Shao-Bo Jin

Publications
Public outreach and news

Articles

Article: EMBO MOLECULAR MEDICINE. 2023;15(2):e16556
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira DV; Coupland KG; Shao W; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Zetterberg H; Lundkvist J; Oberstein SAL; Lendahl U; Karlstrom H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2022;26(3):880-892
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing
Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlstrom H
Article: BMC BIOLOGY. 2021;19(1):229
MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries
Yu R; Liu T; Jin S-B; Ankarcrona M; Lendahl U; Nister M; Zhao J
Article: NEUROLOGY: GENETICS. 2021;7(3):e584
Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions
Arnardottir S; Del Gaudio F; Klironomos S; Braune E-B; Lombrana AA; Oliveira DV; Jin S; Karlstrom H; Lendahl U; Sjostrand C
Article: DISEASE MODELS & MECHANISMS. 2021;14(2):dmm046300
The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
Wu D; Wang S; Oliveira DV; Del Gaudio F; Vanlandewijck M; Lebouvier T; Betsholtz C; Zhao J; Jin S; Lendahl U; Karlstrom H
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:706687
The Molecular Assembly State of Drp1 Controls its Association With the Mitochondrial Recruitment Receptors Mff and MIEF1/2
Yu R; Jin S-B; Ankarcrona M; Lendahl U; Nister M; Zhao J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100593
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion
Landor SKJ; Santio NM; Eccleshall WB; Paramonov VM; Gagliani EK; Hall D; Jin S-B; Dahlstrom KM; Salminen TA; Rivero-Muller A; Lendahl U; Kovall RA; Koskinen PJ; Sahlgren C
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
Article: MATRIX BIOLOGY. 2019;81:107-121
Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling
Papadakos KS; Bartoschek M; Rodriguez C; Gialeli C; Jin S-B; Lendahl U; Pietras K; Blom AM
Article: EMBO JOURNAL. 2019;38(8):e99748
Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery
Yu R; Jin S-B; Lendahl U; Nister M; Zhao J
Article: ONCOGENE. 2018;37(46):6083-6095
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types
Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: BLOOD. 2018;131(15):1712-1719
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis
Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luis TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: SCIENTIFIC REPORTS. 2017;7(1):880
MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
Yu R; Liu T; Jin S-B; Ning C; Lendahl U; Nister M; Zhao J
Article: STEM CELL REPORTS. 2016;6(5):643-651
Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells
Braune E-B; Tsoi YL; Phoon YP; Landor S; Cascales HS; Ramskold D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
Article: BREAST CANCER RESEARCH. 2015;17(1):109
Decoding breast cancer tissue-stroma interactions using species-specific sequencing
Chivukula IV; Ramskold D; Storvall H; Anderberg C; Jin S; Mamaeva V; Sahlgren C; Pietras K; Sandberg R; Lendahl U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(2):409-420
Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System
Henshall TL; Keller A; He L; Johansson BR; Wallgard E; Raschperger E; Mae MA; Jin S; Betsholtz C; Lendahl U
Article: CELL RESEARCH. 2014;24(4):433-450
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Sjoqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(3):1540-1550
Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions
Olsson F; Schmidt S; Althoff V; Munter LM; Jin S; Rosqvist S; Lendahl U; Multhaup G; Lundkvist J
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(18):2893-2904
The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics
Liu T; Yu R; Jin S-B; Han L; Lendahl U; Zhao J; Nister M
Article: ONCOGENE. 2013;32(41):4892-4902
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKb
Jin S; Mutvei AP; Chivukula IV; Andersson ER; Ramskold D; Sandberg R; Lee KL; Kronqvist P; Mamaeva V; Ostling P; Mpindi J-P; Kallioniemi O; Screpanti I; Poellinger L; Sahlgren C; Lendahl U
Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369
Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Lanner F; Lee KL; Ortega GC; Sohl M; Li X; Jin S; Hansson EM; Claesson-Welsh L; Poellinger L; Lendahl U; Farnebo F
Article: PLOS ONE. 2013;8(5):e62959
Notch Signaling Maintains Neural Rosette Polarity
Main H; Radenkovic J; Jin S-B; Lendahl U; Andersson ER
Article: JOURNAL OF NEUROSCIENCE. 2012;32(48):17297-17305
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
Borgegard T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg A-L; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlstrom H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(46):18814-18819
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
Landor SK-J; Mutvei AP; Mamaeva V; Jin S; Busk M; Borra R; Gronroos TJ; Kronqvist P; Lendahl U; Sahlgren CM
Article: EMBO JOURNAL. 2011;30(14):2762-2778
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
Zhao J; Liu T; Jin S; Wang X; Qu M; Uhlen P; Tomilin N; Shupliakov O; Lendahl U; Nister M
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(9):1610-1624
Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells
Main H; Lee KL; Yang H; Haapa-Paananen S; Edgren H; Jin S; Sahlgren C; Kallioniemi O; Poellinger L; Lim B; Lendahl U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;393(1):21-27
Evidence for dimeric BACE-mediated APP processing
Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Falting J; Berg S; Lundkvist J; Lendahl U
Article: JOURNAL OF CELL SCIENCE. 2009;122(13):2252-2262
The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation
Zhao J; Liu T; Jin S-B; Tomilin N; Castro J; Shupliakov O; Lendahl U; Nister M
Article: JOURNAL OF CELL BIOLOGY. 2009;184(4):555-568
Specific combinations of SR proteins associate with single pre-messenger RNAs in vivo and contribute different functions
Bjork P; Jin S; Zhao J; Singh OP; Persson J-O; Hellman U; Wieslander L
Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491
Notch signaling regulates platelet-derived growth factor receptor-β expression in vascular smooth muscle cells
Jin S; Hansson EM; Tikka S; Lanner F; Sahlgren C; Farnebo F; Baumann M; Kalimo H; Lendahl U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(17):6392-6397
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Sahlgren C; Gustafsson MV; Jin S; Poellinger L; Lendahl U
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. 2003;38(Pt 3):231-239
An improved dual-expression concept, generating high-quality antibodies for proteomics research.
Falk R; Agaton C; Kiesler E; Jin S; Wieslander L; Visa N; Hober S; Ståhl S
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2002;81(3):125-137
A novel protein localized to the fibrillar compartment of the nucleolus and to the brush border of a secretory cell
Sun X; Zhao J; Jin S; Palka K; Visa N; Aissouni Y; Daneholt B; Alzhanova-Ericsson AT
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Corrigendum: MOLECULAR THERAPY. 2021;29(1):409
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Meeting abstract: CANCER RESEARCH. 2016;76:b41
Cell-contact dependent epithelial-stromal cross talk, including a modulation of stromal PDGFR expression, drives the progression of early-stage breast cancer lesions
Strell C; Paulsson J; Mezheyeuski A; Jin S-B; Roswall P; Andrea J; Frings O; Warnberg F; Johansson H; Jirstrom K; Pietras K; Hall P; Lendahl U; Betsholtz C; Radisky DC; Ostman A

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