Miriam Scarpa

Articles

Article: SCIENCE SIGNALING. 2022;15(760):eabm3720
M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Dwomoh L; Rossi M; Scarpa M; Khajehali E; Molloy C; Herzyk P; Mistry SN; Bottrill AR; Sexton PM; Christopoulos A; Conn J; Lindsley CW; Bradley SJ; Tobin AB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(50):e2107389118
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.
Scarpa M; Molloy C; Jenkins L; Strellis B; Budgett RF; Hesse S; Dwomoh L; Marsango S; Tejeda GS; Rossi M; Ahmed Z; Milligan G; Hudson BD; Tobin AB; Bradley SJ
Article: NATURE CHEMICAL BIOLOGY. 2020;16(3):240-249
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Bradley SJ; Molloy C; Valuskova P; Dwomoh L; Scarpa M; Rossi M; Finlayson L; Svensson KA; Chernet E; Barth VN; Gherbi K; Sykes DA; Wilson CA; Mistry R; Sexton PM; Christopoulos A; Mogg AJ; Rosethorne EM; Sakata S; John Challiss RA; Broad LM; Tobin AB
Article: BIOCHEMICAL JOURNAL. 2018;475(4):827-838
Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase.
Cao Z; Mitchell L; Hsia O; Scarpa M; Caldwell ST; Alfred AD; Gennaris A; Collet J-F; Hartley RC; Bulleid NJ