Maria Shoshan

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Articles

Article: BMC MEDICAL EDUCATION. 2021;21(1):519
Faculty perceptions of factors that indicate successful educational outcomes of medical students' research projects: a focus group study
Moller R; Wallberg A; Shoshan M
Article: MOLECULAR AND CLINICAL ONCOLOGY. 2021;14(2):42
PGC1α and VDAC1 expression in endometrial cancer
Wersall OC; Lofstedt L; Govorov I; Mints M; Gabrielson M; Shoshan M
Article: BMC MEDICAL EDUCATION. 2019;19(1):93
Does reality meet expectations? An analysis of medical students' expectations and perceived learning during mandatory research projects
Moller R; Shoshan M
Article: INTERNATIONAL JOURNAL OF MEDICAL EDUCATION. 2017;8:375-381
Medical students' perceptions of their learning environment during a mandatory research project.
Möller R; Ponzer S; Shoshan M
Article: BMC MEDICAL EDUCATION. 2017;17(1):51
Medical students' research productivity and career preferences; a 2-year prospective follow-up study
Moller R; Shoshan M
Article: LAKARTIDNINGEN. 2015;112:C43E
[The supervisor has a crucial role in the medical student's degree projects. Experiences from seven semesters at Karolinska Institutet].
Möller R; Shoshan M; Ponzer S
Article: MEDICAL EDUCATION ONLINE. 2015;20:28441
What is the reward? Medical students' learning and personal development during a research project course
Moeller R; Shoshan M; Heikkila K
Article: BIOANALYSIS. 2015;7(2):157-166
Metabolic profiling of epithelial ovarian cancer cell lines: evaluation of harvesting protocols for profiling using NMR spectroscopy
Engskog MKR; Bjorklund M; Haglof J; Arvidsson T; Shoshan M; Pettersson C
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2014;24(8):1389-1394
Metabolic Markers and HSP60 in Chemonaive Serous Solid Ovarian Cancer Versus Ascites
Hjerpe E; Brage SE; Stolt MF; Johansson H; Shoshan M; Avall-Lundqvist E
Article: ACTA OTO-LARYNGOLOGICA. 2014;134(5):448-454
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures
Dammeyer P; Hellberg V; Wallin I; Laurell G; Shoshan M; Ehrsson H; Arner ESJ; Kirkegaard M
Article: PLOS ONE. 2014;9(9):e107109
Expression of Mitochondrial Regulators PGC1α and TFAM as Putative Markers of Subtype and Chemoresistance in Epithelial Ovarian Carcinoma
Gabrielson M; Bjoerklund M; Carlson J; Shoshan M
Article: BMC CLINICAL PATHOLOGY. 2013;13(1):30
Metabolic markers GAPDH, PKM2, ATP5B and BEC-index in advanced serous ovarian cancer.
Hjerpe E; Egyhazi Brage S; Carlson J; Frostvik Stolt M; Schedvins K; Johansson H; Shoshan M; Avall-Lundqvist E
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2013;23(3):448-455
HSP60 Predicts Survival in Advanced Serous Ovarian Cancer
Hjerpe E; Egyhazi S; Carlson J; Stolt MF; Schedvins K; Johansson H; Shoshan M; Avall-Lundqvist E
Article: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2013;14(3):313-330
Potentiation of Anti-Cancer Treatment by Modulators of Energy Metabolism
Shoshan MC
Article: CANCER BIOLOGY & THERAPY. 2012;13(14):1454-1462
Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
Wintzell M; Lofstedt L; Johansson J; Pedersen AB; Fuxe J; Shoshan M
Article: BMC CANCER. 2012;12:359
Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites
Wintzell M; Hjerpe E; Lundqvist EA; Shoshan M
Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2011;68(6):1459-1467
Resveratrol induces SIRT1-and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment
Bjorklund M; Roos J; Gogvadze V; Shoshan M
Article: BLOOD CANCER JOURNAL. 2011;1(7):e31
Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells
Buentke E; Nordstrom A; Lin H; Bjorklund A-C; Laane E; Harada M; Lu L; Tegnebratt T; Stone-Elander S; Heyman M; Soderhall S; Porwit A; Ostenson C-G; Shoshan M; Tamm KP; Grander D
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(10):2450-2455
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model
Fayad W; Brnjic S; Berglind D; Blixt S; Shoshan MC; Berndtsson M; Olofsson MH; Linder S
Article: CARCINOGENESIS. 2009;30(9):1517-1527
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation
Kutuk O; Arisan ED; Tezil T; Shoshan MC; Basaga H
Article: MOLECULAR CANCER THERAPEUTICS. 2009;8(7):1916-1923
Ovarian carcinoma cells with low levels of β-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment
Hernlund E; Hjerpe E; Avail-Lundqvist E; Shoshan M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(12):1607-1613
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation
Hernlund E; Kutuk O; Basaga H; Linder S; Panaretakis T; Shoshan M
Article: JOURNAL OF CHEMICAL BIOLOGY. 2009;2(2):81-87
Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.
Berndtsson M; Hernlund E; Shoshan MC; Linder S
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(1):37-47
Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity
Hellberg V; Wallin I; Eriksson S; Hernlund E; Jerremalm E; Berndtsson M; Eksborg S; Arner ESJ; Shoshan M; Ehrsson H; Laurell G
Article: MOLECULAR CANCER THERAPEUTICS. 2009;8(1):160-170
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells
Pettersson HM; Pietras A; Persson MM; Karlsson J; Johansson L; Shoshan MC; Pahlman S
Article: BMC CHEMICAL BIOLOGY. 2008;8:2
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.
Olofsson MH; Havelka AM; Brnjic S; Shoshan MC; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):476-483
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
Hernlund E; Ihrlund LS; Khan O; Ates YO; Linder S; Panaretakis T; Shoshan MC
Article: MOLECULAR ONCOLOGY. 2008;2(1):94-101
3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs
Ihrlund LS; Hernlund E; Khan O; Shoshan MC
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(1):R1
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
Ostberg T; Wahamaa H; Palmblad K; Ito N; Stridh P; Shoshan M; Lotze MT; Harris HE; Andersson U
Article: CLINICAL CANCER RESEARCH. 2007;13(11):3198-3206
Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
Olofsson MH; Ueno T; Pan Y; Xu R; Cai F; van der Kuip H; Muerdter TE; Sonnenberg M; Aulitzk WE; Schwarz S; Andersson E; Shoshan MC; Havelka AM; Toi M; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;120(1):175-180
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
Berndtsson M; Hagg M; Panaretakis T; Havelka AM; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1581-1589
Two distinct steps of Bak regulation during apoptotic stress signaling: Different roles of MEKK1 and JNK1
Ihrlund LS; Hernlund E; Viktorsson K; Panaretakis T; Barna G; Sabapathy K; Linder S; Shoshan MC
Article: RADIATION ONCOLOGY. 2006;1:4
Is translational research compatible with preclinical publication strategies?
Linder S; Shoshan MC
Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(8):3821-3831
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cδ, and c-Jun NH₂-terminal kinase to induce apoptosis
Panaretakis T; Laane E; Pokrovskaja K; Björklund AC; Moustakas A; Zhivotovsky B; Heyman M; Shoshan MC; Grandér D
Article: FEBS LETTERS. 2005;579(14):3090-3094
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis
Berndtsson M; Konishi Y; Bonni A; Hägg M; Shoshan M; Linder S; Havelka AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(1):192-197
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
Erdal H; Berndtsson M; Castro J; Brunk U; Shoshan MC; Linder S
Article: MOLECULAR CANCER THERAPEUTICS. 2004;3(4):489-497
Induction of endoplasmic reticulum stress by ellipticine plant alkaloids
Hägg M; Berndtsson M; Mandic A; Zhou R; Shoshan MC; Linder S
Article: CANCER RESEARCH. 2004;64(5):1751-1756
Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
Kramer G; Erdal H; Mertens HJMM; Nap M; Mauermann J; Steiner G; Marberger M; Bivén K; Shoshan MC; Linder S
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line
Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: ONCOGENE. 2003;22(29):4543-4556
Interferon-α-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax
Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH. 2003;8(3):263-268
A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera
Bivén K; Erdal H; Hägg M; Ueno T; Zhou R; Lynch M; Rowley B; Wood J; Zhang C; Toi M; Shoshan MC; Linder S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9100-9106
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
Mandic A; Hansson J; Linder S; Shoshan MC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(46):44317-44326
Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin
Panaretakis T; Pokrovskaja K; Shoshan MC; Grandér D
Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259
A novel high-through-put assay for screening of pro-apoptotic drugs
Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
Article: JOURNAL OF NATURAL PRODUCTS. 2002;65(7):973-978
Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa.
Ploutno A; Shoshan M; Carmeli S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(9):3003-3013
Calpain-mediated bid cleavage and calpain-independent Bak modulation: Two separate pathways in cisplatin-induced apoptosis
Mandic A; Viktorsson K; Strandberg L; Heiden T; Hansson J; Linder S; Shoshan MC
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(11):3684-3691
Cisplatin induces the proapoptotic conformation of Bak in a ΔMEKK1-dependent manner
Mandic A; Viktorsson K; Molin M; Akusjärvi G; Eguchi H; Hayashi SI; Toi M; Hansson J; Linder S; Shoshan MC
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2001;173(1):56-64
Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid
Panaretakis T; Shabalina IG; Grandér D; Shoshan MC; DePierre JW
Article: MELANOMA RESEARCH. 2001;11(1):11-19
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis
Mandic A; Viktorsson K; Heiden T; Hansson J; Shoshan MC
Article: APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH. 2000;5(4):355-367
Increased apoptosis and increased clonogenic survival of 12V-H-ras transformed rat fibroblasts in response to cisplatin
Viktorsson K; Heiden T; Molin M; Akusjärvi G; Linder S; Shoshan MC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 1999;55(3):467-471
Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts
Bergman AC; Alaiya AA; Wendler W; Binetruy B; Shoshan M; Sakaguchi K; Bergman T; Kronenwett U; Auer G; Appella E; Jörnvall H; Linder S
Article: CLINICAL AND EXPERIMENTAL METASTASIS. 1999;17(8):649-654
ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation
Seddighzadeh M; Zhou JN; Kronenwett U; Shoshan MC; Auer G; Sten-Linder M; Wiman B; Linder S
Article: JOURNAL OF VIROLOGY. 1998;72(10):8358-8361
Two novel adenovirus vector systems permitting regulated protein expression in gene transfer experiments
Molin M; Shoshan MC; Öhman-Forslund K; Linder S; Akusjärvi G
Article: MOLECULAR CANCER RESEARCH. 1998;9(7):565-573
Down-regulation of tropomyosin-2 expression in c-Jun-transformed rat fibroblasts involves induction of a MEK1-dependent autocrine loop
Ljungdahl S; Linder S; Franzén B; Binétruy B; Auer G; Shoshan MC
Article: MOLECULAR CARCINOGENESIS. 1998;21(4):234-243
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway
Zhou JN; Ljungdahl S; Shoshan MC; Swedenborg J; Linder S
Article: FEBS LETTERS. 1997;417(1):17-20
Increased expression of alpha-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen
Bergman AC; Linder C; Sakaguchi K; StenLinder M; Alaiya AA; Franzen B; Shoshan MC; Bergman T; Wiman B; Auer G; Appella E; Jornvall H; Linder S
Article: THE FEBS JOURNAL. 1997;249(3):648-656
Signal transduction in fibroblasts stably transformed by [Val12]Ras - The activities of extracellular-signal-regulated kinase and Jun N-terminal kinase are only moderately increased, and the activity of the delta-inhibitor of c-Jun is not alleviated
Ljungdahl S; Linder S; Sollerbrant K; Svensson C; Shoshan MC
Article: GENES CHROMOSOMES AND CANCER. 1997;20(1):82-89
Codeletion of the JUN proto-oncogene and the CDKN2A tumor-suppressor gene in HRAS-transformed rat embryo fibroblast cell lines
Zhou JN; Ljungdahl S; Rohme D; Levan G; Shoshan MC; Linder S
Article: ANTICANCER RESEARCH. 1997;17(4A):2347-2352
The Ras farnesylation inhibitor BZA-5B increases the resistance to cisplatin in a human melanoma cell line
Fokstuen T; Rabo YB; Zhou JN; Karlson J; Platz A; Shoshan MC; Hansson J; Linder S
Article: ANTI-CANCER DRUGS. 1997;8(1):62-66
Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-kappa B
Ljungdahl S; Shoshan NC; Linder S
Article: ANTI-CANCER DRUGS. 1996;7(4):422-429
Inhibition of tumor cell growth by monoterpenes in vitro: Evidence of a Ras-independent mechanism of action
Karlson J; BorgKarlson AK; Unelius R; Shoshan MC; Wilking N; Ringborg U; Linder S
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;65(6):821-826
Different mechanisms are responsible for c-jun mRNA induction by cisplatin and ultraviolet light
Rabo YB; Shoshan MC; Linder S; Hansson J
Article: CELLULAR SIGNALLING. 1996;8(3):191-195
H-89 inhibits collagenase induction by phorbol ester through a mechanism that does not involve protein kinase A
Shoshan MC; Ljungdahl S; Linder S
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Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(21):E5370-5370
A Shifty Target: Tumor-Initiating Cells and Their Metabolism
Bezuidenhout N; Shoshan M
Review: GENES. 2018;9(1):E48-48
PGC1α: Friend or Foe in Cancer?
Mastropasqua F; Girolimetti G; Shoshan M
Review: CURRENT OPINION IN ONCOLOGY. 2017;29(1):48-54
On mitochondrial metabolism in tumor biology
Shoshan M
Review: JOURNAL OF BIOENERGETICS AND BIOMEMBRANES. 2012;44(1):7-15
3-bromopyruvate: Targets and outcomes
Shoshan MC
Meeting abstract: EJC SUPPLEMENTS. 2010;8(7):182
Induction of acute apoptosis by cisplatin is not associated with damage to nuclear DNA and is likely to be an "off-target effect"
Linder S; Olofsson M; Fayad W; Shoshan MC
Review: EXPERT OPINION ON DRUG METABOLISM AND TOXICOLOGY. 2008;4(3):273-280
Target specificity and off-target effects as determinants of cancer drug efficacy
Shoshan MC; Linder S
Review: MINI-REVIEWS IN MEDICINAL CHEMISTRY. 2007;7(10):1035-1039
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: Is acute apoptosis an "off-target" effect?
Havelka AM; Berndtsson M; Olofsson MH; Shoshan MC; Linder S
Letter: CANCER RESEARCH. 2007;67(6):2899
Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor
Linder S; Shoshan MC; Gupta RS
Review: EXPERT OPINION ON DRUG DISCOVERY. 2006;1(6):585-594
Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses
Shoshan MC; Havelka AM; Neumann F; Linder S
Meeting abstract: EJC SUPPLEMENTS. 2006;4(12):143
Induction of lysosomal membrane permeabilization by compounds that induce p53-independent apoptosis
Linder S; Berndtsson M; Erdal H; Hagg-Olovsson M; Mandic-Havelka A; Shoshan MC; Beaujouin M; Liaudet-Coopman E
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S48-S49
Anti-rheumatic and HMGB1 blocking effects of oxaliplatin.
Ostberg T; Palmblad K; Wahamaa H; Shoshan M; Lotze M; Andersson U; Harris HE
Review: DRUG RESISTANCE UPDATES. 2005;8(4):199-204
Lysosomes and endoplasmic reticulum: Targets for improved, selective anticancer therapy
Linder S; Shoshan MC
Review: CANCER LETTERS. 2004;214(1):1-9
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker
Linder S; Havelka AM; Ueno T; Shoshan MC
Published conference paper: ELECTROPHORESIS. 2000;21(13):2737-2743
Inhibition of extracellular signal-regulated kinase1/2 activity of the breast cancer cell line MDA-MB-231 leads to major alterations in the pattern of protein expression
Seddighzadeh M; Linder S; Shoshan MC; Auer G; Alaiya AA

Employments

Affiliated to Teaching/Tutoring, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, Karolinska Institutet, 2000

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