson R; Nygren P
Article: SCIENTIFIC REPORTS. 2019;9(1):9841

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Article: BIOCHIMIE. 2019;162:46-54

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

Zhang X; Selvaraju K; Saei AA; D'Arcy P; Zubarev RA; Arner ESJ; Linder S
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019;2019:1659468-11

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Zhang X; Espinosa B; Saei AA; D'Arcy P; Zubarev RA; Linder S
Article: CANCER LETTERS. 2019;448:70-83

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation

Hillert E-K; Brnjic S; Zhang X; Mazurkiewicz M; Saei AA; Mofers A; Selvaraj K; Zubarev R; Linder S; D'Arcy P
Article: PLOS ONE. 2019;14(10):e0223807

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15

Mofers A; Perego P; Selvaraju K; Gatti L; Gullbo J; Linder S; D'Arcy P
Article: FRONTIERS IN ONCOLOGY. 2019;9:224

Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation

Sousa ML; Preto M; Vasconcelos V; Linder S; Urbatzka R
Article: BIOCHEMICAL PHARMACOLOGY. 2018;156:291-301

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and Check for mitochondrial damage

Zhang X; Pellegrini P; Saei AA; Hillert E-K; Mazurkiewicz M; Olofsson MH; Zubarev RA; D'Arcy P; Linder S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Tresaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzen H-SM; Orwar O; Ostman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arner ESJ
Article: CANCER CELL INTERNATIONAL. 2018;18:147

A drug screening assay on cancer cells chronically adapted to acidosis

Pellegrini P; Serviss JT; Lundback T; Bancaro N; Mazurkiewicz M; Kolosenko I; Yu D; Haraldsson M; D'Arcy P; Linder S; De Milito A
Article: ONCOTARGET. 2017;8(52):90225-90237

MYC is downregulated by a mitochondrial checkpoint mechanism

Zhang X; Mofers A; Hydbring P; Olofsson MH; Guo J; Linder S; D'Arcy P
Article: ONCOTARGET. 2017;8(13):21115-21127

Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

Mazurkiewicz M; Hillert E-K; Wang X; Pellegrini P; Olofsson MH; Selvaraju K; D'Arcy P; Linder S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):1-14

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells

Ma R; Karthik G-M; Lovrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: PLOS ONE. 2017;12(12):e0188817

Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action

Ribeiro T; Lemos F; Preto M; Azevedo J; Sousa ML; Leao PN; Campos A; Linder S; Vitorino R; Vasconcelos V; Urbatzka R
Article: SCIENTIFIC REPORTS. 2016;6:38343

Iron chelators target both proliferating and quiescent cancer cells

Fryknas M; Zhang X; Bremberg U; Senkowski W; Olofsson MH; Brandt P; Persson I; D'Arcy P; Gullbo J; Nygren P; Schughart LK; Linder S; Larsson R
Article: EJNMMI RESEARCH. 2016;6(1):58

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

Cheng Q; Wallberg H; Grafstrom J; Lu L; Thorell J-O; Olofsson MH; Linder S; Johansson K; Tegnebratt T; Arner ESJ; Stone-Elander S; Ahlzen H-SM; Stahl S
Article: BLOOD CANCER JOURNAL. 2016;6(11):e492

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

Paulus A; Akhtar S; Caulfield TR; Samuel K; Yousaf H; Bashir Y; Paulus SM; Tran D; Hudec R; Cogen D; Jiang J; Edenfield B; Novak A; Ansell SM; Witzig T; Martin P; Coleman M; Roy V; Ailawadhi S; Chitta K; Linder S; Chanan-Khan A
Article: CANCER RESEARCH. 2016;76(15):4525-4534

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

Shukla N; Somwar R; Smith RS; Ambati S; Munoz S; Merchant M; D'Arcy P; Wang X; Kobos R; Antczak C; Bhinder B; Shum D; Radu C; Yang G; Taylor BS; Ng CKY; Weigelt B; Khodos I; de Stanchina E; Reis-Filho JS; Ouerfelli O; Linder S; Djaballah H; Ladanyi M
Article: SCIENTIFIC REPORTS. 2016;6:26979

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Wang X; Mazurkiewicz M; Hillert E-K; Olofsson MH; Pierrou S; Hillertz P; Gullbo J; Selvaraju K; Paulus A; Akhtar S; Bossler F; Khan AC; Linder S; D'Arcy P
Article: LAKARTIDNINGEN. 2015;112:DSAR

[Handling of misconduct in Swedish research must be improved. More strict investigative procedures, tougher punishments and withdrawals are required].

Linder S
Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2015;86(5):1036-1048

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Wang X; D'Arcy P; Caulfield TR; Paulus A; Chitta K; Mohanty C; Gullbo J; Chanan-Khan A; Linder S
Article: NUTRIENTS. 2015;7(6):4978-4994

Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study

Brodin O; Eksborg S; Wallenberg M; Asker-Hagelberg C; Larsen EH; Mohlkert D; Lenneby-Helleday C; Jacobsson H; Linder S; Misra S; Bjornstedt M
Article: MOLECULAR CANCER THERAPEUTICS. 2015;14(6):1504-1516

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski W; Zhang X; Olofsson MH; Isacson R; Hoglund U; Gustafsson M; Nygren P; Linder S; Larsson R; Fryknas M
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(3):377-390

Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstroom macroglobulinaemia tumour cells

Chitta K; Paulus A; Akhtar S; Blake MKK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):e51-e61

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Kolosenko I; Fryknas M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbacker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grander D; Linder S; Tamm KP; De Milito A
Article: ANTIOXIDANTS & REDOX SIGNALING. 2014;21(17):2271-2285

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic S; Mazurkiewicz M; Fryknas M; Sun C; Zhang X; Larsson R; D'Arcy P; Linder S
Article: CLINICAL CANCER RESEARCH. 2014;20(15):3908-3914

Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets

D'Arcy P; Linder S
Article: MOLECULAR PHARMACOLOGY. 2014;85(6):932-945

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang X; Stafford W; Mazurkiewicz M; Fryknas M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arner ESJ; D'Arcy P; Linder S
Article: AUTOPHAGY. 2014;10(4):562-571

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

Pellegrini P; Strambi A; Zipoli C; Hagg-Olofsson M; Buoncervello M; Linder S; De Milito A
Article: LIVER INTERNATIONAL. 2014;34(3):367-378

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

Thulin P; Nordahl G; Gry M; Yimer G; Aklillu E; Makonnen E; Aderaye G; Lindquist L; Mattsson CM; Ekblom B; Antoine DJ; Park BK; Linder S; Harrill AH; Watkins PB; Glinghammar B; Schuppe-Koistinen I
Article: RSC MEDICINAL CHEMISTRY. 2014;5(3):376-385

Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Haglund C; Mohanty C; Fryknas M; D'Arcy P; Larsson R; Linder S; Rickardson L
Article: BLOOD. 2014;123(5):706-716

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Tian Z; D'Arcy P; Wang X; Ray A; Tai Y-T; Hu Y; Carrasco RD; Richardson P; Linder S; Chauhan D; Anderson KC
Article: PLOS ONE. 2014;9(10):e108839

Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases

Sun C; Roboti P; Puumalainen M-R; Fryknas M; Wang X; D'Arcy P; Hult M; High S; Linder S; Swanton E
Article: NATURE COMMUNICATIONS. 2014;5:3295

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang X; Fryknas M; Hernlund E; Fayad W; De Milito A; Olofsson MH; Gogvadze V; Dang L; Pahlman S; Schughart LAK; Rickardson L; Darcy P; Gullbo J; Nygren P; Larsson R; Linder S
Article: AUTOPHAGY. 2014;10(1):57-69

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab O; Fryknas M; Zhang X; De Milito A; Hammerling U; Linder S; Larsson R; Gustafsson MG
Article: BREAST. 2013;22(5):643-649

Identification of intermediate risk breast cancer patients with1-3 positive lymph nodes and excellent survival after tamoxifen as only systemic adjuvant therapy by use of markers of proliferation and apoptosis

Linderholm BK; Linder S; Arnesson L-G; Stal O
Article: BMC CANCER. 2013;13:374

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknas M; Gullbo J; Wang X; Rickardson L; Jarvius M; Wickstrom M; Hassan S; Andersson C; Gustafsson M; Westman G; Nygren P; Linder S; Larsson R
Article: STEM CELLS. 2013;31(8):1715-1725

Alterations in the Cellular Immune Compartment of Patients Treated with Third-Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation

Jitschin R; Mougiakakos D; Von Bahr L; Voelkl S; Moll G; Ringden O; Kiessling R; Linder S; Le Blanc K
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2013;62(8):1359-1368

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells

Sarhan D; Wennerberg E; D'Arcy P; Gurajada D; Linder S; Lundqvist A
Article: INVESTIGATIONAL NEW DRUGS. 2013;31(3):587-598

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Felth J; Lesiak-Mieczkowska K; D'Arcy P; Haglund C; Gullbo J; Larsson R; Linder S; Bohlin L; Fryknas M; Rickardson L
Article: VIROLOGY. 2013;440(1):41-50

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells

Li R; Sharma BN; Linder S; Gutteberg TJ; Hirsch HH; Rinaldo CH
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(3):2562-2573

Site-specifically ¹¹C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death

Cheng Q; Lu L; Grafstrom J; Olofsson MH; Thorell J-O; Samen E; Johansson K; Ahlzen H-S; Linder S; Arner ESJ; Stone-Elander S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;431(2):117-123

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius M; Fryknas M; D'Arcy P; Sun C; Rickardson L; Gullbo J; Haglund C; Nygren P; Linder S; Larsson R
Article: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2013;13(2):356-363

A Natural Anticancer Agent Thaspine Targets Human Topoisomerase IB

Castelli S; Katkar P; Vassallo O; Falconi M; Linder S; Desideri A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(36):30664-30676

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

Marino ML; Pellegrini P; Di Lernia G; Djavaheri-Mergny M; Brnjic S; Zhang X; Hagg M; Linder S; Fais S; Codogno P; De Milito A
Article: BIOCHEMICAL JOURNAL. 2012;442(3):639-648

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

McKibbin C; Mares A; Piacenti M; Williams H; Roboti P; Puumalainen M; Callan AC; Lesiak-Mieczkowska K; Linder S; Harant H; High S; Flitsch SL; Whitehead RC; Swanton E
Article: EUROPEAN JOURNAL OF CANCER. 2012;48(3):396-406

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund E; Olofsson MH; Fayad W; Fryknas M; Lesiak-Mieczkowska K; Zhang X; Brnjic S; Schmidt V; D'Arcy P; Sjoblom T; De Milito A; Larsson R; Linder S
Article: PLOS ONE. 2012;7(8):e42151

Combining [¹¹C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts

Cheng Q; Lu L; Grafstrom J; Olofsson MH; Thorell J-O; Samen E; Johansson K; Ahlzen H-S; Stone-Elander S; Linder S; Arner ESJ
Article: CANCER SCIENCE. 2011;102(12):2206-2213

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan S; Laryea D; Mahteme H; Felth J; Fryknas M; Fayad W; Linder S; Rickardson L; Gullbo J; Graf W; Pahlman L; Glimelius B; Larsson R; Nygren P
Article: NATURE MEDICINE. 2011;17(12):1636-1640

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

D'Arcy P; Brnjic S; Olofsson MH; Fryknas M; Lindsten K; De Cesare M; Perego P; Sadeghi B; Hassan M; Larsson R; Linder S
Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2011;78(4):547-557

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad W; Rickardson L; Haglund C; Olofsson MH; D'Arcy P; Larsson R; Linder S; Fryknas M
Article: BIOCHEMICAL PHARMACOLOGY. 2011;82(2):139-147

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo J; Fryknas M; Rickardson L; Darcy P; Hagg M; Wickstrom M; Hassan S; Westman G; Brnjic S; Nygren P; Linder S; Larsson R
Article: EUROPEAN JOURNAL OF CANCER. 2011;47(1):131-137

Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer

De Petris L; Branden E; Herrmann R; Sanchez BC; Koyi H; Linderholm B; Lewensohn R; Linder S; Lehtio J
Article: PHYTOMEDICINE. 2010;17(10):789-793

Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus

Bhutani KK; Paul AT; Fayad W; Linder S
Article: INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY. 2010;48(3):258-264

Screening of natural products for therapeutic activity against solid tumors

El-Menshawi BS; Fayad W; Mahmoud K; El-Hallouty SM; El-Manawaty M; Olofsson MH; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(10):2450-2455

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model

Fayad W; Brnjic S; Berglind D; Blixt S; Shoshan MC; Berndtsson M; Olofsson MH; Linder S
Article: PLOS ONE. 2009;4(10):e7238

Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters

Fayad W; Fryknas M; Brnjic S; Olofsson MH; Larsson R; Linder S
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(12):1607-1613

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation

Hernlund E; Kutuk O; Basaga H; Linder S; Panaretakis T; Shoshan M
Article: JOURNAL OF CHEMICAL BIOLOGY. 2009;2(2):81-87

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

Berndtsson M; Hernlund E; Shoshan MC; Linder S
Article: CANCER BIOMARKERS. 2009;5(3):117-125

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker

Olofsson MH; Cummings J; Fayad W; Brnjic S; Herrmann R; Berndtsson M; Hodgkinson C; Dean E; Odedra R; Wilkinson RW; Mundt KE; Busk M; Dive C; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(6):1463-1469

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Berndtsson M; Beaujouin M; Rickardson L; Havelka AM; Larsson R; Westman J; Liaudet-Coopman E; Linder S
Article: ANTICANCER RESEARCH. 2009;29(1):11-18

Utilization of a Right-handed Coiled-coil Protein from Archaebacterium Staphylothermus marinus as a Carrier for Cisplatin

Eriksson M; Hassan S; Larsson R; Linder S; Ramqvist T; Lovborg H; Vikinge T; Figgemeier E; Muller J; Stetefeld J; Dalianis T; Ozbek S
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2009;43(2):98-103

Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines

Ullen A; Schwarz S; Lennartsson L; Kalkner K-M; Sandstrom P; Costa F; Lennernas B; Linder S; Nilsson S
Article: BMC CHEMICAL BIOLOGY. 2008;8:2

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH; Havelka AM; Brnjic S; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):476-483

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir

Hernlund E; Ihrlund LS; Khan O; Ates YO; Linder S; Panaretakis T; Shoshan MC
Article: LABORATORY INVESTIGATION. 2008;88(3):256-263

The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity

Ueno T; Elmberger G; Weaver TE; Toi M; Linder S
Article: JOURNAL OF BIOMOLECULAR SCREENING. 2008;13(1):1-8

Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids

Herrmann R; Fayad W; Schwarz S; Berndtsson M; Linder S
Article: CLINICAL CANCER RESEARCH. 2007;13(11):3198-3206

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy

Olofsson MH; Ueno T; Pan Y; Xu R; Cai F; van der Kuip H; Muerdter TE; Sonnenberg M; Aulitzk WE; Schwarz S; Andersson E; Shoshan MC; Havelka AM; Toi M; Linder S
Article: LUNG CANCER. 2007;56(3):399-404

The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival

Ulukaya E; Yilmaztepe A; Akgoz S; Linder S; Karadag M
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(4):1440-1450

Large-scale proteomics analysis of human ovarian cancer for biomarkers

Bengtsson S; Krogh M; Szigyarto CA-K; Uhlen M; Schedvins K; Silfversward C; Linder S; Auer G; Alaiya A; James P
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(1):175-180

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

Berndtsson M; Hagg M; Panaretakis T; Havelka AM; Shoshan MC; Linder S
Article: JOURNAL OF VIROLOGY. 2006;80(16):8279-8282

Loss of cell membrane integrity in Puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin

Klingstroem J; Hardestam J; Stoltz M; Zuber B; Lundkvist A; Linder S; Ahlm C
Article: BRITISH JOURNAL OF CANCER. 2006;94(11):1592-1598

Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles

Kramer G; Schwarz S; Hagg M; Havelka AM; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589

Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1

Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: RADIATION ONCOLOGY. 2006;1:4

Is translational research compatible with preclinical publication strategies?

Linder S; Shoshan MC
Article: FEBS LETTERS. 2005;579(14):3090-3094

Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis

Berndtsson M; Konishi Y; Bonni A; Hägg M; Shoshan M; Linder S; Havelka AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(1):192-197

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

Erdal H; Berndtsson M; Castro J; Brunk U; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(2):397-405

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

Takada M; Kataoka A; Toi M; Bando H; Toyama K; Horiguchi S; Ueno T; Linder S; Saji S; Hayashi Y; Funata N; Kinoshita J; Murakami S; Ohono S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(16):16178-16184

Processing of pulmonary surfactant protein B by napsin and cathepsin H

Ueno T; Linder S; Na CL; Rice WR; Johansson J; Weaver TE
Article: MOLECULAR CANCER THERAPEUTICS. 2004;3(4):489-497

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids

Hägg M; Berndtsson M; Mandic A; Zhou R; Shoshan MC; Linder S
Article: CANCER RESEARCH. 2004;64(5):1751-1756

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18

Kramer G; Erdal H; Mertens HJMM; Nap M; Mauermann J; Steiner G; Marberger M; Bivén K; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line

Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: APOPTOSIS. 2003;8(3):263-268

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

Bivén K; Erdal H; Hägg M; Ueno T; Zhou R; Lynch M; Rowley B; Wood J; Zhang C; Toi M; Shoshan MC; Linder S
Article: BRITISH JOURNAL OF CANCER. 2003;88(8):1229-1233

Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma

Ueno T; Linder S; Elmberger G
Article: EUROPEAN UROLOGY. 2003;43(4):362-368

Low IL-1α a expression in bladder cancer tissue and survival

Seddighzadeh M; Larsson P; Ulfgren AC; Onelöv E; Berggren P; Tribukait B; Torstensson A; Norming U; Wijkström H; Linder S; Steineck G
Article: EUROPEAN JOURNAL OF CANCER. 2003;39(6):769-774

Measurement of an apoptotic product in the sera of breast cancer patients

Ueno T; Toi M; Bivén K; Bando H; Ogawa T; Linder S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9100-9106

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

Mandic A; Hansson J; Linder S; Shoshan MC
Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259

A novel high-through-put assay for screening of pro-apoptotic drugs

Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;99(5):721-726

Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms

Seddighzadeh M; Steineck G; Larsson P; Wijkström H; Norming U; Onelöv E; Linder S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(9):3003-3013

Calpain-mediated bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis

Mandic A; Viktorsson K; Strandberg L; Heiden T; Hansson J; Linder S; Shoshan MC
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;98(6):895-899

Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles

Alaiya AA; Franzén B; Hagman A; Dysvik B; Roblick UJ; Becker S; Moberger B; Auer G; Linder S
Article: ANTICANCER RESEARCH. 2001;21(4B):2861-2865

Prognostic importance of the uPA/PAI-1 complex in breast cancer

Sten-Linder M; Seddighzadeh M; Engel G; Rutqvist LE; Linder S; Skoog L; Wiman B
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(11):3684-3691

Cisplatin induces the proapoptotic conformation of Bak in a ΔMEKK1-dependent manner

Mandic A; Viktorsson K; Molin M; Akusjärvi G; Eguchi H; Hayashi SI; Toi M; Hansson J; Linder S; Shoshan MC
Article: GENES CHROMOSOMES & CANCER. 2001;31(2):107-116

Haplotype analysis and age estimation of the 113insR CDKN2A founder mutation in Swedish melanoma families

Hashemi J; Bendahl PO; Sandberg T; Platz A; Linder S; Stierner U; Olsson H; Ingvar C; Hansson J; Borg A
Article: BRITISH JOURNAL OF CANCER. 2001;84(3):329-334

Low interleukin-1α messenger RNA levels predict decreased overall survival time of patients with urinary bladder carcinoma

Seddighzadeh M; Steineck G; Jansson O; Larsson P; Wijkström H; Adolfsson J; Portwood N; Hansson J; Linder S
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2001;58(2):307-311

Identification of proteins in human prostate tumor material by two-dimensional gel electrophoresis and mass spectrometry

Alaiya AA; Oppermann M; Langridge J; Roblick U; Egevad L; Brändstedt S; Hellström M; Linder S; Bergman T; Jörnvall H; Auer G
Article: ANTICANCER RESEARCH. 2001;21(1B):509-512

Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx

Nordemar S; Kronenwett U; Auer G; Högmo A; Lindholm J; Edström S; Tryggvasson K; Linder S; Munck-Wikland E
Article: APOPTOSIS. 2000;5(4):355-367

Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin

Viktorsson K; Heiden T; Molin M; Akusjärvi G; Linder S; Shoshan MC
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;86(5):731-736

Classification of human ovarian tumors using multivariate data analysis of polypeptide expression patterns

Alaiya AA; Franzén B; Hagman A; Silfverswärd C; Moberger B; Linder S; Auer G
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2000;92(9):758A-7759

Re:: Biologic and biochemical analyses of p16^INK4a mutations from primary tumors

Hansson J; Hashemi J; Linder S; Platz A
Article: ELECTROPHORESIS. 2000;21(3):679-686

Identification of gel-separated tumor marker proteins by mass spectrometry

Bergman AC; Benjamin T; Alaiya A; Waltham M; Sakaguchi K; Franzén B; Linder S; Bergman T; Auer G; Appella E; Wirth PJ; Jörnvall H
Article: CELLULAR ONCOLOGY. 2000;21(1):1-9

Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma

Alaiya A; Roblick U; Egevad L; Carlsson A; Franzén B; Volz D; Huwendiek S; Linder S; Auer G
Article: FEBS LETTERS. 1999;462(1-2):129-134

Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

Chuman Y; Bergman AC; Ueno T; Saito S; Sakaguchi K; Alaiya AA; Franzén B; Bergman T; Arnott D; Auer G; Appella E; Jörnvall H; Linder S
Article: ANTICANCER RESEARCH. 1999;19(4C):3409-3414

Angiostatin fragments in urine from patients with malignant disease

Sten-Linder M; Linder C; Strander H; Munck-Wikland E; Wersäll P; Linder S; Wiman B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 1999;55(3):467-471

Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts

Bergman AC; Alaiya AA; Wendler W; Binetruy B; Shoshan M; Sakaguchi K; Bergman T; Kronenwett U; Auer G; Appella E; Jörnvall H; Linder S
Article: MELANOMA RESEARCH. 1999;9(1):21-30

Melanoma development in relation to nonfunctional p16/INK4A protein and dysplastic naevus syndrome in Swedish melanoma kindreds

Hashemi J; Linder S; Platz A; Hansson J
Article: CLINICAL & EXPERIMENTAL METASTASIS. 1999;17(8):649-654

ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation

Seddighzadeh M; Zhou JN; Kronenwett U; Shoshan MC; Auer G; Sten-Linder M; Wiman B; Linder S
Article: SOMATIC CELL AND MOLECULAR GENETICS. 1998;24(6):327-339

Analysis of mechanisms and frequency of CDKN2A/B gene loss during progression of RAS-transformed rat embryo fibroblast clones

Zhou JN; Hashemi J; Helou K; Zhang A; Röhme D; Zetterberg A; Levan G; Linder S
Article: JOURNAL OF VIROLOGY. 1998;72(10):8358-8361

Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments

Molin M; Shoshan MC; Öhman-Forslund K; Linder S; Akusjärvi G
Article: INTERNATIONAL JOURNAL OF CANCER. 1998;78(1):95-99

Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors

Zhou ZJ; Wang JM; Han XL; Zhou JN; Linder S
Article: ELECTROPHORESIS. 1998;19(10):1808-1810

Rapid isolation of phage displayed antibodies to β-actin eluted from two-dimensional electrophoresis gel

Zhou JN; Linder S; Franzén B; Auer G; Hochstrasser DF; Persson MAA
Article: MOLECULAR CANCER RESEARCH. 1998;9(7):565-573

Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop

Ljungdahl S; Linder S; Franzén B; Binétruy B; Auer G; Shoshan MC
Article: ANTICANCER RESEARCH. 1998;18(3B):2063-2068

Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma

Linder C; Linder S; Munck-Wikland E; Strander H
Article: MOLECULAR CARCINOGENESIS. 1998;21(4):234-243

Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway

Zhou JN; Ljungdahl S; Shoshan MC; Swedenborg J; Linder S
Article: BRITISH JOURNAL OF CANCER. 1998;77(6):941-945

Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma

Linder C; Byström P; Engel G; Auer G; Aspenblad U; Strander H; Linder S
Article: ANGIOGENESIS. 1998;2(4):365-372

Evaluation of tissue and serum VEGF in patients with head and neck carcinoma.

Linder C; Linder S; Munck-Wikland E; Auer G; Aspenblad U; Strander H
Article: INTERNATIONAL JOURNAL OF CANCER. 1997;73(5):678-683

Phenotypic analysis of ovarian carcinoma: Polypeptide expression in benign, borderline and malignant tumors

Alaiya AA; Franzen B; Fujioka K; Moberger B; Schedvins K; Silversvard C; Linder S; Auer G
Article: FEBS LETTERS. 1997;417(1):17-20

Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen

Bergman AC; Linder C; Sakaguchi K; StenLinder M; Alaiya AA; Franzen B; Shoshan MC; Bergman T; Wiman B; Auer G; Appella E; Jornvall H; Linder S
Article: FEBS JOURNAL. 1997;249(3):648-656

Signal transduction in fibroblasts stably transformed by [Val12]Ras - The activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated

Ljungdahl S; Linder S; Sollerbrant K; Svensson C; Shoshan MC
Article: GENES CHROMOSOMES & CANCER. 1997;20(1):82-89

Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines

Zhou JN; Ljungdahl S; Rohme D; Levan G; Shoshan MC; Linder S
Article: ANTICANCER RESEARCH. 1997;17(4A):2347-2352

The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line

Fokstuen T; Rabo YB; Zhou JN; Karlson J; Platz A; Shoshan MC; Hansson J; Linder S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1997;89(10):697-702

Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma

Platz A; Hansson J; ManssonBrahme E; Lagerlof B; Linder S; Lundqvist E; Sevigny P; Inganas M; Ringborg U
Article: BREAST CANCER RESEARCH AND TREATMENT. 1997;42(3):207-213

Distribution of stromelysin-3 mRNA transcripts and microvessels in human breast carcinomas

Linder C; Engel G; Auer G; Strander H; Linder S
Article: BRITISH JOURNAL OF CANCER. 1997;76(1):54-59

Prognostic significance of Ki-67 antigen and p53 protein expression in pancreatic duct carcinoma: A study of the monoclonal antibodies MIB-1 and DO-7 in formalin-fixed paraffin-embedded tumour material

Linder S; Parrado C; Falkmer UG; Blasjo M; Sundelin P; vonRosen A
Article: ANTI-CANCER DRUGS. 1997;8(1):62-66

Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B

Ljungdahl S; Shoshan NC; Linder S
Article: BRITISH JOURNAL OF CANCER. 1996;74(10):1632-1638

Analysis of polypeptide expression in benign and malignant human breast lesions: Down-regulation of cytokeratins

Franzen B; Linder S; Alaiya AA; Eriksson E; Uruy K; Hirano T; Okuzawa K; Auer G
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;69(5):408-414

Assessment of homogeneity in polypeptide expression in breast carcinomas shows widely variable expression in highly malignant tumors

Franzen B; Auer G; Alaiya AA; Eriksson E; Uryu K; Hirano T; Okuzawa K; Kato H; Linder S
Article: ANTICANCER RESEARCH. 1996;16(4A):1931-1935

Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines

Zhou JN; Linder S
Article: ANTI-CANCER DRUGS. 1996;7(4):422-429

Inhibition of tumor cell growth by monoterpenes in vitro: Evidence of a Ras-independent mechanism of action

Karlson J; BorgKarlson AK; Unelius R; Shoshan MC; Wilking N; Ringborg U; Linder S
Article: JOURNAL OF VIROLOGY. 1996;70(5):3093-3097

A short peptide fluted from the H-2K(b) molecule of a polyomavirus positive tumor corresponds to polyomavirus large T antigen peptide at amino acids 578 to 585 and induces polyomavirus-specific immunity

Berke Z; Palmer S; Bergman T; Wester D; Svedmyr J; Linder S; Jornvall H; Dalianis T
Article: ONCOLOGY REPORTS. 1996;3(3):443-445

Tissue factor mRNA expression in breast carcinoma cells

Zhou JN; StenLinder M; Linder S
Article: BRITISH JOURNAL OF CANCER. 1996;73(7):909-913

Expression of tropomyosin isoforms in benign and malignant human breast lesions

Franzen B; Linder S; Uryu K; Alaiya AA; Hirano T; Kato H; Auer G
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;65(6):821-826

Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light

Rabo YB; Shoshan MC; Linder S; Hansson J
Article: CELLULAR SIGNALLING. 1996;8(3):191-195

H-89 inhibits collagenase induction by phorbol ester through a mechanism that does not involve protein kinase A

Shoshan MC; Ljungdahl S; Linder S
Article: ANTI-CANCER DRUGS. 1995;6(5):657-668

APOPTOSIS AND C-JUN INDUCTION BY CISPLATIN IN A HUMAN-MELANOMA CELL-LINE AND A DRUG-RESISTANT DAUGHTER CELL-LINE

ZHAO R; RABO YB; EGYHAZI S; ANDERSSON A; EDGREN MR; LINDER S; HANSSON J
Article: ONCOLOGY REPORTS. 1995;2(2):303-306

DIFFERENTIAL-EFFECTS OF FIBROBLAST COCULTURE ON MCF-7 AND MDA-231 BREAST-CARCINOMA CELL INVASION THROUGH MATRIGEL

POPOWICZ P; ENGEL G; WILKING N; LINDER S
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(3):663-668

EFFECT OF ADENOVIRUS-2 EARLY REGION-4 PRODUCTS ON E1-TRANSFORMATION

OHMAN K; NORDQVIST K; LINDER S; AKUSJARVI G
Article: NUCLEIC ACIDS RESEARCH. 1995;23(4):588-594

THE DNA-BINDING DOMAINS OF THE YEAST GAL4 AND HUMAN C-JUN TRANSCRIPTION FACTORS INTERACT THROUGH THE ZINC-FINGER AND BZIP MOTIFS

SOLLERBRANT K; AKUSJARVI G; LINDER S; SVENSSON C
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Corrigendum: FRONTIERS IN ONCOLOGY. 2023;13:1228436

Antiproliferative effects of the natural oxadiazine Nocuolin A are associated with impairment of mitochondrial oxidative phosphorylation (vol 9, 224, 2029)

Sousa ML; Preto M; Vasconcelos V; Linder S; Urbatzka R
Review: CANCERS. 2020;12(4):E902-902

Drug Development Targeting the Ubiquitin-Proteasome System (UPS) for the Treatment of Human Cancers

Zhang X; Linder S; Bazzaro M
Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):17501

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (vol 9, 9841, 2019)

Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(1):E229-229

Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer

Emmings E; Mullany S; Chang Z; Landen CNJ; Linder S; Bazzaro M
Review: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2018;81(3):427-441

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Perego P; Hempel G; Linder S; Bradshaw TD; Larsen AK; Peters GJ; Phillips RM
Review: CANCER AND METASTASIS REVIEWS. 2017;36(4):635-653

Proteasome-associated deubiquitinases and cancer

Mofers A; Pellegrini P; Linder S; D'Arcy P
Review: TRENDS IN CANCER. 2016;2(11):657-663

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics

Zhang X; De Milito A; Demiroglu-Zergeroglu A; Gullbo J; D'Arcy P; Linder S
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(11):27313-27326

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Zhang X; de Milito A; Olofsson MH; Gullbo J; D'Arcy P; Linder S
Review: DRUG RESISTANCE UPDATES. 2015;21-22:20-29

Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

Selvaraju K; Mazurkiewicz M; Wang X; Gullbo J; Linder S; D'Arcy P
Review: PHARMACOLOGY & THERAPEUTICS. 2015;147:32-54

Deubiquitinase inhibition as a cancer therapeutic strategy

D'Arcy P; Wang X; Linder S
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2012;44(11):1729-1738

Proteasome deubiquitinases as novel targets for cancer therapy

D'Arcy P; Linder S
Letter: LIVER INTERNATIONAL. 2012;32(2):347-348

Determination of cell death modes using circulating biomarkers

Linder S; Herrmann R
Letter: JOURNAL OF HEPATOLOGY. 2011;55(6):1467

Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - The need for correct terminology

Linder S
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):182

Induction of acute apoptosis by cisplatin is not associated with damage to nuclear DNA and is likely to be an "off-target effect"

Linder S; Olofsson M; Fayad W; Shoshan MC
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):47

Identification of CB3, a novel inhibitor of the ubiquitin-proteasome system

Haglund C; Fryknas M; Larsson R; Linder S; Rickardson L
Review: MOLECULAR BIOSYSTEMS. 2010;6(5):767-774

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis

Brnjic S; Olofsson MH; Havelka AM; Linder S
Review: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 2010;10(3):353-359

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

Linder S; Olofsson MH; Herrmann R; Ulukaya E
Review: BIOMARKERS IN MEDICINE. 2009;3(1):47-54

Serum efficacy biomarkers for oncology

Linder S; Alaiya A
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2008;4(3):273-280

Target specificity and off-target effects as determinants of cancer drug efficacy

Shoshan MC; Linder S
Review: MINI-REVIEWS IN MEDICINAL CHEMISTRY. 2007;7(10):1035-1039

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: Is acute apoptosis an "off-target" effect?

Havelka AM; Berndtsson M; Olofsson MH; Shoshan MC; Linder S
Letter: CANCER RESEARCH. 2007;67(6):2899

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor

Linder S; Shoshan MC; Gupta RS
Review: TUMOR BIOLOGY. 2007;28(4):189-195

Cytokeratin markers come of age

Linder S
Review: EXPERT OPINION ON DRUG DISCOVERY. 2006;1(6):585-594

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses

Shoshan MC; Havelka AM; Neumann F; Linder S
Published conference paper: BIOMEDICINE & PHARMACOTHERAPY. 2005;59:S359-S362

Detection of epithelial cell death in the body by cytokeratin 18 measurement

Ueno T; Toi M; Linder S
Review: JOURNAL OF PROTEOME RESEARCH. 2005;4(4):1213-1222

Clinical cancer proteomics: Promises and pitfalls

Alaiya A; Al-Mohanna M; Linder S
Review: DRUG RESISTANCE UPDATES. 2005;8(4):199-204

Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy

Linder S; Shoshan MC
Review: CANCER LETTERS. 2004;214(1):1-9

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker

Linder S; Havelka AM; Ueno T; Shoshan MC
Published conference paper: ELECTROPHORESIS. 2000;21(13):2737-2743

Inhibition of extracellular signal-regulated kinase1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression

Seddighzadeh M; Linder S; Shoshan MC; Auer G; Alaiya AA
Letter: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2000;92(9):758-760

Re: biologic and biochemical analyses of p16(INK4a) mutations from primary tumors.

Hansson J; Hashemi J; Linder S; Platz A
Review: ELECTROPHORESIS. 2000;21(6):1210-1217

Cancer proteomics:: From identification of novel markers to creation of artificial learning models for tumor classification

Alaiya AA; Franzén B; Auer G; Linder S
Published conference paper: ELECTROPHORESIS. 1999;20(4-5):1039-1046

Two-dimensional gel analysis of protein expression in ovarian tumors shows a low degree of intratumoral heterogeneity

Alaiya AA; Franzén B; Moberger B; Silfverswärd C; Linder S; Auer G
Published conference paper: ELECTROPHORESIS. 1997;18(3-4):582-587

Analysis of polypeptide expression in benign and malignant human breast lesions

Franzen B; Linder S; Alaiya AA; Eriksson E; Fujioka K; Bergman AC; Jornvall H; Auer G
Review: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 1996;24(2):71-96

The metastatic phenotype-prognostic implications

Lindblom A; Linder S
Published conference paper: ELECTROPHORESIS. 1995;16(7):1087-1089

SAMPLE PREPARATION OF HUMAN TUMORS PRIOR TO 2-DIMENSIONAL ELECTROPHORESIS OF PROTEINS

FRANZEN B; HIRANO T; OKUZAWA K; URYU K; ALAIYA AA; LINDER S; AUER G
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