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About me

I work in the applied biostatistics group at the department of Medical Epidemiology and Biostatistics (MEB). My main work focus is on statistical analysis of human genetic data, especially (but not only) genome-wide association studies.


My skills and interests include:

  • Genetics, GWAS and related (genome-wide association, imputation, polygenic risk scores, mendelian randomization, family-based designs, ...)
  • Genome-wide methylation analysis (Illumina 450k chip)
  • R programming, data management, and visualization
  • Linux shell programming and server know-how
  • Parallel processing of large datasets
  • Other programming (python, fortran, C, perl, php/html/css, ...)


I had my basic training in biomathematics (mathematics, computer science, statistics, and biochemistry) at Stockholm University, followed by a PhD in medical science at the department of neuroscience and the department of medical epidemiology and biostatistics at Karolinska Institutet.


A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen X, Gustafsson S, Whitington T, Borné Y, Lorentzen E, Sun J, et al
Human molecular genetics 2018;27(10):1809-1818

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium
Felix Jf, Joubert Br, Baccarelli Aa, Sharp Gc, Almqvist C, Annesi-maesano I, et al
International journal of epidemiology 2018;47(1):22-23u

Common genetic variation and novel loci associated with volumetric mammographic density
Brand Js, Humphreys K, Li J, Karlsson R, Hall P, Czene K
Breast cancer research : BCR 2018;20(1):30-

Eleven loci with new reproducible genetic associations with allergic disease risk
23andme Research Team, Collaborators Of The Share Study, Ferreira Mar, Vonk Jm, Baurecht H, Marenholz I, et al
The Journal of allergy and clinical immunology 2018;():-

Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits
Chen X, Kuja-halkola R, Chang Z, Karlsson R, Hägg S, Svensson P, et al
Journal of the American Heart Association 2018;7(9):-

Exploring the Causal Pathway From Telomere Length to Coronary Heart Disease: A Network Mendelian Randomization Study
Zhan Y, Karlsson Ik, Karlsson R, Tillander A, Reynolds Ca, Pedersen Nl, et al
Circulation research 2017;121(3):214-219

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
Lifelines Cohort Study, Practical Consortium, Ovarian Cancer Association Consortium, Endometrial Cancer Association Consortium, Kconfab/aocs Investigators, Interact Consortium, et al
Nature genetics 2017;49(6):834-841

Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
Uk Testicular Cancer Collaboration, Practical Consortium, Litchfield K, Levy M, Orlando G, Loveday C, et al
Nature genetics 2017;49(7):1133-1140

Mendelian randomisation analysis provides no evidence for a relationship between adult height and testicular cancer risk
Levy M, Hall D, Sud A, Law P, Litchfield K, Dudakia D, et al
Andrology 2017;5(5):914-922

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Testicular Cancer Consortium, Wang Z, Mcglynn Ka, Rajpert-de Meyts E, Bishop Dt, Chung Cc, et al
Nature genetics 2017;49(7):1141-1147

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
23andme Research Team, Lifelines Cohort Study, Bios Consortium, Aagc Collaborators, Ferreira Ma, Vonk Jm, et al
Nature genetics 2017;49(12):1752-1757

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Neurocharge Cognitive Working Group, Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, et al
Translational psychiatry 2017;7(4):e1100-

SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population
Ameur A, Dahlberg J, Olason P, Vezzi F, Karlsson R, Martin M, et al
European journal of human genetics : EJHG 2017;25(11):1253-1260

Gene regulatory mechanisms underpinning prostate cancer susceptibility
Whitington T, Gao P, Song W, Ross-adams H, Lamb Ad, Yang Y, et al
Nature genetics 2016;48(4):387-97

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Lifelines Cohort Study, Okbay A, Baselmans Bm, De Neve Je, Turley P, Nivard Mg, et al
Nature genetics 2016;48(6):624-33

Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Bios Consortium, Lifelines Cohort Study, Barban N, Jansen R, De Vlaming R, Vaez A, et al
Nature genetics 2016;48(12):1462-1472

Genome-wide association study identifies 74 loci associated with educational attainment
Lifelines Cohort Study, Okbay A, Beauchamp Jp, Fontana Ma, Lee Jj, Pers Th, et al
Nature 2016;533(7604):539-42

Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
Members Of The International Cohort Collection For Bipolar Disorder (iccbd), Song J, Bergen Se, Di Florio A, Karlsson R, Charney A, et al
Molecular psychiatry 2016;21(9):1290-7

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
Generation Scotland, Van Den Berg Sm, De Moor Mh, Verweij Kj, Krueger Rf, Luciano M, et al
Behavior genetics 2016;46(2):170-82

A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis
Lekman M, Karlsson R, Graae L, Hössjer O, Kockum I
BioData mining 2015;8():42-

Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models
Chen X, Kuja-halkola R, Rahman I, Arpegård J, Viktorin A, Karlsson R, et al
American journal of human genetics 2015;97(5):708-14

Genome-wide association study of prostate cancer-specific survival
Practical Consortium, Bpc3 Consortium, Australian Prostate Cancer Bioresource, Szulkin R, Karlsson R, Whitington T, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015;24(11):1796-800

Identification of two novel mammographic density loci at 6Q25.1
Brand Js, Li J, Humphreys K, Karlsson R, Eriksson M, Ivansson E, et al
Breast cancer research : BCR 2015;17():75-

Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study
Cederlöf M, Karlsson R, Larsson H, Almqvist C, Magnusson Pk, Nordlind K, et al
The British journal of dermatology 2015;173(1):155-8

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder
Genetics Of Personality Consortium, De Moor Mh, Van Den Berg Sm, Verweij Kj, Krueger Rf, Luciano M, et al
JAMA psychiatry 2015;72(7):642-50

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
Schizophrenia Working Grp Psychiat, Lee Sh, Byrne Em, Hultman Cm, Kahler A, Vinkhuyzen Aae, et al

Telomere Length Shortening and Alzheimer Disease--A Mendelian Randomization Study
Zhan Y, Song C, Karlsson R, Tillander A, Reynolds Ca, Pedersen Nl, et al
JAMA neurology 2015;72(10):1202-3

The risk of prostate cancer for men on aspirin, statin or antidiabetic medications
Nordström T, Clements M, Karlsson R, Adolfsson J, Grönberg H
European journal of cancer (Oxford, England : 1990) 2015;51(6):725-33

Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor
Kristiansen W, Karlsson R, Rounge Tb, Whitington T, Andreassen Bk, Magnusson Pk, et al
Human molecular genetics 2015;24(14):4138-46

A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival
Baecklund F, Foo Jn, Bracci P, Darabi H, Karlsson R, Hjalgrim H, et al

A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk
Karlsson R, Aly M, Clements M, Zheng L, Adolfsson J, Xu J, et al
European urology 2014;65(1):169-76

A genome-wide assessment of variability in human serum metabolism
Hong Mg, Karlsson R, Magnusson Pk, Lewis Mr, Isaacs W, Zheng Ls, et al
Human mutation 2013;34(3):515-24

Genetic variation in AKT1, PTEN and the 8q24 locus, and the risk of testicular germ cell tumor
Andreassen Ke, Kristiansen W, Karlsson R, Aschim El, Dahl O, Fossa Sd, et al
HUMAN REPRODUCTION 2013;28(7):1995-2002

Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4
Karlsson R, Andreassen Ke, Kristiansen W, Aschim El, Bremnes Rm, Dahl O, et al
Human molecular genetics 2013;22(16):3373-80

Gene variations in sex hormone pathways and the risk of testicular germ cell tumour: a case-parent triad study in a Norwegian-Swedish population
Kristiansen W, Andreassen Ke, Karlsson R, Aschim El, Bremnes Rm, Dahl O, et al
HUMAN REPRODUCTION 2012;27(5):1525-35

MAGI1 Copy Number Variation in Bipolar Affective Disorder and Schizophrenia
Karlsson R, Graae L, Lekman M, Wang D, Favis R, Axelsson T, et al
BIOLOGICAL PSYCHIATRY 2012;71(10):922-30

Significant Association of Estrogen Receptor Binding Site Variation with Bipolar Disorder in Females
Graae L, Karlsson R, Paddock S
PLOS ONE 2012;7(2):e32304-

Genome-wide association study identifies new prostate cancer susceptibility loci
Schumacher Fr, Berndt Si, Siddiq A, Jacobs Kb, Wang Zm, Lindstrom S, et al
HUMAN MOLECULAR GENETICS 2011;20(19):3867-75

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