Peter Svensson
Principal Researcher | Docent
E-mail: peter.svensson@ki.se
Telephone: +46852481051
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 BioNut Svensson, 171 77 Stockholm
About me
- The research of the group into the HIV cure field is focused on chromatin,
and especially how transcription and chromatin states transitions
interconnect.
Docent (associate professor) in functional genomics at the Department of
Biosciences and Nutrition.
I completed my Ph.D. at Leiden University Medical Center and Uppsala
University in 2006. After that I did a post-doc in the lab of Leona Samson at
Massachusetts Institute of Technology. In 2010, I became a PI at Karolinska
Institutet. Between 2015 and 2017 I was at the Gladstone Institute of
Virology and Immunology (San Fransisco) as a Visiting scientist.
Research
- HIV infection is a devastating disease affecting 35 million people worldwide.
Current anti-retroviral treatment is highly effective and has made the HIV
infection chronic. However, despite more effective treatments, the prospects
of a cure are distant.
The problem for an HIV cure is that, even though the virus particles are
eradicated, the infected cells maintain the information of remake the virus.
This information is integrated in the host cell as a provirus. The provirus
switches between active and inactive states. Thereby, the infected cells
evade both the immune system and death associated with massive viral
production.
In my lab we characterize the composition of proviral chromatin and how it
connects with transcription and viral production. We are interested in the
fate of the HIV-1 provirus from the time of infection until latency has
been firmly established in resting primary CD4+T-cells. Whereas the
proviruses encompassed in heterochromatin are refractory to activation, we
have shown that latent proviruses with “enhancer” characteristics are
readily activated. Our studies have provided key insights as to detect the
remaining HIV-1 infected cells capable of reseeding the infection and the
mechanisms whereby they are maintained.
Articles
- Article: PLOS PATHOGENS. 2022;18(6):e1010555
- Article: COMMUNICATIONS BIOLOGY. 2022;5(1):357
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1067767
- Article: NATURE COMMUNICATIONS. 2021;12(1):4800
- Article: NUCLEIC ACIDS RESEARCH. 2020;48(13):7154-7168
- Article: EPIGENETICS. 2020;15(6-7):702-714
- Article: SCIENTIFIC REPORTS. 2020;10(1):6055
- Article: PLOS PATHOGENS. 2020;16(1):e1008264
- Article: LIFE SCIENCE ALLIANCE. 2019;2(5):e201900433
- Article: ELIFE. 2018;7:e34655
- Article: CELL HOST & MICROBE. 2016;20(6):785-797
- Article: EMBO REPORTS. 2015;16(12):1673-1687
- Article: MOLECULAR CELL. 2015;59(6):984-997
- Article: GENOME RESEARCH. 2015;25(6):872-883
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2014;21(3):236-243
- Article: LAB ON A CHIP. 2013;13(14):2754-2763
- Article: EMBO JOURNAL. 2012;31(23):4388-4403
- Article: PLOS GENETICS. 2012;8(9):e1002985
- Article: MOLECULAR CELL. 2012;46(5):691-704
- Article: PLOS ONE. 2012;7(5):e37368
- Article: BMC SYSTEMS BIOLOGY. 2011;5:157
- Article: PLOS COMPUTATIONAL BIOLOGY. 2011;7(8):e1002163
- Article: GENES & DEVELOPMENT. 2008;22(19):2621-2626
- Article: PLOS ONE. 2007;2(11):e1252
- Article: PLOS GENETICS. 2007;3(11):e207
- Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2007;617(1-2):58-70
- Journal article: PLOS GENETICS. 2007;3(11):2180-2189
- Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2007;22(1):19-28
- Article: PLOS MEDICINE. 2006;3(10):e422-1914
- Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2005;578(1-2):43-52
- Article: BMC BIOINFORMATICS. 2005;6:177
- Show more
All other publications
- Review: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:668637
- Preprint: BIORXIV. 2018
- Editorial comment: EPIGENOMICS. 2014;6(5):451-454
- Other: PERSONALIZED MEDICINE. 2008;5(6):561-563
- Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2008;49(7):578
- Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2008;49(7):578
- Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2004;1657:82
Grants
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2016 - 31 December 2018
Employments
- Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Degrees and Education
- Docent, Karolinska Institutet, 2012