Mikael Benson
Principal Researcher
Mikael Benson leads the Medical Digital Twin Research Group, which aims at diagnosis and treatment based on digital twin tumour models. MB also coordinates the Swedish Digital Twin Consortium and TWIN
E-mail: mikael.benson@ki.se
Telephone: +46852488964
Visiting address: Hälsovägen, Enheten för öron-,näs och halssjukdomar B61, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Öron näs o halssjukd, 141 52 Huddinge
About me
H index 59
Number of Completed supervisions as principal supervisor:20
Number of Completed supervisions as co-supervisor:2
The goal of my research is to construct digital twin models of individual patients' tumours, and develop methods to computationally treat those models with thousands of drugs to find the optimal treatment for the patient. The models are constructed by combining clinical routine variables with multi-omics data down to the spatial single cell level. A summary is found in a recent article in Nature Biotechnology: https://www.nature.com/articles/s41587-025-02847-x
Research
Please see the Medical Digital Twin Research Group website at KI: https://ki.se/en/clintec/divisions-at-the-department-of-clinical-science-intervention-and-technology/division-of-ear-nose-and-throat-diseases/medical-digital-twin-research-group
We also coordinate the Swedish Digital Twin Consortium (SDTC.se) and the TWIN-MAP consortium (TWIN-MAP.com)
Articles
- Article: CANCER RESEARCH. 2025;85(13):2514-2526Smelik M; Diaz-Roncero Gonzalez D; An X; Heer R; Henningsohn L; Li X; Wang H; Zhao Y; Benson M
- Review: GENOME MEDICINE. 2025;17(1):11Li X; Loscalzo J; Mahmud AKMF; Aly DM; Rzhetsky A; Zitnik M; Benson M
- Article: SCIENTIFIC REPORTS. 2025;15(1):3902Mahmud AKMF; Mansour Aly DG; Zhao Y; Benson M; Smelik M; Sysoev O; Wang H; Li X
- Article: COMMUNICATIONS MEDICINE. 2024;4(1):234Smelik M; Zhao Y; Mansour Aly D; Mahmud AKMF; Sysoev O; Li X; Benson M
- Article: SCIENTIFIC REPORTS. 2024;14(1):12710Smelik M; Zhao Y; Li X; Loscalzo J; Sysoev O; Mahmud F; Mansour Aly D; Benson M
- Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):444Zhao Y; Li X; Loscalzo J; Smelik M; Sysoev O; Wang Y; Mahmud AKMF; Mansour Aly D; Benson M
- Article: GENOME MEDICINE. 2024;16(1):42Schafer S; Smelik M; Sysoev O; Zhao Y; Eklund D; Lilja S; Gustafsson M; Heyn H; Julia A; Kovacs IA; Loscalzo J; Marsal S; Zhang H; Li X; Gawel D; Wang H; Benson M
- Article: HELIYON. 2023;9(12):e22624Benson M; Boda C; Das RR; King L; Park C
- Article: CELL REPORTS MEDICINE. 2023;4(3):100956Lilja S; Li X; Smelik M; Lee EJ; Loscalzo J; Marthanda PB; Hu L; Magnusson M; Sysoev O; Zhang H; Zhao Y; Sjowall C; Gawel D; Wang H; Benson M
- Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(3):410-416Benson M
- Article: EPIGENETICS. 2022;17(9):1040-1055Badam TV; Hellberg S; Mehta RB; Lechner-Scott J; Lea RA; Tost J; Mariette X; Svensson-Arvelund J; Nestor CE; Benson M; Berg G; Jenmalm MC; Gustafsson M; Ernerudh J
- Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:916128Magnusson R; Rundquist O; Kim MJ; Hellberg S; Na CH; Benson M; Gomez-Cabrero D; Kockum I; Tegner JN; Piehl F; Jagodic M; Mellergard J; Altafini C; Ernerudh J; Jenmalm MC; Nestor CE; Kim M-S; Gustafsson M
- Article: GENOME MEDICINE. 2022;14(1):48A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targetsLi X; Lee EJ; Lilja S; Loscalzo J; Schafer S; Smelik M; Strobl MR; Sysoev O; Wang H; Zhang H; Zhao Y; Gawel DR; Bohle B; Benson M
- Article: SUSTAINABILITY. 2022;14(4):2213Benson M; Boda C; Das RR; King L; Park C
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(34):e2110758118Bensberg M; Rundquist O; Selimovic A; Lagerwall C; Benson M; Gustafsson M; Vogt H; Lentini A; Nestor CE
- Review: LAKARTIDNINGEN. 2021;118:20213Melén E; Jacobsson B; Benson M; Orho-Melander M; Halvarson J; Jern C
- Article: LAKARTIDNINGEN. 2021;118:20234Gawel D; Bojner Horwitz E; Sysoev O; Jacobsson B; Jönsson J-I; Melén E; Ynnerman A; Benson M
- Article: RHINOLOGY. 2020;58(4):360-367Lee EJ; Gawel DR; Lilja S; Li X; Schäfer S; Sysoev O; Zhang H; Benson M
- Article: CYTOKINE. 2020;127:154960Lee EJ; Lilja S; Li X; Schäfer S; Zhang H; Benson M
- Article: JOURNAL OF IMMUNOLOGY RESEARCH. 2020;2020:8279619Li X; Lee EJ; Gawel DR; Lilja S; Schäfer S; Zhang H; Benson M
- Show more
All other publications
- Editorial: ETHNIC AND RACIAL STUDIES. 2025;48(13):2496-2501Barbulescu R; South J; Byrne B; Solomos J; Benson M; Silva CCV; Yemane T; Zambelli E; Anghel RG; Bacher S; Torres AMB; Bernard-Verdier M; Bibi R; Boatca M; Bolpagni R; Colon D; Demoule J-P; Dunn AM; Durrant S; Faist T; Finotelli C; Garelli G; Gidley B; Gippet JMW; Gonzalez S; Guareschi S; Heger T; Hill S; Hobbs J; Holmes G; Hulme PE; Jones H; Jacob M-A; Khosa D; Kilkey M; Kusumastuti A; Lavanchy A; Lewis H; Macedo RL; Giralt RM; Musseau CL; Makinejad M; Castro ERN; Pattison Z; Probert A; Roberts JD; Ruland F; Saul W-C; Sciortino G; Shackleton RT; Sigona N; Sokolovska S; Souter J; Sun L; Vathi Z; Vieten U; Vimercati G; Waite L; Wilson P; Yannelli FA
- Editorial: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2024;52(8):1019-1025Glintborg B; Hansson M; Hammer HB; Klareskog L; Saevarsdottir S; Westerlind H; Ronnelid J; Gehring I; Benson M; Esbensen BA; Hetland ML; Padyukov L; Kragstrup TW; Hauge E-M; Axnas BB; Krogh NS; Johannesson M; Askling J
- Preprint: RES SQ. 2024;RES SQBenson M; Smelik M; Li X; Loscalzo J; Sysoev O; Mahmud F; Aly DM; Zhao Y
- Preprint: BIORXIV. 2023;BIORXIVSchäfer S; Smelik M; Sysoev O; Zhao Y; Eklund D; Lilja S; Gustafsson M; Heyn H; Julia A; Kovács IA; Loscalzo J; Marsal S; Zhang H; Li X; Gawel D; Wang H; Benson M
- Corrigendum: CYTOKINE. 2020;133:155087Lee EJ; Lilja S; Li X; Schäfer S; Zhang H; Benson M
- Corrigendum: GENOME MEDICINE. 2020;12(1):37Gawel DR; Serra-Musach J; Lilja S; Aagesen J; Arenas A; Asking B; Bengner M; Bjorkander J; Biggs S; Ernerudh J; Hjortswang H; Karlsson J-E; Kopsen M; Lee EJ; Lentini A; Li X; Magnusson M; Martinez-Enguita D; Matussek A; Nestor CE; Schafer S; Seifert O; Sonmez C; Stjernman H; Tjarnberg A; Wu S; Akesson K; Shalek AK; Stenmarker M; Zhang H; Gustafsson M; Benson M
- Editorial: GENOME MEDICINE. 2019;11(1):9Zhang H; Klareskog L; Matussek A; Pfister SM; Benson M