Mikael Björnstedt

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About me

Mikael Björnstedt is Professor of Pathology at Karolinska Institutet since
2010. His research is about the cellular mechanisms behind selenium's
cytotoxic and cancer-preventive effects.

Articles

Article: CANCER RESEARCH. 2023;83(10):1628-1645

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner.

He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernández-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Björnstedt M; Löhr MJ; Karlsson MCI; Heuchel R; Sarhan D
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(3):2485

Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses.

Kamp JC; Kappe NN; Moro CF; Fuge J; Kuehnel MP; Wrenger S; Welte T; Hoek BV; Jonigk DD; Khedoe PPSJ; Strnad P; Björnstedt M; Stolk J; Janciauskiene S; Nemeth A
Article: BIOMEDICINES. 2023;11(2):295

Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites.

Breuer O; Brodin O; Razaghi A; Brodin D; Gammelgaard B; Björnstedt M
Article: ANTIOXIDANTS. 2023;12(1):167

Exploration of Patient-Derived Pancreatic Ductal Adenocarcinoma Ex Vivo Tissue for Treatment Response.

Szekerczés T; Selvam AK; Moro CF; Elduayen SP; Dillner J; Björnstedt M; Ghaderi M
Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2022;56(1):166-173

Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients.

Razaghi A; Szakos A; Al-Shakarji R; Björnstedt M; Szekely L
Article: DIAGNOSTICS. 2022;12(11):2789

Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers.

Razaghi A; Szakos A; Alouda M; Bozóky B; Björnstedt M; Szekely L
Article: JOURNAL OF MEDICAL IMAGING. 2022;9(3):031503

Can laboratory x-ray virtual histology provide intraoperative 3D tumor resection margin assessment?

Twengström W; Moro CF; Romell J; Larsson JC; Sparrelid E; Björnstedt M; Hertz HM
Article: FRONTIERS IN ONCOLOGY. 2022;12:965182

Drug-induced tumor-specific cytotoxicity in a whole tissue ex vivo model of human pancreatic ductal adenocarcinoma.

Moro CF; Selvam AK; Ghaderi M; Pimenoff VN; Gerling M; Bozóky B; Elduayen SP; Dillner J; Björnstedt M
Article: FRONTIERS IN ONCOLOGY. 2022;12:906134

Soluble PD-L1 Expression After Intravenous Treatment of Cancer Patients With Selenite in Phase I Clinical Trial.

Razaghi A; Mansouri L; Brodin O; Björnstedt M; Lundahl J
Article: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2022;662:25-62

Methods for accurate and reproducible studies of pharmacological effects of selenium in cancer.

Selvam AK; Szekerczés T; Björnstedt S; Razaghi A; Björnstedt M
Article: NEOPLASIA. 2021;23(10):1059-1068

Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy.

Razaghi A; Brusselaers N; Björnstedt M; Durand-Dubief M
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2021;110:433-435

Severe features during outbreak but low mortality observed immediately before and after a March-May 2020 COVID-19 outbreak in Stockholm, Sweden.

Pimenoff VN; Björnstedt M; Dillner J
Article: ANTIOXIDANTS. 2021;10(7):1094

A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine.

Selvam AK; Jawad R; Gramignoli R; Achour A; Salter H; Björnstedt M
Article: CLINICAL INFECTIOUS DISEASES. 2021;72(11):e890-e892

Estimating Total Excess Mortality During a Coronavirus Disease 2019 Outbreak in Stockholm, Sweden.

Pimenoff VN; Elfström M; Baussano I; Björnstedt M; Dillner J
Article: HELIYON. 2021;7(6):e07254

Selenofolate inhibits the proliferation of IGROV1 cancer cells independently from folate receptor alpha.

Razaghi A; Zickler AM; Spallholz J; Kirsch G; Björnstedt M
Article: HELIYON. 2021;7(5):e07134

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death.

Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sönnerborg A; Cao Y; Björnstedt M; Szakos A
Article: PATHOLOGY & ONCOLOGY RESEARCH. 2020;26(4):2401-2407

Mid-Infrared Imaging Is Able to Characterize and Separate Cancer Cell Lines.

Kontsek E; Pesti A; Björnstedt M; Üveges T; Szabó E; Garay T; Gordon P; Gergely S; Kiss A
Article: PATHOLOGY & ONCOLOGY RESEARCH. 2020;26(4):2669-2681

The Effect of Methylselenocysteine and Sodium Selenite Treatment on microRNA Expression in Liver Cancer Cell Lines.

Lendvai G; Szekerczés T; Kontsek E; Selvam A; Szakos A; Schaff Z; Björnstedt M; Kiss A
Article: SCIENTIFIC REPORTS. 2020;10(1):9070

Genome-wide transcriptome profiling of ex-vivo precision-cut slices from human pancreatic ductal adenocarcinoma.

Ghaderi M; Fernández Moro C; Pouso Elduayen S; Hultin E; Verbeke CS; Björnstedt M; Dillner J
Article: NUTRIENTS. 2020;12(4):E1067-1067

Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.

Brodin O; Hackler J; Misra S; Wendt S; Sun Q; Laaf E; Stoppe C; Björnstedt M; Schomburg L
Article: ANTIOXIDANTS. 2020;9(2):E139-139

A Novel Assay Method to Determine the β-Elimination of Se-Methylselenocysteine to Monomethylselenol by Kynurenine Aminotransferase 1.

Selvam AK; Björnstedt M
Article: ANTIOXIDANTS. 2019;8(5):E130-130

The Cell Culture Medium Affects Growth, Phenotype Expression and the Response to Selenium Cytotoxicity in A549 and HepG2 Cells.

Arodin Selenius L; Wallenberg Lundgren M; Jawad R; Danielsson O; Björnstedt M
Article: SCIENTIFIC REPORTS. 2019;9(1):2133

Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma.

Misra S; Moro CF; Del Chiaro M; Pouso S; Sebestyén A; Löhr M; Björnstedt M; Verbeke CS
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures.

Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Björnstedt M; Giebel B; Nordin JZ; Jones JC; El Andaloussi S; Görgens A
Article: WORLD JOURNAL OF HEPATOLOGY. 2017;9(34):1261-1269

Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.

Jawad R; D'souza M; Selenius LA; Lundgren MW; Danielsson O; Nowak G; Björnstedt M; Isaksson B
Article: ONCOTARGET. 2016;7(46):74686-74700

Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells.

Misra S; Selvam AK; Wallenberg M; Ambati A; Matolcsy A; Magalhaes I; Lauter G; Björnstedt M
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2016;408(9):2293-2301

Quantification of low molecular weight selenium metabolites in human plasma after treatment with selenite in pharmacological doses by LC-ICP-MS.

Flouda K; Dersch JM; Gabel-Jensen C; Stürup S; Misra S; Björnstedt M; Gammelgaard B
Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2016;70(1):91-96

Relatively high mortality risk in elderly Swedish subjects with low selenium status.

Alehagen U; Johansson P; Björnstedt M; Rosén A; Post C; Aaseth J
Article: PLOS ONE. 2016;11(11):e0166067

Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification.

Fernández Moro C; Fernandez-Woodbridge A; Alistair D'souza M; Zhang Q; Bozoky B; Kandaswamy SV; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Björnstedt M; Löhr JM; Isaksson B; Verbeke C; Bozóky B
Article: NUTRIENTS. 2015;7(6):4978-4994

Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study.

Brodin O; Eksborg S; Wallenberg M; Asker-Hagelberg C; Larsen EH; Mohlkert D; Lenneby-Helleday C; Jacobsson H; Linder S; Misra S; Björnstedt M
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2014;18(4):671-684

Selenium induces a multi-targeted cell death process in addition to ROS formation.

Wallenberg M; Misra S; Wasik AM; Marzano C; Björnstedt M; Gandin V; Fernandes AP
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;39(4):787-797

Alteration of thioredoxin and glutaredoxin in the progression of Alzheimer's disease.

Arodin L; Lamparter H; Karlsson H; Nennesmo I; Björnstedt M; Schröder J; Fernandes AP
Article: DISEASES OF THE ESOPHAGUS. 2013;26(8):853-858

Nitric oxide and endothelin-1 release after one-lung ventilation during thoracoabdominal esophagectomy.

Lund M; Ny L; Malmström RE; Lundberg JO; Öst Å; Björnstedt M; Lundell L; Tsai JA
Article: JOURNAL OF INHERITED METABOLIC DISEASE. 2013;36(6):1063-1071

High risk of primary liver cancer in a cohort of 179 patients with Acute Hepatic Porphyria.

Sardh E; Wahlin S; Björnstedt M; Harper P; Andersson DEH
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;167(5):1860-1866

Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.

Alehagen U; Johansson P; Björnstedt M; Rosén A; Dahlström U
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(7):1593-1605

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.

Selenius M; Hedman M; Brodin D; Gandin V; Rigobello MP; Flygare J; Marzano C; Bindoli A; Brodin O; Björnstedt M; Fernandes AP
Article: DIGESTIVE DISEASES AND SCIENCES. 2012;57(5):1163-1170

The value of thioredoxin family proteins and proliferation markers in dysplastic and malignant gallbladders in patients with primary sclerosing cholangitis.

Said K; Glaumann H; Björnstedt M; Bergquist A
Article: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY. 2012;21(1):6-12

Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma.

Larsson P; Arvidsson D; Björnstedt M; Isaksson B; Jersenius U; Motarjemi H; Jacobsson H
Article: PLOS ONE. 2012;7(11):e50727

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems.

Fernandes AP; Wallenberg M; Gandin V; Misra S; Tisato F; Marzano C; Rigobello MP; Kumar S; Björnstedt M
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554

Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells.

Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Björkström NK; Björnstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: JOURNAL OF SURGICAL RESEARCH. 2011;169(2):214-219

Continuous assessment of intrahepatic metabolism by microdialysis during and after portal triad clamping.

Isaksson B; D'souza MA; Jersenius U; Ungerstedt J; Lundell L; Permert J; Björnstedt M; Nowak G
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(11):1620-1629

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications.

Rigobello MP; Folda A; Citta A; Scutari G; Gandin V; Fernandes AP; Rundlöf A-K; Marzano C; Björnstedt M; Bindoli A
Article: EPMA JOURNAL. 2010;1(3):389-395

Selenium in the prevention of human cancers.

Björnstedt M; Fernandes AP
Article: BIOCHEMICAL JOURNAL. 2010;429(1):85-93

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.

Wallenberg M; Olm E; Hebert C; Björnstedt M; Fernandes AP
Article: BIOCHEMICAL PHARMACOLOGY. 2010;79(2):90-101

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.

Gandin V; Fernandes AP; Rigobello MP; Dani B; Sorrentino F; Tisato F; Björnstedt M; Bindoli A; Sturaro A; Rella R; Marzano C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;47(6):710-721

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift.

Rigobello MP; Gandin V; Folda A; Rundlöf A-K; Fernandes AP; Bindoli A; Marzano C; Björnstedt M
Article: CANCER LETTERS. 2009;282(1):116-123

Selenite is a potent cytotoxic agent for human primary AML cells.

Olm E; Jönsson-Videsäter K; Ribera-Cortada I; Fernandes AP; Eriksson LC; Lehmann S; Rundlöf A-K; Paul C; Björnstedt M
Article: HISTOPATHOLOGY. 2009;55(3):313-320

Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.

Fernandes AP; Capitanio A; Selenius M; Brodin O; Rundlöf A-K; Björnstedt M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(27):11400-11405

Extracellular thiol-assisted selenium uptake dependent on the x(c)- cystine transporter explains the cancer-specific cytotoxicity of selenite.

Olm E; Fernandes AP; Hebert C; Rundlöf A-K; Larsen EH; Danielsson O; Björnstedt M
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2009;28(1):92

Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure.

Nilsonne G; Olm E; Szulkin A; Mundt F; Stein A; Kocic B; Rundlöf A-K; Fernandes AP; Björnstedt M; Dobra K
Article: FEBS JOURNAL. 2009;276(2):532-540

Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.

Gandin V; Nyström C; Rundlöf A-K; Jönsson-Videsäter K; Schönlau F; Hörkkö J; Björnstedt M; Fernandes AP
Article: BIOCHEMICAL PHARMACOLOGY. 2008;75(11):2092-2099

Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system.

Selenius M; Fernandes AP; Brodin O; Björnstedt M; Rundlöf A-K
Article: GASTROENTEROLOGY. 2007;132(4):1504-1514

Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis.

Karrar A; Broomé U; Södergren T; Jaksch M; Bergquist A; Björnstedt M; Sumitran-Holgersson S
Article: DIFFERENTIATION. 2007;75(2):123-132

Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells.

Rundlöf A-K; Fernandes AP; Selenius M; Babic M; Shariatgorji M; Nilsonne G; Ilag LL; Dobra K; Björnstedt M
Article: JOURNAL OF HEPATOLOGY. 2007;46(1):174-179

Curative bone marrow transplantation in erythropoietic protoporphyria after reversal of severe cholestasis.

Wahlin S; Aschan J; Björnstedt M; Broomé U; Harper P
Article: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. 2007;20(1):17-24

Increased expression of specific thioredoxin family proteins; a pilot immunohistochemical study on human hepatocellular carcinoma.

Cunnea P; Fernandes AP; Capitanio A; Eken S; Spyrou G; Björnstedt M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2006;41(6):874-885

Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress.

Nilsonne G; Sun X; Nyström C; Rundlöf A-K; Potamitou Fernandes A; Björnstedt M; Dobra K
Article: TRANSPLANT INTERNATIONAL. 2005;18(8):992-1000

Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation.

Rissler P; Söderdahl G; Nordman T; Xia L; Torndal U-B; Björnstedt M; Ericzon B-G; Olsson JM; Eriksson LC
Article: BIOCHEMICAL PHARMACOLOGY. 2005;69(12):1765-1772

The role of thioredoxin reductase activity in selenium-induced cytotoxicity.

Madeja Z; Sroka J; Nyström C; Björkhem-Bergman L; Nordman T; Damdimopoulos A; Nalvarte I; Eriksson LC; Spyrou G; Olsson JM; Björnstedt M
Article: BIOCHEMISTRY AND CELL BIOLOGY. 2005;83(2):196-211

Differential effects of selenite and selenate on human melanocytes, keratinocytes, and melanoma cells.

Bandura L; Drukala J; Wolnicka-Glubisz A; Björnstedt M; Korohoda W
Article: CARCINOGENESIS. 2005;26(1):125-131

Selenium prevents tumor development in a rat model for chemical carcinogenesis.

Björkhem-Bergman L; Torndal U-B; Eken S; Nyström C; Capitanio A; Larsen EH; Björnstedt M; Eriksson LC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517

Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.

Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
Article: PEPTIDES. 2004;25(11):1849-1855

Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide.

Björkhem-Bergman L; Jönsson-Videsäter K; Paul C; Björnstedt M; Andersson M
Article: BIOCHEMICAL PHARMACOLOGY. 2004;67(3):513-522

Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system.

Jönsson-Videsäter K; Björkhem-Bergman L; Hossain A; Söderberg A; Eriksson LC; Paul C; Rosén A; Björnstedt M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.

Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
Article: BIOCHEMICAL PHARMACOLOGY. 2002;63(10):1875-1884

Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase.

Björkhem-Bergman L; Jönsson K; Eriksson LC; Olsson JM; Lehmann S; Paul C; Björnstedt M
Article: JOURNAL OF HEPATOLOGY. 2001;35(2):259-264

Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules.

Björkhem L; Teclebrhan H; Kesen E; Olsson JM; Eriksson LC; Björnstedt M
Article: FEBS JOURNAL. 2001;268(5):1486-1490

Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway.

Xia L; Björnstedt M; Nordman T; Eriksson LC; Olsson JM
Article: DIFFERENTIATION. 2000;66(4-5):181-188

Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells.

Sun X; Dobra K; Björnstedt M; Hjerpe A
Article: FEBS LETTERS. 1999;448(1):190-192

Ubiquinone is reduced by lipoamide dehydrogenase and this reaction is potently stimulated by zinc.

Olsson JM; Xia L; Eriksson LC; Björnstedt M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 1998;24(7-8):1176-1186

Measurements of plasma glutaredoxin and thioredoxin in healthy volunteers and during open-heart surgery.

Nakamura H; Vaage J; Valen G; Padilla CA; Björnstedt M; Holmgren A
Article: MOLECULAR IMMUNOLOGY. 1997;34(10):709-717

Human IgG is substrate for the thioredoxin system: differential cleavage pattern of interchain disulfide bridges in IgG subclasses.

Magnusson CG; Björnstedt M; Holmgren A
Article: CANCER RESEARCH. 1996;56(19):4407-4412

Selenite and selenate inhibit human lymphocyte growth via different mechanisms.

Spyrou G; Björnstedt M; Skog S; Holmgren A
Article: BIOCHEMISTRY. 1996;35(26):8511-8516

Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.

Björnstedt M; Odlander B; Kuprin S; Claesson HE; Holmgren A
Article: FEBS LETTERS. 1995;368(1):59-63

AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione.

Spyrou G; Björnstedt M; Kumar S; Holmgren A
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Review: EUROPEAN JOURNAL OF CANCER. 2021;155:256-267

Selenium stimulates the antitumour immunity: Insights to future research.

Razaghi A; Poorebrahim M; Sarhan D; Björnstedt M
Review: NUTRIENTS. 2015;7(5):3536-3556

Redox-active selenium compounds--from toxicity and cell death to cancer treatment.

Misra S; Boylan M; Selvam A; Spallholz JE; Björnstedt M
Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014;114(5):377-386

Selenium cytotoxicity in cancer.

Wallenberg M; Misra S; Björnstedt M
Review: ANTIOXIDANTS & REDOX SIGNALING. 2010;12(7):867-880

Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer.

Selenius M; Rundlöf A-K; Olm E; Fernandes AP; Björnstedt M
Review: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(2):331-348

Molecular and structural basis for redox regulation of beta-actin.

Lassing I; Schmitzberger F; Björnstedt M; Holmgren A; Nordlund P; Schutt CE; Lindberg U
Meeting abstract: LUNG CANCER. 2006;54:S52

Targeting thioredoxin reductase -: a possible new treatment for malignant mesothelioma

Nilsonne G; Stein A; Rundloef A-K; Fernandes AP; Bjoernstedt M; Hjerpe A; Dobra K
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2004;378:131-138

Extramitochondrial reduction of ubiquinone by flavoenzymes.

Björnstedt M; Nordman T; Olsson JM
Published conference paper: BIOFACTORS. 2003;18(1-4):45-50

Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.

Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2002;64(1):159

Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity -: Effects on thioredoxin reductase and glutathione reductase (vol 63, pg 1875, 2002)

Björkhem-Bergman L; Jönsson K; Eriksson LC; Olsson JM; Lehmann S; Paul C; Björnstedt M
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):349-354

Alterations of glutathione levels and related enzyme activities in non-tumourous rat liver cells after long-term treatment with adriamycin and/or cyclosporine A

Carlson T; Björnstedt M; Rissler P; Bai L; Eriksson LC; Olsson JM
Review: BIOMEDICAL AND ENVIRONMENTAL SCIENCES. 1997;10(2-3):271-279

Selenium and the thioredoxin and glutaredoxin systems.

Björnstedt M; Kumar S; Björkhem L; Spyrou G; Holmgren A
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(20):11761-11764

Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols.

Björnstedt M; Hamberg M; Kumar S; Xue J; Holmgren A
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(8):3479-3482

1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity.

Arnér ES; Björnstedt M; Holmgren A
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 1995;252:209-219

Selenite and selenodiglutathione: reactions with thioredoxin systems.

Björnstedt M; Kumar S; Holmgren A
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 1995;252:199-208

Thioredoxin and thioredoxin reductase.

Holmgren A; Björnstedt M

Employments

Professor/Senior Physician, Department of Laboratory Medicine, Karolinska Institutet, 2010-

Degrees and Education

Docent, Karolinska Institutet, 2001
University Medical Degree, Karolinska Institutet, 1993

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