Mikael Björnstedt

About me
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Public outreach and news

About me

Mikael Björnstedt is Professor of Pathology at Karolinska Institutet since
2010. His research is about the cellular mechanisms behind selenium's
cytotoxic and cancer-preventive effects.

Articles

Article: CANCER RESEARCH. 2023;83(10):1628-1645
FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner
He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(3):2485
Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses
Kamp JC; Kappe NN; Moro CF; Fuge J; Kuehnel MP; Wrenger S; Welte T; van Hoek B; Jonigk DD; Khedoe PPSJ; Strnad P; Bjornstedt M; Stolk J; Janciauskiene S; Nemeth A
Article: BIOMEDICINES. 2023;11(2):295
Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
Breuer O; Brodin O; Razaghi A; Brodin D; Gammelgaard B; Bjoernstedt M
Article: ANTIOXIDANTS. 2023;12(1):167
Exploration of Patient-Derived Pancreatic Ductal Adenocarcinoma Ex Vivo Tissue for Treatment Response
Szekerczes T; Selvam AK; Moro CF; Elduayen SP; Dillner J; Bjornstedt M; Ghaderi M
Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2022;56(1):166-173
Morphological changes without histological myocarditis in hearts of COVID-19 deceased patients
Razaghi A; Szakos A; Al-Shakarji R; Bjornstedt M; Szekely L
Article: DIAGNOSTICS. 2022;12(11):2789
Proteomic Analysis of Pleural Effusions from COVID-19 Deceased Patients: Enhanced Inflammatory Markers
Razaghi A; Szakos A; Alouda M; Bozoky B; Bjornstedt M; Szekely L
Article: JOURNAL OF MEDICAL IMAGING. 2022;9(3):031503
Can laboratory x-ray virtual histology provide intraoperative 3D tumor resection margin assessment?
Twengstrom W; Moro CF; Romell J; Larsson JC; Sparrelid E; Bjornstedt M; Hertz HM
Article: FRONTIERS IN ONCOLOGY. 2022;12:906134
Soluble PD-L1 Expression After Intravenous Treatment of Cancer Patients With Selenite in Phase I Clinical Trial
Razaghi A; Mansouri L; Brodin O; Bjoernstedt M; Lundahl J
Article: FRONTIERS IN ONCOLOGY. 2022;12:965182
Drug-induced tumor-specific cytotoxicity in a whole tissue ex vivo model of human pancreatic ductal adenocarcinoma
Moro CF; Selvam AK; Ghaderi M; Pimenoff VN; Gerling M; Bozoky B; Elduayen SP; Dillner J; Bjoernstedt M
Article: METHODS IN ENZYMOLOGY. 2022;662:25-62
Methods for accurate and reproducible studies of pharmacological effects of selenium in cancer.
Selvam AK; Szekerczés T; Björnstedt S; Razaghi A; Björnstedt M
Article: NEOPLASIA: AN INTERNATIONAL JOURNAL FOR ONCOLOGY RESEARCH. 2021;23(10):1059-1068
Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy
Razaghi A; Brusselaers N; Bjornstedt M; Durand-Dubief M
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2021;110:433-435
Severe features during outbreak but low mortality observed imme diately b efore and after a March-May 2020 COVID-19 outbreak in Stockholm, Sweden
Pimenoff VN; Bjornstedt M; Dillner J
Article: ANTIOXIDANTS. 2021;10(7):1094
A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine
Selvam AK; Jawad R; Gramignoli R; Achour A; Salter H; Bjornstedt M
Article: CLINICAL INFECTIOUS DISEASES. 2021;72(11):e890-e892
Estimating Total Excess Mortality During a Coronavirus Disease 2019 Outbreak in Stockholm, Sweden
Pimenoff VN; Elfstrom M; Baussano I; Bjornstedt M; Dillner J
Article: HELIYON. 2021;7(6):e07254
Selenofolate inhibits the proliferation of IGROV1 cancer cells independently from folate receptor alpha
Razaghi A; Zickler AM; Spallholz J; Kirsch G; Bjornstedt M
Article: HELIYON. 2021;7(5):e07134
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death
Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sonnerberg A; Cao Y; Bjornstedt M; Szakos A
Article: PATHOLOGY AND ONCOLOGY RESEARCH. 2020;26(4):2669-2681
The Effect of Methylselenocysteine and Sodium Selenite Treatment on microRNA Expression in Liver Cancer Cell Lines
Lendvai G; Szekerczes T; Kontsek E; Selvam A; Szakos A; Schaff Z; Bjornstedt M; Kiss A
Article: PATHOLOGY AND ONCOLOGY RESEARCH. 2020;26(4):2401-2407
Mid-Infrared Imaging Is Able to Characterize and Separate Cancer Cell Lines
Kontsek E; Pesti A; Bjornstedt M; Uveges T; Szabo E; Garay T; Gordon P; Gergely S; Kiss A
Article: SCIENTIFIC REPORTS. 2020;10(1):9070
Genome-wide transcriptome profiling of ex-vivo precision-cut slices from human pancreatic ductal adenocarcinoma
Ghaderi M; Moro CF; Elduayen SP; Hultin E; Verbeke CS; Bjornstedt M; Dillner J
Article: NUTRIENTS. 2020;12(4):E1067-1067
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite
Brodin O; Hackler J; Misra S; Wendt S; Sun Q; Laaf E; Stoppe C; Bjornstedt M; Schomburg L
Article: ANTIOXIDANTS. 2020;9(2):E139-139
A Novel Assay Method to Determine the β-Elimination of Se-Methylselenocysteine to Monomethylselenol by Kynurenine Aminotransferase 1
Selvam AK; Bjornstedt M
Article: ANTIOXIDANTS. 2019;8(5):E130-130
The Cell Culture Medium Affects Growth, Phenotype Expression and the Response to Selenium Cytotoxicity in A549 and HepG2 Cells
Selenius LA; Lundgren MW; Jawad R; Danielsson O; Bjornstedt M
Article: SCIENTIFIC REPORTS. 2019;9(1):2133
Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma
Misra S; Moro CF; Del Chiaro M; Pouso S; Sebestyen A; Lohr M; Bjornstedt M; Verbeke CS
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: WORLD JOURNAL OF HEPATOLOGY. 2017;9(34):1261-1269
Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.
Jawad R; D'souza M; Selenius LA; Lundgren MW; Danielsson O; Nowak G; Björnstedt M; Isaksson B
Article: ONCOTARGET. 2016;7(46):74686-74700
Selenite promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells
Misra S; Selvam AK; Wallenberg M; Ambati A; Matolcsy A; Magalhaes I; Lauter G; Bjornstedt M
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2016;408(9):2293-2301
Quantification of low molecular weight selenium metabolites in human plasma after treatment with selenite in pharmacological doses by LC-ICP-MS
Flouda K; Dersch JM; Gabel-Jensen C; Sturup S; Misra S; Bjornstedt M; Gammelgaard B
Article: PLOS ONE. 2016;11(11):e0166067
Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification
Moro CF; Fernandez-Woodbridge A; D'souza MA; Zhang Q; Bozoky B; Kandaswamy SV; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Bjornstedt M; Lohr JM; Isaksson B; Verbeke C; Bozoky B
Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2016;70(1):91-96
Relatively high mortality risk in elderly Swedish subjects with low selenium status
Alehagen U; Johansson P; Bjornstedt M; Rosen A; Post C; Aaseth J
Article: NUTRIENTS. 2015;7(6):4978-4994
Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
Brodin O; Eksborg S; Wallenberg M; Asker-Hagelberg C; Larsen EH; Mohlkert D; Lenneby-Helleday C; Jacobsson H; Linder S; Misra S; Bjornstedt M
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2014;18(4):671-684
Selenium induces a multi- targeted cell death process in addition to ROS formation
Wallenberg M; Misra S; Wasik AM; Marzano C; Bjornstedt M; Gandin V; Fernandes AP
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2014;39(4):787-797
Alteration of Thioredoxin and Glutaredoxin in the Progression of Alzheimer's Disease
Arodin L; Lamparter H; Karlsson H; Nennesmo I; Bjoernstedt M; Schroder J; Fernandes AP
Article: JOURNAL OF INHERITED METABOLIC DISEASE. 2013;36(6):1063-1071
High risk of primary liver cancer in a cohort of 179 patients with Acute Hepatic Porphyria
Sardh E; Wahlin S; Bjornstedt M; Harper P; Andersson DEH
Article: DISEASES OF THE ESOPHAGUS. 2013;26(8):853-858
Nitric oxide and endothelin-1 release after one-lung ventilation during thoracoabdominal esophagectomy
Lund M; Ny L; Malmstrom RE; Lundberg JO; Ost A; Bjornstedt M; Lundell L; Tsai JA
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;167(5):1860-1866
Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen U; Johansson P; Bjornstedt M; Rosen A; Dahlstrom U
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(7):1593-1605
Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
Selenius M; Hedman M; Brodin D; Gandin V; Rigobello MP; Flygare J; Marzano C; Bindoli A; Brodin O; Bjornstedt M; Fernandes AP
Article: DIGESTIVE DISEASES AND SCIENCES. 2012;57(5):1163-1170
The Value of Thioredoxin Family Proteins and Proliferation Markers in Dysplastic and Malignant Gallbladders in Patients with Primary Sclerosing Cholangitis
Said K; Glaumann H; Bjornstedt M; Bergquist A
Article: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY. 2012;21(1):6-12
Adding 11C-acetate to 18F-FDG at PET Examination Has an Incremental Value in the Diagnosis of Hepatocellular Carcinoma.
Larsson P; Arvidsson D; Björnstedt M; Isaksson B; Jersenius U; Motarjemi H; Jacobsson H
Article: PLOS ONE. 2012;7(11):e50727
Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems
Fernandes AP; Wallenberg M; Gandin V; Misra S; Tisato F; Marzano C; Rigobello MP; Kumar S; Bjornstedt M
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554
Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Bjoerkstroem NK; Bjornstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: JOURNAL OF SURGICAL RESEARCH. 2011;169(2):214-219
Continuous Assessment of Intrahepatic Metabolism by Microdialysis During and After Portal Triad Clamping
Isaksson B; D'souza MA; Jersenius U; Ungerstedt J; Lundell L; Permert J; Bjoernstedt M; Nowak G
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(11):1620-1629
Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications
Rigobello MP; Folda A; Citta A; Scutari G; Gandin V; Fernandes AP; Rundloef A-K; Marzano C; Bjoernstedt M; Bindoli A
Article: EPMA JOURNAL. 2010;1(3):389-395
Selenium in the prevention of human cancers.
Björnstedt M; Fernandes AP
Article: BIOCHEMICAL JOURNAL. 2010;429(1):85-93
Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity
Wallenberg M; Olm E; Hebert C; Bjornstedt M; Fernandes AP
Article: BIOCHEMICAL PHARMACOLOGY. 2010;79(2):90-101
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
Gandin V; Fernandes AP; Rigobello MP; Dani B; Sorrentino F; Tisato F; Bjornstedt M; Bindoli A; Sturaro A; Rella R; Marzano C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;47(6):710-721
Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift
Rigobello MP; Gandin V; Folda A; Rundlof A-K; Fernandes AP; Bindoli A; Marzano C; Bjornstedt M
Article: CANCER LETTERS. 2009;282(1):116-123
Selenite is a potent cytotoxic agent for human primary AML cells
Olm E; Jonsson-Videsater K; Ribera-Cortada I; Fernandes AP; Eriksson LC; Lehmann S; Rundlof A-K; Paul C; Bjornstedt M
Article: HISTOPATHOLOGY. 2009;55(3):313-320
Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation
Fernandes AP; Capitanio A; Selenius M; Brodin O; Rundlof A-K; Bjornstedt M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(27):11400-11405
Extracellular thiol-assisted selenium uptake dependent on the x_c^- cystine transporter explains the cancer-specific cytotoxicity of selenite
Olm E; Fernandes AP; Hebert C; Rundlof A-K; Larsen EH; Danielsson O; Bjornstedt M
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2009;28(1):92
Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure
Nilsonne G; Olm E; Szulkin A; Mundt F; Stein A; Kocic B; Rundlof A-K; Fernandes AP; Bjornstedt M; Dobra K
Article: THE FEBS JOURNAL. 2009;276(2):532-540
Effects of the antioxidant Pycnogenol^® on cellular redox systems in U1285 human lung carcinoma cells
Gandin V; Nystrom C; Rundlof A-K; Jonsson-Videsater K; Schonlau F; Horkko J; Bjornstedt M; Fernandes AP
Article: BIOCHEMICAL PHARMACOLOGY. 2008;75(11):2092-2099
Treatment of lung cancer cells with cytotoxic levels of sodium selenite:: Effects on the thioredoxin system
Selenius M; Fernandes AP; Brodin O; Bjornstedt M; Rundlof A-K
Article: GASTROENTEROLOGY. 2007;132(4):1504-1514
Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
Karrar A; Broome U; Sodergren T; Jaksch M; Bergquist A; Bjornstedt M; Sumitran-Holgersson S
Article: DIFFERENTIATION. 2007;75(2):123-132
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells
Rundlof A-K; Fernandes AP; Selenius M; Babic M; Shariatgorji M; Nilsonne G; Ilag LL; Dobra K; Bjornstedt M
Article: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. 2007;20(1):17-24
Increased expression of specific thioredoxin family proteins;: A pilot immunohistochemical study on human hepatocellular carcinoma
Cunnea P; Fernandes AP; Capitanio A; Eken S; Spyrou G; Bjornstedt M
Article: JOURNAL OF HEPATOLOGY. 2007;46(1):174-179
Curative bone marrow transplantation in erythropoietic protoporphyria after reversal of severe cholestasis
Wahlin S; Aschan J; Bjornstedt M; Broome U; Harper P
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2006;41(6):874-885
Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress.
Nilsonne G; Sun X; Nyström C; Rundlöf A-K; Potamitou Fernandes A; Björnstedt M; Dobra K
Article: TRANSPLANT INTERNATIONAL. 2005;18(8):992-1000
Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation
Rissler P; Söderdahl G; Nordman T; Xia L; Torndal UB; Björnstedt M; Ericzon BG; Olsson JM; Eriksson LC
Article: BIOCHEMICAL PHARMACOLOGY. 2005;69(12):1765-1772
The role of thioredoxin reductase activity in selenium-induced cytotoxicity
Madeja Z; Sroka J; Nyström C; Björkhem-Bergman L; Nordman T; Damdimopoulos A; Nalvarte I; Eriksson LC; Spyrou G; Olsson JM; Björnstedt M
Article: BIOCHEMISTRY AND CELL BIOLOGY. 2005;83(2):196-211
Differential effects of selenite and selenate on human melanocytes, keratinocytes, and melanoma cells
Bandura L; Drukala J; Wolnicka-Glubisz A; Björnstedt M; Korohoda W
Article: CARCINOGENESIS. 2005;26(1):125-131
Selenium prevents tumor development in a rat model for chemical carcinogenesis
Björkhem-Bergman L; Torndal UB; Eken S; Nyström C; Capitanio A; Larsen EH; Björnstedt M; Eriksson LC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells -: Effect on cell growth and differentiation
Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
Article: PEPTIDES. 2004;25(11):1849-1855
Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide
Björkhem-Bergman L; Jönsson-Videsäter K; Paul C; Björnstedt M; Andersson M
Article: BIOCHEMICAL PHARMACOLOGY. 2004;67(3):513-522
Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system
Jönsson-Videsäter K; Björkhem-Bergman L; Hossain A; Söderberg A; Eriksson LC; Paul C; Rosén A; Björnstedt M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone -: A novel mechanism for defense against oxidative stress
Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
Article: BIOCHEMICAL PHARMACOLOGY. 2002;63(10):1875-1884
Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity -: Effects on thioredoxin reductase and glutathione reductase
Björkhem-Bergman L; Jönsson K; Eriksson LC; Olsson JM; Lehmann S; Paul C; Björnstedt M
Article: JOURNAL OF HEPATOLOGY. 2001;35(2):259-264
Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules
Björkhem L; Teclebrhan H; Kesen E; Olsson JM; Eriksson LC; Björnstedt M
Article: THE FEBS JOURNAL. 2001;268(5):1486-1490
Reduction of ubiquinone by lipoamide dehydrogenase -: An antioxidant regenerating pathway
Xia L; Björnstedt M; Nordman T; Eriksson LC; Olsson JM
Article: DIFFERENTIATION. 2000;66(4-5):181-188
Upregulation of 9 genes, including that for thioredoxin, during epithelial differentiation of mesothelioma cells
Sun XJ; Dobra K; Björnstedt M; Hjerpe A
Article: FEBS LETTERS. 1999;448(1):190-192
Ubiquinone is reduced by lipoamide dehydrogenase and this reaction is potently stimulated by zinc
Olsson JM; Xia L; Eriksson LC; Björnstedt M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 1998;24(7-8):1176-1186
Measurements of plasma glutaredoxin and thioredoxin in healthy volunteers and during open-heart surgery
Nakamura H; Vaage J; Valen G; Padilla CA; Björnstedt M; Holmgren A
Article: MOLECULAR IMMUNOLOGY. 1997;34(10):709-717
Human IgG is substrate for the thioredoxin system:: Differential cleavage pattern of interchain disulfide bridges in IgG subclasses
Magnusson CGM; Björnstedt M; Holmgren A
Article: CANCER RESEARCH. 1996;56(19):4407-4412
Selenite and selenate inhibit human lymphocyte growth via different mechanisms
Spyrou G; Bjornstedt M; Skog S; Holmgren A
Article: BIOCHEMISTRY. 1996;35(26):8511-8516
Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron
Bjornstedt M; Odlander B; Kuprin S; Claesson HE; Holmgren A
Article: FEBS LETTERS. 1995;368(1):59-63
AP-1 DNA-BINDING ACTIVITY IS INHIBITED BY SELENITE AND SELENODIGLUTATHIONE
SPYROU G; BJORNSTEDT M; KUMAR S; HOLMGREN A
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Review: FRONTIERS IN IMMUNOLOGY. 2023;14:1249330
Combining PD-1/PD-L1 blockade with type I interferon in cancer therapy
Razaghi A; Durand-Dubief M; Brusselaers N; Bjornstedt M
Review: EUROPEAN JOURNAL OF CANCER. 2021;155:256-267
Selenium stimulates the antitumour immunity: Insights to future research
Razaghi A; Poorebrahim M; Sarhan D; Bjornstedt M
Review: NUTRIENTS. 2015;7(5):3536-3556
Redox-Active Selenium Compounds-From Toxicity and Cell Death to Cancer Treatment
Misra S; Boylan M; Selvam A; Spallholz JE; Bjornstedt M
Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;114(5):377-386
Selenium Cytotoxicity in Cancer
Wallenberg M; Misra S; Bjornstedt M
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2010;12(7):867-880
Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer
Selenius M; Rundlof A-K; Olm E; Fernandes AP; Bjornstedt M
Review: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(2):331-348
Molecular and structural basis for redox regulation of β-actin
Lassing I; Schmitzberger F; Bjornstedt M; Holmgren A; Nordlund P; Schutt CE; Lindberg U
Meeting abstract: LUNG CANCER. 2006;54:S52
Targeting thioredoxin reductase -: a possible new treatment for malignant mesothelioma
Nilsonne G; Stein A; Rundloef A-K; Fernandes AP; Bjoernstedt M; Hjerpe A; Dobra K
Review: METHODS IN ENZYMOLOGY. 2004;378:131-138
Extramitochondrial reduction of ubiquinone by flavoenzymes
Björnstedt M; Nordman T; Olsson JM
Published conference paper: BIOFACTORS. 2003;18(1-4):45-50
Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2002;64(1):159
Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity -: Effects on thioredoxin reductase and glutathione reductase (vol 63, pg 1875, 2002)
Björkhem-Bergman L; Jönsson K; Eriksson LC; Olsson JM; Lehmann S; Paul C; Björnstedt M
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):349-354
Alterations of glutathione levels and related enzyme activities in non-tumourous rat liver cells after long-term treatment with adriamycin and/or cyclosporine A
Carlson T; Björnstedt M; Rissler P; Bai L; Eriksson LC; Olsson JM
Review: BIOMEDICAL AND ENVIRONMENTAL SCIENCES. 1997;10(2-3):271-279
Selenium and the thioredoxin and glutaredoxin systems.
Björnstedt M; Kumar S; Björkhem L; Spyrou G; Holmgren A
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(20):11761-11764
HUMAN THIOREDOXIN REDUCTASE DIRECTLY REDUCES LIPID HYDROPEROXIDES BY NADPH AND SELENOCYSTINE STRONGLY STIMULATES THE REACTION VIA CATALYTICALLY GENERATED SELENOLS
BJORNSTEDT M; HAMBERG M; KUMAR S; XUE J; HOLMGREN A
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(8):3479-3482
1-CHLORO-2,4-DINITROBENZENE IS AN IRREVERSIBLE INHIBITOR OF HUMAN THIOREDOXIN REDUCTASE - LOSS OF THIOREDOXIN DISULFIDE REDUCTASE-ACTIVITY IS ACCOMPANIED BY A LARGE INCREASE IN NADPH OXIDASE ACTIVITY
ARNER ESJ; BJORNSTEDT M; HOLMGREN A
Review: METHODS IN ENZYMOLOGY. 1995;252:209-219
SELENITE AND SELENODIGLUTATHIONE - REACTIONS WITH THIOREDOXIN SYSTEMS
BJORNSTEDT M; KUMAR S; HOLMGREN A
Review: METHODS IN ENZYMOLOGY. 1995;252:199-208
THIOREDOXIN AND THIOREDOXIN REDUCTASE
HOLMGREN A; BJORNSTEDT M

Employments

Professor/Senior Physician, Department of Laboratory Medicine, Karolinska Institutet, 2010-

Degrees and Education

Docent, Karolinska Institutet, 2001
University Medical Degree, Karolinska Institutet, 1993

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