Niklas Zethraeus

About me
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About me

I'm an associate professor of health economics, working at MMC, LIME at
Karolinska Institutet. I'm also program director of the Master's programme of
health economics, policy and management.

Research

The focus of my research is on economic evaluation studies in different areas
such as congestive heart failure, gallstone disease, osteoporosis and hormone
replacement therapy. I'm also doing research in behavioural (health)
economics, e.g., analysing the effects of hormones on economic behaviour and
clinical outcomes.
Research group web page: Health Economics and Economic Evaluation [1].
[1] https://ki.se/en/lime/health-economics-and-economic-evaluation

Articles

Article: JOURNAL OF MEDICAL ECONOMICS. 2024;27(1):193-200

Validation of overall survival extrapolations made by TLV in the assessment of cost-effectiveness of oncology drugs in Sweden - A pilot study comparing extrapolated and observed life-years gained.

Björnerstedt J; Almqvist H; Lundin D; Zethraeus N
Article: NORDIC JOURNAL OF PSYCHIATRY. 2024;78(2):137-145

Association between pulse width and health-related quality of life after electroconvulsive therapy in patients with unipolar or bipolar depression: an observational register-based study.

Ernstsson O; Heintz E; Nordenskjöld A; Johnson JA; Korkmaz S; Zethraeus N
Article: PAIN REPORTS. 2023;8(6):e1107

Real-world outcomes in spinal cord stimulation: predictors of reported effect and explantation using a comprehensive registry-based approach.

Kirketeig T; Söreskog E; Jacobson T; Karlsten R; Zethraeus N; Borgström F
Article: PAIN. 2023;164(3):666-673

Impact of spinal cord stimulation on sick leave and disability pension in patients with chronic neuropathic pain: a real-world evidence study in Sweden.

Söreskog E; Jacobson T; Kirketeig T; Fritzell P; Karlsten R; Zethraeus N; Borgström F
Article: DISABILITY AND REHABILITATION. 2022;44(26):8471-8479

Health-related quality of life in patients with lower limb amputation - an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry.

Ernstsson O; Hagberg K; Janssen MF; Bonsel GJ; Korkmaz S; Zethraeus N; Heintz E
Article: MEDICINE. 2021;100(46):e27828

Health care costs associated with clinic visits for prevention of mother-to-child transmission of HIV in Dar es Salaam, Tanzania.

Naburi HE; Mujinja P; Kilewo C; Biberfeld G; Bärnighausen T; Manji K; Lyatuu G; Urrio R; Zethraeus N; Orsini N; Ekström AM
Article: BMJ OPEN. 2021;11(8):e051233

Observational study of the implementation of telephone advice nursing in Sweden: did callers follow recommendations and did the rate of healthcare visits change?

Sundberg A; Wahlberg AC; Zethraeus N; Karampampa K
Article: BMJ OPEN. 2020;10(8):e036638

Productivity losses among people with back pain and among population-based references: a register-based study in Sweden.

Gedin F; Alexanderson K; Zethraeus N; Karampampa K
Article: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 2019;22(4):545-554

Cost-effectiveness of an adherence-enhancing intervention for gout based on real-world data.

Lin LW; Teng GG; Lim AYN; Yoong JS-Y; Zethraeus N; Wee H-L
Article: APPLIED HEALTH ECONOMICS AND HEALTH POLICY. 2019;17(1):15-24

Standardized Questionnaire for the Measurement, Valuation, and Estimation of Costs of Informal Care Based on the Opportunity Cost and Proxy Good Method.

Landfeldt E; Zethraeus N; Lindgren P
Article: JOURNAL OF THE ECONOMIC SCIENCE ASSOCIATION. 2019;5(2):149-169

The digit ratio (2D:4D) and economic preferences: no robust associations in a sample of 330 women.

Parslow E; Ranehill E; Zethraeus N; Blomberg L; von Schoultz B; Hirschberg AL; Johannesson M; Dreber A
Article: MANAGEMENT SCIENCE. 2018;64(10):4515-4532

Hormonal Contraceptives Do Not Impact Economic Preferences: Evidence from a Randomized Trial

Ranehill E; Zethraeus N; Blomberg L; von Schoultz B; Hirschberg AL; Johannesson M; Dreber A
Article: FRONTIERS IN ENDOCRINOLOGY. 2018;9:104

Economic Evaluation of PRIMROSE-A Trial-Based Analysis of an Early Childhood Intervention to Prevent Obesity.

Döring N; Zethraeus N; Tynelius P; de Munter J; Sonntag D; Rasmussen F
Article: TRIALS. 2017;18(1):613

Effectiveness, costs and cost-effectiveness of chiropractic care and physiotherapy compared with information and advice in the treatment of non-specific chronic low back pain: study protocol for a randomised controlled trial.

Gedin F; Skeppholm M; Burström K; Sparring V; Tessma M; Zethraeus N
Article: FERTILITY AND STERILITY. 2017;107(5):1238-1245

A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial.

Zethraeus N; Dreber A; Ranehill E; Blomberg L; Labrie F; von Schoultz B; Johannesson M; Hirschberg AL
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):4046-4053

Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial.

Zethraeus N; Dreber A; Ranehill E; Blomberg L; Labrie F; von Schoultz B; Johannesson M; Hirschberg AL
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2016;23(4):420-427

Cost-effectiveness of case-based training for primary care physicians in evidence-based medicine of patients with coronary heart disease.

Groot-Jensen S; Kiessling A; Zethraeus N; Björnstedt-Bennermo M; Henriksson P
Article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2015;25(6):1035-1042

Cost and effects of a universal parenting programme delivered to parents of preschoolers.

Sampaio F; Sarkadi A; Salari R; Zethraeus N; Feldman I
Article: QUALITY OF LIFE RESEARCH. 2015;24(12):2963-2970

Assessment of the Swedish EQ-5D experience-based value sets in a total hip replacement population.

Nemes S; Burström K; Zethraeus N; Eneqvist T; Garellick G; Rolfson O
Article: PLOS ONE. 2015;10(5):e0128270

Barriers to and facilitators of compliance with clinic-based cervical cancer screening: population-based cohort study of women aged 23-60 years.

Östensson E; Alder S; Elfström KM; Sundström K; Zethraeus N; Arbyn M; Andersson S
Article: PLOS ONE. 2015;10(9):e0139062

Cost of Preventing, Managing, and Treating Human Papillomavirus (HPV)-Related Diseases in Sweden before the Introduction of Quadrivalent HPV Vaccination.

Östensson E; Fröberg M; Leval A; Hellström A-C; Bäcklund M; Zethraeus N; Andersson S
Article: QUALITY OF LIFE RESEARCH. 2014;23(2):431-442

Swedish experience-based value sets for EQ-5D health states.

Burström K; Sun S; Gerdtham U-G; Henriksson M; Johannesson M; Levin L-Å; Zethraeus N
Article: EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE. 2014;6(1):29-38

Integrative medicine for back and neck pain: Exploring cost-effectiveness alongside a randomized clinical pilot trial

Sundberg T; Hagberg L; Zethraeus N; Wandell P; Falkenberg T
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2013;92(7):830-840

Projected cost-effectiveness of repeat high-risk human papillomavirus testing using self-collected vaginal samples in the Swedish cervical cancer screening program.

Östensson E; Hellström A-C; Hellman K; Gustavsson I; Gyllensten U; Wilander E; Zethraeus N; Andersson S
Article: FERTILITY AND STERILITY. 2011;95(1):152-157

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women.

Kocoska-Maras L; Zethraeus N; Rådestad AF; Ellingsen T; von Schoultz B; Johannesson M; Hirschberg AL
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2010;89(10):1316-1325

Economic analysis of human papillomavirus triage, repeat cytology, and immediate colposcopy in management of women with minor cytological abnormalities in Sweden.

Ostensson E; Fröberg M; Hjerpe A; Zethraeus N; Andersson S
Article: ITALIAN JOURNAL OF PEDIATRICS. 2010;36:61

Health-care cost reduction resulting from primary-care allergy testing in children in Italy.

Zethraeus N; Petersson CJ; Dozzi M; Borres MP; Vignati G; Fiocchi A
Article: JOURNAL OF WOMENS HEALTH. 2009;18(10):1669-1677

Cost-effectiveness of hormone therapy in the United States.

Lekander I; Borgström F; Ström O; Zethraeus N; Kanis JA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(16):6535-6538

A randomized trial of the effect of estrogen and testosterone on economic behavior.

Zethraeus N; Kocoska-Maras L; Ellingsen T; von Schoultz B; Hirschberg AL; Johannesson M
Article: MENOPAUSE INTERNATIONAL. 2009;15(1):19-25

Cost-effectiveness of hormone replacement therapy for menopausal symptoms in the UK.

Lekander I; Borgström F; Ström O; Zethraeus N; Kanis JA
Article: OSTEOPOROSIS INTERNATIONAL. 2008;19(6):819-827

The cost-effectiveness of the treatment of high risk women with osteoporosis, hypertension and hyperlipidaemia in Sweden.

Zethraeus N; Ström O; Borgström F; Kanis JA; Jönsson B
Article: ACTA ORTHOPAEDICA. 2008;79(2):269-280

Long-term cost and effect on quality of life of osteoporosis-related fractures in Sweden.

Ström O; Borgstrom F; Zethraeus N; Johnell O; Lidgren L; Ponzer S; Svensson O; Abdon P; Ornstein E; Ceder L; Thorngren KG; Sernbo I; Jonsson B
Article: BONE. 2008;42(2):294-306

Cost effectiveness of hormone therapy in women at high risks of fracture in Sweden, the US and the UK--results based on the Women's Health Initiative randomised controlled trial.

Lekander I; Borgström F; Ström O; Zethraeus N; Kanis JA
Article: PHLEBOLOGY. 2006;21(2):90-95

Cost consequences of preoperative duplex examination before varicose vein surgery:: a randomized clinical trial

Blomgren L; Zethraeus N; Johansson G; Jonsson B; Bergqvist D
Article: OSTEOPOROSIS INTERNATIONAL. 2006;17(5):637-650

Costs and quality of life associated with osteoporosis-related fractures in Sweden.

Borgström F; Zethraeus N; Johnell O; Lidgren L; Ponzer S; Svensson O; Abdon P; Ornstein E; Lunsjö K; Thorngren KG; Sernbo I; Rehnberg C; Jönsson B
Article: BONE. 2005;36(1):22-32

Intervention thresholds for osteoporosis in the UK.

Kanis JA; Borgstrom F; Zethraeus N; Johnell O; Oden A; Jönsson B
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2005;21(2):180-186

Cost of lipid lowering in patients with coronary artery disease by case method learning.

Kiessling A; Zethraeus N; Henriksson P
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2004;21(4):433-441

Reassessment of the cost-effectiveness of hormone replacement therapy in Sweden: results based on the Women's Health Initiative randomized controlled trial.

Zethraeus N; Borgström F; Jönsson B; Kanis J
Article: BONE. 2004;34(6):1064-1071

Cost effectiveness of alendronate for the treatment of male osteoporosis in Sweden.

Borgström F; Johnell O; Jönsson B; Zethraeus N; Sen SS
Article: OSTEOPOROSIS INTERNATIONAL. 2004;15(1):20-26

The risk and burden of vertebral fractures in Sweden.

Kanis JA; Johnell O; Oden A; Borgstrom F; Zethraeus N; De Laet C; Jonsson B
Article: UGESKRIFT FOR LAEGER. 2003;165(43):4112-4116

[Cost-effectiveness of alendronate treatment of osteoporosis in Denmark. An economic evaluation based on the Fracture Intervention Trial].

Jönsson L; Borgström F; Zethraeus N
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2003;19(3):507-512

Predicting survival in cost-effectiveness analyses based on clinical trials.

Gerdtham UG; Zethraeus N
Article: EUROPEAN JOURNAL OF HEART FAILURE. 2003;5(1):101-108

Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial.

Cleland JGF; Takala A; Apajasalo M; Zethraeus N; Kobelt G
Article: QUALITY OF LIFE RESEARCH. 2002;11(5):473-481

Femoral neck fractures in the elderly: functional outcome and quality of life according to EuroQol.

Tidermark J; Zethraeus N; Svensson O; Törnkvist H; Ponzer S
Article: JOURNAL OF ORTHOPAEDIC TRAUMA. 2002;16(1):34-38

Quality of life related to fracture displacement among elderly patients with femoral neck fractures treated with internal fixation.

Tidermark J; Zethraeus N; Svensson O; Törnkvist H; Ponzer S
Article: PHARMACOECONOMICS. 2001;19(9):901-916

Cost effectiveness of bisoprolol in the treatment of chronic congestive heart failure in Sweden: analysis using data from the Cardiac Insufficiency Bisoprolol Study II trial.

Ekman M; Zethraeus N; Jönsson B
Article: HEALTH ECONOMICS. 2000;9(7):623-630

Definition, interpretation and calculation of cost-effectiveness acceptability curves.

Löthgren M; Zethraeus N
Article: HEALTH ECONOMICS. 1999;8(6):541-545

A comparison of patient and social tariff values derived from the time trade-off method.

Zethraeus N; Johannesson M
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(2):151-159

Costs of coronary heart disease and stroke: the case of Sweden.

Zethraeus N; Molin T; Henriksson P; Jönsson B
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1999;15(2):352-365

A computer model to analyze the cost-effectiveness of hormone replacement therapy.

Zethraeus N; Johannesson M; Jönsson B
Article: MEDICAL DECISION MAKING. 1998;18(3):330-336

Nonparametric willingness-to-pay measures and confidence statements.

Tambour M; Zethraeus N
Article: HEALTH ECONOMICS. 1998;7(2):143-147

Bootstrap confidence intervals for cost-effectiveness ratios: some simulation results.

Tambour M; Zethraeus N
Article: HEALTH ECONOMICS. 1998;7(1):31-38

Willingness to pay for hormone replacement therapy.

Zethraeus N
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1998;14(3):467-471

A note on confidence intervals in cost-effectiveness analysis.

Tambour M; Zethraeus N; Johannesson M
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 1998;14(2):255-267

Estimating the costs of hip fracture and potential savings.

Zethraeus N; Gerdtham UG
Article: BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 1997;104(10):1191-1195

The impact of hormone replacement therapy on quality of life and willingness to pay.

Zethraeus N; Johannesson M; Henriksson P; Strand RT
Article: ACTA ORTHOPAEDICA. 1997;68(1):13-17

The cost of a hip fracture. Estimates for 1,709 patients in Sweden.

Zethraeus N; Strömberg L; Jönsson B; Svensson O; Ohlén G
Article: AMERICAN JOURNAL OF SURGERY. 1996;172(4):305-310

A cost-minimization analysis of laparoscopic cholecystectomy versus open cholecystectomy.

Berggren U; Zethraeus N; Arvidsson D; Haglund U; Jonsson B
Article: HEALTH POLICY. 1995;34(2):135-143

Value for money? A contingent valuation study of the optimal size of the Swedish health care budget.

Eckerlund I; Johannesson M; Johansson PO; Tambour M; Zethraeus N
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Review: FAMILIAL CANCER. 2024;:1-5

Can our experience with surveillance for inherited pancreatic cancer help to identify early pancreatic cancer in the general population?

Löhr J-M; Öhlund D; Söreskog E; Andersson E; Vujasinovic M; Zethraeus N; Sund M
Review: PHARMACOECONOMICS. 2020;38(7):715-728

Economic Costs of Myasthenia Gravis: A Systematic Review.

Landfeldt E; Pogoryelova O; Sejersen T; Zethraeus N; Breiner A; Lochmüller H
Review: OSTEOPOROSIS INTERNATIONAL. 2007;18(1):9-23

Cost-effectiveness of the treatment and prevention of osteoporosis--a review of the literature and a reference model.

Zethraeus N; Borgström F; Ström O; Kanis JA; Jönsson B
Meeting abstract: VALUE IN HEALTH. 2006;9(6):a383

Long term quality of life related to osteoporotic fractures;: 13-18 months after fracture

Strom O; Borgstrom F; Zethraeus N; Jonsson B
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):S135

Cost-effectiveness analysis of using allergy tests in primary care in Italian children

Ytterström-Ahlstedt U; Zethraeus N; Petersson CJ; Ahlstedt S
Review: OSTEOPOROSIS INTERNATIONAL. 2005;16(6):581-589

Assessment of fracture risk.

Kanis JA; Borgstrom F; De Laet C; Johansson H; Johnell O; Jonsson B; Oden A; Zethraeus N; Pfleger B; Khaltaev N
Meeting abstract: VALUE IN HEALTH. 2004;7(6):691-692

The cost effectiveness of hormone replacement therapy (HRT) for women with menopasual symptoms in Sweden

Borgström F; Zethraeus N; Johnell O; Kanis J; Jönsson B
Meeting abstract: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2004;43(5):408A

Case method learning is a cost effective implementation method of evidence based secondary prevention in primary care

Kiessling A; Zethraeus N; Henriksson P
Review: PHARMACOECONOMICS. 2003;21(1):39-48

Advantages of using the net-benefit approach for analysing uncertainty in economic evaluation studies.

Zethraeus N; Johannesson M; Jönsson B; Löthgren M; Tambour M
Review: OSTEOPOROSIS INTERNATIONAL. 2002;13(11):841-857

Models for assessing the cost-effectiveness of the treatment and prevention of osteoporosis.

Zethraeus N; Ben Sedrine W; Caulin F; Corcaud S; Gathon HJ; Haim M; Johnell O; Jönsson B; Kanis JA; Tsouderos Y; Reginster J-Y
Review: EUROPEAN JOURNAL OF SURGERY, ACTA CHIRURGICA, SUPPLEMENT. 2000;(585):48-56

Costs and benefits of laparoscopic surgery--a review of the literature.

Jönsson B; Zethraeus N

Employments

Principal Researcher, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, 2022-

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