Pavitra Kannan

Publications
CV
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Articles

Article: SCIENTIFIC REPORTS. 2023;13(1):4583
MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia
Lerma Clavero A; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane DP; Kannan P
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
Article: EMBO REPORTS. 2022;23(9):e53221
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models
Kaeppler JR; Chen J; Buono M; Vermeer J; Kannan P; Cheng W-C; Voukantsis D; Thompson JM; Hill MA; Allen D; Gomes A; Kersemans V; Kinchesh P; Smart S; Buffa F; Nerlov C; Muschel RJ; Markelc B
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:883083
An Automated Quantification Tool for Angiogenic Sprouting From Endothelial Spheroids
Kannan P; Schain M; Lane DP
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):6
Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer
Paczkowski M; Kretzschmar WW; Markelc B; Liu SK; Kunz-Schughart LA; Harris AL; Partridge M; Byrne HM; Kannan P
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(8):2026-2035
In vivo characterization of [¹⁸F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
Kannan P; Fueredi A; Dizdarevic S; Wanek T; Mairinger S; Collins J; Falls T; van Dam RM; Maheshwari D; Lee JT; Szakacs G; Langer O
Article: CLINICAL CANCER RESEARCH. 2018;24(19):4694-4704
Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
Kannan P; Kretzschmar WW; Winter H; Warren D; Bates R; Allen PD; Syed N; Irving B; Papiez BW; Kaeppler J; Markelc B; Kinchesh P; Gilchrist S; Smart S; Schnabel JA; Maughan T; Harris AL; Muschel RJ; Partridge M; Sharma RA; Kersemans V
Article: EPILEPSIA. 2018;59(8):1507-1517
The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue
Weidner LD; Kannan P; Mitsios N; Kang SJ; Hall MD; Theodore WH; Innis RB; Mulder J
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37(6):2062-2075
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter
Kannan P; Schain M; Kretzschmar WW; Weidner L; Mitsios N; Gulyas B; Blom H; Gottesman MM; Innis RB; Hall MD; Mulder J
Article: BULLETIN OF MATHEMATICAL BIOLOGY. 2017;79(4):939-974
Bayesian Calibration, Validation and Uncertainty Quantification for Predictive Modelling of Tumour Growth: A Tutorial
Collis J; Connor AJ; Paczkowski M; Kannan P; Pitt-Francis J; Byrne HM; Hubbard ME
Article: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2016;13(116):20160070
Estimating oxygen distribution from vasculature in three-dimensional tumour tissue
Grimes DR; Kannan P; Warren DR; Markelc B; Bates R; Muschel R; Partridge M
Article: DRUG METABOLISM AND DISPOSITION. 2016;44(2):275-282
Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein
Weidner LD; Fung KL; Kannan P; Moen JK; Kumar JS; Mulder J; Innis RB; Gottesman MM; Hall MD
Article: PLOS ONE. 2016;11(4):e0153692
The Role of Oxygen in Avascular Tumor Growth
Grimes DR; Kannan P; McIntyre A; Kavanagh A; Siddiky A; Wigfield S; Harris A; Partridge M
Article: PLOS ONE. 2015;10(6):e0128537
Improving In Vivo High-Resolution CT Imaging of the Tumour Vasculature in Xenograft Mouse Models through Reduction of Motion and Bone-Streak Artefacts
Kersemans V; Kannan P; Beech JS; Bates R; Irving B; Gilchrist S; Allen PD; Thompson J; Kinchesh P; Casteleyn C; Schnabel J; Partridge M; Muschel RJ; Smart SC
Article: RADIOTHERAPY AND ONCOLOGY. 2014;111(1):72-80
Regulation of O₂ consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
Kelly CJ; Hussien K; Fokas E; Kannan P; Shipley RJ; Ashton TM; Stratford M; Pearson N; Muschel RJ
Article: ACS CHEMICAL NEUROSCIENCE. 2011;2(2):82-89
The "Specific" P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)
Kannan P; Telu S; Shukla S; Ambudkar SV; Pike VW; Halldin C; Gottesman MM; Innis RB; Hall MD
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(6):2593-2598
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
Kannan P; Brimacombe KR; Kreisl WC; Liow J-S; Zoghbi SS; Telu S; Zhang Y; Pike VW; Halldin C; Gottesman MM; Innis RB; Hall MD
Article: DRUG METABOLISM AND DISPOSITION. 2010;38(6):917-922
N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier
Kannan P; Brimacombe KR; Zoghbi SS; Liow J-S; Morse C; Taku AK; Pike VW; Halldin C; Innis RB; Gottesman MM; Hall MD
Article: NUCLEAR MEDICINE AND BIOLOGY. 2010;37(3):335-345
Effects of ketoconazole on the biodistribution and metabolism of [¹¹C]loperamide and [¹¹C]N-desmethyl-loperamide in wild-type and P-gp knockout mice
Seneca N; Zoghbi SS; Shetty HU; Tuan E; Kannan P; Taku A; Innis RB; Pike VW
Article: NEUROIMAGE. 2010;49(4):2924-2932
Comparison of [¹¹C]-(R)-PK 11195 and [¹¹C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker
Kreisl WC; Fujita M; Fujimura Y; Kimura N; Jenko KJ; Kannan P; Hong J; Morse CL; Zoghbi SS; Gladding RL; Jacobson S; Oh U; Pike VW; Innis RB
Article: SYNAPSE. 2008;62(9):700-709
Kinetic brain analysis and whole-body imaging in monkey of [¹¹C]MNPA:: A dopamine agonist radioligand
Seneca N; Skinbjerg M; Zoghbi SS; Liow J-S; Gladding RL; Hong J; Kannan P; Tuan E; Sibley DR; Halldin C; Pike VW; Innis RB
Article: BRAIN RESEARCH. 2007;1142:100-109
The adenosine A_2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats
de Vaca SC; Kannan P; Pan Y; Jiang N; Sun Y; Carr KD
Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2006;16(12):3170-3174
Synthetic studies of neoclerodane diterpenes from Salvia divinorum:: Selective modification of the furan ring
Harding WW; Schmidt M; Tidgewell K; Kannan P; Holden KG; Dersch CM; Rothman RB; Prisinzano TE
Article: JOURNAL OF NATURAL PRODUCTS. 2006;69(6):914-918
Synthesis of salvinorin A analogues as opioid receptor probes
Tidgewell K; Harding WW; Lozama A; Cobb H; Shah K; Kannan P; Dersch CM; Parrish D; Deschamps JR; Rothman RB; Prisinzano TE
Article: JOURNAL OF NATURAL PRODUCTS. 2006;69(1):107-112
Synthetic studies of neoclerodane diterpenes from Salvia divinorum:: Semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A
Harding WW; Schmidt M; Tidgewell K; Kannan P; Holden KG; Gilmour B; Navarro H; Rothman RB; Prisinzano TE
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All other publications

Other: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(3):1443
Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin (Retraction of Vol 54, Pg 4987, 2011)
Goldsborough AS; Handley MD; Dulcey AE; Pluchino KM; Kannan P; Brimacombe KR; Hall MD; Griffiths G; Gottesman MM
Review: MOLECULAR PHARMACEUTICS. 2013;10(6):2222-2229
Factors That Limit Positron Emission Tomography Imaging of P-Glycoprotein Density at the Blood-Brain Barrier
Kannan P; Pike VW; Halldin C; Langer O; Gottesman MM; Innis RB; Hall MD
Other: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2009;86(4):368-377
Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications
Kannan P; John C; Zoghbi SS; Halldin C; Gottesman MM; Innis RB; Hall MD
Published conference paper: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2008;327(3):727-735
Radiodefluorination of 3-Fluoro-5-(2-(2-[¹⁸F](fluoromethyl)-thiazol-4-yl) ethynyl)benzonitrile ([¹⁸F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain
Shetty HU; Zoghbi SS; Simeon FG; Liow J-S; Brown AK; Kannan P; Innis RB; Pike VW

Employments

Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2020-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2012

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