Patricia Rodriguez Rodriguez
About me
I am a pharmacist and biochemist with a PhD in neuroscience and extensive experience in the study of molecular mechanisms leading to neurodegeneration.
I obtained my PhD in 2013, funded by a highly competitive national fellowship in Spain. In 2014 I joined The Karolinska Institute (KI) as a postdoctoral fellow, and led a project aimed at understanding the mechanisms behind insulin resistance in Alzheimer's disease (Brain, 2017). https://www.nature.com/articles/nrneurol.2017.158
In 2018 I became an Assistant Professor at Karolinska, and was awarded a H2020 Marie Skłodowska-Curie global individual fellowship that allowed me to join The Rockefeller University in New York, where I started exploring the mechanisms behind the vulnerability of specific neurons to Alzheimer's disease (Neuron, 2020, Brain, 2024). https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/projects-details/31045243/799638/H2020
In 2021 I returned to Karolinska, where I was promoted to a permanent position in 2023. I now lead an independent research line where I use state-of-the-art cell-type specific methods to uncover the mechanisms initiating neurodegeneration in Alzheimer's disease vulnerable neurons.
Research
Our research is focused on understanding how different genetic and non-genetic risk factors and disease drivers trigger the early degeneration of specific regions and neuronal subpopulations in Alzheimer's disease. To achieve this goal we apply a wide variety of cell-type specific transcriptomics and proteomics approaches in human post-mortem brain samples, mouse models and in-vitro systems.
Some of our current projects include:
- Cell-type specific analysis of human entorhinal cortex at early stages of Alzheimer’s disease
In-vivo characterization of subcellular proteomes
- Regional and cell-type specific vulnerability to Alzheimer’s disease risk factors
Identification and validation of novel drivers of Alzheimer’s disease neuropathology
More information can be found here: Research focus and projects
Teaching
- PhD and master course "Neurodegenerative dissorders I: genes, molecular mechanisms and treatment" at Karolinska Institute.
- PhD course "The interplay between neuro-infections and Neurodegenerative diseases", part of the Doctoral Program in Neuroscience at Karolinska Institute. (2023 and 2024).
- Course "Frontiers in Biomedicine" of the Master's programme in Biomedicine at Karolinska Institute (2023 and 2024).
- Teacher at "Protein Metabolism in Health and Disease", a course within the Karolinska Institutet Clinical Research School in Molecular Medicine (2024)
- PhD course "Alzheimer's disease-clinical features and pathogenic mechanisms" at Karolinska Institute. (2023 and 2025)
- Teacher at "Protein Mechanisms of Disease", a course within the Karolinska Institutet Clinical Research School in Molecular Medicine (2017)
- Teacher at the course "Frontiers in Translation Medicine, part of the master program in Biomedicine at Karolinska Institute (2016).
Selected publications
- Preprint: BIORXIV. 2025;BIORXIVRodriguez-Rodriguez P; Wang W; Tsagkogianni C; Feng I; Morello-Megias A; Jain K; Alanko V; Kahvecioglu H-A; Mohammadi E; Li X; Flajolet M; Sandebring-Matton A; Maioli S; Vidal N; Milosevic A; Roussarie J-P
- Article: BRAIN. 2024;147(7):2384-2399Rodriguez-Rodriguez P; Arroyo-Garcia LE; Tsagkogianni C; Li L; Wang W; Vegvari A; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha SC; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
- Article: SCIENCE ADVANCES. 2024;10(4):eadj1354Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
- Preprint: BIORXIV. 2022Zhang R; Knudsen M; Vasques PDC; Tadych A; Rodriguez-Rodriguez P; Greengard P; Roussarie J-P; Milosevic A; Troyanskaya O
- Preprint: BIORXIV. 2022Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
- Article: NEURON. 2020;107(5):821-835.e12Roussarie J-P; Yao V; Rodriguez-Rodriguez P; Oughtred R; Rust J; Plautz Z; Kasturia S; Albornoz C; Wang W; Schmidt EF; Dannenfelser R; Tadych A; Brichta L; Barnea-Cramer A; Heintz N; Hof PR; Heiman M; Dolinski K; Flajolet M; Troyanskaya OG; Greengard P
- Article: BRAIN. 2017;140(12):3269-3285Rodriguez-Rodriguez P; Sandebring-Matton A; Merino-Serrais P; Parrado-Fernandez C; Rabano A; Winblad B; Avila J; Ferrer I; Cedazo-Minguez A
- Article: CELL DEATH AND DIFFERENTIATION. 2012;19(10):1582-1589Rodriguez-Rodriguez P; Fernandez E; Almeida A; Bolanos JP
Articles
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
- Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
- Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
- Article: FRONTIERS IN GENETICS. 2020;11:1022Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
- Article: CEREBRAL CORTEX. 2019;29(1):429-446Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
- Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Ronnback A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(11):2110-2118Parrado-Fernandez C; Sandebring-Matton A; Rodriguez-Rodriguez P; Aarsland D; Cedazo-Minguez A
- Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2013;33(12):1843-1845Rodriguez-Rodriguez P; Fernandez E; Bolanos JP
- Article: FOOD MICROBIOLOGY. 2009;26(8):841-846Munoz R; Gomez A; Robles V; Rodriguez P; Cebollero E; Tabera L; Carrascosa AV; Gonzalez R
All other publications
- Preprint: BIORXIV. 2024;BIORXIVZhang R; Rodriguez-Rodriguez P; Medrihan L; Chang JC; Ferraro T; Del Cioppo Vasques P; Wang W; Menard C; Cathomas F; Chan KL; Parise L; Shaham S; Roussarie J-P; Troyanskaya O; Russo SJ; Milosevic A
- Preprint: BIORXIV. 2024Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
- Conference publication: GLIA. 2023;71:E633Goicolea J; Roussarie JP; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:836196Ondaro J; Hernandez-Eguiazu H; Garciandia-Arcelus M; Loera-Valencia R; Rodriguez-Gomez L; Jimenez-Zuniga A; Goikolea J; Rodriguez-Rodriguez P; Ruiz-Martinez J; Moreno F; Lopez de Munain A; Holt IJ; Gil-Bea FJ; Gerenu G
- Review: ADVANCES IN PHARMACOLOGY. 2021;90:145-171Roussarie J-P; Rodriguez-Rodriguez P
- Corrigendum: BRAIN. 2018;141(5):e43
- Review: NEUROCHEMISTRY INTERNATIONAL. 2013;62(5):750-756Rodriguez-Rodriguez P; Almeida A; Bolanos JP
Grants
- King Gustaf V:s and Queen Victorias Foundation1 January 2025 - 31 December 2025
- Alzheimerfonden1 January 2025
- Petrus och Augusta Hedlunds Stiftelse1 January 2024
- Unravelling the molecular mechanisms behind region-specific vulnerability to Alzheimer’s disease: a novel approach to identify new therapeutic targetsPrivate initiative “Innovative ways to fight Alzheimer’s disease- Leif Lundblad Family and others.1 September 2023 - 31 December 2026
- KI funding for doctoral education (KID)1 September 2023 - 31 October 2027
- Alzheimerfonden1 January 2021 - 31 December 2023
- European Commission1 September 2018 - 31 August 2021
Employments
- Senior Research Specialist, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-
Visiting research fellowships
- Marie-Skłodowska-Curie research fellow, Rockefeller University, 2018-2021