Ruiqing Ni

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About me

Group leader at University of Zurich Institutet for Regenerative Medicine https://www.irem.uzh.ch/en/research/AntibodyBasedRegeneration/Ruiqing_Ni_Research.html

Articles

Journal article: NEURAL REGENERATION RESEARCH. 2026;21(4):1566-1567
Imaging alpha-synuclein pathology in Parkinson's disease
Ni R
Journal article: NEURAL REGENERATION RESEARCH. 2026;21(2):683-684
Biomarkers for synaptic dysfunction in Alzheimer's disease
Ni R
Journal article: LIFE SCIENCES. 2025;376:123759
Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
Tang Z; Sha T; Wang Y; Xiao Y; Ding Y; Ni R; Qi X
Journal article: BIOORGANIC & MEDICINAL CHEMISTRY. 2025;126:118218
Synthesis and in vivo biological characterization of six carbon-11 sigma-1 receptor radiotracers in rodent and nonhuman primate
Soda AK; Huang T; Zhou W; Chen H; Jiang H; Jadhav SB; Xing Z; Yu Y; Tian L; Wong DF; Perlmutter JS; Ni R; Benzinger TLS; Tu Z
Journal article: EUROPEAN JOURNAL OF RADIOLOGY. 2025;189:112188
Head-to-head comparison of[18F]florbetapir and[18F]FDG PET for the early detection of amyloidosis in systemic amyloidosis and plasma cell dyscrasias
Kong Y; Cao L; He B; Zhou Z; Zhang M; Zhang Q; Wang Q; Wang W; Zhu H; Xiao J; Rominger A; Guan Y; Tan H; Ni R
Journal article: NATURE COMMUNICATIONS. 2025;16(1):6356
Synaptic loss pattern is constrained by brain connectome and modulated by phosphorylated tau in Alzheimer's disease
Luan Y; Wang W; Huang Q; Wang Y; Nussbaumer J; Wang J; Steward A; Roemer-Cassiano SN; Guan Y; Ewers M; Schoell M; Ni R; Li B; Franzmeier N; Xie F
Journal article: GENES & DISEASES. 2025;:101710
[18F]florbetapir PET for early detection of amyloidosis in patients with hereditary transthyretin amyloidosis polyneuropathy
Kong Y; Cao L; He B; Zhou Z; Zhang M; Zhang Q; Wang Q; Wang W; Zhu H; Xiao J; Rominger A; Guan Y; Tan H; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2025;21(5):e70333
Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J; Huang Q; Chen X; You Z; He K; Mao X; Huang Y; Franzmeier N; Schoell M; Guo T; Zhao J; Guan Y; Ni R; Li B; Xie F
Journal article: ALZHEIMERS & DEMENTIA. 2025;21(2):e70004
Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner
Wang Y; Wang J; Chen X; Lin Z; You Z; He K; Guo T; Zhao J; Huang Q; Ni R; Guan Y; Li B; Xie F
Journal article: ALZHEIMERS & DEMENTIA. 2025;21(2):e14511
Multimodal imaging of murine cerebrovascular dynamics induced by transcranial pulse stimulation
Karakatsani ME; Nozdriukhin D; Tiemann S; Yoshihara HAI; Storz R; Belau M; Ni R; Razansky D; Dean-Ben XL
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2025;52(2):427-443
Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson's disease
Combes BF; Kalva SK; Benveniste P-L; Tournant A; Law MH; Newton J; Kruger M; Weber RZ; Dias I; Noain D; Dean-Ben XL; Konietzko U; Baumann CR; Gillberg P-G; Hock C; Nitsch RM; Cohen-Adad J; Razansky D; Ni R
Journal article: NEUROIMAGE. 2024;303:120947
Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models
Rui X; Zhao X; Zhang N; Ding Y; Seki C; Ono M; Higuchi M; Zhang M-R; Chu Y; Wei R; Xu M; Cheng C; Zuo C; Kimura Y; Ni R; Kai M; Tian M; Yuan C; Ji B
Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 2):e090779
AssociatIion of metabotropic glutamate receptor 5 with amyloid deposition in Alzheimer's disease's patient and mouse models
Savoldelli S; Kong Y; Maschio C; Konetiko U; Mu L; Klohs J; Nitsch RM; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 2):e083556
Imaging of amyloid, tau and synaptic dysfunction in the brains of type 2 diabetic rats ‐ a multitracer PET study
Kong Y; Zuo C; Xie F; Xiao J; Huang Q; Guan Y; Ni R
Journal article: BRAIN PATHOLOGY. 2024;34(6):e13288
Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo
Straumann N; Combes BF; Dean Ben XL; Sternke-Hoffmann R; Gerez JA; Dias I; Chen Z; Watts B; Rostami I; Shi K; Rominger A; Baumann CR; Luo J; Noain D; Nitsch RM; Okamura N; Razansky D; Ni R
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2024;51(13):3960-3977
Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein
Sobek J; Li J; Combes BF; Gerez JA; Henrich MT; Geibl FF; Nilsson PR; Shi K; Rominger A; Oertel WH; Nitsch RM; Nordberg A; Agren H; Ni R
Journal article: MOLECULAR NEUROBIOLOGY. 2024;61(10):7517-7533
NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer's Disease
Tang Z; Chen Z; Guo M; Peng Y; Xiao Y; Guan Z; Ni R; Qi X
Journal article: MOLECULAR NEUROBIOLOGY. 2024;61(10):8387-8401
Relationship Between Reactive Astrocytes, by [¹⁸F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's Disease
Kong Y; Maschio CA; Shi X; Xie F; Zuo C; Konietzko U; Shi K; Rominger A; Xiao J; Huang Q; Nitsch RM; Guan Y; Ni R
Journal article: NEURAL REGENERATION RESEARCH. 2024;19(10):2115-2116
Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases
Cao L; Ji B; Ni R
Journal article: BIOMEDICINE & PHARMACOTHERAPY. 2024;177:116963
Myricetin ameliorates cognitive impairment in 3xTg x Tg Alzheimer's disease mice by regulating oxidative stress and tau hyperphosphorylation
Wang L; Tang Z; Li B; Peng Y; Yang X; Xiao Y; Ni R; Qi X-L
Journal article: ADVANCED THERAPEUTICS. 2024;7(8)
Effect of APOE ε4 Status on Brain Amyloid-β and Cognitive Function in Amnestic and Nonamnestic Mild Cognitive Impairment: A [18F] Florbetapir PET-CT Study
Wang M; Zhang Z; Wang Y; Huang L; Huang Q; Ren S; Qian L; Ni R; Guo Q; Guan Y; Xie F
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2024;719:150127
Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells
Tang Z; Peng Y; Jiang Y; Wang L; Guo M; Chen Z; Luo C; Zhang T; Xiao Y; Ni R; Qi X
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2024;462:123079
In vivo reactive astrocyte imaging using [¹⁸F]SMBT-1 in tauopathy and familial Alzheimer's disease mouse models: A multi-tracer study
Kong Y; Cao L; Wang J; Zhuang J; Xie F; Zuo C; Huang Q; Shi K; Rominger A; Li M; Wu P; Guan Y; Ni R
Journal article: ACS CHEMICAL NEUROSCIENCE. 2024;15(11):2112-2120
Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [¹⁸F]GSK1482160
Kong Y; Cao L; Wang J; Zhuang J; Liu Y; Bi L; Qiu Y; Hou Y; Huang Q; Xie F; Yang Y; Shi K; Rominger A; Guan Y; Jin H; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2024;20(6):3876-3888
Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment
Wang J; Huang Q; He K; Li J; Guo T; Yang Y; Lin Z; Li S; Vanderlinden G; Huang Y; Van Laere K; Guan Y; Guo Q; Ni R; Li B; Xie F
Journal article: BIOMEDICINE & PHARMACOTHERAPY. 2024;172:116252
Reduced SV2A and GABAA receptor levels in the brains of type 2 diabetic rats revealed by [18F]SDM-8 and [18F]flumazenil PET
Kong Y; Cao L; Xie F; Wang X; Zuo C; Shi K; Rominger A; Huang Q; Xiao J; Jiang D; Guan Y; Ni R
Journal article: ACS CHEMICAL NEUROSCIENCE. 2024;15(1):78-85
Probing Chemical Complexity of Amyloid Plaques in Alzheimer's Disease Mice using Hyperspectral Raman Imaging
Mrdenovic D; Combes BF; Ni R; Zenobi R; Kumar N
Journal article: METHODS IN MOLECULAR BIOLOGY. 2024;2785:271-285
Noninvasive Visualization of Amyloid-Beta Deposits in Alzheimer's Amyloidosis Mice via Fluorescence Molecular Tomography Using Contrast Agent.
Ren W; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S16)
MRI reveals cerebral iron, calcification and spinal cord atrophy in M83 mouse model of Parkinson’s disease
Tournant A; Combes BF; Law MH; Antunes I; Dias S; Noain D; Klohs J; Baumann CR; Razansky D; Nitsch RM; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S16)
Automatic analysis of skull thickness, scalp‐to‐cortex distance and association with age and sex in cognitively normal elderly
Zhang J; Treyer V; Gietl AF; Hock C; Razansky D; Nitsch RM; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S10)
Automatic analysis of skull thickness, scalp‐to‐cortex distance and association with age and sex in cognitively normal elderly
Zhang J; Treyer V; Gietl AF; Hock C; Razansky D; Nitsch RM; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S24)
In vivo [18F]SMBT‐1 imaging of reactive astrocytes in mouse models of Alzheimer’s disease ‐ temporospatial relationship with amyloid, tau and microgliosis
Kong Y; Maschio C; Yao B; Shi K; Rominger A; Xiao J; Huang Q; Guan Y; Ni R
Journal article: BRAIN PATHOLOGY. 2023;33(6):e13189
Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis
Maheshwari U; Mateos JM; Weber-Stadlbauer U; Ni R; Tamatey V; Sridhar S; Restrepo A; de Jong PA; Huang S-F; Schaffenrath J; Stifter SA; Szeri F; Greter M; Koek HL; Keller A
Journal article: EUROPEAN RADIOLOGY. 2023;33(10):7077-7088
Evaluation of novel anti-CEACAM6 antibody-based conjugates for radioimmunotheranostics of pancreatic ductal adenocarcinoma
Kong Y; Xie F; Zhang Z; Wang S; Zhang Y; Di Y; Zhou Z; Jiang D; Li J; Huang Q; Wang J; Li X; Pan Z; Ni R; Guan Y
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023;50(11):3166-3167
Collection on molecular imaging in neurodegeneration
Xie F; Ni R
Journal article: PHOTOACOUSTICS. 2023;32:100532
Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion
Ni R; Straumann N; Fazio S; Dean-Ben XL; Louloudis G; Keller C; Razansky D; Ametamey S; Mu L; Nombela-Arrieta C; Klohs J
Journal article: BIORXIV. 2023;:2023.06.28.546962
Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.
Straumann N; Combes BF; Dean Ben XL; Sternke-Hoffmann R; Gerez JA; Dias I; Chen Z; Watts B; Rostami I; Shi K; Rominger A; Baumann CR; Luo J; Noain D; Nitsch RM; Okamura N; Razansky D; Ni R
Journal article: NATURE COMMUNICATIONS. 2023;14(1):3584
Deep optoacoustic localization microangiography of ischemic stroke in mice
Dean-Ben XL; Robin J; Nozdriukhin D; Ni R; Zhao J; Gluck C; Droux J; Sendon-Lago J; Chen Z; Zhou Q; Weber B; Wegener S; Vidal A; Arand M; El Amki M; Razansky D
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)
Aquaporin 4 is associated with cerebral amyloid‐beta and tau deposits in mouse models
Kecheliev V; Maschio C; Konetiko U; Nitsch RM; Klohs J; Ni R
Journal article: LIFE SCIENCES. 2023;321:121593
Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta
Kecheliev V; Boss L; Maheshwari U; Konietzko U; Keller A; Razansky D; Nitsch RM; Klohs J; Ni R
Journal article: BRAIN STIMULATION. 2023;16(2):653-656
Automatic analysis of skull thickness, scalp-to-cortex distance and association with age and sex in cognitively normal elderly*
Zhang J; Treyer V; Sun J; Zhang C; Gietl A; Hock C; Razansky D; Nitsch RM; Ni R
Journal article: BIOMEDICAL OPTICS EXPRESS. 2023;14(3):1192-1204
Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography
Ren W; Dean-ben XL; Skachokova Z; Augath M-A; Ni R; Chen Z; Razansky D
Journal article: BEHAVIOURAL BRAIN RESEARCH. 2023;438:114174
PET imaging in animal models of Parkinson's disease
Ni R
Journal article: OPTICS LETTERS. 2023;48(3):648-651
Coregistered transcranial optoacoustic and magnetic resonance angiography of the human brain
Ni R; Dean-Ben XL; Treyer V; Gietl A; Hock C; Klohs J; Nitsch RM; Razansky D
Journal article: ADVANCED SCIENCE. 2023;10(3):e2205191
Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain-Wide Sensory Responses in Mice
Chen Z; Gezginer I; Augath M-A; Liu Y-H; Ni R; Dean-Ben XL; Razansky D
Journal article: REDOX BIOLOGY. 2022;58:102554
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation
Zhang J; Liu L; Zhang Y; Yuan Y; Miao Z; Lu K; Zhang X; Ni R; Zhang H; Zhao Y; Wang X
Journal article: LIGHT-SCIENCE & APPLICATIONS. 2022;11(1):332
Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging
Chen Z; Gezginer I; Augath M-A; Ren W; Liu Y-H; Ni R; Dean-Ben XL; Razansky D
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:1018610
Evaluation of cannabinoid type 2 receptor expression and pyridine-based radiotracers in brains from a mouse model of Alzheimer's disease
Kecheliev V; Spinelli F; Herde A; Haider A; Mu L; Klohs J; Ametamey SM; Ni R
Journal article: NATURE BIOMEDICAL ENGINEERING. 2022;6(9):1031-1044
Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice
Ni R; Chen Z; Dean-Ben XL; Voigt FF; Kirschenbaum D; Shi G; Villois A; Zhou Q; Crimi A; Arosio P; Nitsch RM; Nilsson KPR; Aguzzi A; Helmchen F; Klohs J; Razansky D
Journal article: BIOMEDICAL OPTICS EXPRESS. 2022;13(9):4817-4833
Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging
Hu Y; Lafci B; Luzgin A; Wang H; Klohs J; Dean-Ben XL; Ni R; Razansky D; Ren W
Journal article: OPTICS LETTERS. 2022;47(16):4163-4166
Sensitive ultrawideband transparent PVDF-ITO ultrasound detector for optoacoustic microscopy
Liu Y-H; Kurnikov A; Li W; Kazakov V; Ni R; Subochev P; Razansky D
Journal article: ADVANCED SCIENCE. 2022;9(24):2270151
Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain‐Wide Sensory Responses (Adv. Sci. 24/2022)
Chen Z; Zhou Q; Deán‐Ben XL; Gezginer I; Ni R; Reiss M; Shoham S; Razansky D
Journal article: ADVANCED SCIENCE. 2022;9(24):e2105588
Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses
Chen Z; Zhou Q; Dean-Ben XL; Gezginer I; Ni R; Reiss M; Shoham S; Razansky D
Journal article: FRONTIERS IN NEUROSCIENCE. 2022;16:952449
Editorial: Translational imaging in neurodegenerative proteinopathies
Ni R; Sahara N; Ji B
Journal article: BIOMEDICAL OPTICS EXPRESS. 2022;13(7):3809-3822
Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography
Ren W; Li L; Zhang J; Vaas M; Klohs J; Ripoll J; Wolf M; Ni R; Rudin M
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(7):2137-2152
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography
Vagenknecht P; Luzgin A; Ono M; Ji B; Higuchi M; Noain D; Maschio CA; Sobek J; Chen Z; Konietzko U; Gerez JA; Riek R; Razansky D; Klohs J; Nitsch RM; Dean-Ben XL; Ni R
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:825996
Structural MRI Reveals Cervical Spinal Cord Atrophy in the P301L Mouse Model of Tauopathy: Gender and Transgene-Dosing Effects
Sartoretti T; Ganley RP; Ni R; Freund P; Zeilhofer HU; Klohs J
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:838034
Amyloid and Tau Positron Emission Tomography Imaging in Alzheimer's Disease and Other Tauopathies
Maschio C; Ni R
Journal article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022;42(4):686-693
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy
Kindler D; Maschio C; Ni R; Zerbi V; Razansky D; Klohs J
Journal article: FRONTIERS IN MEDICINE. 2022;9:771982
Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics
Ren W; Ji B; Guan Y; Cao L; Ni R
Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:782434
Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways
Lai C; Chen Z; Ding Y; Chen Q; Su S; Liu H; Ni R; Tang Z
Journal article: FRONTIERS IN PHARMACOLOGY. 2022;13:821521
Emodin Protects SH-SY5Y Cells Against Zinc-Induced Synaptic Impairment and Oxidative Stress Through the ERK1/2 Pathway
Chen Q; Lai C; Chen F; Ding Y; Zhou Y; Su S; Ni R; Tang Z
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;13:791679
Magnetic Resonance Imaging in Tauopathy Animal Models
Ni R
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;13:761913
Positron Emission Tomography in Animal Models of Tauopathies
Cao L; Kong Y; Ji B; Ren Y; Guan Y; Ni R
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2022;13:751897
Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia
Ni R; Nitsch RM
Journal article: CURRENT ALZHEIMER RESEARCH. 2022;19(2):104-118
The Impact of Uremic Toxins on Alzheimer's Disease
Zheng Y; Ji B; Chen S; Zhou R; Ni R
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021;48(13):4152-4170
Multi-scale optoacoustic molecular imaging of brain diseases
Razansky D; Klohs J; Ni R
Journal article: ALZHEIMERS & DEMENTIA. 2021;17(S4)
High‐resolution non‐invasive whole brain imaging of tauopathy in a tauopathy mouse model
Vagenknecht P; Dean‐Ben XL; Gerez JA; Mu L; Ji B; Riek R; Razansky D; Klohs J; Nitsch RM; Ni R
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(23):12768
Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis
Ni R
Journal article: PHARMACEUTICALS. 2021;14(11):1179
Positron Emission Tomography in Animal Models of Alzheimer's Disease Amyloidosis: Translational Implications
Ni R
Journal article: MOLECULAR IMAGING AND BIOLOGY. 2021;24(5):700-709
In vivo Imaging of Cannabinoid Type 2 Receptors: Functional and Structural Alterations in Mouse Model of Cerebral Ischemia by PET and MRI
Ni R; Muller Herde A; Haider A; Keller C; Louloudis G; Vaas M; Schibli R; Ametamey SM; Klohs J; Mu L
Journal article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2021;9:746815
Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals
Shi X-F; Ji B; Kong Y; Guan Y; Ni R
Journal article: FRONTIERS IN IMMUNOLOGY. 2021;12:739130
PET Imaging of Neuroinflammation in Alzheimer's Disease
Zhou R; Ji B; Kong Y; Qin L; Ren W; Guan Y; Ni R
Journal article: PHOTOACOUSTICS. 2021;23:100285
In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice
Ni R; Villois A; Dean-Ben XL; Chen Z; Vaas M; Stavrakis S; Shi G; DeMello A; Ran C; Razansky D; Arosio P; Klohs J
Journal article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:609908
The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment
Kong Y; Huang L; Li W; Liu X; Zhou Y; Liu C; Zhang S; Xie F; Zhang Z; Jiang D; Zhou W; Ni R; Zhang C; Sun B; Wang J; Guan Y
Journal article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:675722
Real-World Outcomes of Revascularization Strategies in Patients With Left Ventricular Dysfunction and Three-Vessel Coronary Disease Stratified by Mitral Regurgitation
Fan Q; Liu J; Xu Y; Ni R; Xi R; Wang F; Hu J; Sun H; Yang Z; Zhou M; Zhang R; Zhao Q; Tao R
Journal article: NEURODEGENERATIVE DISEASES. 2021;20(5-6):173-184
Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of Tauopathy
Massalimova A; Ni R; Nitsch RM; Reisert M; von Elverfeldt D; Klohs J
Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;80(4):1723-1737
In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer's Brain Tissue
Ni R; Rojdner J; Voytenko L; Dyrks T; Thiele A; Marutle A; Nordberg A
Journal article: MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 2020;33(6):769-781
SWI and phase imaging reveal intracranial calcifications in the P301L mouse model of human tauopathy
Ni R; Zarb Y; Kuhn GA; Muller R; Yundung Y; Nitsch RM; Kulic L; Keller A; Klohs J
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S4)
Transcranial detection of amyloid‐beta at single plaque resolution in vivo with large‐field multifocal illumination fluorescence microscopy
Ni R; Chen Z; Shi G; Villois A; Zhou Q; Arosio P; Nitsch RM; Nilsson KPR; Klohs J; Razansky D
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S5)
Transcranial detection of tauopathy in vivo in P301L mice with high‐resolution large‐field multifocal illumination fluorescence microscopy
Ni R; Chen Z; Gerez JA; Shi G; Zhou Q; Riek R; Nilsson KPR; Razansky D; Klohs J
Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S4)
Volumetric multispectral optoacoustic tomography of beta‐amyloid deposits in whole mouse brain
Ni R; Dean‐Ben XL; Rudin M; Shi G; Chen Z; Mu L; Nitsch RM; Razansky D; Klohs J
Journal article: BIOMEDICAL OPTICS EXPRESS. 2020;11(9):4989-5002
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy
Ni R; Chen Z; Gerez JA; Shi G; Zhou Q; Riek R; Nilsson KPR; Razansky D; Klohs J
Journal article: NEUROPHOTONICS. 2019;6(2):025001-1
Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies
Ren W; Skulason H; Schlegel F; Rudin M; Klohs J; Ni R
Journal article: ACTA PHARMACOLOGICA SINICA. 2019;40(3):351-357
Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system
Ni R; Mu L; Ametamey S
Journal article: FRONTIERS IN AGING NEUROSCIENCE. 2019;11:27
fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis
Ni R; Kindler DR; Waag R; Rouault M; Ravikumar P; Nitsch R; Rudin M; Camici GG; Liberale L; Kulic L; Klohs J
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_30):p1575
P4‐311: EVALUATION OF CANNABINOID RECEPTOR 2 PET IMAGING TRACERS IN ALZHEIMER'S DISEASE BRAIN
Ni R; Haider A; Herde A; Klohs J; Mu L; Ametamey SM
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_20):p1088-p1089
P3‐063: BRADYKININ ANTAGONIST NOSCAPINE MITIGATES CEREBROVASCULAR DYSFUNCTION IN THE ARCAβ MOUSE MODEL OF ALZHEIMER'S DISEASE
Ni R; Kindler DR; Rouault M; Ielacqua GD; Klohs J
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_31):p1636
O5‐01‐01: IN VIVO OPTOACOUSTIC TOMOGRAPHY OF BRAIN AMYLOID DEPOSITS IN AN ARCAβ MOUSE MODEL OF ALZHEIMER'S DISEASE
Ni R; Vaas M; Arosio P; Klohs J
Journal article: PHOTOACOUSTICS. 2018;10:38-47
Cortical hypoperfusion and reduced cerebral metabolic rate of oxygen in the arcAβ mouse model of Alzheimer's disease
Ni R; Rudin M; Klohs J
Article: JOURNAL OF NUCLEAR MEDICINE. 2018;59(6):960-966
Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
Ni R; Ji B; Ono M; Sahara N; Zhang M-R; Aoki I; Nordberg A; Suhara T; Higuchi M
Journal article: DIGITAL CHINESE MEDICINE. 2018;1(1):47-55
Optimization of GERD Therapeutic Regimen Based on ANN and Realization of MATLAB
Wang W-W; Ni R-Q; Yu F-Y; Lou G-F; Zhao C-D
Journal article: NEUROPHOTONICS. 2018;5(1):015005-1
Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography
Ni R; Vaas M; Ren W; Klohs J
Journal article: JOURNAL OF ALZHEIMERS DISEASE. 2018;61(3):1037-1052
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510
Ishikawa A; Tokunaga M; Maeda J; Minamihisamatsu T; Shimojo M; Takuwa H; Ono M; Ni R; Hirano S; Kuwabara S; Ji B; Zhang M-R; Aoki I; Suhara T; Higuchi M; Sahara N
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:s732-s733
P.1.j.020 Psychological and neural mechanisms of rotating leadership in teams: the impact of engagement and shared mental model
Klett TC; Ni R
Article: ALZHEIMERS & DEMENTIA. 2017;13(4):419-430
Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease
Ni R; Gillberg P-G; Bogdanovic N; Viitanen M; Myllykangas L; Nennesmo I; Langstrom B; Nordberg A
Journal article: FRONTIERS IN NEUROLOGY. 2017;8:85
Extracerebral Tissue Damage in the Intraluminal Filament Mouse Model of Middle Cerebral Artery Occlusion
Vaas M; Ni R; Rudin M; Kipar A; Klohs J
Article: BRAIN. 2017;140(3):764-780
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
Ono M; Sahara N; Kumata K; Ji B; Ni R; Koga S; Dickson DW; Trojanowski JQ; Lee VM-Y; Yoshida M; Hozumi I; Yoshiyama Y; van Swieten JC; Nordberg A; Suhara T; Zhang M-R; Higuchi M
Journal article: ALZHEIMERS & DEMENTIA. 2016;12(7S_Part_15):p725
P2‐257: Radioligand Binding Assays for Comparison of TAU Pet Probes, PBB3 and T807, in Detection of TAU Pathologies in Alzheimer's Disease and PSP Brains, and Neurotoxic TAU Species in a Transgenic Mouse Model
Ni R; Ji B; Ono M; Sahara N; Aoki I; Zhang M-R; Suhara T; Higuchi M
Journal article: ALZHEIMERS & DEMENTIA. 2015;11(7S_Part_19):p878
P4‐254: Characterization of regional binding of clinical amyloid tracers in autosomal dominant and sporadic Alzheimer's disease brains and their interactions with resveratrol
Ni R; Gillberg P-G; Viitanen M; Myllykangas L; Bogdanovic N; Nennesmo I; Långström B; Nordberg A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(7):1119-1132
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
Rodriguez-Vieitez E; Ni R; Gulyas B; Toth M; Haeggkvist J; Halldin C; Voytenko L; Marutle A; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_4):p253
O4‐02‐05: DIFFERENT TIME COURSE OF ASTROCYTOSIS AND AMYLOID DEPOSITION IN ALZHEIMER'S APPSWE TRANSGENICE MICE: A MULTI‐TRACER MICROPET STUDY
Ni R; Rodriguez‐Vieitez E; Voytenko L; Marutle A; Nordberg A
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:90
³H-Deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
Marutle A; Gillberg P-G; Bergfors A; Yu W; Ni R; Nennesmo I; Voytenko L; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2013;9(4S_Part_8):p337
O2–11–03: Astrocytosis precedes amyloid deposition in Alzheimer's Tg2576 APPswe transgenic mice: A multi‐tracer microPET imaging study
Rodriguez‐Vieitez E; Ni R; Gulyás B; Toth M; Häggkvist J; Halldin C; Voytenko L; Marutle A; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2013;9(4S_Part_1):p28
IC‐P‐038: Astrocytosis precedes amyloid deposition in Alzheimer's disease Tg2576 APPswe transgenic mice: A multitracer microPET imaging study
Rodriguez‐Vieitez E; Ni R; Gulyás B; Tot M; Häggkvist J; Halldin C; Voytenko L; Marutle A; Nordberg A
Article: BRAIN. 2013;136(Pt 7):2217-2227
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue
Ni R; Gillberg P-G; Bergfors A; Marutle A; Nordberg A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(4):929-939
Combination of ¹⁸F-FDG PET and Cerebrospinal Fluid Biomarkers as a Better Predictor of the Progression to Alzheimer's Disease in Mild Cognitive Impairment Patients
Choo IH; Ni R; Scholl M; Wall A; Almkvist O; Nordberg A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(3):841-851
Modulation of α7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-β Interactions in Alzheimer's Disease Brain
Ni R; Marutle A; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_24):e16-e17
P4‐301: Evolution of fibrillar amyloid in relation to astro‐ and microgliosis and alterations in α7 nicotinic receptors in Alzheimer APPswe mice as studied with multi‐tracer concept
Thomé C; Ni R; Gillberg P; Marutle A; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_13):s468
P2‐487: Alpha7 nicotinic receptor agonists interrupt the interaction between fibrillar amyloid and nicotinic receptor in Alzheimer's brain
Ni R; Marutle A; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_12):s414-s415
P2‐329: Laminar distributions of fibrillar β‐amyloid and activated astrocytes in Alzheimer's disease autopsy brain: A quantitative autoradiography study
Marutle A; Bergfors A; Ni R; Nennesmo I; Gillberg P; Nordberg A
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Preprint: BIORXIV. 2025
Chemerin-CMKLR1 mediated OGD/R induced Mitochondrial Dysfunction, Oxidative Stress, and Autophagy differentially in Microglia and Neurons
Long P-Y; Tang Z; Cai N; Yan Z-Q; Gao X; Wang Z-W; Guan Z-Z; Qi X-L; Ni R; Xiao Y
Preprint: BIORXIV. 2025
Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer’s disease- associations with Aβ, tau and synaptophysin
Nussbaumer J; Barve A; Zufferey V; Espourteille J; Kirabali T; Konietzko U; Razansky D; Rominger A; Nordberg A; Buée L; Colin M; Nitsch RM; Hock C; Richetin K; Ni R
Conference publication: PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. 2022;12461:1246103-1246103-8-5
Automatic image registration of optoacoustic tomography and magnetic resonance imaging based on deep learning
Hu Y; Lafci B; Luzgin A; Wang H; Klohs J; Deán-Ben XL; Ni R; Razansky D; Ren W
Conference publication: PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. 2022;12146:1214603-1214603-6-2
Noninvasive optoacoustic imaging of the human brain validated with magnetic resonance angiography
Ni R; Deán-Ben XL; Treyer V; Klohs J; Gietl A; Hock C; Nitsch RM; Razansky D
Conference publication: 2022;:jtu3a.47
Evaluation of Transcranial Optoacoustic Imaging of a Human Brain Phantom
Zhang J; Dean-Ben XL; Ni R; Razansky D
Conference publication: 2021;:77
In vivo localization optoacoustic tomography (LOT) with particles smaller than red blood cells
Deán-Ben XL; Robin J; Ni R; Razansky D
Conference publication: 2021;:otu1e.4
Non-invasive optoacoustic imaging of tau in P301L mice
Vagenknecht P; Dean-Ben XL; Gerez JA; Chen Z; Nitsch RM; Klohs J; Razansky D; Ni R
Conference publication: PROGRESS IN BIOMEDICAL OPTICS AND IMAGING - PROCEEDINGS OF SPIE. 2019;11074:110740c-110740c-7-11
Simulation of fluorescence molecular tomography using a registered digital mouse atlas
Polatoglu MN; Liu Y; Ni R; Ripoll J; Rudin M; Wolf M; Ren W
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2019;39:314-315
Non-invasive volumetric mapping of amyloid pathology across the whole mouse brain by photoacoustic tomography
Ni R; Kirchenbaum D; Voigt F; Villios A; Ran C; Helmchen F; Arosio P; Aguzzi A; Klohs J
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2019;39:315
Functional MRI reveals mitigation of cerebrovascular dysfunction by bradykinin receptor 1 and 2 antagonism in a mouse model of cerebral amyloidosis
Ni R; Kindler D; Waag R; Rouault M; Rudin M; Camici G; Liberale L; Kulic L; Klohs J
Conference publication: 2019;:57
International Photoacoustic Standardisation Consortium (IPASC): overview (Conference Presentation)
Bohndiek S; Brunker J; Gröhl J; Hacker L; Joseph J; Vogt WC; Armanetti P; Assi H; Bamber JC; Beard PC; Berer T; Bouchard R; Briggman KA; Cavigli L; Clingman B; Cox BT; Desjardins AE; Heinmiller A; Hwang J; Hysi E; Ivory A; Jose J; Kirchner T; Klohs J; Maier-Hein L; Maneas E; Mannheim J; Manohar S; McNally L; Menichetti L; Miller S; Morscher S; Ni R; Okamura Y; Olivo MC; Pagel M; Parker G; Pelagotti A; Pifferi A; Rajagopal S; Ratto F; Razansky D; Richards LM; Ron A; Kuniyil Ajith Singh M; Waldner M; Wang K; Wang LV; Xia W; Zeqiri B
Conference publication: 2019;:ow2d.4
Automated registration for optoacoustic tomography and MRI
Ren W; Skulason H; Schlegel F; Rudin M; Klohs J; Ni R
Conference publication: 2018;10494:104941g-50
Quantification of amyloid deposits and oxygen extraction fraction in the brain with multispectral optoacoustic imaging in arcAβ mouse model of Alzheimer's disease
Ni R; Vaas M; Rudin M; Klohs J
Conference publication: 2018;10494:104940o-23
Non-invasive detection of matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography
Ni R; Vaas M; Ren W; Klohs J
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S732-S733
Psychological and neural mechanisms of rotating leadership in teams: the impact of engagement and shared mental model
Klett TC; Ni R
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37:284
Degeneration of muscles supplied by the external carotid artery in the intraluminal filament mouse model of middle cerebral artery occlusion
Vaas M; Ni R; Rudin M; Kipar A; Klohs J
Doctoral thesis: 2015
Multiple amyloid binding sites in Alzheimer brain and their interaction with synaptic and inflammatory mechanisms
Ni R
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:20
Alpha7 nicotinic receptors as important targets for neuroprotective mechanisms in new drug targets for Alzheimer's disease
Nordberg A; Lilja A; Ni R; Voytenko L; Gillberg P-G; Marutle A
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S3-S4
Drug interaction between fibrillar amyloid β and alpha7 nicotinic receptor in Alzheimer brain
Ni R; Marutle A; Nordberg A

Grants

Facilitating focused ultrasound-mediated Tau clearance in Alzheimer’s disease and other Tauopathies by understanding the underlying autophagic mechanisms
Swiss National Science Foundation
1 January 2023 - 31 December 2025

Employments

Affiliated to Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2027

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2015

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