Patricia Rodriguez Rodriguez

About me
Publications
Grants
Public outreach and news

Research

My research is focused on understanding where different genetic and non-genetic risk factors and drivers of the disease converge to trigger the early degeneration of specific neuronal subpopulations and regions in Alzheimer's disease. To achieve this goal I apply a wide variety of cell-type specific transcriptomics and proteomics approaches in human post-mortem brain samples and mouse models with relevance for the disease.

Selected publications

Preprint: BIORXIV. 2025;BIORXIV
Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology.
Rodriguez-Rodriguez P; Wang W; Tsagkogianni C; Feng I; Morello-Megias A; Jain K; Alanko V; Kahvecioglu H-A; Mohammadi E; Li X; Flajolet M; Sandebring-Matton A; Maioli S; Vidal N; Milosevic A; Roussarie J-P
Article: BRAIN. 2024;147(7):2384-2399
A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons
Rodriguez-Rodriguez P; Arroyo-Garcia LE; Tsagkogianni C; Li L; Wang W; Vegvari A; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha SC; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
Article: SCIENCE ADVANCES. 2024;10(4):eadj1354
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Preprint: BIORXIV. 2022
Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility
Zhang R; Knudsen M; Vasques PDC; Tadych A; Rodriguez-Rodriguez P; Greengard P; Roussarie J-P; Milosevic A; Troyanskaya O
Preprint: BIORXIV. 2022
Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Article: NEURON. 2020;107(5):821-835.e12
Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis
Roussarie J-P; Yao V; Rodriguez-Rodriguez P; Oughtred R; Rust J; Plautz Z; Kasturia S; Albornoz C; Wang W; Schmidt EF; Dannenfelser R; Tadych A; Brichta L; Barnea-Cramer A; Heintz N; Hof PR; Heiman M; Dolinski K; Flajolet M; Troyanskaya OG; Greengard P
Article: BRAIN. 2017;140(12):3269-3285
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons
Rodriguez-Rodriguez P; Sandebring-Matton A; Merino-Serrais P; Parrado-Fernandez C; Rabano A; Winblad B; Avila J; Ferrer I; Cedazo-Minguez A
Article: CELL DEATH AND DIFFERENTIATION. 2012;19(10):1582-1589
Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
Rodriguez-Rodriguez P; Fernandez E; Almeida A; Bolanos JP

Articles

Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387
Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison
Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228
Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities
Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204
Sex difference in flux of 27-hydroxycholesterol into the brain
Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
Article: FRONTIERS IN GENETICS. 2020;11:1022
Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL
Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
Article: CEREBRAL CORTEX. 2019;29(1):429-446
27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328
Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions
Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Ronnback A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(11):2110-2118
Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways
Parrado-Fernandez C; Sandebring-Matton A; Rodriguez-Rodriguez P; Aarsland D; Cedazo-Minguez A
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2013;33(12):1843-1845
Underestimation of the pentose-phosphate pathway in intact primary neurons as revealed by metabolic flux analysis
Rodriguez-Rodriguez P; Fernandez E; Bolanos JP
Article: FOOD MICROBIOLOGY. 2009;26(8):841-846
Multilocus sequence typing of oenological Saccharomyces cerevisiae strains
Munoz R; Gomez A; Robles V; Rodriguez P; Cebollero E; Tabera L; Carrascosa AV; Gonzalez R

All other publications

Preprint: BIORXIV. 2024;BIORXIV
Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression.
Zhang R; Rodriguez-Rodriguez P; Medrihan L; Chang JC; Ferraro T; Del Cioppo Vasques P; Wang W; Menard C; Cathomas F; Chan KL; Parise L; Shaham S; Roussarie J-P; Troyanskaya O; Russo SJ; Milosevic A
Preprint: BIORXIV. 2024
Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
Conference publication: GLIA. 2023;71:E633
Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goicolea J; Roussarie JP; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:836196
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Ondaro J; Hernandez-Eguiazu H; Garciandia-Arcelus M; Loera-Valencia R; Rodriguez-Gomez L; Jimenez-Zuniga A; Goikolea J; Rodriguez-Rodriguez P; Ruiz-Martinez J; Moreno F; Lopez de Munain A; Holt IJ; Gil-Bea FJ; Gerenu G
Review: ADVANCES IN PHARMACOLOGY. 2021;90:145-171
Deciphering cell-type specific signal transduction in the brain: Challenges and promises.
Roussarie J-P; Rodriguez-Rodriguez P
Corrigendum: BRAIN. 2018;141(5):e43
Corrigendum.
Review: NEUROCHEMISTRY INTERNATIONAL. 2013;62(5):750-756
Brain energy metabolism in glutamate-receptor activation and excitotoxicity: Role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway
Rodriguez-Rodriguez P; Almeida A; Bolanos JP

Grants

Unravelling the molecular mechanisms behind region-specific vulnerability to Alzheimer’s disease: a novel approach to identify new therapeutic targets
Private initiative “Innovative ways to fight Alzheimer’s disease- Leif Lundblad Family and others.
1 November 2023 - 31 October 2026
Identifying the mechanisms behind selective neuronal vulnerability to Alzheimer’s disease
KI funding for doctoral education (KID)
1 September 2023 - 31 October 2027
Cell-specific presynaptic proteomics to identify the mechanisms behind selective neuronal vulnerability to Alzheimer’s disease
Alzheimerfonden
1 January 2021 - 31 December 2023
Understanding selective neuronal vulnerability in Alzheimer’s disease
European Commission
1 September 2018 - 31 August 2021

Research

Selected publications

Articles

All other publications

Grants

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