Stephen Malin

Lipoproteins transport cholesterol and triglycerides to 

Atherosclerosis is a major cause of heart attacks and stroke, which are leading causes of death worldwide. Our approach is aimed at understanding how these diseases are initiated, where in the body this initiation occurs, and the nature of protective and pathogenic responses by the immune system. We create novel models that allow for on-demand APOB-lipoprotein accumulation and combine this with a range of the most modern and classical experimental techniques. This provides us with the opportunity to investigate basic immunology in the context of understanding mechanisms of a global health problem.