Sebastian Edman

Publications
Grants
Public outreach and news

Selected publications

Journal article: EMBO REPORTS. 2024;25(12):5810-5837
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
Edman S; Jones RGIII; Jannig PR; Fernandez-Gonzalo R; Norrbom J; Thomas NT; Khadgi S; Koopmans PJ; Morena F; Chambers TL; Peterson CS; Scott LN; Greene NP; Figueiredo VC; Fry CS; Zhengye L; Lanner JT; Wen Y; Alkner B; Murach KA; von Walden F
Article: FUNCTION. 2024;5(3):zqae005
Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity
Edman S; Horwath O; Van der Stede T; Blackwood SJ; Moberg I; Stromlind H; Nordstrom F; Ekblom M; Katz A; Apro W; Moberg M
Article: MOLECULAR METABOLISM. 2024;79:101854
Need for speed: Human fast-twitch mitochondria favor power over efficiency
Edman S; Flockhart M; Larsen FJ; Apro W

Articles

Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 2025
Exercise-induced plasma mature brain-derived neurotrophic factor elevation in children, adolescents and adults: influence of age, maturity and physical activity
Edman S; Starck J; Corell L; Hangasjarvi W; von Finckenstein A; Reimeringer M; Reitzner S; Norrbom J; Moberg M; von Walden F
Journal article: SKELETAL MUSCLE. 2025;15(1):9
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1-and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Stroemlind H; Moberg M; Edman S; Soederlund K; Checa A; Ruas JL; Blomstrand E
Journal article: EXPERIMENTAL PHYSIOLOGY. 2025;110(2):277-292
Ageing leads to selective type II myofibre deterioration and denervation independent of reinnervative capacity in human skeletal muscle
Horwath O; Moberg M; Edman S; Philp A; Apro W
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2025;16(1):e13613
Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young
Horwath O; Moberg M; Hodson N; Edman S; Johansson M; Andersson E; van Hall G; Rooyackers O; Philp A; Apro W
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2024;327(3):C516-C524
The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic stimulus
Cui M; Jannig P; Halladjian M; Figueiredo VC; Wen Y; Vechetti IJ; Krogh N; Jude B; Edman S; Lanner J; Mccarthy J; Murach KA; Sejersen T; Nielsen H; von Walden F
Journal article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2024;327(2):e172-e182
Elevated heart rate and decreased muscle endothelial nitric oxide synthase in early development of insulin resistance
Blackwood SJ; Tischer D; van de Ven MPF; Ponten M; Edman S; Horwath O; Apro W; Roja J; Ekblom MM; Moberg M; Katz A
Article: FUNCTION. 2023;5(1):zqad062
Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice
Ismaeel A; Thomas NT; Mccashland M; Vechetti IJ; Edman S; Lanner JT; Figueiredo VC; Fry CS; Mccarthy JJ; Wen Y; Murach KA; von Walden F
Article: BIO-PROTOCOL. 2023;13(10):e4678
THRIFTY-A High-throughput Single Muscle Fiber Typing Method Based on Immunofluorescence Detection
Edman S; Horwath O; Apro W
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2022;600(20):4421-4438
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres
Horwath O; Edman S; Andersson A; Larsen FJ; Apro W
Article: METABOLITES. 2021;11(8):508
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: FRONTIERS IN NUTRITION. 2019;6:96
mTORC1 Signaling in Individual Human Muscle Fibers Following Resistance Exercise in Combination With Intake of Essential Amino Acids
Edman S; Soderlund K; Moberg M; Apro W; Blomstrand E

All other publications

Preprint: BIORXIV. 2025
Antioxidant supplementation blunts the proteome response to three weeks of sprint interval training preferentially in human type 2 muscle fibres
Wyckelsma VL; Murgia M; Kamandulis S; Gastaldello S; Brazaitis M; Snieckus A; Eimantas N; Pääsuke M; Edman S; Apro W; Andersson DC; Westerblad H; Venckunas T
Preprint: BIORXIV. 2024
Endurance Exercise Elevates Plasma Mature Brain-Derived Neurotrophic Factor through Child- and Adulthood, with Amplified Effects in Adults
Edman S; Starck J; Corell L; Hangasjärvi W; von Finckenstein A; Reimeringer M; Reitzner S; Norrbom J; Moberg M; von Walden F
Preprint: BIORXIV. 2024
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
Preprint: BIORXIV. 2024
Anabolic sensitivity in healthy, lean, older men is associated with higher expression of amino acid sensors and mTORC1 activators
Horwath O; Moberg M; Hodson N; Edman S; Johansson M; Andersson E; van Hall G; Rooyackers O; Philp A; Apró W
Preprint: BIORXIV. 2024;BIORXIV
The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth.
Edman S; Jones RG; Jannig PR; Fernandez-Gonzalo R; Norrbom J; Thomas NT; Khadgi S; Koopmans PJ; Morena F; Peterson CS; Scott LN; Greene NP; Figueiredo VC; Fry CS; Zhengye L; Lanner JT; Wen Y; Alkner B; Murach KA; von Walden F

Grants

MAX:imize MYC - A heterodimer potentially explaining fiber type specific hypertrophy?
The Swedish Research Council for Sport Science
16 September 2024 - 16 September 2026
Metabolic and muscular health in children with cerebral palsy
Karolinska Institute Research Foundation
30 April 2024 - 30 April 2026
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
Stiftelsen Sunnerdahls Handikappfond
30 April 2024 - 30 April 2025
Muscular and Metabolic Health in Children with Cerebral Palsy
Linnea och Josef Carlssons Stiftelse
31 March 2024 - 31 March 2025
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
Frimurare Barnahuset i Stockholm
16 February 2024 - 6 February 2025
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
Sällskapet Barnavård
16 February 2024 - 6 February 2025
EXTRA-MYC - EXercise induced TRAnscritional regulation by MYC
The Swedish Research Council for Sport Science
1 January 2024 - 31 December 2025
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
Stiftelsen Sunnerdahls Handikappfond
30 April 2023 - 30 April 2024
Muscular and Metabolic Health in Children with Cerebral Palsy
Linnea och Josef Carlssons Stiftelse
30 March 2023 - 30 March 2024
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
H.K.H Kronprinsessan Lovisas Förening för Barnasjukvård
1 March 2023 - 1 March 2024
A Translational Approach to Understanding Muscular and Metabolic Health in Children with Cerebral Palsy
Sällskapet Barnavård
28 February 2023 - 23 February 2024

Selected publications

Articles

All other publications

Grants

News from KI

Events from KI