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About me

I am a researcher and statistician at the Swedish Twin Registry ( and the Department of Medicial Epidemiology and Biostatistics ( I've been working with genetically informative population data since 2009.




Master in mathematics, 2009, Uppsala Univeristy

PhD in epidemiology, 2014, Karolinska Institutet

Research description

Register based research on Borderline Personality Disorder

I am leading an investigation into Borderline Personality Disorder, its causes, comorbidities, consequences, and pharmacological treatments. We use Swedish population-wide register data to unravel associations and investigate hypothesis in the largest sample ever to be investigated for the disorder.

Psychiatric Epidemiology

I am involved in investigation into e.g. ADHD, autism, and anxiety in the groups of Henrik Larsson ( and Paul Lichtenstein (


Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders
Brander G, Isomura K, Chang Z, Kuja-halkola R, Almqvist C, Larsson H, et al
JAMA neurology 2019;():-

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts
Jylhävä J, Hjelmborg J, Soerensen M, Munoz E, Tan Q, Kuja-halkola R, et al
EBioMedicine 2019;():-

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy
Brikell I, Chen Q, Kuja-halkola R, D'onofrio Bm, Wiggs Kk, Lichtenstein P, et al
Epilepsia 2019;60(2):284-293

Sex Differences Along the Autism Continuum: A Twin Study of Brain Structure
Cauvet É, Van't Westeinde A, Toro R, Kuja-halkola R, Neufeld J, Mevel K, et al
Cerebral cortex (New York, N.Y. : 1991) 2019;29(3):1342-1350

Tobacco and type 2 diabetes: is the association explained by genetic factors?
Carlsson S, Kuja-halkola R, Magnusson C, Lagerros Yt, Andersson T
International journal of epidemiology 2019;():-

2D:4D Ratio in Neurodevelopmental Disorders: A Twin Study
Myers L, Van't Westeinde A, Kuja-halkola R, Tammimies K, Bölte S
Journal of autism and developmental disorders 2018;48(9):3244-3252

Alterations in resting state connectivity along the autism trait continuum: a twin study
Neufeld J, Kuja-halkola R, Mevel K, Cauvet É, Fransson P, Bölte S
Molecular psychiatry 2018;23(7):1659-1665

Association between attention deficit hyperactivity disorder and asthma: a systematic review and meta-analysis and a Swedish population-based study
Cortese S, Sun S, Zhang J, Sharma E, Chang Z, Kuja-halkola R, et al
The lancet. Psychiatry 2018;5(9):717-726

Association of Obsessive-Compulsive Disorder With Objective Indicators of Educational Attainment: A Nationwide Register-Based Sibling Control Study
Pérez-vigil A, Fernández De La Cruz L, Brander G, Isomura K, Jangmo A, Feldman I, et al
JAMA psychiatry 2018;75(1):47-55

Association of Tourette Syndrome and Chronic Tic Disorders With Objective Indicators of Educational Attainment: A Population-Based Sibling Comparison Study
Pérez-vigil A, Fernández De La Cruz L, Brander G, Isomura K, Jangmo A, Kuja-halkola R, et al
JAMA neurology 2018;75(9):1098-1105

A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette's/chronic tic disorders
Mataix-cols D, Frans E, Pérez-vigil A, Kuja-halkola R, Gromark C, Isomura K, et al
Molecular psychiatry 2018;23(7):1652-1658

Attention-deficit/hyperactivity disorder and clinically diagnosed obesity in adolescence and young adulthood: a register-based study in Sweden
Chen Q, Hartman Ca, Kuja-halkola R, Faraone Sv, Almqvist C, Larsson H
Psychological medicine 2018;():1-9

Childhood body mass index and development of eating disorder traits across adolescence
Wiklund Ca, Kuja-halkola R, Thornton Lm, Bälter K, Welch E, Bulik Cm
European eating disorders review : the journal of the Eating Disorders Association 2018;26(5):462-471

Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes
Kuja-halkola R, Lind Juto K, Skoglund C, Rück C, Mataix-cols D, Pérez-vigil A, et al
Molecular psychiatry 2018;():-

Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study
Brikell I, Ghirardi L, D'onofrio Bm, Dunn Dw, Almqvist C, Dalsgaard S, et al
Biological psychiatry 2018;83(2):173-180

Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits
Chen X, Kuja-halkola R, Chang Z, Karlsson R, Hägg S, Svensson P, et al
Journal of the American Heart Association 2018;7(9):-

Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study
Ghirardi L, Pettersson E, Taylor Mj, Freitag Cm, Franke B, Asherson P, et al
Psychological medicine 2018;():1-9

Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up
Isomura K, Brander G, Chang Z, Kuja-halkola R, Rück C, Hellner C, et al
Biological psychiatry 2018;84(5):324-331

Need for further analysis to explore the association between ADHD and asthma - Authors' reply
Cortese S, Sun S, Zhang J, Sharma E, Chang Z, Kuja-halkola R, et al
The lancet. Psychiatry 2018;5(12):963-964

Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study
Brander G, Rydell M, Kuja-halkola R, Fernández De La Cruz L, Lichtenstein P, Serlachius E, et al
Molecular psychiatry 2018;23(5):1189-1197

Prevalence and heritability of body dysmorphic symptoms in adolescents and young adults: a population-based nationwide twin study
Enander J, Ivanov Vz, Mataix-cols D, Kuja-halkola R, Ljótsson B, Lundström S, et al
Psychological medicine 2018;48(16):2740-2747

Specificity in Etiology of Subtypes of Bipolar Disorder: Evidence From a Swedish Population-Based Family Study
Song J, Kuja-halkola R, Sjölander A, Bergen Se, Larsson H, Landén M, et al
Biological psychiatry 2018;84(11):810-816

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology
Brikell I, Larsson H, Lu Y, Pettersson E, Chen Q, Kuja-halkola R, et al
Molecular psychiatry 2018;():-

The familial co-aggregation of ASD and ADHD: a register-based cohort study
Ghirardi L, Brikell I, Kuja-halkola R, Freitag Cm, Franke B, Asherson P, et al
Molecular psychiatry 2018;23(2):257-262

The Quantified Behavioral Test Failed to Differentiate ADHD in Adolescents With Neurodevelopmental Problems
Johansson V, Norén Selinus E, Kuja-halkola R, Lundström S, Durbeej N, Anckarsäter H, et al
Journal of attention disorders 2018;():1087054718787034-

The role of general anesthesia on traits of neurodevelopmental disorders in a Swedish cohort of twins
Castellheim A, Lundström S, Molin M, Kuja-halkola R, Gillberg C, Gillberg C
Journal of child psychology and psychiatry, and allied disciplines 2018;59(9):966-972

A longitudinal study of adolescent psychotic experiences and later development of substance use disorder and suicidal behavior
Cederlöf M, Kuja-halkola R, Larsson H, Sjölander A, Östberg P, Lundström S, et al
Schizophrenia research 2017;181():13-16

Association Between Deliberate Self-harm and Violent Criminality
Sahlin H, Kuja-halkola R, Bjureberg J, Lichtenstein P, Molero Y, Rydell M, et al
JAMA psychiatry 2017;74(6):615-621

Birth weight, sex, and celiac disease: a nationwide twin study
Kuja-halkola R, Lebwohl B, Halfvarson J, Emilsson L, Magnusson Pk, Ludvigsson Jf

Estimating Heritability of Prostate Cancer-Specific Survival Using Population-Based Registers
Szulkin R, Clements Ms, Magnusson Pke, Wiklund Fe, Kuja-halkola R
The Prostate 2017;77(8):900-907

Familial aggregation of attention-deficit/hyperactivity disorder
Chen Q, Brikell I, Lichtenstein P, Serlachius E, Kuja-halkola R, Sandin S, et al
Journal of child psychology and psychiatry, and allied disciplines 2017;58(3):231-239

Fetal Growth and Childhood Lung Function in the Swedish Twin Study on Prediction and Prevention of Asthma
Örtqvist Ak, Ullemar V, Lundholm C, Kuja-halkola R, Magnusson Pke, Lichtenstein P, et al
Annals of the American Thoracic Society 2017;14(7):1147-1153

Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M, Foebel Ad, Kuja-halkola R, Karlsson I, Pedersen Nl, Hagg S, et al
AGING-US 2017;9(12):2629-2646

Genetic and environmental aspects in the association between attention-deficit hyperactivity disorder symptoms and binge-eating behavior in adults: a twin study
Capusan Aj, Yao S, Kuja-halkola R, Bulik Cm, Thornton Lm, Bendtsen P, et al
Psychological medicine 2017;47(16):2866-2878

Heritability of hoarding symptoms across adolescence and young adulthood: A longitudinal twin study
Ivanov Vz, Nordsletten A, Mataix-cols D, Serlachius E, Lichtenstein P, Lundström S, et al
PloS one 2017;12(6):e0179541-

Medical history of discordant twins and environmental etiologies of autism
Willfors C, Carlsson T, Anderlid Bm, Nordgren A, Kostrzewa E, Berggren S, et al
Translational psychiatry 2017;7(1):e1014-

Minor physical anomalies in neurodevelopmental disorders: a twin study
Myers L, Anderlid Bm, Nordgren A, Willfors C, Kuja-halkola R, Tammimies K, et al

Polycystic ovary syndrome, personality, and depression: A twin study
Cesta Ce, Kuja-halkola R, Lehto K, Iliadou An, Landén M
Psychoneuroendocrinology 2017;85():63-68

Predictive validity of parent- and self-rated ADHD symptoms in adolescence on adverse socioeconomic and health outcomes
Du Rietz E, Kuja-halkola R, Brikell I, Jangmo A, Sariaslan A, Lichtenstein P, et al
European child & adolescent psychiatry 2017;26(7):857-867

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample
Saha R, Kuja-halkola R, Tornvall P, Marions L
Journal of women's health (2002) 2017;26(2):152-158

Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population
Yao S, Kuja-halkola R, Thornton Lm, Norring C, Almqvist C, D'onofrio Bm, et al
The International journal of eating disorders 2017;50(9):1095-1103

Risk of eating disorders in immigrant populations
Mustelin L, Hedman Am, Thornton Lm, Kuja-halkola R, Keski-rahkonen A, Cantor-graae E, et al
Acta psychiatrica Scandinavica 2017;136(2):156-165

Shared familial risk factors between attention-deficit/hyperactivity disorder and overweight/obesity - a population-based familial coaggregation study in Sweden
Chen Q, Kuja-halkola R, Sjölander A, Serlachius E, Cortese S, Faraone Sv, et al
Journal of child psychology and psychiatry, and allied disciplines 2017;58(6):711-718

The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study
Faraone Sv, Ghirardi L, Kuja-halkola R, Lichtenstein P, Larsson H
Journal of the American Academy of Child and Adolescent Psychiatry 2017;56(2):167-174.e1

The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-halkola R, Hultman C, Larsson H, Reichenberg A
JAMA 2017;318(12):1182-1184

Age at fatherhood: heritability and associations with psychiatric disorders
Frans Em, Lichtenstein P, Hultman Cm, Kuja-halkola R
Psychological medicine 2016;46(14):2981-2988

Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder: A Population-Based Birth Cohort, Sibling Control Study
Brander G, Rydell M, Kuja-halkola R, Fernández De La Cruz L, Lichtenstein P, Serlachius E, et al
JAMA psychiatry 2016;73(11):1135-1144

Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden
Latvala A, Kuja-halkola R, Rück C, D'onofrio Bm, Jernberg T, Almqvist C, et al
JAMA psychiatry 2016;73(12):1268-1275

Carryover Effects in Sibling Comparison Designs
Sjölander A, Frisell T, Kuja-halkola R, Öberg S, Zetterqvist J
Epidemiology (Cambridge, Mass.) 2016;27(6):852-8

Childhood maltreatment and attention deficit hyperactivity disorder symptoms in adults: a large twin study
Capusan Aj, Kuja-halkola R, Bendtsen P, Viding E, Mccrory E, Marteinsdottir I, et al
Psychological medicine 2016;46(12):2637-46

Cognitive ability and risk for substance misuse in men: genetic and environmental correlations in a longitudinal nation-wide family study
Latvala A, Kuja-halkola R, D'onofrio Bm, Larsson H, Lichtenstein P
Addiction (Abingdon, England) 2016;111(10):1814-22

Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
Borg J, Cervenka S, Kuja-halkola R, Matheson Gj, Jönsson Eg, Lichtenstein P, et al
Molecular psychiatry 2016;21(8):1077-84

Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden
Yao S, Kuja-halkola R, Thornton Lm, Runfola Cd, D'onofrio Bm, Almqvist C, et al
JAMA psychiatry 2016;73(3):284-91

Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study
Khemiri L, Kuja-halkola R, Larsson H, Jayaram-lindström N
Psychological medicine 2016;46(5):1091-102

Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins
Kuja-halkola R, Lebwohl B, Halfvarson J, Wijmenga C, Magnusson Pke, Ludvigsson Jf
GUT 2016;65(11):1793-1798

Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression
Viktorin A, Meltzer-brody S, Kuja-halkola R, Sullivan Pf, Landén M, Lichtenstein P, et al
The American journal of psychiatry 2016;173(2):158-65

Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood: Exploring Genetic and Environmental Overlap Across Development
Brikell I, Kuja-halkola R, Larsson Jo, Lahey Bb, Kuntsi J, Lichtenstein P, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2016;55(10):886-95

Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data
Sariaslan A, Fazel S, D'onofrio Bm, Långström N, Larsson H, Bergen Se, et al
Translational psychiatry 2016;6():e796-

Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures
D'onofrio Bm, Class Qa, Rickert Me, Sujan Ac, Larsson H, Kuja-halkola R, et al
Behavior genetics 2016;46(3):315-28

A Longitudinal Study of Resting Heart Rate and Violent Criminality in More Than 700 000 Men
Latvala A, Kuja-halkola R, Almqvist C, Larsson H, Lichtenstein P
JAMA psychiatry 2015;72(10):971-8

Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population
Song J, Bergen Se, Kuja-halkola R, Larsson H, Landén M, Lichtenstein P
Bipolar disorders 2015;17(2):184-93

Codevelopment of ADHD and externalizing behavior from childhood to adulthood
Kuja-halkola R, Lichtenstein P, D'onofrio Bm, Larsson H
Journal of child psychology and psychiatry, and allied disciplines 2015;56(6):640-7

Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models
Chen X, Kuja-halkola R, Rahman I, Arpegard J, Viktorin A, Karlsson R, et al

Genetic and environmental contributions to the association between attention deficit hyperactivity disorder and alcohol dependence in adulthood: A large population-based twin study
Capusan Aj, Bendtsen P, Marteinsdottir I, Kuja-halkola R, Larsson H

Heritability of attention-deficit hyperactivity disorder in adults
Brikell I, Kuja-halkola R, Larsson H

Heritability of endometriosis
Saha R, Pettersson Hj, Svedberg P, Olovsson M, Bergqvist A, Marions L, et al
Fertility and sterility 2015;104(4):947-952

Is Physical Activity Causally Associated With Symptoms of Attention-Deficit/Hyperactivity Disorder?
Rommel As, Lichtenstein P, Rydell M, Kuja-halkola R, Asherson P, Kuntsi J, et al
Journal of the American Academy of Child and Adolescent Psychiatry 2015;54(7):565-70

Paternal Antisocial Behavior and Sons' Cognitive Ability: A Population-Based Quasiexperimental Study
Latvala A, Kuja-halkola R, Langstrom N, Lichtenstein P

Association of height and violent criminality: results from a Swedish total population study
Beckley Al, Kuja-halkola R, Lundholm L, Långström N, Frisell T
International journal of epidemiology 2014;43(3):835-42

Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study
Chang Z, Lichtenstein P, D'onofrio Bm, Almqvist C, Kuja-halkola R, Sjölander A, et al
International journal of epidemiology 2014;43(6):1815-24

Maternal smoking during pregnancy and adverse outcomes in offspring: genetic and environmental sources of covariance
Kuja-halkola R, D'onofrio Bm, Larsson H, Lichtenstein P
Behavior genetics 2014;44(5):456-67

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden
Westerlind H, Ramanujam R, Uvehag D, Kuja-halkola R, Boman M, Bottai M, et al
Brain : a journal of neurology 2014;137(Pt 3):770-8

Paternal age at childbearing and offspring psychiatric and academic morbidity
D'onofrio Bm, Rickert Me, Frans E, Kuja-halkola R, Almqvist C, Sjölander A, et al
JAMA psychiatry 2014;71(4):432-8

Perfect genetic correlation between number of offspring and grandoffspring in an industrialized human population
Zietsch Bp, Kuja-halkola R, Walum H, Verweij Kjh

Practice does not make perfect: no causal effect of music practice on music ability
Mosing Ma, Madison G, Pedersen Nl, Kuja-halkola R, Ullén F
Psychological science 2014;25(9):1795-803

Reply: Shared environmental effects on multiple sclerosis susceptibility: conflicting evidence from twin studies
Westerlind H, Kuja-halkola R, Ramanujam R, Hillert J
Brain : a journal of neurology 2014;137(Pt 7):e288-

The familial risk of autism
Sandin S, Lichtenstein P, Kuja-halkola R, Larsson H, Hultman Cm, Reichenberg A
JAMA 2014;311(17):1770-7

Advancing paternal age and offspring violent offending: a sibling-comparison study
Kuja-halkola R, Pawitan Y, D'onofrio Bm, Långström N, Lichtenstein P
Development and psychopathology 2012;24(3):739-53

Poor school performance in offspring of patients with schizophrenia: what are the mechanisms?
Jundong J, Kuja-halkola R, Hultman C, Langstrom N, D'onofrio Bm, Lichtenstein P

Sibling comparison designs: bias from non-shared confounders and measurement error
Frisell T, Öberg S, Kuja-halkola R, Sjölander A
Epidemiology (Cambridge, Mass.) 2012;23(5):713-20

Prenatal smoking exposure and offspring stress coping in late adolescence: no causal link
Kuja-halkola R, D'onofrio Bm, Iliadou An, Långström N, Lichtenstein P
International journal of epidemiology 2010;39(6):1531-40

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