Ourania Kostopoulou

About me
Publications
CV
Public outreach and news

About me

Education
BSc, Biology 2008, University of Patras, Greece
MSc, Basic Medical Sciences (Pathobiochemistry) 2010, Department of Medicine, University of Patras, Greece
PhD, Basic Medical Sciences 2014, Department of Medicine, University of Patras, Greece
Docent, Experimental Oncology 2022, Karolinska Institutet, Stockholm, Sweden
Team members
Ourania Kostopoulou, PhD, Associate Professor, team leader
Monika Lukoseviciute, PhD student
Emma Need, Master student
Past members in the team
Amelia Irimies, Bachelor student
Albin Dalipi, Medical student
Katerina Theodosopoulou (Erasmus Master student)
Eleni Pappa (Erasmus Bachelor student)
Eleni Poulou (Erasmus Master student)
Christina Papachristofi (Master student)
Erika Rosendahl (Medical student at Linköping University)
Henrietta Maier (Erasmus Master student)
Christina Vasilopoulou (Erasmus Bachelor student)

Funding
Eva and Oscar Foundation
Mary Beves Foundation
Tornspiran Foundation
Magnus Bergvalls Foundation,
Åke Wiberg Foundation
AnnaBrita and Bo Casters Minne Foundation
Svenska Läkaresällskapet (SLS)
Clas Groschinskys minnesfond
Karolinska Institutet

Articles

Article: BIOMEDICINE & PHARMACOTHERAPY. 2024;180:117500
Enhancing targeted therapy by combining PI3K and AKT inhibitors with or without cisplatin or vincristine in medulloblastoma cell lines in vitro
Lukoseviciute M; Need E; Birgersson M; Dalianis T; Kostopoulou ON
Article: BIOMEDICINE & PHARMACOTHERAPY. 2024;177:116993
Combined targeted therapy with PI3K and CDK4/6, or FGFR inhibitors show synergistic effects in a neuroblastoma spheroid culture model
Lukoseviciute M; Need E; Holzhauser S; Dalianis T; Kostopoulou ON
Article: ANTICANCER RESEARCH. 2024;44(5):1863-1876
Curcumin Alone and Combined With PI3K Inhibitors Elicits Positive Effects on Oropharyngeal Cancer Cell Lines Regardless of HPV Status
Lukoceviciute M; Zupancic M; Kostopoulou ON; Holzhauser S; Dalianis T
Article: ORAL ONCOLOGY. 2024;151:106749
Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Zupancic M; Kostopoulou ON; Holzhauser S; Lukoseviciute M; Jylha C; Marklund L; Nasman A; Sivars L; Dalianis T
Article: ONCOLOGY REPORTS. 2023;50(3):166
Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines
Lukoseviciute M; Holzhauser S; Pappa E; Mandal T; Dalianis T; Kostopoulou ON
Article: ONCOLOGY REPORTS. 2023;49(6):125
Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma
Lukoseviciute M; Theodosopoulou A; Holzhauser S; Dalianis T; Kostopoulou ON
Article: CANCERS. 2023;15(7):1954
High Levels of FGF11 Correlate with Poor Survival in Patients with Human Papillomavirus (HPV)-Positive Oropharyngeal Squamous Cell Carcinoma
de Flon CH; Haeggblom L; Holzhauser S; Kostopoulou ON; Zupancic M; Dalianis T; Munck-Wikland E; Marklund L; Nasman A
Article: CANCERS. 2022;15(1):93
Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited
Byskata K; Lukoseviciute M; Tuti F; Zupancic M; Kostopoulou ON; Holzhauser S; Dalianis T
Article: VIRUSES-BASEL. 2022;14(7):1372
Targeted Therapy of HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy between CDK4/6, PI3K and Sometimes FGFR Inhibitors, but Rarely between PARP and WEE1 Inhibitors
Kostopoulou ON; Zupancic M; Pont M; Papin E; Lukoseviciute M; Mikelarena BA; Holzhauser S; Dalianis T
Article: MICROORGANISMS. 2021;9(6):1137
Human Cytomegalovirus Reduces Endothelin-1 Expression in Both Endothelial and Vascular Smooth Muscle Cells
Yaiw K-C; Mohammad A-A; Taher C; Cui HL; Costa H; Kostopoulou ON; Jung M; Assinger A; Wilhelmi V; Yang J; Straat K; Rahbar A; Pernow J; Soderberg-Naucler C
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(7):3664
Heterogeneities in Cell Cycle Checkpoint Activation Following Doxorubicin Treatment Reveal Targetable Vulnerabilities in TP53 Mutated Ultra High-Risk Neuroblastoma Cell Lines
Jonsson LO; Sahi M; Lopez-Lorenzo X; Keller FL; Kostopoulou ON; Herold N; Ahrlund-Richter L; Fard SS
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2021;58(2):211-225
Effects of PI3K and FGFR inhibitors alone and in combination, and with/without cytostatics in childhood neuroblastoma cell lines
Holzhauser S; Lukoseviciute M; Papachristofi C; Vasilopoulou C; Herold N; Wickstrom M; Kostopoulou ON; Dalianis T
Article: FRONTIERS IN ONCOLOGY. 2021;11:748657
Targeting PI3K, FGFR, CDK4/6 Signaling Pathways Together With Cytostatics and Radiotherapy in Two Medulloblastoma Cell Lines
Lukoseviciute M; Maier H; Poulou-Sidiropoulou E; Rosendahl E; Holzhauser S; Dalianis T; Kostopoulou ON
Article: FRONTIERS IN ONCOLOGY. 2021;11:640490
Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations
Holzhauser S; Wild N; Zupancic M; Ursu RG; Bersani C; Nasman A; Kostopoulou ON; Dalianis T
Article: BIOLOGY-BASEL. 2020;9(3):44
Human Cytomegalovirus Infection Induces High Expression of Prolactin and Prolactin Receptors in Ovarian Cancer
Rahbar A; AlKharusi A; Costa H; Pantalone MR; Kostopoulou ON; Cui HL; Carlsson J; Radestad AF; Soderberg-Naucler C; Norstedt G
Article: ANTICANCER RESEARCH. 2020;40(1):53-66
Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines
Holzhauser S; Lukoseviciute M; Andonova T; Ursu RG; Dalianis T; Wickstrom M; Kostopoulou ON
Article: ONCOLOGY LETTERS. 2019;18(6):6249-6260
In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines
Holzhauser S; Kostopoulou ON; Ohmayer A; Lange BKA; Ramqvist T; Andonova T; Bersani C; Wickstrom M; Dalianis T
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2019;55(6):1372-1384
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines
Kostopoulou ON; Holzhauser S; Lange BKA; Ohmayer A; Andonova T; Bersani C; Wickstrom M; Dalianis T
Article: TRANSLATIONAL ONCOLOGY. 2018;11(6):1292-1300
Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer
Radestad AF; Estekizadeh A; Cui HL; Kostopoulou ON; Davoudi B; Hirschberg AL; Carlson J; Rahbar A; Soderberg-Naucler C
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;142(6):1266-1276
Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance
Kostopoulou ON; Mohammad A-A; Bartek JJ; Winter J; Jung M; Stragliotto G; Soderberg-Naucler C; Landazuri N
Article: ONCOTARGET. 2017;8(57):96536-96552
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes
Kostopoulou ON; Wilhelmi V; Raiss S; Ananthaseshan S; Lindstrom MS; Bartek J; Soderberg-Naucler C
Article: ONCOTARGET. 2016;7(30):47221-47231
Human cytomegalovirus may promote tumour progression by upregulating arginase-2
Costa H; Xu X; Overbeek G; Vasaikar S; Patro CPK; Kostopoulou ON; Jung M; Shafi G; Ananthaseshan S; Tsipras G; Davoudi B; Mohammad A-A; Lam H; Straat K; Wilhelmi V; Shang M; Tegner J; Tong JC; Wong KT; Soderberg-Naucler C; Yaiw K-C
Article: JOURNAL OF GENERAL VIROLOGY. 2015;96(12):3598-3612
Direct infection of primary endothelial cells with human cytomegalovirus prevents angiogenesis and migration
Gustafsson RKL; Jeffery HC; Yaiw K-C; Wilhelmi V; Kostopoulou ON; Davoudi B; Rahbar A; Benard M; Renne T; Soderberg-Naucler C; Butler LM
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2015;23(13):3163-3174
Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.
Magoulas GE; Kostopoulou ON; Garnelis T; Athanassopoulos CM; Kournoutou GG; Leotsinidis M; Dinos GP; Papaioannou D; Kalpaxis DL
Article: JOURNAL OF ENDOUROLOGY. 2015;29(5):580-589
Evaluation of the distribution of Paclitaxel by immunohistochemistry and nuclear magnetic resonance spectroscopy after the application of a drug-eluting balloon in the porcine ureter.
Liourdi D; Kallidonis P; Kyriazis I; Tsamandas A; Karnabatidis D; Kitrou P; Spyroulias GA; Kostopoulou ON; Marousis K; Kalpaxis DL; Goumenos DS; Liatsikos E
Article: PLOS ONE. 2015;10(8):e0134526
Synthesis and Evaluation of Chloramphenicol Homodimers: Molecular Target, Antimicrobial Activity, and Toxicity against Human Cells
Kostopoulou ON; Magoulas GE; Papadopoulos GE; Mouzaki A; Dinos GP; Papaioannou D; Kalpaxis DL
Article: NUCLEIC ACIDS RESEARCH. 2014;42(13):8621-8634
Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol.
Kostopoulou ON; Kouvela EC; Magoulas GE; Garnelis T; Panagoulias I; Rodi M; Papadopoulos G; Mouzaki A; Dinos GP; Papaioannou D; Kalpaxis DL
Article: PHARMAZIE. 2013;68(7):616-621
Clindamycin binding to ribosomes revisited: foot printing and computational detection of two binding sites within the peptidyl transferase center.
Kostopoulou ON; Papadopoulos G; Kouvela EC; Kalpaxis DL
Article: NUCLEIC ACIDS RESEARCH. 2012;40(11):5078-5087
Investigating the entire course of telithromycin binding to Escherichia coli ribosomes.
Kostopoulou ON; Petropoulos AD; Dinos GP; Choli-Papadopoulou T; Kalpaxis DL
Journal article: OPEN ENZYME INHIBITION JOURNAL. 2011;4(1):1-10
Insights into the Chloramphenicol Inhibition Effect on Peptidyl Transferase Activity, Using Two New Analogs of the Drug
Kostopoulou ON
Article: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2010;35(3):235-239
Dissecting the ribosomal inhibition mechanism of a new ketolide carrying an alkyl-aryl group at C-13 of its lactone ring.
Krokidis MG; Kostopoulou ON; Kalpaxis DL; Dinos GP
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All other publications

Review: ANTICANCER RESEARCH. 2023;43(9):3829-3839
New Approaches Towards Targeted Therapy for Childhood Neuroblastoma
Dalianis T; Lukoseviciute M; Holzhauser S; Kostopoulou ON
Review: VIRUSES-BASEL. 2021;13(5):910
Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma
Nasman A; Holzhauser S; Kostopoulou ON; Zupancic M; Ahrlund-Richter A; Du J; Dalianis T
Review: ANTICANCER RESEARCH. 2021;41(4):1715-1726
New Approaches in Targeted Therapy for Medulloblastoma in Children
Maier H; Dalianis T; Kostopoulou ON

Employments

Senior Research Specialist, Department of Oncology-Pathology, Karolinska Institutet, 2023-
Lecturer, Department of Oncology-Pathology, Karolinska Institutet, 2024-2024

Degrees and Education

Docent, Karolinska Institutet, 2022

About me

Articles

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Employments

Degrees and Education

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