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Research description

Research projects are focused on examining the regenerative capacity of soft connective tissues within the oral cavity during health and disease. We are particularly concerned with the complications that result following hematopoietic stem cell transplantation in the form of Graft versus Host Disease. Oral manifestations are one of the most common and debilitating complications, and the histopathology poorly understood. Studies are ongoing to define the histopathological features of chronic graft versus host disease with the aim to couple clinical presentation to provide improved pathological diagnostics. The oral cavity has a huge potential to heal without scaring and many sources of cells have been identified in the soft tissues, including, gingiva, labial and buccal mucosal. A key to harnessing the cells potential and facilitating novel treatment strategies for cGVHD is to understand the stem cell niche and the role of the extracellular matrix (ECM) in maintaining this niche supporting the reparative process. Thus, research is also focusing on the role of the ECM in supporting the resident cell niche during wound healing and tissue repair, and regeneration of these tissues.

Participants:

Rachael Sugars

Karin Garming-Legert

Victor Tollemar Wilmenius (Doctoral Student)

Nikocle Tudzarovski

 

 

Publications

Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination
Iacobaeus E, Sugars Rv, Törnqvist Andrén A, Alm Jj, Qian H, Frantzen J, et al
Stem cells translational medicine 2017;6(10):1840-1851

Effects of polyhexamethylene guanidine phosphate on human gingival fibroblasts
Vitt A, Slizen V, Boström Ea, Yucel-lindberg T, Kats A, Sugars Rv, et al
Acta odontologica Scandinavica 2017;75(7):524-529

Antimicrobial activity of polyhexamethylene guanidine phosphate in comparison to chlorhexidine using the quantitative suspension method
Vitt A, Sofrata A, Slizen V, Sugars Rv, Gustafsson A, Gudkova Ei, et al
Annals of clinical microbiology and antimicrobials 2015;14():36-

Enhanced oral healing following local mesenchymal stromal cell therapy
Garming-legert K, Tour G, Sugars R, Von Bahr L, Davies Lc, Le Blanc K
Oral oncology 2015;51(12):e97-9

The glycosylation profile of osteoadherin alters during endochondral bone formation
Sugars Rv, Olsson Ml, Marchner S, Hultenby K, Wendel M
Bone 2013;53(2):459-67

Microarray Profiling of Diaphyseal Bone of Rats Suffering from Hypervitaminosis A
Lind T, Hu Lj, Lind Pm, Sugars R, Andersson G, Jacobson A, et al
CALCIFIED TISSUE INTERNATIONAL 2012;90(3):219-29

Osteoadherin Accumulates in the Predentin towards the Mineralization Front in the Developing Tooth
Nikdin H, Olsson Ml, Hultenby K, Sugars Rv
PLOS ONE 2012;7(2):e31525-

Localization and Expression of Prothrombin in Rodent Osteoclasts and Long Bones
Karlstrom E, Norgard M, Hultenby K, Somogyi-ganss E, Sugars R, Andersson G, et al
CALCIFIED TISSUE INTERNATIONAL 2011;88(3):179-88

Dynamics of gene expression during bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
Karner E, Backesjo Cm, Cedervall J, Sugars Rv, Ahrlund-richter L, Wendel M
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2009;1790(2):110-8

Human Embryonic stem cells and bone regeneration
Wendel M, Sugars R, Karner E
FEBS JOURNAL 2009;:31-31

TGF-beta/Extracellular Matrix Interactions in Dentin Matrix: A Role in Regulating Sequestration and Protection of Bioactivity
Baker Sm, Sugars Rv, Wendel M, Smith Aj, Waddington Rj, Cooper Pr, et al
CALCIFIED TISSUE INTERNATIONAL 2009;85(1):66-74

Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization
Rehn Ap, Cerny R, Sugars Rv, Kaukua N, Wendel M
CALCIFIED TISSUE INTERNATIONAL 2008;82(6):454-64

Bone matrix formation in osteogenic cultures derived from human embryonic stem cells in vitro
Karner E, Unger C, Sloan Aj, Ahrlund-richter L, Sugars Rv, Wendel M
STEM CELLS AND DEVELOPMENT 2007;16(1):39-52

Expression of HMGB1 during tooth development
Sugars R, Karlstrom E, Christersson C, Olsson Ml, Wendel M, Fried K
CELL AND TISSUE RESEARCH 2007;327(3):511-9

Adsorption and interactions of dentine phosphoprotein with hydroxyapatite and collagen
Milan Am, Sugars Rv, Embery G, Waddington Rj
EUROPEAN JOURNAL OF ORAL SCIENCES 2006;114(3):223-31

Substitution of bovine dentine sialoprotein with chondroitin sulfate glycosaminoglycan chains
Sugars Rv, Olsson Ml, Waddington R, Wendel M
EUROPEAN JOURNAL OF ORAL SCIENCES 2006;114(1):89-92

Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation
Sugars Rv, Karner E, Petersson U, Ganss B, Wendel M
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2006;1763(10):1031-9

Modulation of collagen fibrillogenesis by dentinal proteoglycans
Milan Am, Sugars Rv, Embery G, Waddington Rj
CALCIFIED TISSUE INTERNATIONAL 2005;76(2):127-35

Dentinal proteoglycans demonstrate an increasing order of affinity for hydroxyapatite crystals during the transition of predentine to dentine
Milan Am, Sugars Rv, Embery G, Waddington Rj
CALCIFIED TISSUE INTERNATIONAL 2004;75(3):197-204

Nucleobindin - a Ca2+-binding protein present in the cells and mineralized tissues of the tooth
Somogyi E, Petersson U, Sugars Rv, Hultenby K, Wendell M
CALCIFIED TISSUE INTERNATIONAL 2004;74(4):366-76

Nucleobindin is produced by bone cells and secreted into the osteoid, with potential role as a modulator of matrix maturation
Petersson U, Somogyi E, Reinholt Fp, Karlsson T, Sugars Rv, Wendel M
BONE 2004;34(6):949-60

Organized development from human embryonic stem cells after injection into immunodeficient mice
Gertow K, Wolbank S, Rozell B, Sugars R, Andang M, Parish Cl, et al
STEM CELLS AND DEVELOPMENT 2004;13(4):421-35

Differential roles for small leucine-rich proteoglycans in bone formation
Waddington Rj, Roberts Hc, Sugars Rv, Schönherr E
European cells & materials 2003;6():12-21

Functional roles for dentinal proteoglycans and their constituent glycosaminoglycans in regulating mineralization.
Milan Am, Sugars Rv, Waddington R, Embery G
JOURNAL OF DENTAL RESEARCH 2003;:B76-B76

Identification, distribution, and expression of nucleobindin during tooth formation.
Petersson U, Somogyi E, Sugars Rv, Wendel M
JOURNAL OF DENTAL RESEARCH 2003;:B77-B77

Molecular interaction of recombinant decorin and biglycan with type I collagen influences crystal growth
Sugars Rv, Milan Aa, Brown Jo, Waddington Rj, Hall Rc, Embery G
CONNECTIVE TISSUE RESEARCH 2003;:189-95

Real-time biomolecular interaction analysis of small leucine-rich proteoglycans with type 1 collagen.
Sugars Rv, Waddington Rj, Embery G
JOURNAL OF DENTAL RESEARCH 2003;:490-490

TGF-beta/extracellular matrix interactions and dentin matrix.
Baker Sm, Sloan Aj, Sugars Rv, Williams Dw, Waddington R, Smith Aj
JOURNAL OF DENTAL RESEARCH 2003;:B46-B46

The interaction of recombinant decorin with alpha 2HS-glycoprotein - Implications for structural and functional investigations
Sugars Rv, Waddington Rj, Embery G
PROTEIN EXPRESSION AND PURIFICATION 2002;25(1):180-8

The interaction of truncated decorin forms in regulating collagen fibrillogenesis.
Sugars Rv, Waddington Rj, Embery G
JOURNAL OF DENTAL RESEARCH 2002;:A439-A439

Modulation of hydroxyapatite seeded crystal growth by decorin and biglycan
Sugars Rv, Milan Am, Hall Rc, Waddington Rj, Embery G
JOURNAL OF DENTAL RESEARCH 2001;80(4):1181-1181

Evidence for interactions of mineralised tissue proteins with alpha(2) HS-glycoprotein during their purification.
Sugars Rv
JOURNAL OF DENTAL RESEARCH 2000;79(5):1176-1176

Characterisations of chondroitin sulphate rich recombinant decorin and biglycan proteoglycans
Sugars Rv, Waddington Rj, Embery G
JOURNAL OF DENTAL RESEARCH 1999;78(5):1054-1054

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