Maria Shoshan

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Articles

Article: BMC MEDICAL EDUCATION. 2021;21(1):519

Faculty perceptions of factors that indicate successful educational outcomes of medical students' research projects: a focus group study.

Möller R; Wallberg A; Shoshan M
Article: MOLECULAR AND CLINICAL ONCOLOGY. 2021;14(2):42

PGC1α and VDAC1 expression in endometrial cancer.

Wersäll OC; Löfstedt L; Govorov I; Mints M; Gabrielson M; Shoshan M
Article: BMC MEDICAL EDUCATION. 2019;19(1):93

Does reality meet expectations? An analysis of medical students' expectations and perceived learning during mandatory research projects.

Möller R; Shoshan M
Article: INTERNATIONAL JOURNAL OF MEDICAL EDUCATION. 2017;8:375-381

Medical students' perceptions of their learning environment during a mandatory research project.

Möller R; Ponzer S; Shoshan M
Article: BMC MEDICAL EDUCATION. 2017;17(1):51

Medical students' research productivity and career preferences; a 2-year prospective follow-up study.

Möller R; Shoshan M
Article: LAKARTIDNINGEN. 2015;112:C43E

[The supervisor has a crucial role in the medical student's degree projects. Experiences from seven semesters at Karolinska Institutet].

Möller R; Shoshan M; Ponzer S
Article: BIOANALYSIS. 2015;7(2):157-166

Metabolic profiling of epithelial ovarian cancer cell lines: evaluation of harvesting protocols for profiling using NMR spectroscopy.

Engskog MKR; Björklund M; Haglöf J; Arvidsson T; Shoshan M; Pettersson C
Article: MEDICAL EDUCATION ONLINE. 2015;20:28441

What is the reward? Medical students' learning and personal development during a research project course.

Möller R; Shoshan M; Heikkilä K
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2014;24(8):1389-1394

Metabolic markers and HSP60 in chemonaive serous solid ovarian cancer versus ascites.

Hjerpe E; Brage SE; Frostvik Stolt M; Johansson H; Shoshan M; Avall-Lundqvist E
Article: ACTA OTO-LARYNGOLOGICA. 2014;134(5):448-454

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures.

Dammeyer P; Hellberg V; Wallin I; Laurell G; Shoshan M; Ehrsson H; Arnér ESJ; Kirkegaard M
Article: PLOS ONE. 2014;9(9):e107109

Expression of mitochondrial regulators PGC1α and TFAM as putative markers of subtype and chemoresistance in epithelial ovarian carcinoma.

Gabrielson M; Björklund M; Carlson J; Shoshan M
Article: BMC CLINICAL PATHOLOGY. 2013;13(1):30

Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.

Hjerpe E; Egyhazi Brage S; Carlson J; Frostvik Stolt M; Schedvins K; Johansson H; Shoshan M; Avall-Lundqvist E
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2013;23(3):448-455

HSP60 predicts survival in advanced serous ovarian cancer.

Hjerpe E; Egyhazi S; Carlson J; Stolt MF; Schedvins K; Johansson H; Shoshan M; Avall-Lundqvist E
Article: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2013;14(3):313-330

Potentiation of anti-cancer treatment by modulators of energy metabolism.

Shoshan MC
Article: CANCER BIOLOGY & THERAPY. 2012;13(14):1454-1462

Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate.

Wintzell M; Löfstedt L; Johansson J; Pedersen AB; Fuxe J; Shoshan M
Article: BMC CANCER. 2012;12:359

Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites.

Wintzell M; Hjerpe E; Åvall Lundqvist E; Shoshan M
Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2011;68(6):1459-1467

Resveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment.

Björklund M; Roos J; Gogvadze V; Shoshan M
Article: BLOOD CANCER JOURNAL. 2011;1(7):e31

Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells.

Buentke E; Nordström A; Lin H; Björklund A-C; Laane E; Harada M; Lu L; Tegnebratt T; Stone-Elander S; Heyman M; Söderhäll S; Porwit A; Ostenson C-G; Shoshan M; Tamm KP; Grandér D
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(10):2450-2455

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W; Brnjic S; Berglind D; Blixt S; Shoshan MC; Berndtsson M; Olofsson MH; Linder S
Article: CARCINOGENESIS. 2009;30(9):1517-1527

Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.

Kutuk O; Arisan ED; Tezil T; Shoshan MC; Basaga H
Article: MOLECULAR CANCER THERAPEUTICS. 2009;8(7):1916-1923

Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment.

Hernlund E; Hjerpe E; Avall-Lundqvist E; Shoshan M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(12):1607-1613

Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation.

Hernlund E; Kutuk O; Basaga H; Linder S; Panaretakis T; Shoshan M
Article: JOURNAL OF CHEMICAL BIOLOGY. 2009;2(2):81-87

Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

Berndtsson M; Hernlund E; Shoshan MC; Linder S
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(1):37-47

Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity.

Hellberg V; Wallin I; Eriksson S; Hernlund E; Jerremalm E; Berndtsson M; Eksborg S; Arnér ESJ; Shoshan M; Ehrsson H; Laurell G
Article: MOLECULAR CANCER THERAPEUTICS. 2009;8(1):160-170

Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells.

Pettersson HM; Pietras A; Munksgaard Persson M; Karlsson J; Johansson L; Shoshan MC; Påhlman S
Article: BMC CHEMICAL BIOLOGY. 2008;8:2

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH; Havelka AM; Brnjic S; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):476-483

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.

Hernlund E; Ihrlund LS; Khan O; Ates YO; Linder S; Panaretakis T; Shoshan MC
Article: MOLECULAR ONCOLOGY. 2008;2(1):94-101

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.

Ihrlund LS; Hernlund E; Khan O; Shoshan MC
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(1):R1

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.

Ostberg T; Wähämaa H; Palmblad K; Ito N; Stridh P; Shoshan M; Lotze MT; Harris HE; Andersson U
Article: CLINICAL CANCER RESEARCH. 2007;13(11):3198-3206

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.

Olofsson MH; Ueno T; Pan Y; Xu R; Cai F; van der Kuip H; Muerdter TE; Sonnenberg M; Aulitzky WE; Schwarz S; Andersson E; Shoshan MC; Havelka AM; Toi M; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(1):175-180

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.

Berndtsson M; Hägg M; Panaretakis T; Havelka AM; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589

Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: RADIATION ONCOLOGY. 2006;1:4

Is translational research compatible with preclinical publication strategies?

Linder S; Shoshan MC
Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(8):3821-3831

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Panaretakis T; Laane E; Pokrovskaja K; Björklund A-C; Moustakas A; Zhivotovsky B; Heyman M; Shoshan MC; Grandér D
Article: FEBS LETTERS. 2005;579(14):3090-3094

Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.

Berndtsson M; Konishi Y; Bonni A; Hägg M; Shoshan M; Linder S; Havelka AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(1):192-197

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.

Erdal H; Berndtsson M; Castro J; Brunk U; Shoshan MC; Linder S
Article: MOLECULAR CANCER THERAPEUTICS. 2004;3(4):489-497

Induction of endoplasmic reticulum stress by ellipticine plant alkaloids.

Hägg M; Berndtsson M; Mandic A; Zhou R; Shoshan MC; Linder S
Article: CANCER RESEARCH. 2004;64(5):1751-1756

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

Kramer G; Erdal H; Mertens HJMM; Nap M; Mauermann J; Steiner G; Marberger M; Bivén K; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264

Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line.

Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: ONCOGENE. 2003;22(29):4543-4556

Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax.

Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: APOPTOSIS. 2003;8(3):263-268

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera.

Bivén K; Erdal H; Hägg M; Ueno T; Zhou R; Lynch M; Rowley B; Wood J; Zhang C; Toi M; Shoshan MC; Linder S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9100-9106

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling.

Mandic A; Hansson J; Linder S; Shoshan MC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(46):44317-44326

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259

A novel high-through-put assay for screening of pro-apoptotic drugs.

Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
Article: JOURNAL OF NATURAL PRODUCTS. 2002;65(7):973-978

Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa.

Ploutno A; Shoshan M; Carmeli S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(9):3003-3013

Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis.

Mandic A; Viktorsson K; Strandberg L; Heiden T; Hansson J; Linder S; Shoshan MC
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(11):3684-3691

Cisplatin induces the proapoptotic conformation of Bak in a deltaMEKK1-dependent manner.

Mandic A; Viktorsson K; Molin M; Akusjärvi G; Eguchi H; Hayashi SI; Toi M; Hansson J; Linder S; Shoshan MC
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2001;173(1):56-64

Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid.

Panaretakis T; Shabalina IG; Grandér D; Shoshan MC; DePierre JW
Article: MELANOMA RESEARCH. 2001;11(1):11-19

The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis.

Mandic A; Viktorsson K; Heiden T; Hansson J; Shoshan MC
Article: APOPTOSIS. 2000;5(4):355-367

Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin.

Viktorsson K; Heiden T; Molin M; Akusjärvi G; Linder S; Shoshan MC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 1999;55(3):467-471

Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts.

Bergman AC; Alaiya AA; Wendler W; Binetruy B; Shoshan M; Sakaguchi K; Bergman T; Kronenwett U; Auer G; Appella E; Jörnvall H; Linder S
Article: CLINICAL & EXPERIMENTAL METASTASIS. 1999;17(8):649-654

ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation.

Seddighzadeh M; Zhou JN; Kronenwett U; Shoshan MC; Auer G; Sten-Linder M; Wiman B; Linder S
Article: JOURNAL OF VIROLOGY. 1998;72(10):8358-8361

Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments.

Molin M; Shoshan MC; Ohman-Forslund K; Linder S; Akusjärvi G
Article: MOLECULAR CANCER RESEARCH. 1998;9(7):565-573

Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop.

Ljungdahl S; Linder S; Franzén B; Binétruy B; Auer G; Shoshan MC
Article: MOLECULAR CARCINOGENESIS. 1998;21(4):234-243

Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.

Zhou JN; Ljungdahl S; Shoshan MC; Swedenborg J; Linder S
Article: FEBS LETTERS. 1997;417(1):17-20

Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen.

Bergman AC; Linder C; Sakaguchi K; Sten-Linder M; Alaiya AA; Franzén B; Shoshan MC; Bergman T; Wiman B; Auer G; Appella E; Jörnvall H; Linder S
Article: FEBS JOURNAL. 1997;249(3):648-656

Signal transduction in fibroblasts stably transformed by [Val12]Ras--the activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated.

Ljungdahl S; Linder S; Sollerbrant K; Svensson C; Shoshan MC
Article: GENES CHROMOSOMES & CANCER. 1997;20(1):82-89

Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines.

Zhou JN; Ljungdahl S; Röhme D; Levan G; Shoshan MC; Linder S
Article: ANTICANCER RESEARCH. 1997;17(4A):2347-2352

The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line.

Fokstuen T; Rabo YB; Zhou JN; Karlson J; Platz A; Shoshan MC; Hansson J; Linder S
Article: ANTI-CANCER DRUGS. 1997;8(1):62-66

Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B.

Ljungdahl S; Shoshan MC; Linder S
Article: ANTI-CANCER DRUGS. 1996;7(4):422-429

Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.

Karlson J; Borg-Karlson AK; Unelius R; Shoshan MC; Wilking N; Ringborg U; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;65(6):821-826

Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light.

Rabo YB; Shoshan MC; Linder S; Hansson J
Article: CELLULAR SIGNALLING. 1996;8(3):191-195

H-89 inhibits collagenase induction by phorbol ester through a mechanism that does not involve protein kinase A.

Shoshan MC; Ljungdahl S; Linder S
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Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(21):E5370-5370

A Shifty Target: Tumor-Initiating Cells and Their Metabolism.

Bezuidenhout N; Shoshan M
Review: GENES. 2018;9(1):E48-48

PGC1α: Friend or Foe in Cancer?

Mastropasqua F; Girolimetti G; Shoshan M
Review: CURRENT OPINION IN ONCOLOGY. 2017;29(1):48-54

On mitochondrial metabolism in tumor biology.

Shoshan M
Review: JOURNAL OF BIOENERGETICS AND BIOMEMBRANES. 2012;44(1):7-15

3-Bromopyruvate: targets and outcomes.

Shoshan MC
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):182

Induction of acute apoptosis by cisplatin is not associated with damage to nuclear DNA and is likely to be an "off-target effect"

Linder S; Olofsson M; Fayad W; Shoshan MC
Review: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 2008;4(3):273-280

Target specificity and off-target effects as determinants of cancer drug efficacy.

Shoshan MC; Linder S
Review: MINI-REVIEWS IN MEDICINAL CHEMISTRY. 2007;7(10):1035-1039

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM; Berndtsson M; Olofsson MH; Shoshan MC; Linder S
Letter: CANCER RESEARCH. 2007;67(6):2899

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor.

Linder S; Shoshan MC; Gupta RS
Review: EXPERT OPINION ON DRUG DISCOVERY. 2006;1(6):585-594

Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.

Shoshan MC; Havelka APPIAM; Neumann F; Linder S
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2006;4(12):143

Induction of lysosomal membrane permeabilization by compounds that induce p53-independent apoptosis

Linder S; Berndtsson M; Erdal H; Hagg-Olovsson M; Mandic-Havelka A; Shoshan MC; Beaujouin M; Liaudet-Coopman E
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S48-S49

Anti-rheumatic and HMGB1 blocking effects of oxaliplatin.

Ostberg T; Palmblad K; Wahamaa H; Shoshan M; Lotze M; Andersson U; Harris HE
Review: DRUG RESISTANCE UPDATES. 2005;8(4):199-204

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy.

Linder S; Shoshan MC
Review: CANCER LETTERS. 2004;214(1):1-9

Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.

Linder S; Havelka AM; Ueno T; Shoshan MC
Published paper: ELECTROPHORESIS. 2000;21(13):2737-2743

Inhibition of extracellular signal-regulated kinase 1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression.

Seddighzadeh M; Linder S; Shoshan MC; Auer G; Alaiya AA

Employments

Affiliated to Teaching/Tutoring, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, Karolinska Institutet, 2000

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