Miklós Tóth

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Articles

Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(20):3732-3736
Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [¹⁸F]FE-PE2I-OH for Translational Dopamine Transporter Imaging
Schou M; Amini N; Takano A; Arakawa R; Dahl K; Toth M; Svedberg M; Varrone A; Halldin C
Article: ACS CHEMICAL NEUROSCIENCE. 2021;12(24):4580-4586
PET Imaging of VMAT2 with the Novel Radioligand [¹⁸F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [¹¹C]DTBZ and [¹⁸F]FE-DTBZ
Nag S; Jahan M; Toth M; Nakao R; Varrone A; Halldin C
Article: BIOCONJUGATE CHEMISTRY. 2021;32(3):497-501
Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma
Kondrashov M; Svensson SPS; Strom P; Westermark A; Jacobson-Ingemyr H; Takano A; Tari L; Toth M; Cai M; Hruby VJ; Schou M
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(15):8608-8633
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu L; Prime ME; Lee MR; Khetarpal V; Brown CJ; Johnson PD; Miranda-Azpiazu P; Chen X; Clark-Frew D; Coe S; Davis R; Dickie A; Ebneth A; Esposito S; Gadouleau E; Gai X; Galan S; Green S; Greenaway C; Giles P; Halldin C; Hayes S; Herbst T; Herrmann F; Hessmann M; Jia Z; Kiselyov A; Kotey A; Krulle T; Mangette JE; Marston RW; Menta S; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Svedberg M; Takano A; Taylor M; Thomas W; Toth M; Vaidya D; Vanras K; Weddell D; Wigginton I; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(12):1756-1761
Synthesis and Preclinical Evaluation of 6-[¹⁸F]Fluorine-α- methyl-L-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake
Krasikova R; Kondrashov M; Avagliano C; Petukhov M; Vazquez-Romero A; Revunov E; Johnstrom P; Tari L; Toth M; Haggkvist J; Erhardt S; Cervenka S; Schou M
Article: TALANTA. 2020;208:120449
New approach in radiometabolite analysis of positron emission tomography (PET) radioligands; lead-shielded microextraction by packed sorbent as a tool for in vivo radiometabolite analysis of [¹¹C]SMW139 in rat plasma
Moein MM; Toth M; Tari L; Varrone A; Abdel-Rehim M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2019;60(12):1818-1824
Performance Evaluation of a High-Resolution Nonhuman Primate PET/CT System
Sarnyai Z; Nagy K; Patay G; Molnar M; Rosenqvist G; Toth M; Takano A; Gulyas B; Major P; Halldin C; Varrone A
Article: NATURE MEDICINE. 2019;25(7):1131-1142
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease
Zeitler B; Froelich S; Marlen K; Shivak DA; Yu Q; Li D; Pearl JR; Miller JC; Zhang L; Paschon DE; Hinkley SJ; Ankoudinova I; Lam S; Guschin D; Kopan L; Cherone JM; Nguyen H-OB; Qiao G; Ataei Y; Mendel MC; Amora R; Surosky R; Laganiere J; Vu BJ; Narayanan A; Sedaghat Y; Tillack K; Thiede C; Gaertner A; Kwak S; Bard J; Mrzljak L; Park L; Heikkinen T; Lehtimaki KK; Svedberg MM; Haggkvist J; Tari L; Toth M; Varrone A; Halldin C; Kudwa AE; Ramboz S; Day M; Kondapalli J; Surmeier DJ; Urnov FD; Gregory PD; Rebar EJ; Munoz-Sanjuan I; Zhang HS
Article: EUROPEAN PSYCHIATRY. 2018;50:21-27
The MINDVIEW project: First results
Benlloch JM; Gonzalez AJ; Pani R; Preziosi E; Jackson C; Murphy J; Barbera J; Correcher C; Aussenhofer S; Gareis D; Visvikis D; Bert J; Langstrom B; Farde L; Toth M; Haggkvist J; Caixeta FV; Kullander K; Somlai-Schweiger I; Schwaiger M
Article: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. 2017;1(1):169-180
Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [18F]FDG-μPET Study.
Venzi M; Tóth M; Häggkvist J; Bogstedt A; Rachalski A; Mattsson A; Frumento P; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2017;58(4):617-622
Longitudinal Small-Animal PET Imaging of the zQ175 Mouse Model of Huntington Disease Shows In Vivo Changes of Molecular Targets in the Striatum and Cerebral Cortex
Haggkvist J; Toth M; Tari L; Varnas K; Svedberg M; Forsberg A; Nag S; Dominguez C; Munoz-Sanjuan I; Bard J; Wityak J; Varrone A; Halldin C; Mrzljak L
Article: CURRENT RADIOPHARMACEUTICALS. 2017;10(1):35-40
Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.
Igawa H; Stepanov V; Tari L; Okuda S; Yamamoto S; Kasai S; Nagisa Y; Haggkvist J; Svedberg M; Toth M; Takano A; Halldin C
Article: NEURON. 2016;92(6):1220-1237
Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models
Beaumont V; Zhong S; Lin H; Xu W; Bradaia A; Steidl E; Gleyzes M; Wadel K; Buisson B; Padovan-Neto FE; Chakroborty S; Ward KM; Harms JF; Beltran J; Kwan M; Ghavami A; Haggkvist J; Toth M; Halldin C; Varrone A; Schaab C; Dybowski JN; Elschenbroich S; Lehtimaki K; Heikkinen T; Park L; Rosinski J; Mrzljak L; Lavery D; West AR; Schmidt CJ; Zaleska MM; Munoz-Sanjuan I
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(8):pyw023
Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [¹⁸F]Lu AF10628
Varnas K; Finnema SJ; Stepanov V; Takano A; Toth M; Svedberg M; Nielsen SM; Khanzhin NA; Juhl K; Bang-Andersen B; Halldin C; Farde L
Article: BRAIN STRUCTURE AND FUNCTION. 2016;221(3):1279-1290
Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking
Toth M; Little P; Arnberg F; Haggkvist J; Mulder J; Halldin C; Gulyas B; Holmin S
Article: MOLECULAR IMAGING AND BIOLOGY. 2015;17(4):445-449
Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [¹¹C]T-773
Toth M; Haggkvist J; Stepanov V; Takano A; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Gulyas B; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(7):1119-1132
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
Rodriguez-Vieitez E; Ni R; Gulyas B; Toth M; Haeggkvist J; Halldin C; Voytenko L; Marutle A; Nordberg A
Article: PLOS ONE. 2015;10(5):e0125917
Positron Emission Tomography studies with [¹¹C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation
Toth M; Doorduin J; Haggkvist J; Varrone A; Amini N; Halldin C; Gulyas B
Article: EJNMMI RESEARCH. 2014;4(1):64
ABC transporter-dependent brain uptake of the 5-HT_1B receptor radioligand [¹¹C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig
Toth M; Haggkvist J; Varrone A; Finnema SJ; Doorduin J; Tokunaga M; Higuchi M; Gulyas B; Halldin C
Article: SCIENCE TRANSLATIONAL MEDICINE. 2014;6(263):263ra158
The gut microbiota influences blood-brain barrier permeability in mice
Braniste V; Al-Asmakh M; Kowal C; Anuar F; Abbaspour A; Toth M; Korecka A; Bakocevic N; Ng LG; Kundu P; Gulyas B; Halldin C; Hultenby K; Nilsson H; Hebert H; Volpe BT; Diamond B; Pettersson S
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2013;21(21):6634-6641
Development of a novel fluorine-18 labeled deuterated fluororasagiline ([¹⁸F]fluororasagiline-D₂) radioligand for PET studies of monoamino oxidase B (MAO-B)
Nag S; Lehmann L; Kettschau G; Toth M; Heinrich T; Thiele A; Varrone A; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2013;54(10):1825-1832
Performance Evaluation of the Small-Animal nanoScan PET/MRI System
Nagy K; Toth M; Major P; Patay G; Egri G; Haggkvist J; Varrone A; Farde L; Halldin C; Gulyas B
Article: SYNAPSE. 2013;67(5):258-264
Brain uptake and distribution of the dopamine D3/D2 receptor partial agonist [11C]cariprazine: An in vivo positron emission tomography study in nonhuman primates
Toth M; Varrone A; Steiger C; Laszlovszky I; Horvath A; Kiss B; Gyertyan I; Adham N; Halldin C; Gulyas B
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(2):228-237
Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT
Schain M; Toth M; Cselenyi Z; Arakawa R; Halldin C; Farde L; Varrone A
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(11):1794-1801
Preclinical Characterization of a Novel Class of ¹⁸F-Labeled PET Tracers for Amyloid-β
Brockschnieder D; Schmitt-Willich H; Heinrich T; Varrone A; Gulyas B; Toth M; Andersson J; Boemer U; Krause S; Friebe M; Dinkelborg L; Halldin C; Dyrks T
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2012;320(1-2):110-117
Evolution of microglial activation in ischaemic core and pen-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [¹¹C]vinpocetine
Gulyas B; Toth M; Schain M; Airaksinen A; Vas A; Kostulas K; Lindstrom P; Hillert J; Halldin C
Article: SYNAPSE. 2012;66(4):323-330
In vivo evaluation in cynomolgus monkey brain and metabolism of [18F]fluorodeprenyl: A new MAO-B pet radioligand
Nag S; Varrone A; Toth M; Thiele A; Kettschau G; Heinrich T; Lehmann L; Halldin C
Article: NEUROIMAGE. 2012;60(1):800-807
Quantification of serotonin transporter availability with [¹¹C]MADAM - A comparison between the ECAT HRRT and HR systems
Schain M; Toth M; Cselenyi Z; Stenkrona P; Halldin C; Farde L; Varrone A
Article: CURRENT RADIOPHARMACEUTICALS. 2012;5(1):19-28
Visualising neuroinflammation in post-stroke patients: a comparative PET study with the TSPO molecular imaging biomarkers [11C]PK11195 and [11C]vinpocetine.
Gulyas B; Toth M; Vas A; Shchukin E; Kostulas K; Hillert J; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(8):1313-1321
Imaging of the Striatal and Extrastriatal Dopamine Transporter with ¹⁸F-LBT-999: Quantification, Biodistribution, and Radiation Dosimetry in Nonhuman Primates
Varrone A; Stepanov V; Nakao R; Toth M; Gulyas B; Emond P; Deloye JB; Vercouillie J; Stabin MG; Jonsson C; Guilloteau D; Halldin C
Article: NEUROIMAGE. 2011;56(3):1111-1121
Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [¹¹C]vinpocetine
Gulyas B; Vas A; Toth M; Takano A; Varrone A; Cselenyi Z; Schain M; Mattsson P; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(1):132-139
Kinetic Analysis and Quantification of the Dopamine Transporter in the Nonhuman Primate Brain with ¹¹C-PE2I and ¹⁸F-FE-PE2I
Varrone A; Toth M; Steiger C; Takano A; Guilloteau D; Ichise M; Gulyas B; Halldin C
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Thesis / dissertation: 2015
Methodological developments in small animal PET neuroimaging
Tóth, Miklós

Employments

Research Specialist, Department of Clinical Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2015

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