Rikard Wedin

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About me

M.D., Associate Professor
Orthopedic surgeon working at Karolinska University Hospital in Solna since
1993. The main research area is surgical treatment of metastatic bone disease
and approxiamtely 30 papers in this field have been published so far
Founder of International Bone Metastasis Registry in collaboration with
Regional Cancer Center Stockholm/Gotland.
Co-developer of PATHFx (see links and presentations) together with Professor
Jonathan Forsberg, Johns Hopkins University &
Murtha Cancer Center,
Washington D.C.
Advising consultant to the Royal Swedish Ballet School Stockholm
Med school: Karolinska Institute 1981-1987, University of Pennsylvania 1982,
McMaster University 1985
Specialist orthopaedic surgery 1993, Karolinska University Hospital
PhD: Metastatic Bone Disease, 2000, Karolinska Institute
Associate Professor, KI, 2012

Articles

Article: THE JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS. 2024;32(6):e293-e301
Life Expectancy After Treatment of Metastatic Bone Disease: An International Trend Analysis
Rogers DL; Raad M; Rivera JA; Wedin R; Laitinen M; Sorensen MS; Petersen MM; Hilton T; Morris CD; Levin AS; Forsberg JA
Article: JOURNAL OF AUTOIMMUNITY. 2023;136:103022
The human bone marrow plasma cell compartment in rheumatoid arthritis-Clonal relationships and anti-citrulline autoantibody producing cells
Hensvold A; Horuluoglu B; Sahlstrom P; Thyagarajan R; Boada JSD; Hansson M; Mathsson-Alm L; Gerstner C; Sippl N; Israelsson L; Wedin R; Steen J; Klareskog L; Rethi B; Catrina AI; Diaz-Gallo L-M; Malmstrom V; Gronwall C
Article: ACTA ORTHOPAEDICA. 2022;93:721-731
Can a Bayesian belief network for survival prediction in patients with extremity metastases (PATHFx) be exter-nally validated in an Asian cohort of 356 surgically treated patients?
Hsieh H-C; Lai Y-H; Lee C-C; Yen H-K; Tseng T-E; Yang J-J; Lin S-Y; Hu M-H; Hou C-H; Yang R-S; Wedin R; Forsberg JA; Lin W-H
Article: BMC CANCER. 2022;22(1):476
Machine learning algorithms to estimate 10-Year survival in patients with bone metastases due to prostate cancer: toward a disease-specific survival estimation tool
Anderson AB; Grazal C; Wedin R; Kuo C; Chen Y; Christensen BR; Cullen J; Forsberg JA
Article: ACTA ORTHOPAEDICA. 2022;93:185-189
The obesity paradox and mortality after pathological hip fractures: a Swedish registry study
Ehne J; Tsagozis P; Lind A; Wedin R; Hedstrom M
Article: BRAIN AND SPINE. 2022;2:101669
Predicting survival of patients with spinal metastatic disease using PathFx 3.0-A validation study of 668 patients in Sweden
Carrwik C; Tsagkozis P; Wedin R; Robinson Y
Article: JOURNAL OF GASTROINTESTINAL ONCOLOGY. 2021;12(5):2150-2156
Outcome of surgical treatment for bone metastases caused by colorectal cancer
Byttner M; Wedin R; Bauer H; Tsagozis P
Article: JOURNAL OF BONE ONCOLOGY. 2021;29:100376
Prosthesis or osteosynthesis for the treatment of a pathological hip fracture? A nationwide registry-based cohort study
Tsagkozis P; Ehne J; Wedin R; Hedstrom M
Article: ACTA ORTHOPAEDICA. 2021;92(3):352-357
Surgical treatment of skeletal metastases in proximal tibia: a multicenter case series of 74 patients
Kilk K; Ehne J; Stevenson JD; Kask G; Nieminen J; Wedin R; Parry MC; Laitinen MK
Article: JOURNAL OF ORTHOPAEDIC RESEARCH. 2020;38(10):2149-2156
Validation of PATHFx 2.0: An open-source tool for estimating survival in patients undergoing pathologic fracture fixation
Overmann AL; Clark DM; Tsagkozis P; Wedin R; Forsberg JA
Article: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2020;478(4):808-818
External Validation of PATHFx Version 3.0 in Patients Treated Surgically and Nonsurgically for Symptomatic Skeletal Metastases
Anderson AB; Wedin R; Fabbri N; Boland P; Healey J; Forsberg JA
Article: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2017;475(9):2263-2270
Can A Multivariate Model for Survival Estimation in Skeletal Metastases (PATHFx) Be Externally Validated Using Japanese Patients?
Ogura K; Gokita T; Shinoda Y; Kawano H; Takagi T; Ae K; Kawai A; Wedin R; Forsberg JA
Article: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2017;475(4):1252-1261
Can We Estimate Short- and Intermediate-term Survival in Patients Undergoing Surgery for Metastatic Bone Disease?
Forsberg JA; Wedin R; Boland PJ; Healey JH
Article: ACTA ORTHOPAEDICA. 2016;87(2):183-188
Surgery of non-spinal skeletal metastases in renal cell carcinoma
Ratasvuori M; Sillanpaa N; Wedin R; Trovik C; Hansen BH; Laitinen M
Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2015;41(7):886-892
Survival and complications of skeletal reconstructions after surgical treatment of bony metastatic renal cell carcinoma
Laitinen M; Parry M; Ratasvuori M; Wedin R; Albergo JI; Jeys L; Abudu A; Carter S; Gaston L; Tillman R; Grimer R
Article: BMC CANCER. 2015;15:424
How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease-decision analysis and comparison of three international patient populations
Piccioli A; Spinelli MS; Forsberg JA; Wedin R; Healey JH; Ippolito V; Daolio PA; Ruggieri P; Maccauro G; Gasbarrini A; Biagini R; Piana R; Fazioli F; Luzzati A; Di Martino A; Nicolosi F; Camnasio F; Rosa MA; Campanacci DA; Denaro V; Capanna R
Article: CASE REPORTS IN UROLOGY. 2015;2015:583851-3
Femoral Metastasis from Penile Carcinoma: Report of 2 Cases.
Braumann L; Tsagozis P; Wedin R; Brosjö O
Article: ACTA ORTHOPAEDICA. 2015;86(6):690-694
Reconstruction of metastatic acetabular defects using a modified Harrington procedure Good outcome after surgical treatment of 70 patients
Tsagozis P; Wedin R; Brosjo O; Bauer H
Article: JOURNAL OF SURGICAL ONCOLOGY. 2014;110(4):360-365
Prognostic role of en-bloc resection and late onset of bone metastasis in patients with bone-seeking carcinomas of the kidney, breast, lung, and prostate: SSG study on 672 operated skeletal metastases
Ratasvuori M; Wedin R; Hansen BH; Keller J; Trovik C; Zaikova O; Bergh P; Kalen A; Laitinen M
Article: BREAST. 2014;23(3):286-290
Skeletal metastases in 301 breast cancer patients: Patient survival and complications after surgery
Weiss RJ; Tullberg E; Forsberg JA; Bauer HC; Wedin R
Article: JOURNAL OF SURGICAL ONCOLOGY. 2013;107(5):498-504
Pathological subtrochanteric fractures in 194 patients: A comparison of outcome after surgical treatment of pathological and non-pathological fractures
Weiss RJ; Ekstrom W; Hansen BH; Keller J; Laitinen M; Trovik C; Zaikova O; Wedin R
Article: BMC CANCER. 2012;12:493
External validation of the Bayesian Estimated Tools for Survival (BETS) models in patients with surgically treated skeletal metastases
Forsberg JA; Wedin R; Bauer HCF; Hansen BH; Laitinen M; Trovik CS; Keller JO; Boland PJ; Healey JH
Article: JOURNAL OF SHOULDER AND ELBOW SURGERY. 2012;21(8):1049-1055
Complications and survival after surgical treatment of 214 metastatic lesions of the humerus
Wedin R; Hansen BH; Laitinen M; Trovik C; Zaikova O; Bergh P; Kalen A; Schwarz-Lausten G; von Steyern FV; Walloe A; Keller J; Weiss RJ
Article: ACTA ORTHOPAEDICA BELGICA. 2012;78(2):246-253
Surgical treatment of skeletal metastases in 31 melanoma patients
Wedin R; Falkenius J; Weiss RJ; Hansson J
Article: ACTA ORTHOPAEDICA. 2012;83(1):74-79
Surgery of skeletal metastases in 306 patients with prostate cancer Indications, complications, and survival
Weiss RJ; Forsberg JA; Wedin R
Article: ACTA ORTHOPAEDICA. 2011;82(1):96-101
Surgery for skeletal metastases in lung cancer
Weiss RJ; Wedin R
Article: PLOS ONE. 2011;6(5):e19956
Estimating Survival in Patients with Operable Skeletal Metastases: An Application of a Bayesian Belief Network
Forsberg JA; Eberhardt J; Boland PJ; Wedin R; Healey JH
Article: CLINICAL AND EXPERIMENTAL METASTASIS. 2011;28(1):65-73
Differential expression of tartrate-resistant acid phosphatase isoforms 5a and 5b by tumor and stromal cells in human metastatic bone disease
Zenger S; He W; Ek-Rylander B; Vassiliou D; Wedin R; Bauer H; Andersson G
Article: ACTA ORTHOPAEDICA. 2009;80:85-90
The Scandinavian Sarcoma Group Skeletal Metastasis Registry Functional outcome and pain after surgery for bone metastases in the pelvis and extremities
Hansen BH; Keller J; Laitinen M; Berg P; Skjeldal S; Trovik C; Nilsson J; Walloe A; Kalen A; Wedin R
Article: JOURNAL OF BONE AND JOINT SURGERY - SERIES B. 2005;87B(12):1653-1657
Surgical treatment of skeletal metastatic lesions of the proximal femur - Endoprosthesis or reconstruction nail?
Wedin R; Bauer HCF
Article: AMERICAN JOURNAL OF PATHOLOGY. 2004;164(5):1645-1653
Activation of the GLI oncogene through fusion with the β-actin gene (ACTB) in a group of distinctive pericytic neoplasms -: Pericytoma with t(7;12)
Dahlén A; Fletcher CDM; Mertens F; Fletcher JA; Perez-Atayde AR; Hicks MJ; Debiec-Rychter M; Sciot R; Wejde J; Wedin R; Mandahl N; Panagopoulos L
Article: ACTA ORTHOPAEDICA SCANDINAVICA, SUPPLEMENT. 2004;75(311):11-15
The Scandinavian Sarcoma Group skeletal metastasis register -: Survival after surgery for bone metastases in the pelvis and extremities
Hansen BH; Keller J; Laitinen M; Berg P; Skjeldal S; Trovik C; Nilsson J; Walloe A; Kalén A; Wedin R
Article: ACTA ONCOLOGICA. 2004;43(5):460-466
Proliferation rate, hormone receptor status and p53 expression in skeletal metastasis of breast carcinoma
Wedin R; Skoog L; Bauer HCF
Article: CANCER. 2001;92(2):257-262
Surgical treatment for skeletal breast cancer metastases -: A population-based study of 641 patients
Wedin R; Bauer HCF; Rutqvist LE
Article: ACTA ORTHOPAEDICA SCANDINAVICA, SUPPLEMENT. 2001;72(302):2p.-29
Surgical treatment for pathologic fracture.
Wedin R
Article: ACTA ORTHOPAEDICA. 2001;72:3-29
Surgical treatment for pathologic fracture
Wedin R
Article: JOURNAL OF BONE AND JOINT SURGERY - SERIES B. 2000;82B(5):673-678
Cytological diagnosis of skeletal lesions -: Fine-needle aspiration biopsy in 110 tumours
Wedin R; Bauer HCF; Skoog L; Söderlund V; Tani E
Article: ACTA ORTHOPAEDICA. 1995;66(2):143-146
SURVIVAL AFTER SURGERY FOR SPINAL AND EXTREMITY METASTASES - PROGNOSTICATION IN 241 PATIENTS
BAUER HCF; WEDIN R
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All other publications

Published conference paper: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2018;476(9):1823-1833
What Factors Are Associated With Implant Breakage and Revision After Intramedullary Nailing for Femoral Metastases?
Willeumier JJ; Kaynak M; van der Zwaal P; Meylaerts SAG; Mathijssen NMC; Jutte PC; Tsagozis P; Wedin R; van de Sande MAJ; Fiocco M; Dijkstra PDS
Review: SURGICAL ONCOLOGY. 2013;22(2):132-138
Insight opinion to surgically treated metastatic bone disease: Scandinavian Sarcoma Group Skeletal Metastasis Registry report of 1195 operated skeletal metastasis
Ratasvuori M; Wedin R; Keller J; Nottrott M; Zaikova O; Bergh P; Kalen A; Nilsson J; Jonsson H; Laitinen M
Published conference paper: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2013;471(3):735-740
Which Implant Is Best After Failed Treatment for Pathologic Femur Fractures?
Forsberg JA; Wedin R; Bauer H
Thesis / dissertation: 2000
Metastatic bone disease
Wedin, Rikard
Published conference paper: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 1999;(358):128-139
Failures after operation for skeletal metastatic lesions of long bones
Wedin R; Bauer HCF; Wersäll P

Employments

Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2024-2025

Degrees and Education

Docent, Karolinska Institutet, 2012
Doctor Of Philosophy, Dept of Surgical Science, Karolinska Institutet, 2000

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