Licenced physician 2018
PhD 2015, Uppsala University
MD 2011, Uppsala University
The aim of my research is to understand mechanisms involved in autoimmune disease and to improve diagnostic opportunities for these disorders.
Autoantibodies as markers of disease. We use proteome arrays to characterize autoantibody responses and to identify biomarkers. We also develop targeted panels to support clinical diagnostics of autoimmune disorders. We are currently developing a tool to screen many thousands of samples for autoantibodies in parallel.
Defects in immune tolerance. We study rare monogenic disorders as models to understand the role of central tolerance (APS1) and peripheral tolerance (IPEX) in the development of autoimmunity.
Transglutaminases as autoimmune targets. One of the autoantigens we have identified, transglutaminase 4, is a prostate-specific member of the transglutaminase protein family. Previous studies have identified other members of this protein family as autoantigens in distinct autoimmune disorders. Inspired by this, we now pursue remaining transglutaminases as candidate autoantigens.
Sex differences in autoimmunity. Women face a three-fold higher risk of developing an autoimmune disorder. In an ongoing collaboration we follow men and women undergoing sex change, as a unique model to study how sex hormones affect the human immune system. Samples are collected before and during hormone therapy, and analyzed using a combination of omics technologies.
Academic honours, awards and prizes
Swedish Society for Medical Research Postdoctoral Fellowship, 2018
The Swedish Association of Endocrinologists’ Research Stipend of the Year, 2017
The Crafoord Stipend, 2016
Benzeliusbelöning, from the Royal Society of Sciences in Uppsala, 2015
Best Thesis award from the Department of Medical Sciences, Uppsala University, 2015
Thesis of the Year from The Swedish Association of Endocrinologists, 2015
SciLifeLab Scientific Highlight, recognizing Landegren et al. Science Translational Medicine 2015
Swedish Society for Medical Research Travel grant for exchange to Stanford University, 2012