Sebastian Thams

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF INFLAMMATION. 2023;20(1):22
Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation
Lindblad C; Neumann S; Kolbeinsdottir S; Zachariadis V; Thelin EP; Enge M; Thams S; Brundin L; Svensson M
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2023;24(3-4):237-245
Dying from ALS in Sweden: clinical status, setting, and symptoms
Sennfalt S; Klappe U; Thams S; Samuelsson K; Press R; Fang F; Ingre C
Article: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION. 2023;24(1-2):45-53
The path to diagnosis in ALS: delay, referrals, alternate diagnoses, and clinical progression
Sennfalt S; Klappe U; Thams S; Samuelsson K; Press R; Fang F; Ingre C
Article: NEUROLOGY: GENETICS. 2020;6(6):e526
Heterozygous variants in DCC: Beyond congenital mirror movements
Thams S; Islam M; Lindefeldt M; Nordgren A; Granberg T; Tesi B; Barbany G; Nilsson D; Paucar M
Article: CELL CHEMICAL BIOLOGY. 2019;26(12):1703-1715.e37
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents
Bos PH; Lowry ER; Costa J; Thams S; Garcia-Diaz A; Zask A; Wichterle H; Stockwell BR
Article: CELL STEM CELL. 2019;25(2):193-209.e7
Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration
Tung Y-T; Peng K-C; Chen Y-C; Yen Y-P; Chang M; Thams S; Chen J-A
Article: JOURNAL OF PHYSIOLOGY. 2019;597(12):3133-3146
Intact single muscle fibres from SOD1^G93A amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training-like adaptations
Cheng AJ; Allodi I; Chaillou T; Schlittler M; Ivarsson N; Lanner JT; Thams S; Hedlund E; Andersson DC
Article: SCIENTIFIC REPORTS. 2019;9(1):4965
Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity
Foo KS; Skowronski AA; Baum D; Firdessa-Fite R; Thams S; Shang L; Creusot RJ; LeDuc CA; Egli D; Leibel RL
Article: MOLECULAR THERAPY. 2019;27(1):87-101
A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress
Thams S; Lowry ER; Larraufie M-H; Spiller KJ; Li H; Williams DJ; Phuong H; Jiang E; Williams LA; Sandoe J; Eggan K; Lieberam I; Kanning KC; Stockwell BR; Henderson CE; Wichterle H
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: CELL REPORTS. 2015;11(8):1305-1318
Mir-17∼92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN.
Tung Y-T; Lu Y-L; Peng K-C; Yen Y-P; Chang M; Li J; Jung H; Thams S; Huang Y-P; Hung J-H; Chen J-A
Article: CELL STEM CELL. 2014;14(6):781-795
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Kiskinis E; Sandoe J; Williams LA; Boulting GL; Moccia R; Wainger BJ; Han S; Peng T; Thams S; Mikkilineni S; Mellin C; Merkle FT; Davis-Dusenbery BN; Ziller M; Oakley D; Ichida J; Di Costanzo S; Atwater N; Maeder ML; Goodwin MJ; Nemesh J; Handsaker RE; Paull D; Noggle S; McCarroll SA; Joung JK; Woolf CJ; Brown RH; Eggan K
Article: PLOS ONE. 2013;8(3):e59647
The Extent of Synaptic Stripping of Motoneurons after Axotomy Is Not Correlated to Activation of Surrounding Glia or Downregulation of Postsynaptic Adhesion Molecules
Berg A; Zelano J; Thams S; Cullheim S
Article: EXPERIMENTAL NEUROLOGY. 2012;237(1):8-17
Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3
Berg A; Zelano J; Stephan A; Thams S; Barres BA; Pekny M; Pekna M; Cullheim S
Article: RESTORATIVE NEUROLOGY AND NEUROSCIENCE. 2012;30(2):91-102
FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection
Nordblom J; Persson JKE; Aberg J; Blom H; Engqvist H; Brismar H; Sjodahl J; Josephson A; Frostell A; Thams S; Brundin L; Svensson M; Mattsson P
Article: GLIA. 2011;59(1):45-57
Evidence of Hypothalamic Degeneration in the Anorectic anx/anx Mouse
Nilsson IAK; Thams S; Lindfors C; Bergstrand A; Cullheim S; Hokfelt T; Johansen JE
Article: NEUROSCIENTIST. 2010;16(6):600-607
Classic Major Histocompatibility Complex Class I Molecules: New Actors at the Neuromuscular Junction
Cullheim S; Thams S
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500
Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE^-/- Mice
Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng C-N; Bjorkstrom NK; Malmberg K-J; Lindbom L; Eriksson EE
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2009;517(5):670-682
SynCAM1 Expression Correlates With Restoration of Central Synapses on Spinal Motoneurons After Two Different Models of Peripheral Nerve Injury
Zelano J; Berg A; Thams S; Hailer NP; Cullheim S
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515
Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction
Thams S; Brodin P; Plantman S; Saxelin R; Karre K; Cullheim S
Article: ATHEROSCLEROSIS. 2009;202(1):111-118
ApoE^-/-/Lysozyme M^EGFP/EGFP mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosis
Rotzius P; Soehnlein O; Kenne E; Lindbom L; Nystrom K; Thams S; Eriksson EE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(4):1325-1330
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Ekstrand MI; Terzioglu M; Galter D; Zhu S; Hofstetter C; Lindqvist E; Thams S; Bergstrand A; Hansson FS; Trifunovic A; Hoffer B; Cullheim S; Mohammed AH; Olson L; Larsson N-G
Article: JOURNAL OF NEUROSCIENCE. 2005;25(14):3692-3700
Impeded interaction between Schwann cells and axons in the absence of laminin α4
Wallquist W; Plantman S; Thams S; Thyboll J; Kortesmaa J; Lännergren J; Domogatskaya A; Ögren SO; Risling M; Hammarberg H; Tryggvason K; Cullheim S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(51):17843-17848
A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy
Oliveira ALR; Thams S; Lidman O; Piehl F; Hökfelt T; Kärre K; Lindä H; Cullheim S
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2002;454(3):284-293
Laminin chains in rat and human peripheral nerve: Distribution and regulation during development and after axonal injury
Wallquist W; Patarroyo M; Thams S; Carlstedt T; Stark B; Cullheim S; Hammarberg H
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All other publications

Editorial comment: NEUROLOGY: GENETICS. 2021;7(6):e636
Predominant Spastic Paraparesis Associated With the D178N Mutation in PRNP
Thams S; Paucar M; Wingard L; Thonberg H; Smith C; Nennesmo I; Svenningsson P
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(7):3582
The Role of BDNF in Experimental and Clinical Traumatic Brain Injury
Gustafsson D; Klang A; Thams S; Rostami E
Thesis / dissertation: 2009
Immune recognition molecules in synaptic plasticity and regeneration of spinal motoneurons
Thams, Sebastian
Published conference paper: BRAIN RESEARCH REVIEWS. 2008;57(1):265-269
MHC class I expression and synaptic plasticity after nerve lesion
Thams S; Oliveira A; Cullheim S
Published conference paper: BRAIN RESEARCH REVIEWS. 2007;55(1):89-96
The microglial networks of the brain and their role in neuronal network plasticity after lesion
Cullheim S; Thams S

Employments

Senior Research Specialist, Department of Neuroscience, Karolinska Institutet, 2024-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2009
University Medical Degree, Karolinska Institutet, 2006

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