Denna sida på svenska
Loading profile information...

About me

I am a researcher and statistician at the Swedish Twin Registry ( and the Department of Medicial Epidemiology and Biostatistics ( I've been working with genetically informative population data since 2009.




Master in mathematics, 2009, Uppsala Univeristy

PhD in epidemiology, 2014, Karolinska Institutet

Research description

Register based research on Borderline Personality Disorder

I am leading an investigation into Borderline Personality Disorder, its causes, comorbidities, consequences, and pharmacological treatments. We use Swedish population-wide register data to unravel associations and investigate hypothesis in the largest sample ever to be investigated for the disorder.

Psychiatric Epidemiology

I am involved in investigation into e.g. ADHD, autism, and anxiety in the groups of Henrik Larsson ( and Paul Lichtenstein (


[Analysis on the heritability of diabetes, based on data from the Chinese adult twins]
Gan Fx, Gao Wj, Lyu J, Yu Cq, Wang Sf, Pang Zc, et al
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2019;40(4):389-393

Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders
Brander G, Isomura K, Chang Z, Kuja-halkola R, Almqvist C, Larsson H, et al
JAMA neurology 2019;():-

Attention-Deficit/Hyperactivity Disorder, School Performance, and Effect of Medication
Jangmo A, Stålhandske A, Chang Z, Chen Q, Almqvist C, Feldman I, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2019;58(4):423-432

Genetic and environmental sources of familial coaggregation of obsessive-compulsive disorder and suicidal behavior: a population-based birth cohort and family study
Sidorchuk A, Kuja-halkola R, Runeson B, Lichtenstein P, Larsson H, Rück C, et al
Molecular psychiatry 2019;():-

Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding
Xu H, Kuja-halkola R, Chen X, Magnusson Pke, Svensson P, Carrero Jj
Kidney international 2019;95(5):1225-1233

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts
Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-halkola R, et al
EBioMedicine 2019;40():710-716

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy
Brikell I, Chen Q, Kuja-halkola R, D'onofrio Bm, Wiggs Kk, Lichtenstein P, et al
Epilepsia 2019;60(2):284-293

Sex Differences Along the Autism Continuum: A Twin Study of Brain Structure
Cauvet É, Van't Westeinde A, Toro R, Kuja-halkola R, Neufeld J, Mevel K, et al
Cerebral cortex (New York, N.Y. : 1991) 2019;29(3):1342-1350

Social Cognition in Autism and Other Neurodevelopmental Disorders: A Co-twin Control Study
Isaksson J, Van't Westeinde A, Cauvet É, Kuja-halkola R, Lundin K, Neufeld J, et al
Journal of autism and developmental disorders 2019;():-

Tobacco and type 2 diabetes: is the association explained by genetic factors?
Carlsson S, Kuja-halkola R, Magnusson C, Lagerros Yt, Andersson T
International journal of epidemiology 2019;():-

2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study
Myers L, Van't Westeinde A, Kuja-halkola R, Tammimies K, Bölte S
Journal of autism and developmental disorders 2018;48(9):3244-3252

Alterations in resting state connectivity along the autism trait continuum: a twin study
Neufeld J, Kuja-halkola R, Mevel K, Cauvet É, Fransson P, Bölte S
Molecular psychiatry 2018;23(7):1659-1665

Association between attention deficit hyperactivity disorder and asthma: a systematic review and meta-analysis and a Swedish population-based study
Cortese S, Sun S, Zhang J, Sharma E, Chang Z, Kuja-halkola R, et al
The lancet. Psychiatry 2018;5(9):717-726

Association of Obsessive-Compulsive Disorder With Objective Indicators of Educational Attainment: A Nationwide Register-Based Sibling Control Study
Pérez-vigil A, Fernández De La Cruz L, Brander G, Isomura K, Jangmo A, Feldman I, et al
JAMA psychiatry 2018;75(1):47-55

Association of Tourette Syndrome and Chronic Tic Disorders With Objective Indicators of Educational Attainment: A Population-Based Sibling Comparison Study
Pérez-vigil A, Fernández De La Cruz L, Brander G, Isomura K, Jangmo A, Kuja-halkola R, et al
JAMA neurology 2018;75(9):1098-1105

A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders
Mataix-cols D, Frans E, Pérez-vigil A, Kuja-halkola R, Gromark C, Isomura K, et al
Molecular psychiatry 2018;23(7):1652-1658

Attention-deficit/hyperactivity disorder and clinically diagnosed obesity in adolescence and young adulthood: a register-based study in Sweden
Chen Q, Hartman Ca, Kuja-halkola R, Faraone Sv, Almqvist C, Larsson H
Psychological medicine 2018;():1-9

Childhood body mass index and development of eating disorder traits across adolescence
Wiklund Ca, Kuja-halkola R, Thornton Lm, Bälter K, Welch E, Bulik Cm
European eating disorders review : the journal of the Eating Disorders Association 2018;26(5):462-471

Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes
Kuja-halkola R, Lind Juto K, Skoglund C, Rück C, Mataix-cols D, Pérez-vigil A, et al
Molecular psychiatry 2018;():-

Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study
Brikell I, Ghirardi L, D'onofrio Bm, Dunn Dw, Almqvist C, Dalsgaard S, et al
Biological psychiatry 2018;83(2):173-180

Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits
Chen X, Kuja-halkola R, Chang Z, Karlsson R, Hägg S, Svensson P, et al
Journal of the American Heart Association 2018;7(9):-

Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study
Ghirardi L, Pettersson E, Taylor Mj, Freitag Cm, Franke B, Asherson P, et al
Psychological medicine 2018;():1-9

Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up
Isomura K, Brander G, Chang Z, Kuja-halkola R, Rück C, Hellner C, et al
Biological psychiatry 2018;84(5):324-331

Need for further analysis to explore the association between ADHD and asthma - Authors' reply
Cortese S, Sun S, Zhang J, Sharma E, Chang Z, Kuja-halkola R, et al
The lancet. Psychiatry 2018;5(12):963-964

Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study
Brander G, Rydell M, Kuja-halkola R, Fernández De La Cruz L, Lichtenstein P, Serlachius E, et al
Molecular psychiatry 2018;23(5):1189-1197

Prevalence and heritability of body dysmorphic symptoms in adolescents and young adults: a population-based nationwide twin study
Enander J, Ivanov Vz, Mataix-cols D, Kuja-halkola R, Ljótsson B, Lundström S, et al
Psychological medicine 2018;48(16):2740-2747

Specificity in Etiology of Subtypes of Bipolar Disorder: Evidence From a Swedish Population-Based Family Study
Song J, Kuja-halkola R, Sjölander A, Bergen Se, Larsson H, Landén M, et al
Biological psychiatry 2018;84(11):810-816

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology
Brikell I, Larsson H, Lu Y, Pettersson E, Chen Q, Kuja-halkola R, et al
Molecular psychiatry 2018;():-

The familial co-aggregation of ASD and ADHD: a register-based cohort study
Ghirardi L, Brikell I, Kuja-halkola R, Freitag Cm, Franke B, Asherson P, et al
Molecular psychiatry 2018;23(2):257-262

The Quantified Behavioral Test Failed to Differentiate ADHD in Adolescents With Neurodevelopmental Problems
Johansson V, Norén Selinus E, Kuja-halkola R, Lundström S, Durbeej N, Anckarsäter H, et al
Journal of attention disorders 2018;():1087054718787034-

The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins
Castellheim A, Lundström S, Molin M, Kuja-halkola R, Gillberg C, Gillberg C
Journal of child psychology and psychiatry, and allied disciplines 2018;59(9):966-972

A longitudinal study of adolescent psychotic experiences and later development of substance use disorder and suicidal behavior
Cederlöf M, Kuja-halkola R, Larsson H, Sjölander A, Östberg P, Lundström S, et al
Schizophrenia research 2017;181():13-16

Association Between Deliberate Self-harm and Violent Criminality
Sahlin H, Kuja-halkola R, Bjureberg J, Lichtenstein P, Molero Y, Rydell M, et al
JAMA psychiatry 2017;74(6):615-621

Birth weight, sex, and celiac disease: a nationwide twin study
Kuja-halkola R, Lebwohl B, Halfvarson J, Emilsson L, Magnusson Pk, Ludvigsson Jf

Estimating Heritability of Prostate Cancer-Specific Survival Using Population-Based Registers
Szulkin R, Clements Ms, Magnusson Pke, Wiklund Fe, Kuja-halkola R
The Prostate 2017;77(8):900-907

Familial aggregation of attention-deficit/hyperactivity disorder
Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-halkola R, Sandin S, et al
Journal of child psychology and psychiatry, and allied disciplines 2017;58(3):231-239

Fetal Growth and Childhood Lung Function in the Swedish Twin Study on Prediction and Prevention of Asthma
Örtqvist Ak, Ullemar V, Lundholm C, Kuja-halkola R, Magnusson Pke, Lichtenstein P, et al
Annals of the American Thoracic Society 2017;14(7):1147-1153

Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M, Foebel Ad, Kuja-halkola R, Karlsson I, Pedersen Nl, Hagg S, et al
AGING-US 2017;9(12):2629-2646

Genetic and environmental aspects in the association between attention-deficit hyperactivity disorder symptoms and binge-eating behavior in adults: a twin study
Capusan Aj, Yao S, Kuja-halkola R, Bulik Cm, Thornton Lm, Bendtsen P, et al
Psychological medicine 2017;47(16):2866-2878

Heritability of hoarding symptoms across adolescence and young adulthood: A longitudinal twin study
Ivanov Vz, Nordsletten A, Mataix-cols D, Serlachius E, Lichtenstein P, Lundström S, et al
PloS one 2017;12(6):e0179541-

Medical history of discordant twins and environmental etiologies of autism
Willfors C, Carlsson T, Anderlid Bm, Nordgren A, Kostrzewa E, Berggren S, et al
Translational psychiatry 2017;7(1):e1014-

Minor physical anomalies in neurodevelopmental disorders: a twin study
Myers L, Anderlid Bm, Nordgren A, Willfors C, Kuja-halkola R, Tammimies K, et al

Polycystic ovary syndrome, personality, and depression: A twin study
Cesta Ce, Kuja-halkola R, Lehto K, Iliadou An, Landén M
Psychoneuroendocrinology 2017;85():63-68

Predictive validity of parent- and self-rated ADHD symptoms in adolescence on adverse socioeconomic and health outcomes
Du Rietz E, Kuja-halkola R, Brikell I, Jangmo A, Sariaslan A, Lichtenstein P, et al
European child & adolescent psychiatry 2017;26(7):857-867

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample
Saha R, Kuja-halkola R, Tornvall P, Marions L
Journal of women's health (2002) 2017;26(2):152-158

Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population
Yao S, Kuja-halkola R, Thornton Lm, Norring C, Almqvist C, D'onofrio Bm, et al
The International journal of eating disorders 2017;50(9):1095-1103

Risk of eating disorders in immigrant populations
Mustelin L, Hedman Am, Thornton Lm, Kuja-halkola R, Keski-rahkonen A, Cantor-graae E, et al
Acta psychiatrica Scandinavica 2017;136(2):156-165

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden
Chen Q, Kuja-halkola R, Sjölander A, Serlachius E, Cortese S, Faraone Sv, et al
Journal of child psychology and psychiatry, and allied disciplines 2017;58(6):711-718

The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study
Faraone Sv, Ghirardi L, Kuja-halkola R, Lichtenstein P, Larsson H
Journal of the American Academy of Child and Adolescent Psychiatry 2017;56(2):167-174.e1

The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-halkola R, Hultman C, Larsson H, Reichenberg A
JAMA 2017;318(12):1182-1184

Age at fatherhood: heritability and associations with psychiatric disorders
Frans Em, Lichtenstein P, Hultman Cm, Kuja-halkola R
Psychological medicine 2016;46(14):2981-2988

Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study
Brander G, Rydell M, Kuja-halkola R, Fernández De La Cruz L, Lichtenstein P, Serlachius E, et al
JAMA psychiatry 2016;73(11):1135-1144

Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden
Latvala A, Kuja-halkola R, Rück C, D'onofrio Bm, Jernberg T, Almqvist C, et al
JAMA psychiatry 2016;73(12):1268-1275

Carryover Effects in Sibling Comparison Designs
Sjölander A, Frisell T, Kuja-halkola R, Öberg S, Zetterqvist J
Epidemiology (Cambridge, Mass.) 2016;27(6):852-8

Childhood maltreatment and attention deficit hyperactivity disorder symptoms in adults: a large twin study
Capusan Aj, Kuja-halkola R, Bendtsen P, Viding E, Mccrory E, Marteinsdottir I, et al
Psychological medicine 2016;46(12):2637-46

Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study
Latvala A, Kuja-halkola R, D'onofrio Bm, Larsson H, Lichtenstein P
Addiction (Abingdon, England) 2016;111(10):1814-22

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
Borg J, Cervenka S, Kuja-halkola R, Matheson Gj, Jönsson Eg, Lichtenstein P, et al
Molecular psychiatry 2016;21(8):1077-84

Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden
Yao S, Kuja-halkola R, Thornton Lm, Runfola Cd, D'onofrio Bm, Almqvist C, et al
JAMA psychiatry 2016;73(3):284-91

Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study
Khemiri L, Kuja-halkola R, Larsson H, Jayaram-lindström N
Psychological medicine 2016;46(5):1091-102

Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins
Kuja-halkola R, Lebwohl B, Halfvarson J, Wijmenga C, Magnusson Pke, Ludvigsson Jf
GUT 2016;65(11):1793-1798

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression
Viktorin A, Meltzer-brody S, Kuja-halkola R, Sullivan Pf, Landén M, Lichtenstein P, et al
The American journal of psychiatry 2016;173(2):158-65

Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood: Exploring Genetic and Environmental Overlap Across Development
Brikell I, Kuja-halkola R, Larsson Jo, Lahey Bb, Kuntsi J, Lichtenstein P, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2016;55(10):886-95

Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data
Sariaslan A, Fazel S, D'onofrio Bm, Långström N, Larsson H, Bergen Se, et al
Translational psychiatry 2016;6():e796-

Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures
D'onofrio Bm, Class Qa, Rickert Me, Sujan Ac, Larsson H, Kuja-halkola R, et al
Behavior genetics 2016;46(3):315-28

A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men
Latvala A, Kuja-halkola R, Almqvist C, Larsson H, Lichtenstein P
JAMA psychiatry 2015;72(10):971-8

Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population
Song J, Bergen Se, Kuja-halkola R, Larsson H, Landén M, Lichtenstein P
Bipolar disorders 2015;17(2):184-93

Codevelopment of ADHD and externalizing behavior from childhood to adulthood
Kuja-halkola R, Lichtenstein P, D'onofrio Bm, Larsson H
Journal of child psychology and psychiatry, and allied disciplines 2015;56(6):640-7

Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models
Chen X, Kuja-halkola R, Rahman I, Arpegard J, Viktorin A, Karlsson R, et al

Genetic and environmental contributions to the association between attention deficit hyperactivity disorder and alcohol dependence in adulthood: A large population-based twin study
Capusan Aj, Bendtsen P, Marteinsdottir I, Kuja-halkola R, Larsson H

Heritability of attention-deficit hyperactivity disorder in adults
Brikell I, Kuja-halkola R, Larsson H

Heritability of endometriosis
Saha R, Pettersson Hj, Svedberg P, Olovsson M, Bergqvist A, Marions L, et al
Fertility and sterility 2015;104(4):947-952

Is Physical Activity Causally Associated With Symptoms of Attention-Deficit/Hyperactivity Disorder?
Rommel As, Lichtenstein P, Rydell M, Kuja-halkola R, Asherson P, Kuntsi J, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2015;54(7):565-70

Paternal Antisocial Behavior and Sons' Cognitive Ability: A Population-Based Quasiexperimental Study
Latvala A, Kuja-halkola R, Langstrom N, Lichtenstein P

Association of height and violent criminality: results from a Swedish total population study
Beckley Al, Kuja-halkola R, Lundholm L, Långström N, Frisell T
International journal of epidemiology 2014;43(3):835-42

Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study
Chang Z, Lichtenstein P, D'onofrio Bm, Almqvist C, Kuja-halkola R, Sjölander A, et al
International journal of epidemiology 2014;43(6):1815-24

Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance
Kuja-halkola R, D'onofrio Bm, Larsson H, Lichtenstein P
Behavior genetics 2014;44(5):456-67

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden
Westerlind H, Ramanujam R, Uvehag D, Kuja-halkola R, Boman M, Bottai M, et al
Brain : a journal of neurology 2014;137(Pt 3):770-8

Paternal age at childbearing and offspring psychiatric and academic morbidity
D'onofrio Bm, Rickert Me, Frans E, Kuja-halkola R, Almqvist C, Sjölander A, et al
JAMA psychiatry 2014;71(4):432-8

Perfect genetic correlation between number of offspring and grandoffspring in an industrialized human population
Zietsch Bp, Kuja-halkola R, Walum H, Verweij Kjh

Practice does not make perfect: no causal effect of music practice on music ability
Mosing Ma, Madison G, Pedersen Nl, Kuja-halkola R, Ullén F
Psychological science 2014;25(9):1795-803

Reply: Shared environmental effects on multiple sclerosis susceptibility: conflicting evidence from twin studies
Westerlind H, Kuja-halkola R, Ramanujam R, Hillert J
Brain : a journal of neurology 2014;137(Pt 7):e288-

The familial risk of autism
Sandin S, Lichtenstein P, Kuja-halkola R, Larsson H, Hultman Cm, Reichenberg A
JAMA 2014;311(17):1770-7

Advancing paternal age and offspring violent offending: a sibling-comparison study
Kuja-halkola R, Pawitan Y, D'onofrio Bm, Långström N, Lichtenstein P
Development and psychopathology 2012;24(3):739-53

Poor school performance in offspring of patients with schizophrenia: what are the mechanisms?
Jundong J, Kuja-halkola R, Hultman C, Langstrom N, D'onofrio Bm, Lichtenstein P

Sibling comparison designs: bias from non-shared confounders and measurement error
Frisell T, Öberg S, Kuja-halkola R, Sjölander A
Epidemiology (Cambridge, Mass.) 2012;23(5):713-20

Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link
Kuja-halkola R, D'onofrio Bm, Iliadou An, Långström N, Lichtenstein P
International journal of epidemiology 2010;39(6):1531-40

Show all publications