Per Nilsson

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Articles

Article: BIOLOGY OF SEX DIFFERENCES. 2025;16(1):29
ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease
Demetriou A; Lindqvist B; Ali HG; Shamekh MM; Varshney M; Inzunza J; Maioli S; Nilsson P; Nalvarte I
Article: ALZHEIMERS & DEMENTIA. 2025;21(1):e14375
Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis
Canal-Garcia A; Branca RM; Francis PT; Ballard C; Winblad B; Lehtio J; Nilsson P; Aarsland D; Pereira JB; Bereczki E
Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;100(3):1017-1037
Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease
Portal B; Sodergren M; Pares i Borrell T; Giraud R; Metzendorf NG; Hultqvist G; Nilsson P; Lindskog M
Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
Article: ACS CHEMICAL NEUROSCIENCE. 2024;15(10):2058-2069
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and App ^NL-F Mice
Parvin F; Haglund S; Wegenast-Braun B; Jucker M; Saito T; Saido TC; Nilsson KPR; Nilsson P; Nystrom S; Hammarstrom P
Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease
Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
Article: TRAFFIC. 2024;25(4):e12934
Inhibition of Autophagy Alters Intracellular Transport of APP Resulting in Increased APP Processing
Mayer J; Boeck D; Werner M; Frankenhauser D; Geley S; Farhan H; Shimozawa M; Nilsson P
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(4):glae029
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
Wang H-L; Siow R; Schmauck-Medina T; Zhang J; Sandset PM; Filshie C; Lund O; Partridge L; Bergersen LH; Juel Rasmussen L; Palikaras K; Sotiropoulos I; Storm-Mathisen J; Rubinsztein DC; Spillantini MG; De ZCI; Watne LO; Vyhnalek M; Veverova K; Liang KX; Tavernarakis N; Bohr VA; Yokote K; Saarela J; Nilsen H; Gonos ES; Scheibye-Knudsen M; Chen G; Kato H; Selbaek G; Fladby T; Nilsson P; Simonsen A; Aarsland D; Lautrup S; Ottersen OP; Cox LS; Fang EF
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):3622
DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App^N-LF Mice and Influences Presymptomatic Pathology
Axenhus M; Doeswijk T; Nilsson P; Matton A; Winblad B; Tjernberg L; Schedin-Weiss S
Article: NEURON. 2023;111(23):3745-3764.e7
Molecular anatomy of adult mouse leptomeninges
Pietila R; Del Gaudio F; He L; Vazquez-Liebanas E; Vanlandewijck M; Muhl L; Mocci G; Bjornholm KD; Lindblad C; Fletcher-Sandersjoo A; Svensson M; Thelin EP; Liu J; van Voorden AJ; Torres M; Antila S; Xin L; Karlstrom H; Storm-Mathisen J; Bergersen LH; Moggio A; Hansson EM; Ulvmar MH; Nilsson P; Makinen T; Mae MA; Alitalo K; Proulx ST; Engelhardt B; McDonald DM; Lendahl U; Andrae J; Betsholtz C
Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
Article: MOLECULAR PSYCHIATRY. 2023;28(9):3966-3981
Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
Naia L; Shimozawa M; Bereczki E; Li X; Liu J; Jiang R; Giraud R; Leal NS; Pinho CM; Berger E; Falk VL; Dentoni G; Ankarcrona M; Nilsson P
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):137
Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App^NL-G-F knock-in Alzheimer mice
Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg LU; Darreh-Shori T; Behbahani H; Nilsson P; Eriksdotter M
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2023;232:115465
Identification of glycolytic proteins as binding partners of Bri2 BRICHOS domain
Tigro H; Shimozawa M; Nilsson P; Lyashkov A; Khadeer M; Järving I; Ferrucci L; Shimmo R; Johansson J; Moaddel R
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2023;125:103843
Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain
Shimozawa M; Tigro H; Biverstal H; Shevchenko G; Bergquist J; Moaddel R; Johansson J; Nilsson P
Article: BIOLOGY-BASEL. 2023;12(6):805
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in App^NL-G-F Knock-In Mice
Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):90
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
Gustavsson T; Metzendorf NG; Wik E; Roshanbin S; Julku U; Chourlia A; Nilsson P; Andersson KG; Laudon H; Hultqvist G; Syvanen S; Sehlin D
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: CELL REPORTS: METHODS. 2023;3(3):100431
A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature
Bjornholm KD; Del Gaudio F; Li H; Li W; Vazquez-Liebanas E; Mae MA; Lendahl U; Betsholtz C; Nilsson P; Karlstrom H; Vanlandewijck M
Article: MOLECULAR THERAPY. 2023;31(2):487-502
Intravenous treatment with a molecular chaperone designed against f3-amyloid toxicity improves Alzheimer?s disease pathology in mouse models
Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad001
Translational potential of synaptic alterations in Alzheimer's disease patients and amyloid precursor protein knock-in mice
Medina-Vera D; Enache D; Tambaro S; Abuhashish E; Rosell-Valle C; Winblad B; de Fonseca FR; Bereczki E; Nilsson P
Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;90(2):565-583
Mitochondrial Alterations in Neurons Derived from the Murine App^{NL- F} Knock-In Model of Alzheimer's Disease
Dentoni G; Naia L; Portal B; Leal NS; Nilsson P; Lindskog M; Ankarcrona M
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis
Jiang R; Smailovic U; Haytural H; Tijms BM; Li H; Haret RM; Shevchenko G; Chen G; Abelein A; Gobom J; Frykman S; Sekiguchi M; Fujioka R; Watamura N; Sasaguri H; Nystrom S; Hammarstrom P; Saido TC; Jelic V; Syvanen S; Zetterberg H; Winblad B; Bergquist J; Visser PJ; Nilsson P
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App^{NL-G-F/NL-G-F} mice
Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
Article: MOLECULAR PSYCHIATRY. 2022;27(3):1816-1828
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K_ATP channel pathway
Watamura N; Kakiya N; Nilsson P; Tsubuki S; Kamano N; Takahashi M; Hashimoto S; Sasaguri H; Saito T; Saido TC
Article: CELL RESEARCH. 2022;32(2):157-175
An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments
Pang K; Jiang R; Zhang W; Yang Z; Li L-L; Shimozawa M; Tambaro S; Mayer J; Zhang B; Li M; Wang J; Liu H; Yang A; Chen X; Liu J; Winblad B; Han H; Jiang T; Wang W; Nilsson P; Guo W; Lu B
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
Autophagy Impairment in App Knock-in Alzheimer's Model Mice
Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App^NL-G-F mouse model of Alzheimer's disease
Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(1):355-366
Synaptic Molecular and Neurophysiological Markers Are Independent Predictors of Progression in Alzheimer's Disease
Smailovic U; Kareholt I; Koenig T; Ashton NJ; Winblad B; Hoglund K; Nilsson P; Zetterberg H; Blennow K; Jelic V
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2021;9(1):116
Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease
Emre C; Do KV; Jun B; Hjorth E; Alcalde SG; Kautzmann M-AI; Gordon WC; Nilsson P; Bazan NG; Schultzberg M
Article: MOVEMENT DISORDERS. 2021;36(5):1137-1146
Involvement of Autophagy in Levodopa-Induced Dyskinesia
Feyder M; Plewnia C; Lieberman OJ; Spigolon G; Piccin A; Urbina L; Dehay B; Li Q; Nilsson P; Altun M; Santini E; Sulzer D; Bezard E; Borgkvist A; Fisone G
Article: BMC BIOLOGY. 2021;19(1):57
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2021;9(1):46
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease
Reyes JF; Ekmark-Lewen S; Perdiki M; Klingstedt T; Hoffmann A; Wiechec E; Nilsson P; Nilsson KPR; Alafuzoff I; Ingelsson M; Hallbeck M
Article: JOURNAL OF NEUROCHEMISTRY. 2021;156(6):1003-1019
Benzimidazole-based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T
Pravin N; Kumar R; Tripathi S; Kumar P; Mohite GM; Navalkar A; Panigrahi R; Singh N; Gadhe LG; Manchanda S; Shimozawa M; Nilsson P; Johansson J; Kumar A; Maji SK; Shanmugam M
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334
Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71
Sandebring-Matton A; Axenhus M; Bogdanovic N; Winblad B; Schedin-Weiss S; Nilsson P; Tjernberg LO
Article: THERANOSTICS. 2021;11(2):789-804
Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
Rofo F; Yilmaz CU; Metzendorf N; Gustavsson T; Beretta C; Erlandsson A; Sehlin D; Syvanen S; Nilsson P; Hultqvist G
Article: CELLS. 2020;9(12):E2552-2552
Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer's Disease-Related Models
Leal NS; Dentoni G; Schreiner B; Naia L; Piras A; Graff C; Cattaneo A; Meli G; Hamasaki M; Nilsson P; Ankarcrona M
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;77(3):1143-1155
Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease
Enache D; Pereira JB; Jelic V; Winblad B; Nilsson P; Aarsland D; Bereczki E
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2020;105:103498
Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons
Galan-Acosta L; Sierra C; Leppert A; Pouliopoulos AN; Kwon N; Noel RL; Tambaro S; Presto J; Nilsson P; Konofagou EE; Johansson J
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;75(1):321-335
Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ₄₂-Induced Pathways to Alzheimer's Disease Pathology
Schedin-Weiss S; Nilsson P; Sandebring-Matton A; Axenhus M; Sekiguchi M; Saito T; Winblad B; Saido T; Tjernberg LO
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
Article: SCIENCE ADVANCES. 2019;5(4):eaau8237
GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA_A receptor trafficking and social behavior
Hui KK; Takashima N; Watanabe A; Chater TE; Matsukawa H; Nekooki-Machida Y; Nilsson P; Endo R; Goda Y; Saido TC; Yoshikawa T; Tanaka M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice
Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1864(4):331-345
Molecular recognition of mRNA 5′ cap by 3′ poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins
Niedzwiecka A; Nilsson P; Worch R; Stepinski J; Darzynkiewicz E; Virtanen A
Article: PROTEOMICS. 2015;15(19):3349-3355
Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice
Nilsson P; Loganathan K; Sekiguchi M; Winblad B; Iwata N; Saido TC; Tjernberg LO
Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(2):305-313
Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi
Nilsson P; Sekiguchi M; Akagi T; Izumi S; Komor T; Hui K; Soergjerd K; Tanaka M; Saito T; Iwata N; Saido TC
Article: BIOESSAYS. 2014;36(6):570-578
Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
Nilsson P; Saido TC
Article: NATURE NEUROSCIENCE. 2014;17(5):661-663
Single App knock-in mouse models of Alzheimer's disease.
Saito T; Matsuba Y; Mihira N; Takano J; Nilsson P; Itohara S; Iwata N; Saido TC
Article: CELL REPORTS. 2013;5(1):61-69
Aβ secretion and plaque formation depend on autophagy.
Nilsson P; Loganathan K; Sekiguchi M; Matsuba Y; Hui K; Tsubuki S; Tanaka M; Iwata N; Saito T; Saido TC
Article: BIOCHEMISTRY. 2013;52(20):3532-3542
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.
Sörgjerd KM; Zako T; Sakono M; Stirling PC; Leroux MR; Saito T; Nilsson P; Sekimoto M; Saido TC; Maeda M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29362-29372
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Kakiya N; Saito T; Nilsson P; Matsuba Y; Tsubuki S; Takei N; Nawa H; Saido TC
Article: BIOPHYSICAL CHEMISTRY. 2011;158(2-3):141-149
Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering.
Niedzwiecka A; Lekka M; Nilsson P; Virtanen A
Article: NATURE NEUROSCIENCE. 2011;14(8):1023-1032
Potent amyloidogenicity and pathogenicity of Aβ43.
Saito T; Suemoto T; Brouwers N; Sleegers K; Funamoto S; Mihira N; Matsuba Y; Yamada K; Nilsson P; Takano J; Nishimura M; Iwata N; Van Broeckhoven C; Ihara Y; Saido TC
Article: BLOOD CELLS MOLECULES AND DISEASES. 2010;45(1):23-28
Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan anemia.
Schuster J; Fröjmark A-S; Nilsson P; Badhai J; Virtanen A; Dahl N
Article: EMBO JOURNAL. 2010;29(10):1674-1687
Nuclear deadenylation/polyadenylation factors regulate 3' processing in response to DNA damage.
Cevher MA; Zhang X; Fernandez S; Kim S; Baquero J; Nilsson P; Lee S; Virtanen A; Kleiman FE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(1):163-170
Recognition of adenosine residues by the active site of poly(A)-specific ribonuclease.
Henriksson N; Nilsson P; Wu M; Song H; Virtanen A
Article: STRUCTURE. 2009;17(2):276-286
Structural basis of m(7)GpppG binding to poly(A)-specific ribonuclease.
Wu M; Nilsson P; Henriksson N; Niedzwiecka A; Lim MK; Cheng Z; Kokkoris K; Virtanen A; Song H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(45):32902-32911
A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties.
Nilsson P; Henriksson N; Niedzwiecka A; Balatsos NAA; Kokkoris K; Eriksson J; Virtanen A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(7):4517-4522
Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).
Balatsos NAA; Nilsson P; Mazza C; Cusack S; Virtanen A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(30):27923-27929
The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation.
Martînez J; Ren YG; Nilsson P; Ehrenberg M; Virtanen A
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Employments

Principal Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2024

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