Mirna Abraham Nordling
About me
MD. PhD. Associate Professor of Surgery at Karolinska Institutet
Works as Senior Consultant Surgeon at Karolinska University Hospital
Research overview
Mirna Abraham Nordling works as a colorectal surgeon at Karolinska University Hospital.
Her focus research area is studies that aims to understand and improve colorectal cancer treatment, aftercare and to prevent and avoid severe complications such as low anterior resection syndrome (LARS)/bowel dysfunction and anastomotic leakage.
Colorectal cancer is one of the most common forms of cancer in both sexes. Treatment has improved significantly in recent decades. Despite the progress, patients can experience serious complications such as low anterior resection syndrome (LARS)/bowel dysfunction and leakage at the bowel junction (anastomosis) after cancer surgery. A recently published randomized trial from our group investigating treatment methods for LARS showed that water irrigation/transanal irrigation (TAI) reduces LARS symptoms and increases quality of life. Mirna Abraham Nordling was the PI for this TAI study, it was a multicenter study in collaboration with Karolinska University Hospital, Danderyd Hospital and Södersjukhuset (A Randomized Controlled Clinical Trial of Transanal Irrigation Versus Conservative Treatment in Patients With Low Anterior Resection Syndrome After Rectal Cancer Surgery. Ann Surg 2023 Jan).
Current studies are about: Can TAI be a long-term sustainable treatment for LARS and provide increased quality of life? Is there any difference between different anastomosis types (how the intestinal ends are sewn together) with regard to leakage and intestinal dysfunction? Evaluation of the various anastomotic methods and their impact on bowel function and anastomotic leakage. Can LARS and anastomosis leakage be predicted even before surgery?
Research
Supervision of doctoral students:
- Main supervisor: Boglarka Rethy, ongoing doctoral education
- Co- supervisor: Parisa Golshani, ongoing doctoral education
- Main supervisor: Mahmood Mahmood, dissertation 2024
- Main supervisor: Emil Pieniowski, dissertation 2022
- Co- supervisor: Naseer Baloch, dissertation 2021
- Co- supervisor: Erik Rollvén, dissertation 2017
Articles
- Article: BJS OPEN. 2024;8(5):zrae089
- Journal article: BRITISH JOURNAL OF SURGERY. 2024;111:znae175.062
- Article: BMJ OPEN. 2024;14(2):e076538
- Article: BMJ OPEN GASTROENTEROLOGY. 2024;11(1):e001274
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2024;59(2):176-182
- Article: GYNECOLOGIC ONCOLOGY. 2023;170:259-265
- Article: ANNALS OF SURGERY. 2023;277(1):30-37
- Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2022;48(12):2518-2524
- Journal article: BRITISH JOURNAL OF SURGERY. 2022;109(12):1251-1263
- Article: ANNALS OF SURGERY. 2022;276(1):46-54
- Article: BJS OPEN. 2021;5(1):zraa055
- Article: COLORECTAL DISEASE. 2020;22(12):1933-1940
- Article: BJS OPEN. 2020;4(5):935-942
- Article: COLORECTAL DISEASE. 2020;22(10):1258-1262
- Article: COLORECTAL DISEASE. 2020;22(9):1184-1188
- Article: ANNALS OF SURGERY. 2019;270(5):899-905
- Article: THYROID. 2019;29(11):1545-1557
- Article: EUROPEAN JOURNAL OF NUTRITION. 2019;58(6):2393-2400
- Article: BJS OPEN. 2019;3(4):516-520
- Article: ABDOMINAL RADIOLOGY. 2019;44(5):1712-1721
- Article: ANNALS OF SURGERY. 2019;269(2):315-321
- Article: DIGESTIVE SURGERY. 2019;36(4):281-288
- Article: DISEASES OF THE COLON AND RECTUM. 2019;62(1):14-20
- Article: SURGICAL ENDOSCOPY. 2018;32(12):4707-4715
- Article: COLORECTAL DISEASE. 2018;20(11):1028-1040
- Article: COLORECTAL DISEASE. 2018;20:47-57
- Article: COLORECTAL DISEASE. 2018;20:33-46
- Article: COLORECTAL DISEASE. 2018;20:58-68
- Article: COLORECTAL DISEASE. 2018;20:69-89
- Article: CLINICAL RADIOLOGY. 2018;73(8):756.e11-756.e16
- Article: BRITISH JOURNAL OF SURGERY. 2018;105(6):650-657
- Article: ACTA RADIOLOGICA. 2017;58(11):1288-1293
- Article: COLORECTAL DISEASE. 2017;20(3):219-227
- Article: COLORECTAL DISEASE. 2017;19(8):O296-O311
- Article: CANCER IMAGING. 2017;17(1):3
- Article: WORLD JOURNAL OF SURGICAL ONCOLOGY. 2016;14(1):232
- Article: CLINICAL ENDOCRINOLOGY. 2016;84(5):729-735
- Article: BRITISH JOURNAL OF SURGERY. 2015;102(1):119-124
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2014;99(9):3217-3223
- Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2013;25(6):474-480
- Article: ACTA RADIOLOGICA. 2013;54(3):237-241
- Article: COMPUTATIONAL BIOLOGY AND CHEMISTRY. 2012;39:29-34
- Article: BRITISH JOURNAL OF SURGERY. 2012;99(2):186-191
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2011;165(6):899-905
- Article: BMC RESEARCH NOTES. 2010;3:270
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2010;163(4):651-657
- Journal article: L'ENDOCRINOLOGO. 2009;10(4):172-173
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2009;94(10):3700-3707
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2009;160(3):437-441
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2009;160(2):201-206
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2008;158(6):823-827
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2008;158(1):69-75
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2007;156(2):173-179
- Article: THYROID. 2005;15(11):1279-1286
- Article: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2003;17(3):183-191
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All other publications
- Review: BRITISH JOURNAL OF SURGERY. 2024;111(3):znae042
- Editorial comment: BRITISH JOURNAL OF SURGERY. 2023;110(12):1730-1731
- Review: CANCERS. 2022;14(5):1161
- Editorial comment: BRITISH JOURNAL OF SURGERY. 2020;107(11):e470-e471
- Letter: BRITISH JOURNAL OF SURGERY. 2020;107(11):e547-e548
- Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2019;15(11):628
- Review: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2019;45(10):1787-1795
- Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:646
- Thesis / dissertation: 2008
Employments
- Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2024-2027
- Clinical Position, ME Bäckencancer, Karolinska Universitetssjukhuset
Degrees and Education
- Associate professor, MMK, 2013
- Docent, Kirurgi, Karolinska Institutet, Karolinska Institute, 2013
- Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2008
- University Medical Degree, Karolinska Institutet, 2001
Supervisor
- Emil Pienowski, Aspects of low anterior resection syndrome
- prevalence, risk factors and treatment, 2017
- Mahmood Mahmood
- Pieniowski Emil
- Baloch Naseer
- Rollven Erik