Pär Nordlund

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2025;16(1):4234
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
Liang YY; Khalid K; Le HV; Teo HMV; Raitelaitis M; Gerault M-A; Lee JJH; Lyu J; Chan A; Jeyasekharan AD; Tam WL; Nordlund P; Prabhu N
Article: CELL REPORTS. 2024;43(10):114784
Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery
Ramos AD; Liang YY; Surova O; Bacanu S; Gerault M-A; Mandal T; Ceder S; Langeback A; Osterroos A; Ward GA; Bergh J; Wiman KG; Lehmann S; Prabhu N; Loof S; Nordlund P
Article: CELL CHEMICAL BIOLOGY. 2024;31(4):743-759.e8
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development
Wirjanata G; Lin J; Dziekan JM; El Sahili A; Chung Z; Tjia S; Zulkifli NEB; Boentoro J; Tham R; Jia LS; Go KD; Yu H; Partridge A; Olsen D; Prabhu N; Sobota RM; Nordlund P; Lescar J; Bozdech Z
Article: BRIEFINGS IN BIOINFORMATICS. 2024;25(3):bbae128
IMPRINTS.CETSA and IMPRINTS.CETSA.app: an R package and a Shiny application for the analysis and interpretation of IMPRINTS-CETSA data
Gerault M-A; Granjeaud S; Camoin L; Nordlund P; Dai L
Article: ACTA PHARMACOLOGICA SINICA. 2024;45(2):391-404
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma
Yang F; Jia L; Zhou H-C; Huang J-N; Hou M-Y; Liu F-T; Prabhu N; Li Z-J; Yang C-B; Zou C; Nordlund P; Wang J-G; Dai L-Y
Article: SCIENTIFIC REPORTS. 2024;14(1):1878
Deep learning based CETSA feature prediction cross multiple cell lines with latent space representation
Zhao S; Yang X; Zeng Z; Qian P; Zhao Z; Dai L; Prabhu N; Nordlund P; Tam WL
Article: NATURE COMMUNICATIONS. 2022;13(1):4854
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
Frosi Y; Lin Y-C; Jiang S; Ramlan SR; Hew K; Engman AH; Pillai A; Yeung K; Cheng YX; Cornvik T; Nordlund P; Goh M; Lama D; Gates ZP; Verma CS; Thean D; Lane DP; Asial I; Brown CJ
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: CELL DEATH & DISEASE. 2021;12(7):709
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
Article: NATURE PROTOCOLS. 2020;15(6):1881-1921
Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome
Dziekan JM; Wirjanata G; Dai L; Go KD; Yu H; Lim YT; Chen L; Wang LC; Puspita B; Prabhu N; Sobota RM; Nordlund P; Bozdech Z
Article: SCIENTIFIC REPORTS. 2019;9(1):19384
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
Article: REDOX BIOLOGY. 2019;24:101168
Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA
Sun W; Dai L; Yu H; Puspita B; Zhao T; Li F; Tan JL; Lim YT; Chen MW; Sobota RM; Tenen DG; Prabhu N; Nordlund P
Article: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(473):eaau3174
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
Dziekan JM; Yu H; Chen D; Dai L; Wirjanata G; Larsson A; Prabhu N; Sobota RM; Bozdech Z; Nordlund P
Article: METHODS IN MOLECULAR BIOLOGY. 2019;2025:299-320
Hot CoFi Blot: A High-Throughput Colony-Based Screen for Identifying More Thermally Stable Protein Variants.
Asial I; Nordlund P; Dahlroth S-L
Article: CHEMICAL SCIENCE. 2018;9(45):8608-8618
Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe
Lebraud H; Surova O; Courtin A; O'Reilly M; Valenzano CR; Nordlund P; Heightman TD
Article: PLOS ONE. 2018;13(12):e0208273
An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions
Lim YT; Prabhu N; Dai L; Go KD; Chen D; Sreekumar L; Egeblad L; Eriksson S; Chen L; Veerappan S; Teo HL; Tan CSH; Lengqvist J; Larsson A; Sobota RM; Nordlund P
Article: CELL. 2018;173(6):1481-1494.e13
Modulation of Protein-Interaction States through the Cell Cycle
Dai L; Zhao T; Bisteau X; Sun W; Prabhu N; Lim YT; Sobota RM; Kaldis P; Nordlund P
Article: SCIENCE. 2018;359(6380):1170-1177
Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells
Tan CSH; Go KD; Bisteau X; Dai L; Yong CH; Prabhu N; Ozturk MB; Lim YT; Sreekumar L; Lengqvist J; Tergaonkar V; Kaldis P; Sobota RM; Nordlund P
Article: NATURE COMMUNICATIONS. 2017;8(1):2200
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Kitagawa M; Liao P-J; Lee KH; Wong J; Shang SC; Minami N; Sampetrean O; Saya H; Lingyun D; Prabhu N; Diam GK; Sobota R; Larsson A; Nordlund P; McCormick F; Ghosh S; Epstein DM; Dymock BW; Lee SH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(32):13449-13458
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
Chen D; Jansson A; Sim D; Larsson A; Nordlund P
Article: JOURNAL OF VIROLOGY. 2017;91(2):e01947-e01916
Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus
Hew K; Veerappan S; Sim D; Cornvik T; Nordlund P; Dahlroth S-L
Article: BMC BIOLOGY. 2016;14(1):82
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD
Quistgaard EM; Weininger U; Ural-Blimke Y; Modig K; Nordlund P; Akke M; Loew C
Article: NATURE METHODS. 2016;13(4):345-351
A saposin-lipoprotein nanoparticle system for membrane proteins
Frauenfeld J; Loving R; Armache J-P; Sonnen AF-P; Guettou F; Moberg P; Zhu L; Jegerschold C; Flayhan A; Briggs JAG; Garoff H; Low C; Cheng Y; Nordlund P
Article: NATURE COMMUNICATIONS. 2016;7:11040
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Almqvist H; Axelsson H; Jafari R; Dan C; Mateus A; Haraldsson M; Larsson A; Molina DM; Artursson P; Lundback T; Nordlund P
Article: BIOCHEMISTRY. 2016;55(9):1384-1397
Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family
Mills SJ; Silvander C; Cozier G; Tresaugues L; Nordlund P; Potter BVL
Article: FEBS JOURNAL. 2016;283(6):1107-1123
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a-an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity
Lim SM; Yeung K; Tresaugues L; Ling TH; Nordlund P
Article: PLOS ONE. 2015;10(12):e0143947
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine
Hew K; Dahlroth S-L; Veerappan S; Pan LX; Cornvik T; Nordlund P
Article: JOURNAL OF VIROLOGY. 2015;89(17):8828-8839
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1
Patel V; Dahlroth S-L; Rajakannan V; Ho HT; Cornvik T; Nordlund P
Article: VIROLOGY. 2015;482:105-110
Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein
Li Y; Jain N; Limpanawat S; To J; Quistgaard EM; Nordlund P; Thanabalu T; Torres J
Article: SCIENTIFIC REPORTS. 2015;5:12116
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays
Tan BX; Brown CJ; Ferrer FJ; Yuen TY; Quah ST; Chan BH; Jansson AE; Teo HL; Nordlund P; Lane DP
Article: PLOS ONE. 2015;10(6):e0131507
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate
Tresaugues L; Lundback T; Welin M; Flodin S; Nyman T; Silvander C; Graslund S; Nordlund P
Article: JOURNAL OF GENERAL VIROLOGY. 2015;96(Pt 6):1436-1445
VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies
Hew K; Dahlroth S-L; Pan LX; Cornvik T; Nordlund P
Article: SCIENCE. 2014;346(6205):1255784
Tracking cancer drugs in living cells by thermal profiling of the proteome
Savitski MM; Reinhard FBM; Franken H; Werner T; Savitski MF; Eberhard D; Molina DM; Jafari R; Dovega RB; Klaeger S; Kuster B; Nordlund P; Bantscheff M; Drewes G
Article: NATURE PROTOCOLS. 2014;9(9):2100-2122
The cellular thermal shift assay for evaluating drug target interactions in cells
Jafari R; Almqvist H; Axelsson H; Ignatushchenko M; Lundback T; Nordlund P; Molina DM
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2014;21(8):728-731
Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2
Guettou F; Quistgaard EM; Raba M; Moberg P; Low C; Nordlund P
Article: PLOS ONE. 2014;9(7):e101846
Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A
Dovega R; Tsutakawa S; Quistgaard EM; Anandapadamanaban M; Low C; Nordlund P
Article: BIOLOGICAL CHEMISTRY. 2014;395(7-8):881-889
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A
Low C; Quistgaard EM; Kovermann M; Anandapadamanaban M; Balbach J; Nordlund P
Article: STRUCTURE. 2014;22(5):744-755
Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases
Tresaugues L; Silvander C; Flodin S; Welin M; Nyman T; Graslund S; Hammarstrom M; Berglund H; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2013;425(22):4323-4333
Substrate Specificity and Oligomerization of Human GMP Synthetase
Welin M; Lehtlo L; Johansson A; Flodin S; Nyman T; Tresaugues L; Hammarstrom M; Graslund S; Nordlund P
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2013;184(2):375-378
Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms
Quistgaard EM; Low C; Moberg P; Nordlund P
Article: PLOS ONE. 2013;8(10):e77984
Nanobody Mediated Crystallization of an Archeal Mechanosensitive Channel
Low C; Yau YH; Pardon E; Jegerschold C; Wahlin L; Quistgaard EM; Moberg P; Geifman-Shochat S; Steyaert J; Nordlund P
Article: EMBO REPORTS. 2013;14(9):804-810
Structural insights into substrate recognition in proton-dependent oligopeptide transporters
Guettou F; Quistgaard EM; Tresaugues L; Moberg P; Jegerschold C; Zhu L; Jong AJO; Nordlund P; Low C
Article: PLOS ONE. 2013;8(8):e71111
Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31
Quistgaard EM; Low C; Moberg P; Guettou F; Maddi K; Nordlund P
Article: SCIENCE. 2013;341(6141):84-87
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Molina DM; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(11):4497-4508
Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases
Larsson EA; Jansson A; Ng FM; Then SW; Panicker R; Liu B; Sangthongpitag K; Pendharkar V; Tai SJ; Hill J; Dan C; Ho SY; Cheong WW; Poulsen A; Blanchard S; Lin GR; Alam J; Keller TH; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(6):766-768
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters
Quistgaard EM; Low C; Moberg P; Tresaugues L; Nordlund P
Article: JOURNAL OF LIPID RESEARCH. 2013;54(6):1630-1643
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
Lim SM; Chen D; Teo H; Roos A; Jansson AE; Nyman T; Tresaugues L; Pervushin K; Nordlund P
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(6):3497-3508
High-throughput analytical gel filtration screening of integral membrane proteins for structural studies
Low C; Moberg P; Quistgaard EM; Hedren M; Guettou F; Frauenfeld J; Haneskog L; Nordlund P
Article: NUCLEIC ACIDS RESEARCH. 2013;41(7):4295-4306
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor
Hew K; Dahlroth S-L; Venkatachalam R; Nasertorabi F; Lim BT; Cornvik T; Nordlund P
Article: NATURE COMMUNICATIONS. 2013;4:2901
Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell
Asial I; Cheng YX; Engman H; Dollhopf M; Wu B; Nordlund P; Cornvik T
Article: FASEB JOURNAL. 2012;26(10):4003-4013
High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA
Quistgaard EM; Nordlund P; Low C
Article: PLOS ONE. 2012;7(6):e38244
Optimisation of Over-Expression in E. coli and Biophysical Characterisation of Human Membrane Protein Synaptogyrin 1
Low C; Jegerschold C; Kovermann M; Moberg P; Nordlund P
Article: PLOS ONE. 2012;7(5):e37724
Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism
Egeblad L; Welin M; Flodin S; Graslund S; Wang L; Balzarini J; Eriksson S; Nordlund P
Article: ACS CHEMICAL BIOLOGY. 2012;7(5):822-828
A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery
Mills SJ; Persson C; Cozier G; Thomas MP; Tresaugues L; Erneux C; Riley AM; Nordlund P; Potter BVL
Article: NATURE CHEMICAL BIOLOGY. 2011;7(12):950-958
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)₈ barrel enzymes
Patton GC; Stenmark P; Gollapalli DR; Sevastik R; Kursula P; Flodin S; Schuler H; Swales CT; Eklund H; Himo F; Nordlund P; Hedstrom L
Article: PLOS ONE. 2011;6(9):e25022
HF-EPR, Raman, UV/VIS Light Spectroscopic, and DFT Studies of the Ribonucleotide Reductase R2 Tyrosyl Radical from Epstein-Barr Virus
Tomter AB; Zoppellaro G; Schmitzberger F; Andersen NH; Barra A-L; Engman H; Nordlund P; Andersson KK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;408(4):684-696
Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II
Wallden K; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011;18(3):316-U102
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Fairman JW; Wijerathna SR; Ahmad MF; Xu H; Nakano R; Jha S; Prendergast J; Welin RM; Flodin S; Roos A; Nordlund P; Li Z; Walz T; Dealwis CG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776
Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase
Rinaldo-Matthis A; Wetterholm A; Molina DM; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggstrom JZ
Article: FEBS JOURNAL. 2010;277(23):4920-4930
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1
Welin M; Egeblad L; Johansson A; Stenmark P; Wang L; Flodin S; Nyman T; Tresaugues L; Kotenyova T; Johansson I; Eriksson S; Eklund H; Nordlund P
Article: NUCLEIC ACIDS RESEARCH. 2010;38(20):7308-7319
Structural studies of tri-functional human GART
Welin M; Grossmann JG; Flodin S; Nyman T; Stenmark P; Tresaugues L; Kotenyova T; Johansson I; Nordlund P; Lehtio L
Article: ACS CHEMICAL BIOLOGY. 2010;5(10):933-942
Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases
Larsson K-M; Logan DT; Nordlund P
Article: PLOS ONE. 2010;5(9):e12907
The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface
Nyman T; Tresaugues L; Welin M; Lehtio L; Flodin S; Persson C; Johansson I; Hammarstrom M; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2010;66(Pt 6):734-737
Expression, purification, crystallization and preliminary X-ray analysis of ORF60, the small subunit (R2) of ribonucleotide reductase from Kaposi's sarcoma-associated herpesvirus (KSHV)
Gurmu D; Dahlroth S-L; Haas J; Nordlund P; Erlandsen H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):157-163
Understanding specificity in metabolic pathways-Structural biology of human nucleotide metabolism
Welin M; Nordlund P
Article: CRITICAL CARE. 2010;14(2):R67
Pre-existing disease: the most important factor for health related quality of life long-term after critical illness: a prospective, longitudinal, multicentre trial.
Orwelius L; Nordlund A; Nordlund P; Simonsson E; Bäckman C; Samuelsson A; Sjöberg F
Article: PROTEIN EXPRESSION AND PURIFICATION. 2009;68(2):121-127
Screening Colonies of Pooled ORFeomes (SCOOP): A rapid and efficient strategy for expression screening ORFeomes in Escherichia coli
Dahlroth S-L; Lieu V; Haas J; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 11):1091-1096
Structures of BIR domains from human NAIP and cIAP2
Herman MD; Moche M; Flodin S; Welin M; Tresaugues L; Johansson I; Nilsson M; Nordlund P; Nyman T
Article: FEBS JOURNAL. 2009;276(22):6636-6645
Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus
Dahlroth S-L; Gurmu D; Haas J; Erlandsen H; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2009;65(Pt 8):839-846
Structure of the C-terminal domain of nsp4 from feline coronavirus
Manolaridis I; Wojdyla JA; Panjikar S; Snijder EJ; Gorbalenya AE; Berglind H; Nordlund P; Coutard B; Tucker PA
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2009;74(1):212-221
The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle
Magnusdottir A; Stenmark P; Flodin S; Nyman T; Kotenyova T; Graslund S; Ogg D; Nordlund P
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2009;74(1):18-31
The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins
Gurmu D; Lu J; Johnson KA; Nordlund P; Holrngren A; Erlandsen H
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2008;73(4):1047-1052
The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site
Tresaugues L; Stenmark P; Schuler H; Flodin S; Welin M; Nyman T; Hammarstrom M; Moche M; Graslund S; Nordlund P
Article: FEBS LETTERS. 2008;582(25-26):3590-3594
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
Herman MD; Nyman T; Welin M; Lehtio L; Flodin S; Tresaugues L; Kotenyova T; Flores A; Nordlund P
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(1):1-6
High-level expression, purification, and crystallization of recombinant rat leukotriene C₄ synthase from the yeast Pichia pastoris
Wetterholm A; Molina DM; Nordlund P; Eshaghi S; Haeggstrom JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(18):11861-11865
The crystal structure of the human Toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer
Nyman T; Stenmark P; Flodin S; Johansson I; Hammarstroem M; Nordlund P
Article: PROTEIN SCIENCE. 2008;17(4):673-680
Engineering membrane protein overproduction in Escherichia coli
Molina DM; Cornvik T; Eshaghi S; Haeggstrom JZ; Nordlund P; Sabet MI
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;58(2):210-221
The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins
Graeslund S; Sagemark J; Berglund H; Dahlgren L-G; Flores A; Hammarstroem M; Johansson I; Kotenyova T; Nilsson M; Nordlund P; Weigelt J
Article: ANTIVIRAL RESEARCH. 2008;78(1):37-46
The VIZIER project: preparedness against pathogenic RNA viruses.
Coutard B; Gorbalenya AE; Snijder EJ; Leontovich AM; Poupon A; De Lamballerie X; Charrel R; Gould EA; Gunther S; Norder H; Klempa B; Bourhy H; Rohayem J; L'hermite E; Nordlund P; Stuart DI; Owens RJ; Grimes JM; Tucker PA; Bolognesi M; Mattevi A; Coll M; Jones TA; Aqvist J; Unge T; Hilgenfeld R; Bricogne G; Neyts J; La Colla P; Puerstinger G; Gonzalez JP; Leroy E; Cambillau C; Romette JL; Canard B
Article: BIOCHEMISTRY. 2007;46(48):13809-13818
Crystal structures of human and murine deoxyribonucleotidases:: Insights into recognition of substrates and nucleotide analogues
Wallden K; Rinaldo-Matthis A; Ruzzenente B; Rampazzo C; Bianchi V; Nordlund P
Article: NATURE METHODS. 2007;4(12):1019-1021
In situ proteolysis for protein crystallization and structure determination
Dong A; Xu X; Edward AM
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;373(1):48-64
The crystal structure of the bifunctional deaminase/reductase RibD of the riboflavin biosynthetic pathway in Escherichia coli:: Implications for the reductive mechanism
Stenmark P; Moche M; Gurmu D; Nordlund P
Article: NATURE. 2007;448(7153):613-616
Structural basis for synthesis of inflammatory mediators by human leukotriene C₄ synthase
Molina DM; Wetterholm A; Kohl A; McCarthy AA; Niegowski D; Ohlson E; Hammarberg T; Eshaghi S; Haeggstroem JZ; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(27):19644-19652
Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site
Bakali HMA; Herman MD; Johnson KA; Kelly AA; Wieslander A; Hallberg BM; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(24):17828-17836
Crystal structure of human cytosolic 5′-nucleotidase II -: Insights into allosteric regulation and substrate recognition
Wallden K; Stenmark P; Nyman T; Flodin S; Graslund S; Loppnau P; Bianchi V; Nordlund P
Article: JOURNAL OF NEUROCHEMISTRY. 2007;101(4):906-917
The structure of human collapsin response mediator protein 2, a regulator of axonal growth
Stenmark P; Ogg D; Flodin S; Flores A; Kotenyova T; Nyman T; Nordlund P; Kursula P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(5):3182-3187
Crystal structure of human inosine triphosphatase -: Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T
Stenmark P; Kursula P; Flodin S; Graslund S; Landry R; Nordlund P; Schuler H
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 11):1294-1299
Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue
Kursula P; Schuler H; Flodin S; Nilsson-Ehle P; Ogg DJ; Savitsky P; Nordlund P; Stenmark P
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2006;65(2):266-273
An efficient and generic strategy for producing soluble human proteins and domains in E-coli by screening construct libraries
Cornvik T; Dahlroth S-L; Magnusdottir A; Flodin S; Engvall B; Lieu V; Ekberg M; Nordlund P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(43):15835-15840
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
Vedadi M; Niesen FH; Allali-Hassani A; Fedorov OY; Finerty PJJ; Wasney GA; Yeung R; Arrowsmith C; Ball LJ; Berglund H; Hui R; Marsden BD; Nordlund P; Sundstrom M; Weigelt J; Edwards AM
Article: ANALYTICAL BIOCHEMISTRY. 2006;357(2):289-298
Thermofluor-based high-throughput stability optimization of proteins for structural studies
Ericsson UB; Hallberg BM; DeTitta GT; Dekker N; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1227-1231
GRETA, a new multifermenter system for structural genomics and process optimization
Hedren M; Ballagi A; Mortsell L; Rajkai G; Stenmark P; Sturesson C; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1196-1207
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
Fogg MJ; Alzari P; Bahar M; Bertini I; Betton J-M; Burmeister WP; Cambillau C; Canard B; Carrondo M; Coll M; Daenke S; Dym O; Egloff M-P; Enguita FJ; Geerlof A; Haouz A; Jones TA; Ma Q; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1125-1136
The impact of protein characterization in structural proteomics
Geerlof A; Brown J; Coutard B; Egloff M-P; Enguita FJ; Fogg MJ; Gilbert RJC; Groves MR; Haouz A; Nettleship JE; Nordlund P; Owens RJ; Ruff M; Sainsbury S; Svergun DI; Wilmanns M
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 10):1103-1113
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE
Alzari PM; Berglund H; Berrow NS; Blagova E; Busso D; Cambillau C; Campanacci V; Christodoulou E; Eiler S; Fogg MJ; Folkers G; Geerlof A; Hart D; Haouz A; Herman MD; Macieira S; Nordlund P; Perrakis A; Quevillon-Cheruel S; Tarandeau F; van Tilbeurgh H; Unger T; Luna-Vargas MPA; Velarde M; Willmanns M; Owens RJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(32):22434-22438
The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions
Magnusdottir A; Stenmark P; Flodin S; Nyman T; Hammarstrom M; Ehn M; Bakali H MA; Berglund H; Nordlund P
Article: SCIENCE. 2006;313(5785):354-357
Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution
Eshaghi S; Niegowski D; Kohl A; Molina DM; Lesley SA; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;360(4):774-787
The structure of the RNA m⁵C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain
Hallberg BM; Ericsson UB; Johnson KA; Andersen NM; Douthwaite S; Nordlund P; Beuscher AE; Erlandsen H
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 7):613-617
Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
Kursula P; Flodin S; Ehn M; Hammarstrom M; Schuler H; Nordlund P; Stenmark P
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 3):295-297
Expression, purification, crystallization and preliminary diffraction studies of the mammalian DAG kinase homologue YegS from Escherichia coli
Bakali HMA; Nordlund P; Hallberg BM
Article: NATURE PROTOCOLS. 2006;1(1):253-258
Colony filtration blotting for screening soluble expression in Escherichia coli
Dahlroth S-L; Nordlund P; Cornvik T
Article: JOURNAL OF PHYSICAL CHEMISTRY B. 2005;109(42):20004-20008
Reaction mechanism of deoxyribonucleotidase: A theoretical study
Himo F; Guo JD; Rinaldo-Matthis A; Nordlund P
Article: STRUCTURE. 2005;13(7):1081-1088
Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
Walldén K; Ruzzenente B; Rinaldo-Matthis A; Bianchi V; Nordlund P
Article: NATURE METHODS. 2005;2(7):507-509
Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli
Cornvik T; Dahlroth SL; Magnusdottir A; Herman MD; Knaust R; Ekberg M; Nordlund P
Article: MOLECULAR & CELLULAR PROTEOMICS. 2005;4(6):827-834
A high throughput method for the detection of metalloproteins on a microgram scale.
Högbom M; Ericsson UB; Lam R; Bakali H MA; Kuznetsova E; Nordlund P; Zamble DB
Article: PROTEIN SCIENCE. 2005;14(3):676-683
An efficient strategy for high-throughput expression screening of recombinant integral membrane proteins.
Eshaghi S; Hedrén M; Nasser MIA; Hammarberg T; Thornell A; Nordlund P
Article: BIOCHEMISTRY. 2004;43(44):13996-14003
Crystal structure of CaiB, a type-III CoA transferase in carnitine metabolism.
Stenmark P; Gurmu D; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2004;11(11):1142-1149
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase
Larsson KM; Jordan A; Eliasson R; Reichard P; Logan DT; Nordlund P
Article: SCIENCE. 2004;305(5681):245-248
The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass.
Högbom M; Stenmark P; Voevodskaya N; McClarty G; Gräslund A; Nordlund P
Article: BIOCHEMISTRY. 2004;43(24):7966-7972
Structural and mutational studies of the carboxylate cluster in iron-free ribonucleotide reductase R2.
Andersson ME; Högbom M; Rinaldo-Matthis A; Blodig W; Liang Y; Persson B-O; Sjöberg B-M; Su X-D; Nordlund P
Article: FEBS LETTERS. 2004;567(2-3):179-182
A protein carboxylate coordinated oxo-centered tri-nuclear iron complex with possible implications for ferritin mineralization.
Högbom M; Nordlund P
Article: FEBS LETTERS. 2004;565(1-3):59-64
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold
Ericsson UB; Nordlund P; Hallberg BM
Article: MOLECULAR PHARMACOLOGY. 2004;65(4):860-867
Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors.
Rinaldo-Matthis A; Rampazzo C; Balzarini J; Reichard P; Bianchi V; Nordlund P
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2004;60(Pt 4):775-776
Expression, purification, crystallization and preliminary diffraction studies of the tRNA pseudouridine synthase TruD from Escherichia coli
Ericsson UB; Andersson ME; Engvall B; Nordlund P; Hallberg BM
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2004;60(Pt 2):376-378
Crystals of the ribonucleotide reductase R2 protein from Chlamydia trachomatis obtained by heavy-atom co-crystallization.
Stenmark P; Högbom M; Roshick C; McClarty G; Nordlund P
Article: FEBS LETTERS. 2003;552(2-3):189-192
A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans.
Stenmark P; Nordlund P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(6):3209-3214
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data.
Högbom M; Galander M; Andersson M; Kolberg M; Hofbauer W; Lassmann G; Nordlund P; Lendzian F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(6):3191-3196
Structural basis for recognition by an in vitro evolved affibody.
Högbom M; Eklund M; Nygren P-A; Nordlund P
Article: PROTEIN SCIENCE. 2003;12(1):124-134
Screening for functional expression and overexpression of a family of diiron-containing interfacial membrane proteins using the univector recombination system.
Berthold DA; Stenmark P; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(46):43608-43614
EPR studies of the mitochondrial alternative oxidase. Evidence for a diiron carboxylate center.
Berthold DA; Voevodskaya N; Stenmark P; Gräslund A; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2002;9(10):779-787
Crystal structure of a human mitochondrial deoxyribonucleotidase
Rinaldo-Matthis A; Rampazzo C; Reichard P; Bianchi V; Nordlund P
Article: BIOCHEMISTRY. 2002;41(4):1381-1389
Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes.
Högbom M; Huque Y; Sjöberg B-M; Nordlund P
Article: FEBS LETTERS. 2001;507(2):220-224
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli.
Drew DE; von Heijne G; Nordlund P; de Gier JW
Article: ANALYTICAL BIOCHEMISTRY. 2001;297(1):79-85
Screening for soluble expression of recombinant proteins in a 96-well format.
Knaust RK; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(36):33297-33300
A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.
Stenmark P; Grünler J; Mattsson J; Sindelar PJ; Nordlund P; Berthold DA
Article: STRUCTURE. 2001;9(8):739-750
Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases.
Larsson KM; Andersson J; Sjöberg BM; Nordlund P; Logan DT
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(29):26852-26859
Restoring proper radical generation by azide binding to the iron site of the E238A mutant R2 protein of ribonucleotide reductase from Escherichia coli.
Assarsson M; Andersson ME; Högbom M; Persson BO; Sahlin M; Barra AL; Sjöberg BM; Nordlund P; Gräslund A
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2001;6(3):315-323
Crystal structures of oxidized dinuclear manganese centres in Mn-substituted class I ribonucleotide reductase from Escherichia coli: carboxylate shifts with implications for O2 activation and radical generation.
Högbom M; Andersson ME; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2001;8(2):131-135
Crystal structure of human leukotriene A₄ hydrolase, a bifunctional enzyme in inflammation
Thunnissen MMGM; Nordlund P; Haeggström JZ
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1999;36(3):370-379
Mechanism of substrate dephosphorylation in low Mr protein tyrosine phosphatase.
Kolmodin K; Nordlund P; Aqvist J
Article: FEBS LETTERS. 1999;456(1):73-78
The low Mr phosphotyrosine protein phosphatase behaves differently when phosphorylated at Tyr131 or Tyr132 by Src kinase.
Bucciantini M; Chiarugi P; Cirri P; Taddei L; Stefani M; Raugei G; Nordlund P; Ramponi G
Article: FEBS LETTERS. 1999;449(1):17-22
A revised model of the active site of alternative oxidase.
Andersson ME; Nordlund P
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1999;121(11):2346-2352
The crystal structure of an azide complex of the diferrous R2 subunit of ribonucleotide reductase displays a novel carboxylate shift with important mechanistic implications for diiron-catalyzed oxygen activation
Andersson ME; Högbom M; Rinaldo-Matthis A; Andersson KK; Sjoberg BM; Nordlund P
Article: SCIENCE. 1999;283(5407):1499-1504
A glycyl radical site in the crystal structure of a class III ribonucleotide reductase.
Logan DT; Andersson J; Sjöberg BM; Nordlund P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):21003-21008
Preserved catalytic activity in an engineered ribonucleotide reductase R2 protein with a nonphysiological radical transfer pathway. The importance of hydrogen bond connections between the participating residues.
Ekberg M; Pötsch S; Sandin E; Thunnissen M; Nordlund P; Sahlin M; Sjöberg BM
Article: BIOCHEMISTRY. 1998;37(30):10798-10807
Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.
Logan DT; deMaré F; Persson BO; Slaby A; Sjöberg BM; Nordlund P
Article: FEBS LETTERS. 1998;426(1):52-56
Expression, purification and preliminary crystal analysis of the human low Mr phosphotyrosine protein phosphatase isoform 1.
Marzocchini R; Bucciantini M; Stefani M; Taddei N; Thunnissen MG; Nordlund P; Ramponi G
Article: INORGANICA CHIMICA ACTA. 1997;263(1-2):255-262
Re-engineering the diiron site in rubrerythrin towards that in ribonucleotide reductase
deMare F; Nordlund P; Gupta N; Shenvi NV; Cui XY; Kurtz DM
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 1997;29(2):141-152
Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Rosenzweig AC; Brandstetter H; Whittington DA; Nordlund P; Lippard SJ; Frederick CA
Article: BIOCHEMISTRY. 1997;36(23):7217-7224
Structural and kinetic investigations on the 15-21 and 42-45 loops of muscle acylphosphatase: evidence for their involvement in enzyme catalysis and conformational stabilization.
Taddei N; Chiti F; Magherini F; Stefani M; Thunnissen MM; Nordlund P; Ramponi G
Article: JOURNAL OF MOLECULAR BIOLOGY. 1997;265(2):118-127
Energetics of nucleophile activation in a protein tyrosine phosphatase.
Hansson T; Nordlund P; Aqvist J
Article: STRUCTURE. 1997;5(1):69-79
Crystal structure of common type acylphosphatase from bovine testis.
Thunnissen MM; Taddei N; Liguri G; Ramponi G; Nordlund P
Article: STRUCTURE. 1996;4(9):1053-1064
Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.
Logan DT; Su XD; Aberg A; Regnström K; Hajdu J; Eklund H; Nordlund P
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 1996;3(6):539-546
The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains.
deMaré F; Kurtz DM; Nordlund P
Article: FEBS JOURNAL. 1996;237(1):58-63
Structural and functional characterization of two mutated R2 proteins of Escherichia coli ribonucleotide reductase.
Larsson A; Climent I; Nordlund P; Sahlin M; Sjöberg BM
Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 1995;5(6):758-766
Di-iron-carboxylate proteins.
Nordlund P; Eklund H
Article: FEBS LETTERS. 1995;370(3):209-211
The structure of a reduced mutant T4 glutaredoxin.
Ingelman M; Nordlund P; Eklund H
Article: CHEMISTRY AND BIOLOGY. 1995;2(6):409-418
Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states.
Rosenzweig AC; Nordlund P; Takahara PM; Frederick CA; Lippard SJ
Article: FEBS LETTERS. 1995;364(3):243-244
Crystallisation and preliminary X-ray analysis of the 'common-type' acylphosphatase.
Thunnissen MM; Agango EG; Taddei N; Liguri G; Cecchi C; Pieri A; Ramponi G; Nordlund P
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Review: MEDICINAL RESEARCH REVIEWS. 2021;41(6):2893-2926
Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules
Sun J; Prabhu N; Tang J; Yang F; Jia L; Guo J; Xiao K; Tam WL; Nordlund P; Dai L
Review: PHARMACOLOGY & THERAPEUTICS. 2020;216:107690
Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020
Dai L; Li Z; Chen D; Jia L; Guo J; Zhao T; Nordlund P
Published conference paper: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2020;114:104668
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop
Mahony C; Ashton RS; Birk B; Boobis AR; Cull T; Daston GP; Ewart L; Knudsen TB; Manou I; Maurer-Stroh S; Margiotta-Casaluci L; Muller BP; Nordlund P; Roberts RA; Steger-Hartmann T; Vandenbossche E; Viant MR; Vinken M; Whelan M; Zvonimir Z; Cronin MTD
Review: CURRENT OPINION IN CHEMICAL BIOLOGY. 2020;54:54-62
CETSA in integrated proteomics studies of cellular processes
Prabhu N; Dai L; Nordlund P
Review: ANNUAL REVIEW OF BIOCHEMISTRY. 2019;88:383-408
Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA)
Dai L; Prabhu N; Yu LY; Bacanu S; Ramos AD; Nordlund P
Meeting abstract: CANCER RESEARCH. 2016;76:4386
CETSA as a new strategy to understand efficacy, adverse effects and resistance development of anticancer drugs
Nordlund P; Loof S; Laursen H; Oberg A; Lengqvist J; Jafari R; Dai L; Go KD; Prabhu N; Sobota R; Larsson A; Jansson A; Soon CHT; Sreekumar L; Lim YT; Molina DM
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2016;17(2):123-132
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
Quistgaard EM; Low C; Guettou F; Nordlund P
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2016;56:141-161
The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies
Molina DM; Nordlund P
Review: CURRENT OPINION IN CHEMICAL BIOLOGY. 2011;15(4):482-488
Efficiency of hit generation and structural characterization in fragment-based ligand discovery
Larsson A; Jansson A; Aberg A; Nordlund P
Corrigendum: FEBS JOURNAL. 2011;278(8):1379
Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus (vol 276, pg 6636, 2009)
Dahlroth S-L; Gurmu D; Schmitzberger F; Engman H; Haas J; Erlandsen H; Nordlund P
Editorial comment: JOURNAL OF STRUCTURAL BIOLOGY. 2010;172(1):1-2
New trends in protein expression.
Albeck S; Nordlund P; Sussman JL
Letter: NATURE METHODS. 2009;6(7):477-478
Enabling IMaC purification of low abundance recombinant proteins from E. coli lysates
Magnusdottir A; Johansson I; Dahlgren L-G; Nordlund P; Berglund H
Review: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2008;18(4):442-449
Catalysis within the lipid bilayer - structure and mechanism of the MAPEG family of integral membrane proteins
Molina DM; Eshaghi S; Nordlund P
Review: NATURE METHODS. 2008;5(2):135-146
Protein production and purification
Graslund S; Nordlund P; Weigelt J; Bray J; Hallberg BM; Gileadi O; Knapp S; Oppermann U; Arrowsmith C; Hui R; Ming J; dhe-Paganon S; Park H-W; Savchenko A; Yee A; Edwards A; Vincentelli R; Cambillau C; Kim R; Kim S-H; Rao Z; Shi Y; Terwilliger TC; Kim C-Y; Hung L-W; Waldo GS; Peleg Y; Albeck S; Unger T; Dym O; Prilusky J; Sussman JL; Stevens RC; Lesley SA; Wilson IA; Joachimiak A; Collart F; Dementieva I; Donnelly MI; Eschenfeldt WH; Kim Y; Stols L; Wu R; Zhou M; Burley SK; Emtage JS; Sauder JM; Thompson D; Bain K; Luz J; Gheyi T; Zhang F; Atwell S; Almo SC; Bonanno JB; Fiser A; Swaminathan S; Studier FW; Chance MR; Sali A; Acton TB; Xiao R; Zhao L; Ma LC; Hunt JF; Tong L; Cunningham K; Inouye M; Anderson S; Janjua H; Shastry R; Ho CK; Wang D; Wang H; Jiang M; Montelione GT; Stuart DI; Owens RJ; Daenke S; Schutz A; Heinemann U; Yokoyama S; Bussow K; Gunsalus KC
Review: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(2):331-348
Molecular and structural basis for redox regulation of β-actin
Lassing I; Schmitzberger F; Bjornstedt M; Holmgren A; Nordlund P; Schutt CE; Lindberg U
Corrigendum: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2006;62:1571
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (vol 62, pg 1196, 2006)
Fogg MJ; Alzari P; Bahar M; Bertini I; Betton J-M; Burmeister WP; Cambillau C; Canard B; Carrondo MA; Coll M; Daenke S; Dym O; Egloff M-P; Enguita FJ; Geerlof A; Haouz A; Jones TA; Qingjun M; Manicka SN; Migliardi M; Nordlund P; Owens RJ; Peleg Y; Schneider G; Schnell R; Stuart DI; Tarbouriech N; Unge T; Wilkinson AJ; Wilmanns M; Wilson KS; Zimhony O; Grimes JM
Published conference paper: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2006;39(1-3):83-87
A simple strategy towards membrane protein purification and crystallization
Niegowski D; Hedren M; Nordlund P; Eshaghi S
Review: ANNUAL REVIEW OF BIOCHEMISTRY. 2006;75:681-706
Ribonucleotide reductases
Nordlund P; Reichard P
Meeting abstract: JOURNAL OF INORGANIC BIOCHEMISTRY. 2003;96(1):235
Crystal structure of the R2 subunit of ribonucleotide reductase from Chlamydia trachomatis
Stenmark P; Högbom M; Nordlund P; McClarty G
Meeting abstract: JOURNAL OF INORGANIC BIOCHEMISTRY. 2003;96(1):149
Conformation of the tyrosyl radical in Escherichia coli ribonucleotide reductase R2
Högbom M; Andersson M; Kolberg M; Nordlund P; Galander M; Lendzian F
Meeting abstract: JOURNAL OF INORGANIC BIOCHEMISTRY. 2003;96(1):64
Tyrosyl radicals in iron enzymes:: Structural information from high-field EPR on frozen solutions and single crystals
Lendzian F; Galander M; Högbom M; Nordlund P; Jung C; Schünemann V; Barra AL
Review: THE SCIENTIFIC WORLD JOURNAL. 2002;2:1734-1749
Functional properties and molecular architecture of leukotriene A4 hydrolase, a pivotal catalyst of chemotactic leukotriene formation.
Haeggström JZ; Nordlund P; Thunnissen MMGM
Review: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. 2001;77(3):177-268
Structure and function of the radical enzyme ribonucleotide reductase.
Eklund H; Uhlin U; Färnegårdh M; Logan DT; Nordlund P
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2000;1460(2-3):241-254
New insight into the structure and function of the alternative oxidase.
Berthold DA; Andersson ME; Nordlund P
Corrigendum: FEBS LETTERS. 1998;431(1):129
Expression, purification and preliminary crystal analysis of the human low M_r phosphotyrosine protein phosphate isoform 1 (vol 426, pg 52, 1998)
Marzocchini R; Bucciantini M; Stefani M; Taddei N; Thunnissen MGMM; Nordlund P; Ramponi G
Editorial comment: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 1998;3(3):314-317
Mechanism of methane monooxygenase - a structural and quantum chemical perspective
Siegbahn PEM; Crabtree RH; Nordlund P
Review: BIOLOGICAL CHEMISTRY. 1997;378(8):821-825
Ribonucleotide reductase--structural studies of a radical enzyme.
Eklund H; Eriksson M; Uhlin U; Nordlund P; Logan D
Corrigendum: CHEMISTRY AND BIOLOGY. 1995;2(9):632
GEOMETRY OF THE SOLUBLE METHANE MONOOXYGENASE CATALYTIC DIIRON CENTER IN 2 OXIDATION-STATES (VOL 2, PG 409, 1995)
ROSENZWEIG AC; NORDLUND P; TAKAHARA PM; FREDERICK CA; LIPPARD SJ
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