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Research description


RECOVERY OF THE IMMUNE SYSTEM AND RESISTANCE AGAINST INFECTIONS IN PAEDIATRIC PATIENTS UNDERGOING CHEMOTHERAPY. The overall vision with our research is to provide an optimal life quality – in terms of resistance to infections – for children that have undergone or are undergoing treatment against cancers. To this end, our in vivo and in vitro projects examine in detail how cell cytotoxic treatments influence children’s immune responses to infectious agents. Both during an acute state, while the treatment is ongoing, as well as during long-term, after cessation of chemotherapy. Through further collaborations, we investigate how the recovery of the immune system and its functions, as well as chemotherapy efficacy itself, are influenced by the gut microbiome. In addition, in order to broaden and update our knowledge about infections among the paediatric population in Sweden, our ongoing clinical research projects assess vaccination coverage, and the prevalence and type of infections, in healthy children and children with underling comorbidities.

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Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses
Saghafian-hedengren S, Söderström I, Sverremark-ekström E, Nilsson A
Blood reviews 2018;32(1):71-80

Assessment of Cytokine and Chemokine Signatures as Potential Biomarkers of Childhood Community-acquired Pneumonia Severity: A Nested Cohort Study in India
Saghafian-hedengren S, Mathew Jl, Hagel E, Singhi S, Ray P, Ygberg S, et al
The Pediatric infectious disease journal 2017;36(1):102-108

Epstein-Barr Virus, but Not Cytomegalovirus, Latency Accelerates the Decay of Childhood Measles and Rubella Vaccine Responses-A 10-Year Follow-up of a Swedish Birth Cohort
Lasaviciute G, Björkander S, Carvalho-queiroz C, Hed Myrberg I, Nussbaum B, Nilsson C, et al
Frontiers in immunology 2017;8():1865-

Associations between EBV and CMV Seropositivity, Early Exposures, and Gut Microbiota in a Prospective Birth Cohort: A 10-Year Follow-up
Carvalho-queiroz C, Johansson Ma, Persson Jo, Jörtsö E, Kjerstadius T, Nilsson C, et al
Frontiers in pediatrics 2016;4():93-

Etiology of community acquired pneumonia among children in India: prospective, cohort study
Mathew Jl, Singhi S, Ray P, Hagel E, Saghafian-hedengren S, Bansal A, et al
Journal of global health 2015;5(2):050418-

Selective loss of vaccine-specific memory B cells in a rhesus macaque model of chemotherapy: influence of doxorubicin on immunological memory
Ingelman-sundberg Hm, Saghafian-hedengren S, Jahnmatz M, Eksborg S, Jonker M, Nilsson A
Haematologica 2015;100(4):e158-61

Pre-eclampsia affects cord blood NK cell expression of activation receptors and serum cytokine levels but not CB monocyte characteristics
Sohlberg E, Saghafian-hedengren S, Bachmayer N, Hamad Rr, Bremme K, Holmlund U
American journal of reproductive immunology (New York, N.Y. : 1989) 2014;71(2):178-88

A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27(-)IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
Bemark M, Friskopp L, Saghafian-hedengren S, Koethe S, Fasth A, Abrahamsson J, et al
CLINICAL IMMUNOLOGY 2013;149(3):421-31

Cytomegalovirus-seropositive children show inhibition of in vitro EBV infection that is associated with CD8+CD57+ T cell enrichment and IFN-γ
Sohlberg E, Saghafian-hedengren S, Rasul E, Marchini G, Nilsson C, Klein E, et al
Journal of immunology (Baltimore, Md. : 1950) 2013;191(11):5669-76

Epstein-Barr virus coinfection in children boosts cytomegalovirus-induced differentiation of natural killer cells
Saghafian-hedengren S, Sohlberg E, Theorell J, Carvalho-queiroz C, Nagy N, Persson Jo, et al
Journal of virology 2013;87(24):13446-55

Age at Epstein-Barr virus infection and Epstein-Barr virus nuclear antigen-1 antibodies in Swedish children
Simon Kc, Saghafian-hedengren S, Sverremark-ekstrom E, Nilsson C, Ascherio A

Early-life gut bacteria associate with IL-4-, IL-10- and IFN-γ production at two years of age
Johansson Ma, Saghafian-hedengren S, Haileselassie Y, Roos S, Troye-blomberg M, Nilsson C, et al
PloS one 2012;7(11):e49315-

Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses
Sohlberg E, Saghafian-hedengren S, Bremme K, Sverremark-ekström E
Immunology 2011;133(1):41-50

Early-life EBV infection protects against persistent IgE sensitization
Saghafian-hedengren S, Sverremark-ekström E, Linde A, Lilja G, Nilsson C
The Journal of allergy and clinical immunology 2010;125(2):433-8

Herpesvirus seropositivity in childhood associates with decreased monocyte-induced NK cell IFN-gamma production
Saghafian-hedengren S, Sundström Y, Sohlberg E, Nilsson C, Linde A, Troye-blomberg M, et al
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2511-7

Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children
Amoudruz P, Holmlund U, Saghafian-hedengren S, Nilsson C, Sverremark-ekström E
Clinical and experimental immunology 2009;155(3):387-94

Maternal allergy influences p38-mitogen-activated protein kinase activity upon microbial challenge in CD14+ monocytes from 2-year-old children
Saghafian-hedengren S, Holmlund U, Amoudruz P, Nilsson C, Sverremark-ekström E
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(3):449-57

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