Peder Olofsson

About me
Publications
CV
Public outreach and news

About me

MD, PhD, Professor

Articles

Journal article: SCIENTIFIC REPORTS. 2024;14(1):8196

RSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells

Hayderi A; Kumawat AK; Shavva VS; Dreifaldt M; Sigvant B; Petri MH; Kragsterman B; Olofsson PS; Sirsjö A; Ljungberg LU
Journal article: NATURE CARDIOVASCULAR RESEARCH. 2024;:356-371

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
Article: JOURNAL OF CROHNS & COLITIS. 2023;17(12):1897-1909

Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn's Disease Patients: A Prospective Open-label Study.

D'Haens G; Eberhardson M; Cabrijan Z; Danese S; van den Berg R; Löwenberg M; Fiorino G; Schuurman PR; Lind G; Almqvist P; Olofsson PS; Tracey KJ; Hanauer SB; Zitnik R; Chernoff D; Levine YA
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3294

Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 ameliorates atherosclerosis and selectively modulates aortic myeloid cell phenotype

Macritchie N; Shoaran M; Gurgone D; Gu S; Mcshane L; Bin Khunayn AMA; Caiazzo E; Giacca M; Zentilin L; Monaco C; Pasterkamp G; Olofsson PS; Guzik TJ; Graham GJ; Maffia P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2212476120

Cholinergic regulation of vascular endothelial function by human ChAT+ T cells.

Tarnawski L; Shavva VS; Kort EJ; Zhuge Z; Nilsson I; Gallina AL; Martínez-Enguita D; Heller Sahlgren B; Weiland M; Caravaca AS; Schmidt S; Chen P; Abbas K; Wang F-H; Ahmed O; Eberhardson M; Färnert A; Weitzberg E; Gustafsson M; Kehr J; Malin SG; Hult H; Carlström M; Jovinge S; Olofsson PS
Article: BIOELECTRONIC MEDICINE. 2023;9(1):6

Hepatic stellate cell activation markers are regulated by the vagus nerve in systemic inflammation.

Ahmed O; Caravaca AS; Crespo M; Dai W; Liu T; Guo Q; Leiva M; Sabio G; Shavva VS; Malin SG; Olofsson PS
Article: NATURE MATERIALS. 2023;22(2):242-248

Ion-tunable antiambipolarity in mixed ion-electron conducting polymers enables biorealistic organic electrochemical neurons.

Harikesh PC; Yang C-Y; Wu H-Y; Zhang S; Donahue MJ; Caravaca AS; Huang J-D; Olofsson PS; Berggren M; Tu D; Fabiano S
Article: JOURNAL OF NEURAL ENGINEERING. 2022;19(6):066031

Wireless optoelectronic devices for vagus nerve stimulation in mice.

Donahue MJ; Ejneby MS; Jakešová M; Caravaca AS; Andersson G; Sahalianov I; Đerek V; Hult H; Olofsson PS; Głowacki ED
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(21):e2201378

Tailored Biocompatible Polyurethane-Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial.

Speidel AT; Chivers PRA; Wood CS; Roberts DA; Correia IP; Caravaca AS; Chan YKV; Hansel CS; Heimgärtner J; Müller E; Ziesmer J; Sotiriou GA; Olofsson PS; Stevens MM
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(17):e2200075

Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields.

Botzanowski B; Donahue MJ; Ejneby MS; Gallina AL; Ngom I; Missey F; Acerbo E; Byun D; Carron R; Cassarà AM; Neufeld E; Jirsa V; Olofsson PS; Głowacki ED; Williamson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(22):e2023285119

Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit.

Caravaca AS; Gallina AL; Tarnawski L; Shavva VS; Colas RA; Dalli J; Malin SG; Hult H; Arnardottir H; Olofsson PS
Article: NATURE. 2022;605(7908):152-159

Neuroimmune cardiovascular interfaces control atherosclerosis.

Mohanta SK; Peng L; Li Y; Lu S; Sun T; Carnevale L; Perrotta M; Ma Z; Förstera B; Stanic K; Zhang C; Zhang X; Szczepaniak P; Bianchini M; Saeed BR; Carnevale R; Hu D; Nosalski R; Pallante F; Beer M; Santovito D; Ertürk A; Mettenleiter TC; Klupp BG; Megens RTA; Steffens S; Pelisek J; Eckstein H-H; Kleemann R; Habenicht L; Mallat Z; Michel J-B; Bernhagen J; Dichgans M; D'Agostino G; Guzik TJ; Olofsson PS; Yin C; Weber C; Lembo G; Carnevale D; Habenicht AJR
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:831039

Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice.

Kumawat AK; Zegeye MM; Paramel GV; Baumgartner R; Gisterå A; Amegavie O; Hellberg S; Jin H; Caravaca AS; Söderström LÅ; Gudmundsdotter L; Frejd FY; Ljungberg LU; Olofsson PS; Ketelhuth DFJ; Sirsjö A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883

The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection.

Arnardottir H; Thul S; Pawelzik S-C; Karadimou G; Artiach G; Gallina AL; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Bäck M
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(7):921-927

Plasma HMGB1 levels and physical performance in ICU survivors.

Brück E; Svensson-Raskh A; Larsson JW; Caravaca AS; Gallina AL; Eberhardson M; Sackey PV; Olofsson PS
Article: BIOELECTRONIC MEDICINE. 2021;7(1):7

The Fourth Bioelectronic Medicine Summit "Technology Targeting Molecular Mechanisms": current progress, challenges, and charting the future.

Datta-Chaudhuri T; Zanos T; Chang EH; Olofsson PS; Bickel S; Bouton C; Grande D; Rieth L; Aranow C; Bloom O; Mehta AD; Civillico G; Stevens MM; Głowacki E; Bettinger C; Schüettler M; Puleo C; Rennaker R; Mohanta S; Carnevale D; Conde SV; Bonaz B; Chernoff D; Kapa S; Berggren M; Ludwig K; Zanos S; Miller L; Weber D; Yoshor D; Steinman L; Chavan SS; Pavlov VA; Al-Abed Y; Tracey KJ
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:613979

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial.

Sangaleti CT; Katayama KY; De Angelis K; Lemos de Moraes T; Araújo AA; Lopes HF; Camacho C; Bortolotto LA; Michelini LC; Irigoyen MC; Olofsson PS; Barnaby DP; Tracey KJ; Pavlov VA; Consolim Colombo FM
Article: FRONTIERS IN NEUROSCIENCE. 2021;15:730407

Vagus Nerve Stimulation Reduces Indomethacin-Induced Small Bowel Inflammation.

Caravaca AS; Levine YA; Drake A; Eberhardson M; Olofsson PS
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gisterå A; Malin SG; Tarnawski L; Matic L; Olofsson PS
Article: SCIENTIFIC REPORTS. 2020;10(1):19108

Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.

Paramel GV; Karadimou G; Eremo AG; Ljungberg LU; Hedin U; Olofsson PS; Folkersen L; Paulsson-Berne G; Sirsjö A; Fransén K
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(3):321-334

Treatment with a Toll-like Receptor 7 ligand evokes protective immunity against atherosclerosis in hypercholesterolaemic mice.

Karadimou G; Gisterå A; Gallina AL; Caravaca AS; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson PS; Paulsson-Berne G
Journal article: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):584

Corrigendum.
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2020;10(3):a034181

Neural Control of Inflammation: Bioelectronic Medicine in Treatment of Chronic Inflammatory Disease.

Eberhardson M; Tarnawski L; Centa M; Olofsson PS
Article: REDOX BIOLOGY. 2020;28:101387

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.

Peleli M; Ferreira DMS; Tarnawski L; McCann Haworth S; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlström M
Article: EUROPEAN HEART JOURNAL. 2019;40(30):2495-2503

Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade.

Christersdottir T; Pirault J; Gisterå A; Bergman O; Gallina AL; Baumgartner R; Lundberg AM; Eriksson P; Yan Z-Q; Paulsson-Berne G; Hansson GK; Olofsson PS; Halle M
Article: CRITICAL CARE. 2019;23(1):253

Lack of clinically relevant correlation between subjective and objective cognitive function in ICU survivors: a prospective 12-month follow-up study.

Brück E; Larsson JW; Lasselin J; Bottai M; Hirvikoski T; Sundman E; Eberhardson M; Sackey P; Olofsson PS
Article: SCIENCE. 2019;363(6427):639-644

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA; Duncan GS; Lin GHY; Steinberg BE; Yu LX; Brenner D; Buckler LN; Elia AJ; Wakeham AC; Nieman B; Dominguez-Brauer C; Elford AR; Gill KT; Kubli SP; Haight J; Berger T; Ohashi PS; Tracey KJ; Olofsson PS; Mak TW
Article: FRONTIERS IN NEUROSCIENCE. 2019;13:877

An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation.

Caravaca AS; Gallina AL; Tarnawski L; Tracey KJ; Pavlov VA; Levine YA; Olofsson PS
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:585

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation.

Lehner KR; Silverman HA; Addorisio ME; Roy A; Al-Onaizi MA; Levine Y; Olofsson PS; Chavan SS; Gros R; Nathanson NM; Al-Abed Y; Metz CN; Prado VF; Prado MAM; Tracey KJ; Pavlov VA
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2648

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Tarnawski L; Reardon C; Caravaca AS; Rosas-Ballina M; Tusche MW; Drake AR; Hudson LK; Hanes WM; Li JH; Parrish WR; Ojamaa K; Al-Abed Y; Faltys M; Pavlov VA; Andersson U; Chavan SS; Levine YA; Mak TW; Tracey KJ; Olofsson PS
Article: JOURNAL OF NEURAL ENGINEERING. 2017;14(6):066005

A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve.

Caravaca AS; Tsaava T; Goldman L; Silverman H; Riggott G; Chavan SS; Bouton C; Tracey KJ; Desimone R; Boyden ES; Sohal HS; Olofsson PS
Article: CIRCULATION JOURNAL. 2017;81(12):1945-1952

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A.

Söderström LÅ; Jin H; Caravaca AS; Klement ML; Li Y; Gisterå A; Hedin U; Maegdefessel L; Hansson GK; Olofsson PS
Article: REDOX BIOLOGY. 2017;13:320-330

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.

Yang T; Zhang X-M; Tarnawski L; Peleli M; Zhuge Z; Terrando N; Harris RA; Olofsson PS; Larsson E; Persson AEG; Lundberg JO; Weitzberg E; Carlstrom M
Article: JCI INSIGHT. 2017;2(14):93340

Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial.

Consolim-Colombo FM; Sangaleti CT; Costa FO; Morais TL; Lopes HF; Motta JM; Irigoyen MC; Bortoloto LA; Rochitte CE; Harris YT; Satapathy SK; Olofsson PS; Akerman M; Chavan SS; MacKay M; Barnaby DP; Lesser ML; Roth J; Tracey KJ; Pavlov VA
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1673

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors.

Zaghloul N; Addorisio ME; Silverman HA; Patel HL; Valdés-Ferrer SI; Ayasolla KR; Lehner KR; Olofsson PS; Nasim M; Metz CN; Wang P; Ahmed M; Chavan SS; Diamond B; Tracey KJ; Pavlov VA
Article: NATURE BIOTECHNOLOGY. 2016;34(10):1066-1071

Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.

Olofsson PS; Steinberg BE; Sobbi R; Cox MA; Ahmed MN; Oswald M; Szekeres F; Hanes WM; Introini A; Liu SF; Holodick NE; Rothstein TL; Lövdahl C; Chavan SS; Yang H; Pavlov VA; Broliden K; Andersson U; Diamond B; Miller EJ; Arner A; Gregersen PK; Backx PH; Mak TW; Tracey KJ
Article: MOLECULAR MEDICINE. 2016;22:585-596

Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice.

Hudson LK; Dancho ME; Li J; Bruchfeld JB; Ragab AA; He MM; Bragg M; Lenaghan D; Quinn MD; Fritz JR; Tanzi MV; Silverman HA; Hanes WM; Levine YA; Pavlov VA; Olofsson PS; Roth J; Al-Abed Y; Andersson U; Tracey KJ; Chavan SS
Article: JCI INSIGHT. 2016;1(7):85375

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Article: MOLECULAR MEDICINE. 2016;21(1):951-958

HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors.

Valdés-Ferrer SI; Papoin J; Dancho ME; Olofsson PS; Li J; Lipton JM; Avancena P; Yang H; Zou Y-R; Chavan SS; Volpe BT; Gardenghi S; Rivella S; Diamond B; Andersson U; Steinberg BM; Blanc L; Tracey KJ
Article: BIOELECTRONIC MEDICINE. 2016;3:18-28

Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes.

Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
Article: MOLECULAR MEDICINE. 2015;21(1):702-708

Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Nonobese Diabetic Mice.

Hanes WM; Olofsson PS; Kwan K; Hudson LK; Chavan SS; Pavlov VA; Tracey KJ
Journal article: BIOELECTRONIC MEDICINE. 2015;2(1):37-42

Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia

Olofsson PS; Levine YA; Caravaca A; Chavan SS; Pavlov VA; Faltys M; Tracey KJ
Journal article: JOURNAL OF IMMUNOLOGY. 2015;194(1_Supplement):197.2

Neuronal circuits modulate antigen flow through lymph nodes (IRC11P.420)

Hanes W; Olofsson P; Tsaava T; Levine Y; Chavan S; Tracey K
Article: MOLECULAR MEDICINE. 2015;20(1):601-611

Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation.

Silverman HA; Dancho M; Regnier-Golanov A; Nasim M; Ochani M; Olofsson PS; Ahmed M; Miller EJ; Chavan SS; Golanov E; Metz CN; Tracey KJ; Pavlov VA
Article: BRAIN BEHAVIOR AND IMMUNITY. 2015;44:19-27

Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation.

Rosas-Ballina M; Valdés-Ferrer SI; Dancho ME; Ochani M; Katz D; Cheng KF; Olofsson PS; Chavan SS; Al-Abed Y; Tracey KJ; Pavlov VA
Article: JOURNAL OF INTERNAL MEDICINE. 2014;276(5):525-536

The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions.

Ovchinnikova OA; Folkersen L; Persson J; Lindeman JHN; Ueland T; Aukrust P; Gavrisheva N; Shlyakhto E; Paulsson-Berne G; Hedin U; Olofsson PS; Hansson GK
Article: MOLECULAR MEDICINE. 2014;20(1):456-465

Human genetic evidence for involvement of CD137 in atherosclerosis.

Söderström LÅ; Gertow K; Folkersen L; Sabater-Lleal M; Sundman E; Sheikine Y; Goel A; Baldassarre D; Humphries SE; de Faire U; Watkins H; Tremoli E; Veglia F; Hamsten A; Hansson GK; Olofsson PS
Article: MOLECULAR MEDICINE. 2014;20(1):350-358

α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release.

Lu B; Kwan K; Levine YA; Olofsson PS; Yang H; Li J; Joshi S; Wang H; Andersson U; Chavan SS; Tracey KJ
Article: ADVANCES IN PHYSIOLOGY EDUCATION. 2014;38(2):135-139

Neural control of the immune system.

Sundman E; Olofsson PS
Article: SHOCK. 2013;40(6):492-495

High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model.

Valdés-Ferrer SI; Rosas-Ballina M; Olofsson PS; Lu B; Dancho ME; Li J; Yang H; Pavlov VA; Chavan SS; Tracey KJ
Article: JOURNAL OF INTERNAL MEDICINE. 2013;274(4):381-390

HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.

Valdés-Ferrer SI; Rosas-Ballina M; Olofsson PS; Lu B; Dancho ME; Ochani M; Li JH; Scheinerman JA; Katz DA; Levine YA; Hudson LK; Yang H; Pavlov VA; Roth J; Blanc L; Antoine DJ; Chavan SS; Andersson U; Diamond B; Tracey KJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(4):1410-1415

Lymphocyte-derived ACh regulates local innate but not adaptive immunity.

Reardon C; Duncan GS; Brüstle A; Brenner D; Tusche MW; Olofsson PS; Rosas-Ballina M; Tracey KJ; Mak TW
Article: NATURE. 2012;488(7413):670-674

Novel role of PKR in inflammasome activation and HMGB1 release.

Lu B; Nakamura T; Inouye K; Li J; Tang Y; Lundbäck P; Valdes-Ferrer SI; Olofsson PS; Kalb T; Roth J; Zou Y; Erlandsson-Harris H; Yang H; Ting JP-Y; Wang H; Andersson U; Antoine DJ; Chavan SS; Hotamisligil GS; Tracey KJ
Article: MOLECULAR MEDICINE. 2012;18(1):539-543

α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.

Olofsson PS; Katz DA; Rosas-Ballina M; Levine YA; Ochani M; Valdés-Ferrer SI; Pavlov VA; Tracey KJ; Chavan SS
Article: MOLECULAR MEDICINE. 2012;18(1):712-718

A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis.

Krivospitskaya O; Elmabsout AA; Sundman E; Söderström LA; Ovchinnikova O; Gidlöf AC; Scherbak N; Norata GD; Samnegård A; Törmä H; Abdel-Halim SM; Jansson J-H; Eriksson P; Sirsjö A; Olofsson PS
Article: PLOS ONE. 2012;7(5):e36839

Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells.

Elmabsout AA; Kumawat A; Saenz-Méndez P; Krivospitskaya O; Sävenstrand H; Olofsson PS; Eriksson LA; Strid A; Valen G; Törmä H; Sirsjö A
Article: SCIENCE. 2011;334(6052):98-101

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.

Rosas-Ballina M; Olofsson PS; Ochani M; Valdés-Ferrer SI; Levine YA; Reardon C; Tusche MW; Pavlov VA; Andersson U; Chavan S; Mak TW; Tracey KJ
Article: MOLECULAR MEDICINE. 2011;17(7-8):599-606

Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice.

Satapathy SK; Ochani M; Dancho M; Hudson LK; Rosas-Ballina M; Valdes-Ferrer SI; Olofsson PS; Harris YT; Roth J; Chavan S; Tracey KJ; Pavlov VA
Article: JOURNAL OF VASCULAR RESEARCH. 2011;48(1):23-30

CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells.

Ocaya PA; Elmabsout AA; Olofsson PS; Törmä H; Gidlöf AC; Sirsjö A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;402(3):471-476

Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice.

Sheikine Y; Deodato B; Olofsson PS; Söderström LA; Lundberg AM; Bodin I; Rudling M; Theodorsson E; Hansson GK
Article: CIRCULATION JOURNAL. 2009;73(8):1531-1536

A functional interleukin-1 receptor antagonist polymorphism influences atherosclerosis development. The interleukin-1beta:interleukin-1 receptor antagonist balance in atherosclerosis.

Olofsson PS; Sheikine Y; Jatta K; Ghaderi M; Samnegård A; Eriksson P; Sirsjö A
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2009;87(4):337-346

Genetic variants of TNFSF4 and risk for carotid artery disease and stroke.

Olofsson PS; Söderström LA; Jern C; Sirsjö A; Ria M; Sundler E; de Faire U; Wiklund PG; Ohrvik J; Hedin U; Paulsson-Berne G; Hamsten A; Eriksson P; Hansson GK
Article: CIRCULATION RESEARCH. 2009;104(1):60-68

Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.

Sandberg WJ; Halvorsen B; Yndestad A; Smith C; Otterdal K; Brosstad FR; Frøland SS; Olofsson PS; Damås JK; Gullestad L; Hansson GK; Oie E; Aukrust P
Article: JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2008;59(2):239-252

Abrogation of mitochondrial transcription in smooth muscle cells impairs smooth muscle contractility and vascular tone.

Jawien J; Bian Z; Sheikine Y; Olofsson PS; Pang Y; Edholm T; Dou Y; Metzger D; Hellström PM; Feil R; Hansson GK
Article: CIRCULATION. 2008;117(10):1292-1301

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.

Olofsson PS; Söderström LA; Wågsäter D; Sheikine Y; Ocaya P; Lang F; Rabu C; Chen L; Rudling M; Aukrust P; Hedin U; Paulsson-Berne G; Sirsjö A; Hansson GK
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(7):1542-1548

CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells.

Ocaya P; Gidlöf AC; Olofsson PS; Törmä H; Sirsjö A
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2006;48(8):1591-1599

Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation.

Smith C; Damås JK; Otterdal K; Øie E; Sandberg WJ; Yndestad A; Waehre T; Scholz H; Endresen K; Olofsson PS; Halvorsen B; Gullestad L; Frøland SS; Hansson GK; Aukrust P
Article: JOURNAL OF VASCULAR RESEARCH. 2006;43(4):392-398

Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells.

Gidlof AC; Ocaya P; Olofsson PS; Torma H; Sirsjo A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(7):e113-e116

The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.

Olofsson PS; Jatta K; Wågsäter D; Gredmark S; Hedin U; Paulsson-Berne G; Söderberg-Nauclér C; Hansson GK; Sirsjö A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;325(4):1187-1193

The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma.

Wågsäter D; Olofsson PS; Norgren L; Stenberg B; Sirsjö A
Journal article: [TITLE FIELD MISSING]. 2004;5(1):6

W01.24 Expression of 4-IBB (CD137) and its ligand 4-1BBL in human atherosclerosis

Ghaderi M; Wågsäter D; Olofsson P; Sheikine Y; Sirsjö A
Journal article:

Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis

Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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All other publications

Preprint: 2024;bioRxiv

Adipose tissue microvascular endothelial cells form a tight vascular barrier that selectively transcytoses fatty acid tracers

Schipper R; Ioannidou A; Maestri A; Baganha F; Werngren O; Olofsson PS; Malin SG; Fisher RM; Hagberg CE
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:s756-s757

Statins regulate PNPLA3 through a mechanism that requires SREBF2 in human liver cells

Ahmed O; Shavva VS; Dai W; Tarnawski L; Malin S; Franco-Cereceda A; Eriksson P; Bjorck H; Olofsson P
Conference publication: 2023

Organic Electrochemical Neurons

Padinhare Cholakkal H; Fabiano S; Tu D; Wu H-Y; Zhang S; Massetti M; Yang C-Y; Donahue M; Caravaca A; Olofsson P; Berggren M; Huang J-D
Preprint: 2022;bioRxiv

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Björck HM; Francis R; Fagerberg L; Gisterå A; Zhang X; Metso J; Manfé V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
Preprint: 2021;bioRxiv

Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields

Botzanowski B; Donahue MJ; Ejneby MS; Gallina AL; Ngom I; Missey F; Acerbo E; Byun D; Carron R; Cassarà AM; Neufeld E; Jirsa V; Olofsson PS; Głowacki ED; Williamson A
Conference publication: 2021

Targeting Molecular Mechanisms in Excessive Inflammation with Bioelectronic Medicine

Olofsson P
Conference publication: ATHEROSCLEROSIS. 2021;331:E9

THE RESOLVIN D1 RECEPTOR GPR32 TRANSDUCES INFLAMMATION-RESOLUTION AND ATHEROPROTECTION

Arnardottir H; Thul S; Karadimou G; Pawelzik S-C; Artiach G; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
Review: INTERNATIONAL IMMUNOLOGY. 2021;33(6):349-356

The brain-gut axis, inflammatory bowel disease and bioelectronic medicine.

Eberhardson M; Levine YA; Tarnawski L; Olofsson PS
Conference publication: HEART. 2021;107:A170

TAM RECEPTOR AXL LOSS REGULATES SMOOTH MUSCLE CELL DIFFERENTIATION AND ACCELERATES ATHEROSCLEROSIS IN MICE

Mcshane L; Gurgone D; Bin-Khunayn AM; Crespo E; Grassia G; MacRitchie N; Giacca M; Zentilin L; Karadimou G; Paulsson-Berne G; Olofsson PS; Otto TD; Guzik TJ; Kurowska-Stolarska M; Maffia P
Preprint: 2021;bioRxiv

Identification and Characterization of Human Activation-Induced ChAT+CD4+ T Cells

Tarnawski L; Gallina A; Kort E; Shavva V; Zhuge Z; Martínez-Enguita D; Weiland M; Caravaca A; Schmidt S; Wang F; Färnert A; Weitzberg E; Gustafsson M; Eberhardson M; Hult H; Kehr J; Malin S; Carlström M; Jovinge S; Olofsson P
Corrigendum: SCIENTIFIC REPORTS. 2021;11(1):8852

Author Correction: Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.

Paramel GV; Karadimou G; Eremo AG; Ljungberg LU; Hedin U; Olofsson PS; Folkersen L; Paulsson-Berne G; Sirsjö A; Fransén K
Review: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(11):e1352

Inflammation neuroscience: neuro-immune crosstalk and interfaces.

Tarnawski L; Olofsson PS
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:93

Neuroimmune cardiovascular interfaces in atherosclerosis

Mohanta S; Peng L; Li Y; Yin C; Lu S; Sun T; Carnevale L; Perrotta M; Pelisek J; Forstera B; Erturl A; Szczepaniak P; Megens R; Habenicht L; Agostino GDP; Guzik T; Olofsson P; Erturk A; Mettenleiter T; Weber C; Lembo G; Carnevlae D; Habenicht A
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3832

Treating ApoE-/- mice with Toll-like receptor 7 ligand lead to expansion of marginal zone B cells, reduced plasma cholesterol and decreased atherosclerosis

Paulsson-Berne G; Karadimou G; Gistera A; Gallina A; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson P
Preprint: 2020;bioRxiv

Alternate models of acute dyslipidemia reveal divergent pathways upon atherosclerosis initiation

Hellberg S; Shavva VS; Metso J; Chen G; Li Q-Z; Manfè V; Olofsson PS; Jauhiainen M; Binder CJ; Malin SG
Review: CURRENT OPINION IN NEUROBIOLOGY. 2020;62:115-121

Functions of acetylcholine-producing lymphocytes in immunobiology.

Malin SG; Shavva VS; Tarnawski L; Olofsson PS
Letter: INTENSIVE CARE MEDICINE. 2020;46(4):811-812

Prolonged elevation of plasma HMGB1 is associated with cognitive impairment in intensive care unit survivors.

Brück E; Lasselin J; HICUS study group; Andersson U; Sackey PV; Olofsson PS
Review: BIOELECTRONIC MEDICINE. 2020;6:3

Neural reflex control of vascular inflammation.

Caravaca AS; Centa M; Gallina AL; Tarnawski L; Olofsson PS
Preprint: 2020;SSRN Electronic Journal

Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis

Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):237-239

Bioelectronic medicine: an unexpected path to new therapies.

Olofsson PS; Bouton C
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(3):e12745

Towards improved control of inflammatory bowel disease.

Eberhardson M; Hedin CRH; Carlson M; Tarnawski L; Levine YA; Olofsson PS
Conference publication: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2019;63(8):E26

Prolonged elevation of HMGB1 after intensive care

Bruck E; Caravaca A; Gallina A; Andersson U; Eberhardson M; Sackey P; Olofsson PS
Corrigendum: JCI INSIGHT. 2018;3(24):126617

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Other: JCI INSIGHT. 2018;3(24):126616

Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.

Yang H; Wang H; Levine YA; Gunasekaran MK; Wang Y; Addorisio M; Zhu S; Li W; Li J; de Kleijn DP; Olofsson PS; Warren HS; He M; Al-Abed Y; Roth J; Antoine DJ; Chavan SS; Andersson U; Tracey KJ
Review: ATHEROSCLEROSIS. 2018;272:66-72

CD137: A checkpoint regulator involved in atherosclerosis.

Söderström LÅ; Tarnawski L; Olofsson PS
Book chapter: 2018;p. xi-xiii

List of Contributors of Volume 3

Abell T; Abraham WT; Alabbad A; Al-Kaisy A; Andréll P; McKinley RA; Angeli CA; Ardell JL; Arnold A; Audu M; Baker KB; Barolat G; Baskin JZ; Benderro GF; Bennett ME; Bikson M; Bouton CE; Buckley U; Carvalho S; Cavuoto J; Chae J; Chen JDZ; Chen S; Cohn JA; Creasey GH; Czura CJ; Damato EG; de Groat WC; Decker MJ; DiMarco AF; Dipietro L; Dmochowski RR; Dorman MF; Duarte RV; Durand DM; Germany RE; Emala C; Errico JP; Faltys M; Franke M; Fregni F; French M; Fritz JR; Gassler JP; Calle AG; Harkema SJ; Hassouna M; Horsch S; Humayun MS; Huston JM; Jin H; Kapural L; Kaufman MR; Kilgore KL; Knutson JS; Kobetic R; Kowalski KE; Kowalik CG; Krames ES; Leite J; Levine YA; Li Y; Loudin J; Lu PL; Machado AG; Makowski NS; Malde S; Ackermann DM; Milam DF; Mogilner AY; Mousa HM; Moynahan M; Murray D; Olofsson PS; Onders RP; Peckham PH; Perryman L; Piedemonte F; Prager JP; Rejc E; Reynolds WS; Sahai A; Salavatian S; Schiefer MA; Schneider M; Schulte S; Selkirk S; Simis M; Simon B; Simon J; Snyder J; Staats P; Strohl KP; Thibaut A; Thomson SJ; Triolo RJ; Tyler DJ; Unal G; Vasquez A; Wagner T; Wathen CA; Weiland JD; Wilson BS; Wilson RD; Yao S; Yin J; Yoruk A; Zitnik R
Book chapter: 2018;p. 1483-1492

Chapter 125 Vagus Nerve Stimulation and Regulation of Inflammation

Olofsson PS
Book chapter: 2018;p. 68-76

Immune-Mediated Mechanisms of Atherosclerosis

Bäck M; Ketelhuth DFJ; Malin S; Olofsson PS; Paulsson-Berne G; Yan Z-Q; Hansson GK
Book chapter: 2018;p.

Immune-Mediated Mechanisms of Atherosclerosis

Bäck M; Ketelhuth DFJ; Malin S; Olofsson PS; Paulsson-Berne G; Yan Z-Q; Hansson GK
Book chapter: 2017;p. 1485-1516

The Neuroimmune Communicatome in Inflammation

Olofsson PS; Metz CN; Pavlov VA
Review: EPILEPSIA. 2017;58 Suppl 3(Suppl 3):69-82

Clinical studies and anti-inflammatory mechanisms of treatments.

French JA; Koepp M; Naegelin Y; Vigevano F; Auvin S; Rho JM; Rosenberg E; Devinsky O; Olofsson PS; Dichter MA
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;282(1):3-4

Bioelectronic medicine: technology targeting molecular mechanisms for therapy.

Olofsson PS; Tracey KJ
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):279-280

Choline acetyltransferase is expressed by activated human T cells

Tarnawski L; Admassu H; Olofsson PS
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):268

Electrical vagus nerve stimulation accelerates resolution of inflammation in experimental peritonitis

Caravaca AS; Tarnawski L; Arnardottir H; Back M; Olofsson PS
Review: ANESTHESIOLOGY. 2016;124(5):1174-1189

Neural Control of Inflammation: Implications for Perioperative and Critical Care.

Steinberg BE; Sundman E; Terrando N; Eriksson LI; Olofsson PS
Conference publication: JOURNAL OF IMMUNOLOGY. 2015;194:65.22

Choline acetyltransferase plus lymphocytes regulate endothelial nitric oxide synthase

Olofsson P; Hanes W; Steinberg B; Oswald M; Ahmed M; Hudson L; Valdes-Ferrer S; Liu S; Pavlov V; Chavan S; Andersson U; Diamond B; Miller E; Gregersen P; Tracey K
Corrigendum: SHOCK. 2014;41(3):266

HMGB1 Mediates Persistent Splenocyte Priming In Sepsis Survivors: Evidence From A Murine Model (vol 40, pg 492, 2013)

Valdes-Ferrer SI; Rosas-Ballina M; Olofsson PS; Lu B; Dancho ME; Ochani M; Li JH; Scheinerman JA; Katz DA; Levine YA
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:116.10

Cholinergic neuronal signals attenuate inflammasome activation through inhibiting mitochondrial stress

Lu B; Levine Y; Yang H; Kwan K; Olofsson P; Andersson U; Chavan S; Tracey K
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(13):5269

Lymphocyte-derived ACh regulates local innate but not adaptive immunity (vol 110, pg 1410, 2013)

Reardon C; Duncan GS; Bruestle A; Brenner D; Tusche MW; Olofsson PS; Rosas-Ballina M; Tracey KJ; Mak TW
Conference publication: SHOCK. 2013;39:20

CHOLINERGIC NEURONAL SIGNALS ATTENUATE INFLAMMASOME ACTIVATION THROUGH INHIBITING MITOCHONDRIAL STRESS

Lu B; Levine Y; Kwan K; Yang H; Olofsson PS; Andersson U; Chavan SS; Tracey K
Review: IMMUNOLOGICAL REVIEWS. 2012;248(1):188-204

Rethinking inflammation: neural circuits in the regulation of immunity.

Olofsson PS; Rosas-Ballina M; Levine YA; Tracey KJ
Conference publication: JOURNAL OF IMMUNOLOGY. 2012;188:114.7

PKR is required for NLRP3 inflammasome activation and HMGB1 release

Lu B; Nakamura T; Inouye K; Valdes-Ferrer S; Olofsson P; Li J; Wang H; Erlandsson-Harris H; Kalb T; Andersson U; Yang H; Chavan S; Hotamisligil G; Tracey K
Editorial comment: CIRCULATION RESEARCH. 2012;110(6):800-801

Targeting T cell costimulation to prevent atherothrombosis.

Olofsson PS
Conference publication: SHOCK. 2012;37:29

PKR IS REQUIRED FOR NLRP3 INFLAMMASOME ACTIVATION AND HMGB1 RELEASE

Lu B; Nakamura T; Inouye K; Valdes-Ferrer SI; Olofsson PS; Li J; Wang H; Andersson U; Yang H; Chavan SS; Hotamisligi GS; Tracey K
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2007;8(1):214

Polymorphism in the CYP26B1 gene and association with the susceptibility of myocardial infarction

Krivospitskaya O; Jatta K; Johansson L; Jansson JH; Hurtig-Wennlof A; Olofsson P; Sirsjo A
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):393

CD137 and CD137 ligand in vascular smooth muscle cells

Wågsäter D; Olofsson PS; Sirsjö A
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2004;5(1):6

Expression of 4-1BB(CD137) and its ligand 4-1BBL in human atherosclerosis

Ghaderi M; Wågsäter D; Olofsson P; Sheikine Y; Sirsjö A
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2004;5(1):13-14

Cytomegalovirus inducible gene 5 is induced in human and rodent vascular inflammation and atherosclerosis

Olofsson P; Wågsäter D; Hansson G; Sirsjö A
Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2004;5(1):13

Gene profiling of the atherosclerotic lesion after all-trans retinoic acid exposure

Ocaya P; Jatta K; Olofsson P; Stenberg B; Norgren L; Sirsjö A
Conference publication: FASEB JOURNAL. 2002;16(4):A210

Cytomegalo virus inducible gene 5 (CIG5)and CIG49 are induced in human vascular inflammation

Olofsson P; Olsson A; Hansson GK; Sirsjö A
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2001;21(4):697

Retinoids modulate expression of nitric oxide synthase-2 in vascular smooth muscle cells.

Olofsson P; Olsson A; Gidlöf AC; Yan ZQ; Hansson GK; Sirsjö A
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Employments

Professor, Department of Medicine, Karolinska Institutet, 2024-
Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-2024
Faculty, Professor, Institute of Bioelectronic Medicine, Feinstein Institute for Medical Research, 2015-2023

Degrees and Education

Docent, Karolinska Institutet, 2018
Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2008

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