Shireen Sindi
About me
Shireen Sindi, PhD is Associate Professor (Docent) at Karolinska Institute (Sweden),
- Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics. She completed her former studies at McGill University (Canada), with a Bachelor’s degree (B.A) in psychology, and master's and doctoral degrees (MSc and PhD) at McGill’s Integrated Program in Neuroscience. More recently, she also completed an MSc in Clinical Trials at the London School of Hygiene and Tropical Medicine (LSHTM) and an MBA at Imperial College Business School.
Research
As an Associate Professor (Docent) at the Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institute, Sweden, her research centers on uncovering multi-system biological mechanisms contributing to cognitive decline and dementia risk factors. Specifically, she investigates the intricate relationships between stress, sleep disturbances, and sex differences across the spectrum from normal aging to Alzheimer’s disease.
Her achievements include serving as Principal Investigator (PI) for several project grants, employing multi-center designs to enhance statistical power and generalizability. She has established interdisciplinary international collaborations where she has led the study design, project management, and the publication of articles and book chapters.
Her research integrates various biomarkers, including cortisol, neuroimaging, Alzheimer’s disease biomarkers (beta-amyloid, tau), neuroinflammation markers, and allostatic load (reflecting chronic stress). Furthermore, she explores the impacts of multidomain lifestyle interventions encompassing diet, exercise, cognitive training, and vascular/metabolic risk management on cognition and sleep, delving into underlying mechanisms such as telomere length and the microbiome.
Notably, her research has unveiled groundbreaking insights, including associations between cortisol and AD biomarkers, neuroinflammation, allostatic load and neuroimaging markers. She has also published on the associations between sleep disturbances, the risk for dementia and cognitive decline, multimorbidity, and the underlying mechanisms. Her research also showed for the first time an effect of a lifestyle interventions on telomere length in a sample at risk for dementia, and the peresence of sex differences in dementia incidence and risk factors.
She is also the Coordinator for Data-Driven and AI Research at KI (DDKI), which is an initiative that has been established by the KI Committee for Research to promote this rapidly advancing area of research and to facilitate its translation to address clinical and educational needs.
She also has a solid track record for supervising and mentoring students and postdocs at various levels at several institutes (e.g. Karolinska Institute, Imperial College London, Stockholm University, University of Eastern Finland).
- Additionally, her leadership roles, such as former Chair for Junior Faculty and current Chair for National Junior Faculty (Sweden), underscores her commitment to advancing scientific careers and opportunities, while her representation on committees with Senior Leadership Teams at various universities demonstrates her leadership and collaborative skills.
Articles
- Journal article: INTERNATIONAL PSYCHOGERIATRICS. 2024;:100009
- Journal article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):364
- Journal article: ISEE CONFERENCE ABSTRACTS. 2024;2024(1)
- Article: ALZHEIMER'S RESEARCH AND THERAPY. 2024;16(1):147
- Journal article: CURRENT DEVELOPMENTS IN NUTRITION. 2024;8:103625
- Article: ALZHEIMER'S AND DEMENTIA. 2024;20(7):4486-4498
- Article: SLEEP MEDICINE. 2024;119:179-186
- Article: ALZHEIMER'S RESEARCH AND THERAPY. 2024;16(1):118
- Journal article: BRAIN COMMUNICATIONS. 2024;6(3):fcae144
- Article: HEALTH PSYCHOLOGY. 2024;43(5):388-395
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;118:499-509
- Journal article: SLEEP. 2024;47:A94
- Article: ARCHIVES OF GERONTOLOGY AND GERIATRICS. 2024;119:105316
- Article: SLEEP. 2024;47(3):zsad244
- Article: BRAIN COMMUNICATIONS. 2024;6(3):fcae144
- Article: THE JOURNAL OF PREVENTION OF ALZHEIMER'S DISEASE. 2024;11(6):1798-1808
- Journal article: INNOVATION IN AGING. 2023;7:377
- Article: JOURNAL OF NUTRITION. 2023;153(12):3506-3520
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S22)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S17)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S23)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S8)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S2)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S2)
- Article: CURRENT DEVELOPMENTS IN NUTRITION. 2023;7(6):100096
- Article: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH. 2023;28:100592
- Article: ARCHIVES OF GERONTOLOGY AND GERIATRICS. 2023;104:104802
- Article: GERONTOLOGY. 2023;69(8):972-985
- Journal article: ALZHEIMER'S AND DEMENTIA. 2022;18(S5)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2022;18(S11)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2022;18(S7)
- Article: ALZHEIMER'S AND DEMENTIA. 2022;18(12):2438-2447
- Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2022;70(11):3138-3151
- Article: BMC NEUROLOGY. 2022;22(1):5
- Article: BMJ NEUROLOGY OPEN. 2022;4(2):e000344
- Article: THE JOURNAL OF PREVENTION OF ALZHEIMER'S DISEASE. 2022;9(1):30-39
- Journal article: ALZHEIMER'S AND DEMENTIA. 2021;17(S5)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2021;17(S10)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2021;17(S10)
- Article: ALZHEIMER'S AND DEMENTIA. 2021;17(7):1166-1178
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2021;76(3):491-498
- Journal article: INNOVATION IN AGING. 2021;5(Suppl 1):377Sleep Disturbances and the Speed of Multimorbidity Development in Old Age
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:716594
- Article: FRONTIERS IN PUBLIC HEALTH. 2021;9:753964
- Article: BMC MEDICINE. 2020;18(1):382
- Journal article: ALZHEIMER'S AND DEMENTIA. 2020;16(S10)
- Article: INTERNATIONAL PSYCHOGERIATRICS. 2020;32(11):1317-1324
- Article: BMC GERIATRICS. 2020;20(1):99
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2020;318(2):E184-E188
- Article: FRONTIERS IN NUTRITION. 2020;7:40
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2019;70(2):553-562
- Journal article: ALZHEIMER'S AND DEMENTIA. 2019;15(7S_Part_31):p1639
- Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2019;20(7):843-849.e5
- Article: AMERICAN JOURNAL OF MEDICINE. 2019;132(3):367-373
- Article: SLEEP MEDICINE. 2018;52:26-33
- Article: NUTRIENTS. 2018;10(11):E1649-1649
- Article: ALZHEIMER'S AND DEMENTIA. 2018;14(10):1235-1242
- Journal article: ALZHEIMER'S AND DEMENTIA. 2018;14(7S_Part_11):p638-p639
- Article: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. 2017;1(1):219-227
- Article: JOURNALS OF GERONTOLOGY - SERIES B PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES. 2017;72(6):1044-1053
- Article: THE LANCET. 2017;390(10100):1084-1150
- Article: JOURNAL OF NEUROLOGY. 2017;264(9):1996-2002
- Article: JOURNAL OF ALZHEIMER'S DISEASE. 2017;59(4):1459-1470
- Journal article: INNOVATION IN AGING. 2017;1(suppl_1):659-660
- Journal article: INNOVATION IN AGING. 2017;1(suppl_1):156
- Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_10):p514
- Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_25):p1199
- Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_19):p927
- Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_25):p1198
- Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_10):p505
- Journal article: INNOVATION IN AGING. 2017;1(Suppl 1):156SLEEP EARLIER IN LIFE AND LATE LIFE COGNITION: MULTICENTER POPULATION DATA FROM SWEDEN AND FINLAND
- Journal article: INNOVATION IN AGING. 2017;1(Suppl 1):659-660SLEEP EARLIER IN LIFE AND LATE-LIFE DEMENTIA: MULTI-CENTER POPULATION DATA FROM SWEDEN AND FINLAND
- Article: THE LANCET. 2016;388(10053):1813-1850
- Article: THE LANCET. 2016;388(10053):1775-1812
- Article: THE LANCET HIV. 2016;3(8):E361-E387
- Article: ANXIETY, STRESS AND COPING. 2016;29(2):119-138
- Journal article: ÉDUCATION ET FRANCOPHONIE. 2016;43(2):6-29
- Article: NEURAL PLASTICITY. 2016;2016:3136743-12
- Article: ALZHEIMER'S AND DEMENTIA: DIAGNOSIS, ASSESSMENT AND DISEASE MONITORING. 2015;1(3):328-333
- Article: BIOLOGICAL PSYCHIATRY. 2015;77(7):668-676
- Article: INTERNATIONAL JOURNAL OF STROKE. 2015;10(2):231-244
- Article: HIPPOCAMPUS. 2014;24(12):1623-1632
- Journal article: ALZHEIMER'S AND DEMENTIA. 2014;10(4S_Part_20):p746
- Article: DEVELOPMENT AND PSYCHOPATHOLOGY. 2013;25(4):1017-1027
- Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(8):1388-1396
- Article: PSYCHOSOMATIC MEDICINE. 2013;75(2):103-116
- Journal article: EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY. 2012;3(1):19556
- Journal article: EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY. 2012;3(1):19557
- Article: STRESS. 2012;15(6):569-577
- Journal article: EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY. 2012;3(0)
- Journal article: EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY. 2012;3(0)
- Journal article: EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY. 2012;3(0)
- Article: STRESS. 2012;15(2):130-137
- Article: PHYSIOLOGY AND BEHAVIOR. 2011;104(2):360-364
- Article: DEVELOPMENT AND PSYCHOPATHOLOGY. 2011;23(3):725-776
- Article: PSYCHONEUROENDOCRINOLOGY. 2011;36(6):797-805
- Journal article: ALZHEIMER'S AND DEMENTIA. 2011;7(4S_Part_12):s425
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All other publications
- Editorial comment: FRONTIERS IN NUTRITION. 2023;10:1333933
- Conference publication: INNOVATION IN AGING. 2022;6:610
- Conference publication: INNOVATION IN AGING. 2022;6:220
- Corrigendum: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2022;322(2):E197
- Conference publication: INNOVATION IN AGING. 2021;5:377
- Book chapter: SEX AND GENDER DIFFERENCES IN ALZHEIMER'S DISEASE. 2021;p. 269-308
- Conference publication: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. 2021;28(SUPPL 1):S200
- Corrigendum: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. 2019;26(1):108-109
- Conference publication: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. 2018;25:S153-S154
- Conference publication: INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE. 2018;25:S167-S168
- Letter: LANCET NEUROLOGY. 2018;17(1):27
- Conference publication: PSYCHONEUROENDOCRINOLOGY. 2017;83:50
- Book chapter: HORMONES, BRAIN AND BEHAVIOR. 2017;p. 311-340
- Book chapter: DEVELOPMENTAL PSYCHOPATHOLOGY. 2016;p. 1-54
- Review: STROKE. 2015;46(6):1740-1747
- Review: EXPERT REVIEW OF NEUROTHERAPEUTICS. 2015;15(1):83-105
- Review: F1000 PRIME REPORTS. 2015;7:50
- Review: NEUROBIOLOGY OF LEARNING AND MEMORY. 2011;96(4):583-595
- Review: DEMENTIA & NEUROPSYCHOLOGIA. 2011;5(1):8-16
- Book chapter: HORMONES, BRAIN AND BEHAVIOR. 2009;p. 3049-3083
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Grants
- Swedish Research Council for Health Working Life and Welfare1 October 2023 - 30 September 2029
- Swedish Research Council for Health Working Life and Welfare1 July 2023 - 30 June 2026
- Swedish Research Council1 January 2021 - 31 December 2024
- Swedish Research Council for Health Working Life and Welfare1 July 2019 - 30 June 2022
- Fonds de Recherche du Québec - Santé1 April 2015 - 31 March 2016
- Fonds de Recherche du Québec - Santé1 April 2013 - 31 March 2015
- Stress, Memory and Hippocampal Volume in Young and Older AdultsCanadian Institutes of Health Research1 May 2011 - 30 September 2013
Employments
- Senior Research Specialist, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2023-
Degrees and Education
- Docent, Karolinska Institutet, 2024