Mikael Adner

Publications
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Public outreach and news

Articles

Article: RESPIRATORY RESEARCH. 2024;25(1):146

A novel quinoline with airway relaxant effects and anti-inflammatory properties

Bergwik J; Liu J; Padra M; Bhongir RKV; Tanner L; Xiang Y; Lundblad M; Egesten A; Adner M
Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2024;78(2):313-319

Granzyme B is elevated in esophageal biopsies from children with eosinophilic esophagitis

Thulin H; Safholm J; Lundahl J; Jovic V; Adner M; Nilsson C
Article: SCIENCE IMMUNOLOGY. 2023;8(87):eadf7702

Laboratory mice with a wild microbiota generate strong allergic immune responses

Ma J; Urgard E; Runge S; Classon CH; Mathae L; Stark JM; Cheng L; Alvarez JA; Von Zedtwitz S; Baleviciute A; Hoyer SM; Li M; Gernand AM; Osbelt L; Bielecka AA; Lesker TR; Huang H-J; Vrtala S; Boon L; Beyaert R; Adner M; Gonzalez IM; Strowig T; Du J; Nylen S; Rosshart SP; Coquet JM
Article: JOURNAL OF IMMUNOLOGY RESEARCH. 2023;2023:9393497-10

House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Ramos-Ramirez P; Liu J; Mogren S; Gregory J; Noreby M; Petren A; Lei Y; Olsson H; van Hage M; Kervinen J; Hellman L; Andersson C; Nilsson G; Adner M
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1151754

Analysis of human lung mast cells by single cell RNA sequencing

Ronnberg E; Ravindran A; Mazzurana L; Gong Y; Safholm J; Lorent J; Dethlefsen O; Orre A-C; Al-Ameri M; Adner M; Dahlen S-E; Dahlin JS; Mjosberg J; Nilsson G
Article: NATURE METABOLISM. 2022;4(12):1674-1683

COVID-19 instigates adipose browning and atrophy through VEGF in small mammals

Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: SCIENTIFIC REPORTS. 2022;12(1):18924

Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Liu J; Nie M; Dong C; Safholm J; Pejler G; Nilsson G; Adner M
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2022;934:175257

Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor

Safholm J; Abma W; Bankova LG; Boyce JA; Al-Ameri M; Orre A-C; Wheelock CE; Dahlen S-E; Adner M
Article: ALLERGY. 2022;77(10):2987-3001

Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses

Stark JM; Liu J; Tibbitt CA; Christian M; Ma J; Wintersand A; Dunst J; Kreslavsky T; Murrell B; Adner M; Gronlund H; Gafvelin G; Coquet JM
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:999180

Pharmacological OGG1 inhibition decreases murine allergic airway inflammation

Tanner L; Bergwik J; Bhongir RKV; Pan L; Dong C; Wallner O; Kalderen C; Helleday T; Boldogh I; Adner M; Egesten A
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2021;907:174282

Prostaglandin D₂ inhibits mediator release and antigen induced bronchoconstriction in the Guinea pig trachea by activation of DP₁ receptors

Safholm J; Abma W; Liu J; Balgoma D; Fauland A; Kolmert J; Wheelock CE; Adner M; Dahlen S-E
Article: ALLERGY. 2021;76(7):2057-2069

Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma

Mendez-Enriquez E; Alvarado-Vazquez PA; Abma W; Simonson OE; Rodin S; Feyerabend TB; Rodewald H-R; Malinovschi A; Janson C; Adner M; Hallgren J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021;548:91-97

Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation

Wu R; Hogberg J; Adner M; Stenius U; Zheng H
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:761317

Complex Involvement of Interleukin-26 in Bacterial Lung Infection

Che KF; Paulsson M; Piersiala K; Sax J; Mboob I; Rahman M; Rekha RS; Safholm J; Adner M; Bergman P; Cardell L-O; Riesbeck K; Linden A
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:804812

Immunoprofiling Reveals Novel Mast Cell Receptors and the Continuous Nature of Human Lung Mast Cell Heterogeneity

Ronnberg E; Boey DZH; Ravindran A; Safholm J; Orre A-C; Al-Ameri M; Adner M; Dahlen S-E; Dahlin JS; Nilsson G
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(23):E8990-8990

Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation

Ramos-Ramirez P; Malmhall C; Johansson K; Adner M; Lotvall J; Bossios A
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2020;50(10):1184-1195

A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig

Ramos-Ramirez P; Noreby M; Liu J; Ji J; Abdillahi SM; Olsson H; Dahlen S-E; Nilsson G; Adner M
Article: PARTICLE AND FIBRE TOXICOLOGY. 2020;17(1):39

Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

Wu R; Hogberg J; Adner M; Ramos-Ramirez P; Stenius U; Zheng H
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2020;149:106428

Lipoxin A₄ reduces house dust mite and TNFα-induced hyperreactivity in the mouse trachea

Abma W; Noreby M; Wheelock CE; Dahlen S-E; Adner M; Safholm J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(3):808-817.e2

IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways

Manson ML; Safholm J; James A; Johnsson A-K; Bergman P; Al-Ameri M; Orre A-C; Karrman-Mardh C; Dahlen S-E; Adner M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(4):984-992

Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection

Safholm J; Manson ML; Bood J; Al-Ameri M; Orre A-C; Raud J; Dahlen S-E; Adner M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2019;317(3):L305-L316

Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells

McGovern T; Farahnak S; Chen M; Larsson K; Martin JG; Adner M
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1361

Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions

Ronnberg E; Ghaib A; Ceriol C; Enoksson M; Arock M; Safholm J; Orre A-C; Al-Ameri M; Adner M; Dahlen S-E; Ekoff M; Nilsson G
Article: ANALYTICAL CHEMISTRY. 2018;90(17):10239-10248

Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research

Kolmert J; Fauland A; Fuchs D; Safholm J; Gomez C; Adner M; Dahlen S-E; Wheelock CE
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2018;137:20-29

Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model

Kolmert J; Pineiro-Hermida S; Hamberg M; Gregory JA; Lopez IP; Fauland A; Wheelock CE; Dahlen S-E; Pichel JG; Adner M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2018;314(3):L484-L492

Mast cell-dependent IL-33/ST2 signaling is protective against the development of airway hyperresponsiveness in a house dust mite mouse model of asthma

Nilsson AMZ; Lei Y; Adner M; Nilsson GP
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2018;48:203-210

Effects of tiotropium bromide on airway hyperresponsiveness and inflammation in mice exposed to organic dust

Gregory JA; Kemi C; Ji J; Karen J; Delin I; Gerde P; Pieper MP; Adner M; Larsson K
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:2193

An Optimized Protocol for the Isolation and Functional Analysis of Human Lung Mast Cells

Ravindran A; Ronnberg E; Dahlin JS; Mazzurana L; Safholm J; Orre A-C; Al-Ameri M; Peachell P; Adner M; Dahlen S-E; Mjosberg J; Nilsson G
Article: ALLERGY. 2017;72(9):1317-1326

Attenuated airway hyperresponsiveness and mucus secretion in HDM-exposed Igf1r-deficient mice

Pineiro-Hermida S; Gregory JA; Lopez IP; Torrens R; Ruiz-Martinez C; Adner M; Pichel JG
Article: SCIENTIFIC REPORTS. 2017;7(1):4219

Interleukin 33 exacerbates antigen driven airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma

Sjoberg LC; Nilsson AZ; Lei Y; Gregory JA; Adner M; Nilsson GP
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69^-CD56^dim cells

Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Article: PLOS ONE. 2017;12(12):e0190159

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma

Pineiro-Hermida S; Alfaro-Arnedo E; Gregory JA; Torrens R; Ruiz-Martinez C; Adner M; Lopez IP; Pichel JAG
Article: PLOS ONE. 2017;12(12):e0188909

Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo

Bao A; Che KF; Bozinovski S; Ji J; Gregory JA; Georen SK; Adner M; Cardell L-O; Linden A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2016;310(11):L1121-L1129

The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation

Larsson OJ; Manson ML; Starkhammar M; Fuchs B; Adner M; Georen SK; Cardell L-O
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2016;776:132-138

Stimulation of cannabinoid CB₁ receptors prevents nerve-mediated airway hyperreactivity in NGF-induced inflammation in mouse airways

Bozkurt TE; Larsson O; Adner M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(3):479-490

The interleukin-33 receptor ST2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma

Zoltowska AM; Lei Y; Fuchs B; Rask C; Adner M; Nilsson GP
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2016;310(2):L155-L165

Neutrophilic oxidative stress mediates organic dust-induced pulmonary inflammation and airway hyperresponsiveness

McGovern TK; Chen M; Allard B; Larsson K; Martin JG; Adner M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(5):1232-9.e1

Prostaglandin E₂ inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor

Safholm J; Manson ML; Bood J; Delin I; Orre A-C; Bergman P; Al-Ameri M; Dahlen S-E; Adner M
Article: RESPIRATORY RESEARCH. 2015;16:129

TNFα-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma

Starkhammar M; Georen SK; Dahlen S-E; Cardell L-O; Adner M
Article: ALLERGY. 2015;70(5):514-521

Interleukin-33 exacerbates allergic bronchoconstriction in the mice via activation of mast cells

Sjoberg LC; Gregory JA; Dahlen S-E; Nilsson GP; Adner M
Article: PLOS ONE. 2015;10(7):e0133774

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma

Lei Y; Boinapally V; Zoltowska A; Adner M; Hellman L; Nilsson G
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;740:302-311

Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle

Manson ML; Safholm J; Al-Ameri M; Bergman P; Orre A-C; Sward K; James A; Dahlen S-E; Adner M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2014;165(3):195-205

Development of a Mouse Model for Chronic Cat Allergen-Induced Asthma

Grundstrom J; Saarne T; Kemi C; Gregory JA; Waden K; Pils MC; Adner M; Gafvelin G; van Hage M
Article: PLOS ONE. 2014;9(8):e104114

Toll-Like Receptor Ligands LPS and Poly (I:C) Exacerbate Airway Hyperresponsiveness in a Model of Airway Allergy in Mice, Independently of Inflammation

Starkhammar M; Larsson O; Georen SK; Leino M; Dahlen S-E; Adner M; Cardell L-O
Article: CLINICAL SCIENCE. 2013;125(11-12):533-542

Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma

Riley JP; Fuchs B; Sjoberg L; Nilsson GP; Karlsson L; Dahlen S-E; Rao NL; Adner M
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;718(1-3):544-551

Toll-like receptor (TLR) 7 decreases and TLR9 increases the airway responses in mice with established allergic inflammation

Adner M; Starkhammar M; Georen SK; Dahlen S-E; Cardell L-O
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;718(1-3):277-282

Antagonising EP₁ and EP2 receptors reveal that the TP receptor mediates a component of antigen-induced contraction of the guinea pig trachea

Safholm J; Dahlen S-E; Adner M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2013;168(4):794-806

PGE₂ maintains the tone of the guinea pig trachea through a balance between activation of contractile EP₁ receptors and relaxant EP₂ receptors

Safholm J; Dahlen S-E; Delin I; Maxey K; Stark K; Cardell L-O; Adner M
Article: JOURNAL OF LIPID RESEARCH. 2013;54(1):116-126

Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations

Lundstrom SL; Saluja R; Adner M; Haeggstrom JZ; Nilsson G; Wheelock CE
Article: PLOS ONE. 2013;8(7):e68701

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists

Kvarnhammar AM; Tengroth L; Adner M; Cardell L-O
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;303(12):L1027-L1036

Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model

Fuchs B; Sjoberg L; Westerberg CM; Ekoff M; Swedin L; Dahlen S-E; Adner M; Nilsson GP
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;303(11):L956-L966

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea

Pulkkinen V; Manson ML; Safholm J; Adner M; Dahlen S-E
Article: ALLERGY. 2012;67(7):958-961

Corticosteroid treatment selectively decreases mast cells in the smooth muscle and epithelium of asthmatic bronchi

James A; Gyllfors P; Henriksson E; Dahlen SE; Adner M; Nilsson G; Dahlen B
Article: PLOS ONE. 2012;7(2):e32110

Intranasal Administration of poly(I:C) and LPS in BALB/c Mice Induces Airway Hyperresponsiveness and Inflammation via Different Pathways

Starkhammar M; Georen SK; Swedin L; Dahlen S-E; Adner M; Cardell LO
Article: PLOS ONE. 2012;7(8):e43547

FcεR₁-Mediated Mast Cell Reactivity Is Amplified through Prolonged Toll-Like Receptor-Ligand Treatment

Saluja R; Delin I; Nilsson GP; Adner M
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2012;159(1):6-14

Systemic Up-Regulation of TLR4 Causes Lipopolysaccharide-Induced Augmentation of Nasal Cytokine Release in Allergic Rhinitis

Ekman A-K; Virtala R; Fransson M; Adner M; Benson M; Jansson L; Cardell LO
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;669(1-3):136-142

Prostaglandin D₂ induces contractions through activation of TP receptors in peripheral lung tissue from the guinea pig

Larsson A-K; Hagfjard A; Dahlen S-E; Adner M
Article: BMC PULMONARY MEDICINE. 2011;11:39

The asthma candidate gene NPSR1 mediates isoform specific downstream signalling

Pietras CO; Vendelin J; Anedda F; Bruce S; Adner M; Sundman L; Pulkkinen V; Alenius H; D'Amato M; Soderhall C; Kere J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;652(1-3):145-151

Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle

Ekman A-K; Adner M; Cardell L-O
Article: ALLERGY. 2010;65(10):1222-1226

Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?

Bogefors J; Rydberg C; Uddman R; Fransson M; Mansson A; Benson M; Adner M; Cardell LO
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2010;92(1-4):44-53

Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant

Swedin L; Ellis R; Neimert-Andersson T; Ryrfeldt A; Nilsson G; Inman M; Dahlen S-E; Adner M
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2010;333(1):273-280

Budesonide Prevents Cytokine-Induced Decrease of the Relaxant Responses to Formoterol and Terbutaline, but Not to Salmeterol, in Mouse Trachea

Adner M; Larsson B; Safholm J; Naya I; Miller-Larsson A
Article: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2010;20(6):476-483

Leukocyte Phenotype Changes Induced by Specific Immunotherapy in Patients With Birch Allergy

Mansson A; Bachar O; Adner M; Bjornsson S; Cardell LO
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(2):118-128

TLR3 in Human Eosinophils: Functional Effects and Decreased Expression during Allergic Rhinitis

Mansson A; Fransson M; Adner M; Benson M; Uddman R; Bjornsson S; Cardell L-O
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;153(3):249-258

Comparison of Aerosol and Intranasal Challenge in a Mouse Model of Allergic Airway Inflammation and Hyperresponsiveness

Swedin L; Ellis R; Kemi C; Ryrfeldt A; Inman M; Dahlen S-E; Adner M
Article: ALLERGY. 2009;64(9):1292-1300

Nasal CpG oligodeoxynucleotide administration induces a local inflammatory response in nonallergic individuals

Mansson A; Bachar O; Adner M; Cardell L-O
Article: ALLERGY. 2009;64(9):1301-1308

Genes regulating molecular and cellular functions in noninfectious nonallergic rhinitis

Cardell LO; Andersson M; Cervin A; Davidsson A; Hellgren J; Holmstrom M; Lundblad L; Stierna P; Stjarne P; Adner M
Article: EUROPEAN RESPIRATORY JOURNAL. 2009;34(1):200-208

Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice

Swedin L; Neimert-Andersson T; Hjoberg J; Jonasson S; van Hage M; Adner M; Ryrfeldt A; Dahlen S-E
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2009;149(2):154-160

Nasal Challenge with LPS Stimulates the Release of Macrophage Inflammatory Protein 1α

Ekman A-K; Fransson M; Rydberg C; Adner M; Cardell L-O
Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2008;53(3):413-420

Differentiated S100A7 expression in infected tonsils and tonsils from allergic individuals

Bryborn M; Mansson A; Cardell LO; Adner M
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2008;21(4):675-681

Interleukin-1β up-regulates tumor necrosis factor receptors in the mouse airways

Cardell LO; Uddman R; Zhang Y; Adner M
Article: RESPIRATORY RESEARCH. 2008;9(1):29

Comprehensive evaluation of genetic variation in S100A7 suggests an association with the occurrence of allergic rhinitis

Bryborn M; Hallden C; Sall T; Adner M; Cardell LO
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(12):1773-1780

Lipopolysaccharide administration to the allergic nose contributes to lower airway inflammation

Bachar O; Gustafsson J; Jansson L; Adner M; Cardell LO
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2007;36(6):697-705

IL-1β-induced transcriptional up-regulation of bradykinin B₁ and B₂ receptors in murine airways

Zhang Y; Adner M; Cardell L-O
Article: RESPIRATORY RESEARCH. 2007;8(1):29

IL-1β induces murine airway 5-HT_2A receptor hyperresponsiveness via a non-transcriptional MAPK-dependent mechanism

Zhang Y; Cardell L-O; Adner M
Article: ACTA OTO-LARYNGOLOGICA. 2007;127(3):285-291

Lipopolysaccharide-induced down-regulation of uteroglobin in the human nose

Fransson M; Adner M; Uddman R; Cardell L-O
Article: RESPIRATORY RESEARCH. 2007;8(1):17

Expression of Toll-like Receptor 9 in nose, peripheral blood and bone marrow during symptomatic allergic rhinitis

Fransson M; Benson M; Erjefalt JS; Jansson L; Uddman R; Bjornsson S; Cardell L-O; Adner M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2006;291(6):C1326-C1335

Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1

Shakirova Y; Bonnevier J; Albinsson S; Adner M; Rippe B; Broman J; Arner A; Sward K
Article: IMMUNOLOGY. 2006;118(4):539-548

A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by Pam₃CSK₄, R-837 and CpG-2006 stimulation

Mansson A; Adner M; Hockerfelt U; Cardell L-O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;118(1):220-225

A network-based analysis of the late-phase reaction of the skin

Benson M; Langston MA; Adner M; Andersson B; Torinssson-Naluai A; Cardell LO
Article: ACTA OTO-LARYNGOLOGICA. 2006;126(4):375-380

Topical steroids do not downregulate expression of growth-related oncogene-α in nasal polyps

Cardell LO; Bogefors J; Bjartell A; Adner M; Uddman R; Egesten A
Article: RESPIRATORY RESEARCH. 2006;7(1):36

Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis

Mansson A; Adner M; Cardell LO
Article: RESPIRATORY RESEARCH. 2005;6(1):132

Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis -: art. no. 132

Cardell LO; Hägge M; Uddman R; Adner M
Article: RESPIRATORY RESEARCH. 2005;6(1):118

Psoriasin, one of several new proteins identified in nasal lavage fluid from allergic and non-allergic individuals using 2-dimensional gel electrophoresis and mass spectrometry

Bryborn M; Adner M; Cardell LO
Article: RESPIRATORY RESEARCH. 2005;6(1):100

Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis -: art. no. 100

Fransson M; Adner M; Erjefält J; Jansson L; Uddman R; Cardell LO
Article: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2005;147(1):81-89

Prolonged exposure to NT-3 attenuates cholinergic nerve-mediated contractions in cultured murine airways

Bachar O; Adner M; Uddman R; Cardell LO
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(4):531-538

Glucocorticoids suppress transcriptional up-regulation of bradykinin receptors in a murine in vitro model of chronic airway inflammation

Zhang Y; Adner M; Cardell LO
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(4):473-478

Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis

Benson M; Jansson L; Adner M; Luts A; Uddman R; Cardell LO
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2005;144(2):220-230

TNFα reduces tachykinin, PGE₂-dependent, relaxation of the cultured mouse trachea by increasing the activity of COX-2

Bachar O; Rose AC; Adner M; Wang XD; Prendergast CE; Kempf A; Shankley NP; Cardell LO
Article: ACTA OTO-LARYNGOLOGICA. 2004;124(7):813-819

DNA microarray analysis of chromosomal susceptibility regions to identify candidate genes for allergic disease:: A pilot study

Benson M; Svensson PA; Adner M; Carén H; Carlsson B; Carlsson LMS; Martinsson T; Rudemo M; Cardell LO
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(9):1480-1487

Interleukin-1β attenuates endothelin B receptor-mediated airway contractions in a murine in vitro model of asthma:: roles of endothelin converting enzyme and mitogen-activated protein kinase pathways

Zhang Y; Adner M; Cardell LO
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(8):1291-1298

Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B₁-receptors and altered signalling along mitogen-activated protein kinase pathways

Bryborn M; Adner M; Cardell LO
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(6):1137-1143

Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps

Benson M; Carlsson L; Adner M; Jernås M; Rudemo M; Sjögren A; Svensson PA; Uddman R; Cardell LO
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2004;489(1-2):117-126

Up-regulation of bradykinin receptors in a murine in-vitro model of chronic airway inflammation

Zhang YP; Adner M; Cardell LO
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(4):1196-1207

Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-κB signaling pathways

Bachar O; Adner M; Uddman R; Cardell LO
Article: CIRCULATION RESEARCH. 2003;93(9):839-847

Cholesterol depletion impairs vascular reactivity to endothelin-1 by reducing store-operated Ca²⁺ entry dependent on TRPC1

Bergdahl A; Gomez MF; Dreja K; Xu SZ; Adner M; Beech DJ; Broman J; Hellstrand P; Swärd K
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(7):942-949

Pituitary adenylate cyclase-activating polypeptide, effects in the human nose

Kinhult J; Adner M; Uddman R; Cardell LO
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2002;137(7):971-982

An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle:: evidence that TNFα up-regulates 5-HT_2A-mediated contraction

Adner M; Rose AC; Zhang YP; Swärd K; Benson M; Uddman R; Shankley NP; Cardell LO
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2002;454(2-3):209-215

Analysis of the time course for organ culture-induced endothelin ET_B receptor upregulation in rat mesenteric arteries

Möller S; Uddman E; Welsh N; Edvinsson L; Adner M
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2002;452(2):215-222

Protein kinase C inhibitors decrease endothelin ET_B receptor mRNA expression and contraction during organ culture of rat mesenteric artery

Uddman E; Adner M; Edvinsson L
Article: MOLECULAR PHARMACOLOGY. 2002;62(3):705-713

Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists

Andersson DA; Adner M; Högestätt ED; Zygmunt PM
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 2001;224(1-2):151-158

Endocardial expression and functional characterization of endothelin-1

Opgaard OS; Adner M; Peters THF; Xu CB; Stevenow L; Gulbenkian S; Erlinge D; Edvinsson L; Sharma HS
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2001;133(6):927-935

Evidence that ET-1, but not ET-3 and S6b, ET_A-receptor mediated contractions in isolated rat mesenteric arteries are modulated by co-activation of ET_B receptors

Adner M; Shankley N; Edvinsson L
Article: EUROPEAN JOURNAL OF HEART FAILURE. 2001;3(3):293-299

Enhanced endothelin-1-induced contractions in mesenteric arteries from rats with congestive heart failure:: role of ET_B receptors

Bergdahl A; Valdemarsson S; Adner M; Sun XY; Hedner T; Edvinsson L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2000;131(1):51-56

The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery

Malmsjö M; Adner M; Harden TK; Pendergast W; Edvinsson L; Erlinge D
Article: NEUROREPORT. 1999;10(11):2355-2359

Cytokines increase endothelin ET_B receptor contractile activity in rat cerebral artery

Leseth KH; Adner M; Berg HK; White LR; Aasly J; Edvinsson L
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1999;376(3):223-232

Cytokines induce increased endothelin ET_B receptor-mediated contraction

Uddman E; Möller S; Adner M; Edvinsson L
Article: REGULATORY PEPTIDES. 1999;81(1-3):89-95

Interleukin-1β potentiates endothelin ET_B receptor-mediated contraction in cultured segments of human temporal artery

White LR; Leseth KH; Möller S; Juul R; Adner M; Cappelen J; Bovim G; Aasly J; Edvinsson L
Article: BLOOD PRESSURE. 1999;8(1):9-15

Selective increase of the contractile response to endothelin-1 in subcutaneous arteries from patients with essential hypertension

Lind H; Adner M; Erlinge D; Brunkwall J; Edvinsson L
Article: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 1998;25(10):788-794

Increased levels of endothelin ET_B receptor mRNA in human omental arteries after organ culture:: Quantification by competitive reverse transcription polymerase chain reaction

Möller S; Adner M; Edvinsson L
Article: ACTA PHYSIOLOGICA. 1998;164(1):21-27

Increased endothelin ET_B contractile activity in cultured segments of human temporal artery

White LR; Leseth KH; Juul R; Adner M; Cappelen J; Aasly J; Edvinsson L
Article: ACTA PHYSIOLOGICA. 1998;163(2):121-129

Appearance of contractile endothelin-B receptors in rat mesenteric arterial segments following organ culture

Adner M; Geary GG; Edvinsson L
Article: CARDIOVASCULAR RESEARCH. 1998;37(1):254-262

Regional variation in appearance of vascular contractile endothelin-B receptors following organ culture

Adner M; Uddman E; Cardell LO; Edvinsson L
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;340(1):75-79

Neuropeptide Y Y₁ receptor blockade does not alter adrenergic nerve responses of the rat tail artery

Duckles SP; Adner M; Edvinsson L; Krause DN
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 1997;10(5-6):293-298

Characterisation of endothelin induced relaxation in guinea-pig airways:: Evidence for dilatory ET_A and ET_B-receptors

Granstrom B; Adner M; Uddman R; Edvinsson L; Cardell LO
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1997;329(1):69-77

Transcriptional regulated plasticity of vascular contractile endothelin ETB receptors after organ culture

Moller S; Edvinsson L; Adner M
Article: NEUROSURGERY. 1997;40(2):346-351

Presence of contractile endothelin-A and dilatory endothelin-B receptors in human cerebral arteries

Nilsson T; Cantera L; Adner M; Edvinsson L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1996;119(6):1159-1166

Plasticity of contractile endothelin-B receptors in human arteries after organ culture

Adner M; Cantera L; Ehlert F; Nilsson L; Edvinsson L
Article: REGULATORY PEPTIDES. 1996;63(2-3):149-156

Endothelin-A and -B receptors in human coronary arteries and veins

Opgaard OS; Cantera L; Adner M; Edvinsson L
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 1996;16(4):698-704

Characterization of endothelin receptors in the cerebral vasculature and their lack of effect on spreading depression

Goadsby PJ; Adner M; Edvinsson L
Article: EUROPEAN RESPIRATORY JOURNAL. 1996;9(2):351-355

Contractile endothelin-B (ETB) receptors in human small bronchi

Adner M; Cardell LO; Sjoberg T; Ottosson A; Edvinsson L
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Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2023;53(10):1062-1066

Combined exposure to the alarmins TSLP, IL-33 and IL-25 enhances mast cell-dependent contractions of human bronchi

Belikova M; Safholm J; Al-Ameri M; Orre A-C; Dahlen S-E; Adner M
Letter: ALLERGY. 2022;77(3):1025-1028

Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway

Maccarana M; Liu J; Lampinen M; Rollman O; Adner M; Pejler G; Paivandy A
Letter: ALLERGY. 2021;76(7):2270-2273

Distinct effects of antigen and Compound 48/80 in the guinea pig trachea

Liu J; Kolmert J; Safholm J; Johnsson A-K; Zurita J; Wheelock CE; Dahlen S-E; Nilsson G; Adner M
Review: CLINICAL SCIENCE. 2020;134(11):1219-1242

Back to the future: re-establishing guinea pig in vivo asthma models.

Adner M; Canning BJ; Meurs H; Ford W; Ramos Ramírez P; van den Berg MPM; Birrell MA; Stoffels E; Lundblad LKA; Nilsson GP; Olsson HK; Belvisi MG; Dahlén S-E
Letter: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2016;311(1):L178-L179

The bronchodilatory capacity of imiquimod: the existence of two mechanisms

Larsson OJ; Manson ML; Starkhammar M; Fuchs B; Adner M; Georen SK; Cardell L-O
Review: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2013;26(5):532-539

Insights into mast cell functions in asthma using mouse models

Lei Y; Gregory JA; Nilsson GP; Adner M
Editorial comment: JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(5):846

AIRWAY HYPERRESPONSIVENESS-AN IMPORTANT PHENOMENON WITH UNCLEAR MECHANISMS

Adner M
Review: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2011;24(4):361-366

Inflammation-induced airway smooth muscle responsiveness is strain dependent in mice

Safholm J; Lovdahl C; Swedin L; Boels PJM; Dahlen S-E; Arner A; Adner M
Editorial comment: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2006;291(3):L322-L323

Toll-like receptor activation in airway smooth muscle: dual actions via separate MAPK pathways

Bachar O; Adner M; Cardell L-O
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):S92

Budesonide prevents cytokine-induced decrease of the relaxant response to β₂-agonists in mouse trachea

Adner M; Cardell L; Miller-Larsson A
Published conference paper: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(7):1137-1145

Nerve growth factor enhances cholinergic innervation and contractile response to electric field stimulation in a murine in vitro model of chronic asthma

Bachar O; Adner M; Uddman R; Cardell LO
Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(3):361-367

Cytokines and cytokine receptors in allergic rhinitis: how do they relate to the Th2 hypothesis in allergy?

Benson M; Adner M; Cardell LO
Published conference paper: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 1995;26:S314-S316

UP-REGULATION OF A NON-ET(A) RECEPTOR IN HUMAN ARTERIES IN-VITRO

ADNER M; ERLINGE D; NILSSON L; EDVINSSON L
Published conference paper: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 1995;26:S211-S213

EFFECTS OF THE COMBINED ET(A) AND ET(B) RECEPTOR ANTAGONIST PD145065 ON ARTERIES, ARTERIOLES, AND VEINS IN THE CAT HINDLIMB

EKELUND U; ADNER M; EDVINSSON L; MELLANDER S

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Senior Lecturer, Institute of Environmental Medicine, Karolinska Institutet, 2021-

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Docent, Karolinska Institutet, 2006

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