Michael Sachs

About me
Publications
CV
Public outreach and news

About me

Michael Sachs is a biostatistical researcher at the Karolinska Institute. He
has a PhD degree in biostatistics from the University of Washington, Seattle,
WA. He is a member of the Applied Biostatistics Group [1] at MEB [2] where he
collaborates with researchers from around the institute.
His research interests are the development and evaluation of risk prediction
models and biomarkers, assay development and validation, statistical
computing, causal inference in observational studies, and tools for
reproducible research.
[1] https://ki.se/en/meb/meb-biostatistics-group
[2] https://ki.se/en/meb/

Articles

Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2024;39(3):313-322

Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case-control study in Sweden

Dehara M; Kullberg S; Bixo M; Sachs MC; Grunewald J; Arkema EV
Article: STATISTICS IN MEDICINE. 2024;43(3):534-547

Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation

Gabriel EE; Sachs MC; Martinussen T; Waernbaum I; Goetghebeur E; Vansteelandt S; Sjolander A
Article: BIOSTATISTICS. 2023;25(1):220-236

Flexible evaluation of surrogacy in platform studies

Sachs MC; Gabriel EE; Crippa A; Daniels MJ
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2023;21(12):3132-3142

Increasing Risk of Lymphoma Over Time in Crohn's Disease but Not in Ulcerative Colitis: A Scandinavian Cohort Study

Olen O; Smedby KE; Erichsen R; Pedersen L; Halfvarson J; Hallqvist-Everhov A; Askling J; Ekbom A; Sachs MC; Sorensen HT; Ludvigsson JF
Article: BIOSTATISTICS. 2023;24(4):1017-1030

Cross-direct effects in settings with two mediators

Gabriel EE; Sjolander A; Follmann D; Sachs MC
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(544):2446-2453

Sharp Nonparametric Bounds for Decomposition Effects with Two Binary Mediators

Gabriel EE; Sachs MC; Sjolander A
Article: DIGESTIVE DISEASES AND SCIENCES. 2023;68(9):3596-3604

Suboptimal Guideline Adherence and Biomarker Underutilization in Monitoring of Post-operative Crohn's Disease

Li T; Click B; Bachour S; Sachs M; Barnes EL; Cohen BL; Contreras S; Axelrad J
Article: INFLAMMATORY BOWEL DISEASES. 2023;29(6):888-897

Early Initiation of Antitumor Necrosis Factor Therapy Reduces Postoperative Recurrence of Crohn's Disease Following Ileocecal Resection

Axelrad JE; Li T; Bachour SP; Nakamura TI; Shah R; Sachs MC; Chang S; Hudesman DP; Holubar SD; Lightner AL; Barnes EL; Cohen BL; Rieder F; Esen E; Remzi F; Regueiro M; Click B
Article: JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS. 2023;32(2):567-576

A General Method for Deriving Tight Symbolic Bounds on Causal Effects

Sachs MC; Jonzon G; Sjolander A; Gabriel EE
Article: BRITISH JOURNAL OF CANCER. 2023;128(7):1278-1285

Confirmatory prediction-driven RCTs in comparative effectiveness settings for cancer treatment

Brand A; Sachs MC; Sjoelander A; Gabriel EEE
Article: ERJ OPEN RESEARCH. 2023;9(2):492-2022

Modifiable lifestyle risk factors for sarcoidosis: a nested case-control study

Dehara M; Sachs MC; Grunewald J; Blomberg A; Arkema EV
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(541):684-692

Nonparametric Bounds for Causal Effects in Imperfect Randomized Experiments

Gabriel EE; Sjolander A; Sachs MC
Article: JOURNAL OF BIOPHARMACEUTICAL STATISTICS. 2022;32(6):858-870

Survival stacking with multiple data types using pseudo-observation-based-AUC loss

Ginestet PG; Gabriel EE; Sachs MC
Article: BRITISH JOURNAL OF CANCER. 2022;127(9):1636-1641

Confidence bands in survival analysis

Sachs MC; Brand A; Gabriel EE
Article: NUTRITION & DIABETES. 2022;12(1):43

The association of serum vitamin D with incident diabetes in an African American population

Joseph JJ; Langan S; Lunyera J; Kluwe B; Williams A; Chen H; Sachs MC; Hairston KG; Bertoni AG; Hsueh WA; Golden SH
Journal article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2022;117(10S):e567

S796 Monitoring in Post-Operative Crohn’s Disease: Describing Approaches and the Impact of Guidelines

Li T; Click B; Bachour S; Sachs M; Axelrad J
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2022;56(3):491-500

Age determines the risk of familial inflammatory bowel disease-A nationwide study

Halfvarson JF; Ludvigsson JF; Bresso F; Askling J; Sachs MC; Olen O
Journal article: GASTROENTEROLOGY. 2022;162(7):s-853

Tu1029: UNDERSTANDING SURVEILLANCE AND GUIDELINE ADHERENCE IN POST-OPERATIVE CROHN’S PATIENTS

Li T; Click B; Bachour SP; Sachs M; Axelrad JE
Journal article: GASTROENTEROLOGY. 2022;162(7):s-183-s-184

720: EARLY INITIATION OF ANTI-TUMOR NECROSIS FACTOR THERAPY REDUCES POSTOPERATIVE RECURRENCE OF CROHN'S DISEASE FOLLOWING ILEOCECAL RESECTION

Axelrad JE; Li T; Nakamura T; Bachour SP; Shah RS; Sachs M; Chang S; Hudesman D; Holubar SD; Cohen BL; Rieder F; Lightner AL; Esen E; Barnes EL; Remzi FH; Regueiro MD; Click B
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2022;117(538):939-950

Causal Bounds for Outcome-Dependent Sampling in Observational Studies

Gabriel EE; Sachs MC; Sjolander A
Article: ANNALS OF EPIDEMIOLOGY. 2022;66:1-4

Direct modeling of relative and absolute risks in register data: Mortality risk in sarcoidosis

Gabriel EE; Arkema EV; Sachs MC
Article: BMC PULMONARY MEDICINE. 2022;22(1):43

Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study

Dehara M; Sachs MC; Kullberg S; Grunewald J; Blomberg A; Arkema EV
Article: JOURNAL OF STATISTICAL SOFTWARE. 2022;102(9):1-34

Event History Regression with Pseudo-Observations: Computational Approaches and an Implementation in R

Sachs MC; Gabriel EE
Article: JOURNAL OF PEDIATRICS. 2021;238:66-73.e1

Serious Infections in Pediatric Inflammatory Bowel Disease 2002-2017-A Nationwide Cohort Study

Ludvigsson JF; Sachs MC; Jaras J; Malmborg P; Olen O
Article: MICROBIOLOGY SPECTRUM. 2021;9(2):e0054921-e00521

Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy

Saccon E; Bandera A; Sciume M; Mikaeloff F; Lashari AA; Aliberti S; Sachs MC; Billi F; Blasi F; Gabriel EE; Costantino G; De Roberto P; Krishnan S; Gori A; Peyvandi F; Scudeller L; Canetta C; Lorson CL; Valenti L; Singh K; Baldini L; Fracchiolla NS; Neogi U
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021;56(10):1152-1162

Adult-onset inflammatory bowel disease and rate of serious infections compared to the general population: a nationwide register-based cohort study 2002-2017

Ludvigsson JF; Holmgren J; Grip O; Halfvarson J; Askling J; Sachs MC; Olen O
Journal article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2021;116(1):s462

S966 Surveillance Rates and Modalities in Post-Op Crohn's Disease

Li T; Axelrad J; Click B; Sachs M; Bachour SP
Article: JOURNAL OF CROHNS & COLITIS. 2021;15(5):757-765

Association Between Statin Use and Inflammatory Bowel Diseases: Results from a Swedish, Nationwide, Population-based Case-control Study

Lochhead P; Khalili H; Sachs MC; Chan AT; Olen O; Ludvigsson JF
Journal article: GASTROENTEROLOGY. 2021;160(6):s-698-s-699

Su455 SIMILAR RATES OF POSTOPERATIVE OBJECTIVE RECURRENCE IN ADULT CROHN'S DISEASE PATIENTS ON DIFFERENT POSTOPERATIVE BIOLOGIC THERAPIES

Nakamura TI; Shah RS; Bachour SP; Sachs MC; Chang S; Hudesman D; Regueiro MD; Click BH; Axelrad JE
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2021;30(5):886-894

Hepatobiliary Cancer Risk in Patients with Inflammatory Bowel Disease: A Scandinavian Population-Based Cohort Study

Erichsen R; Olen O; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Ludvigsson JF; Sorensen HT
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021;56(4):410-421

Capturing biologic treatment for IBD in the Swedish Prescribed Drug Register and the Swedish National Patient Register - a validation study

Broms G; Soderling J; Sachs MC; Halfvarson J; Myrelid P; Ludvigsson JF; Everhov AH; Olen O
Article: GUT. 2021;70(2):297-308

Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden

Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(4):471-483

Drug survival of anti-TNF agents compared with vedolizumab as a second-line biological treatment in inflammatory bowel disease: results from nationwide Swedish registers

Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Article: BIOMETRICS. 2020;76(4):1053-1063

A unified evaluation of differential vaccine efficacy

Gabriel EE; Sachs MC; Follmann DA; Andersson TM-L
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2020;18(11):2491-2499.e3

Mortality of Patients With Microscopic Colitis in Sweden

Khalili H; Bergman D; Roelstraete B; Burke KE; Sachs MC; Olen O; Ludvigsson JF
Article: BRITISH JOURNAL OF SURGERY. 2020;107(11):1529-1538

Decrease in primary but not in secondary abdominal surgery for Crohn's disease: nationwide cohort study, 1990-2014

Kalman TD; Everhov AH; Nordenvall C; Sachs MC; Halfvarson J; Ekbom A; Ludvigsson JE; Myrelid P; Olen O
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2020;52(1):143-154

Inflammatory bowel disease and pancreatic cancer: a Scandinavian register-based cohort study 1969-2017

Everhov AH; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Ludvigsson JF; Sorensen HT; Olen O
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2020;51(11):1022-1030

Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study

Liu B; Wanders A; Wirdefeldt K; Sjolander A; Sachs MC; Eberhardson M; Ye W; Ekbom A; Olen O; Ludvigsson JF
Journal article: GASTROENTEROLOGY. 2020;158(6):s-408-s-409

Sa1752 POSTOPERATIVE CROHN'S DISEASE RECURRENCE BASED ON GUIDELINE CONCORDANT RISK STRATIFICATION

Shah RS; Nakamura TI; Sachs M; Hudesman D; Regueiro MD; Axelrad JE; Click BH
Journal article: GASTROENTEROLOGY. 2020;158(6):s-698-s-699

Su1911 CORRELATION BETWEEN HISTOLOGIC AND ENDOSCOPIC SCORING INDICES FOR EVALUATION OF POSTOPERATIVE DISEASE ACTIVITY IN CROHN'S DISEASE

Nakamura TI; Chauhan K; Sachs MC; Chang S; Hudesman D; Axelrad JE
Journal article: GASTROENTEROLOGY. 2020;158(6):s-924-s-926

Mo1796 TUMOR NECROSIS FACTOR ANTAGONISTS ARE SUPERIOR TO ANTI-INTEGRIN AND ANTI-IL-12/23 THERAPIES FOR PREVENTING POSTOPERATIVE RECURRENCE IN ADULT CROHN'S DISEASE PATIENTS REQUIRING POSTOPERATIVE THERAPY

Nakamura TI; Shah RS; Chauhan K; Sachs M; Chang S; Hudesman D; Click BH; Regueiro MD; Axelrad JE
Article: LANCET GASTROENTEROLOGY & HEPATOLOGY. 2020;5(5):475-484

Colorectal cancer in Crohn's disease: a Scandinavian population-based cohort study

Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: GASTROENTEROLOGY. 2020;158(6):1574-1583.e2

Microscopic Colitis and Risk of In flammatory Bowel Disease in a Nationwide Cohort Study

Khalili H; Burke KE; Roelstraete B; Sachs MC; Olen O; Ludvigsson JF
Article: EPIDEMIOLOGY. 2020;31(3):359-364

Aim for Clinical Utility, Not Just Predictive Accuracy

Sachs MC; Sjolander A; Gabriel EE
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2020;55(4):430-435

The use of ICD codes to identify IBD subtypes and phenotypes of the Montreal classification in the Swedish National Patient Register

Shrestha S; Olen O; Eriksson C; Everhov AH; Myrelid P; Visuri I; Ludvigsson JF; Schoultz I; Montgomery S; Sachs MC; Halfvarson J; Olsson M; Hjortswang H; Bengtsson J; Strid H; Andersson M; Jaghult S; Eberhardson M; Nordenvall C; Bjork J; Fagerberg UL; Rejler M; Grip O; Karling P; Block M; Angenete E; Hellstrom PM; Gustaysson A
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2020;51(8):789-800

Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study

Mouratidou N; Malmborg P; Sachs MC; Askling J; Ekbom A; Neovius M; Smedby KE; Savendahl L; Ludvigsson JF; Olen O
Article: GUT. 2020;69(3):453-461

Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964-2014

Olen O; Askling J; Sachs MC; Neovius M; Smedby KE; Ekbom A; Ludvigsson JF
Journal article: JOURNAL OF CROHNS & COLITIS. 2020;14(Supplement_1):s436-s437

P502 Tumour necrosis factor antagonists are superior to anti-integrin and anti-IL-12/23 therapies for preventing postoperative recurrence in adult Crohn’s disease patients requiring postoperative therapy

Nakamura T; Shah R; Sachs M; Chang S; Hudesman D; Click B; Axelrad J
Article: LANCET. 2020;395(10218):123-131

Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study

Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: CLINICAL EPIDEMIOLOGY. 2020;12:1059-1072

A Novel Method for Quantifying Intestinal Inflammatory Burden in Inflammatory Bowel Disease Using Register Data

Axelrad JE; Sachs MC; Ludvigsson JF; Olen O
Article: CLINICAL EPIDEMIOLOGY. 2020;12:273-285

Work Loss in Relation to Pharmacological and Surgical Treatment for Crohn's Disease: A Population-Based Cohort Study

Everhov A; Sachs M; Ludvigsson J; Khalili H; Askling J; Neovius M; Myrelid P; Halfvarson J; Nordenvall C; Soderling J; Olen O
Article: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS. 2019;68(5):1431-1446

Ensemble prediction of time-to-event outcomes with competing risks: a case-study of surgical complications in Crohn's disease

Sachs MC; Discacciati A; Everhov AH; Olen O; Gabriel EE
Article: INFLAMMATORY BOWEL DISEASES. 2019;25(10):1663-1673

Effects of Childhood-onset Inflammatory Bowel Disease on School Performance: A Nationwide Population-based Cohort Study Using Swedish Health and Educational Registers

Malmborg P; Mouratidou N; Sachs MC; Hammar U; Khalili H; Neovius M; Hjern A; Smedby KE; Ekbom A; Askling J; Ludvigsson JF; Olen O
Article: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. 2019;143(9):1106-1118

The Biospecimen Preanalytical Variables Program A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality

Carithers LJ; Agarwal R; Guan P; Odeh H; Sachs MC; Engel KB; Greytak SR; Barcus M; Soria C; Lih C-JJ; Williams PM; Branton PA; Sobin L; Fombonne B; Bocklage T; Andry C; Duffy ER; Sica G; Dhir R; Jewell S; Roche N; Moore HM; Das B; Camalier C; Burges R; Smith A; Elbum KM; Krubit T; Vatanian N; Matose T; Bradbury D; Seleski J; Shive C; Qi L; Hariharan P; Hunter S; McLean J; Robinson K; Gover E; Bavarva J; Tabor D; Rohrer D; Valley D; Hostetter G; Dosunmu-Dorincy E; Butler C; Burnes B; Yu K; Higgins K; Martinez C; Schultz F; Spencer C; Lurie-Marino M; Chavlovich A; Green A
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2019;17(7):1311-1322.e7

Gastrointestinal Infection Increases Odds of Inflammatory Bowel Disease in a Nationwide Case-Control Study

Axelrad JE; Olen O; Askling J; Lebwohl B; Khalili H; Sachs MC; Ludvigsson JF
Article: STATISTICS IN MEDICINE. 2019;38(7):1135-1146

Optimizing and evaluating biomarker combinations as trial-level general surrogates

Gabriel EE; Sachs MC; Daniels MJ; Halloran ME
Article: GASTROENTEROLOGY. 2019;156(3):614-622

Increased Mortality of Patients With Childhood- Onset Inflammatory Bowel Diseases, Compared With the General Population

Olen O; Askling J; Sachs MC; Frumento P; Neovius M; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2019;114(2):291-304

Fracture Risk in Patients With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study From 1964 to 2014

Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Article: BMC MEDICINE. 2019;17(1):14

From high to low malaria transmission in Zanzibar-challenges and opportunities to achieve elimination

Bjorkman A; Shakely D; Ali AS; Morris U; Mkali H; Abbas AK; Al-Mafazy A-W; Haji KA; Mcha J; Omar R; Cook J; Elfving K; Petzold M; Sachs MC; Aydin-Schmidt B; Drakeley C; Msellem M; Martensson A
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2019;54(1):55-63

Changes in inflammatory bowel disease subtype during follow-up and over time in 44,302 patients

Everhov AH; Sachs MC; Malmborg P; Nordenvall C; Myrelid P; Khalili H; Elmberg M; Ekbom A; Askling J; Jakobsson G; Halfvarson J; Ludvigsson JF; Olen O
Article: INFLAMMATORY BOWEL DISEASES. 2019;25(1):111-123

Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study

Weimers P; Halfvarson J; Sachs MC; Saunders-Pullman R; Ludvigsson JF; Peter I; Burisch J; Olen O
Article: BMC MEDICINE. 2018;16(1):215

A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination settinghigh coverage and safety, but no significant impact on transmission

Morris U; Msellem MI; Mkali H; Islam A; Aydin-Schmidt B; Jovel I; Shija SJ; Khamis M; Ali SM; Hodzic L; Magnusson E; Poirot E; Bennett A; Sachs MC; Tarning J; Martensson A; Ali AS; Bjorkman A
Article: BIOPRESERVATION AND BIOBANKING. 2018;16(6):467-476

Small Nucleolar RNA Score: An Assay to Detect Formalin-Overfixed Tissue

Ammerlaan W; Trouet J; Sachs MC; Guan P; Carithers L; Lambert P; Frasquilho S; Antunes L; Kofanova O; Rohrer D; Valley DR; Blanski A; Jewell S; Moore H; Betsou F
Article: BIOSTATISTICS. 2018;19(3):307-324

Evaluation and comparison of predictive individual-level general surrogates

Gabriel EE; Sachs MC; Halloran ME
Article: STATISTICS IN MEDICINE. 2018;37(4):519-529

Measuring precision in bioassays: Rethinking assay validation

Fay MP; Sachs MC; Miura K
Article: GASTROENTEROLOGY. 2018;154(3):518-528.e15

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden

Everhov AH; Halfvarson J; Myrelid P; Sachs MC; Nordenvall C; Soderling J; Ekbom A; Neovius M; Ludvigsson JF; Askling J; Olen O
Article: BMJ-BRITISH MEDICAL JOURNAL. 2017;358:j3951

Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014

Olen O; Askling J; Sachs MC; Frumento P; Neovius M; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Article: JOURNAL OF STATISTICAL SOFTWARE. 2017;79(CN2):2

plotROC: A Tool for Plotting ROC Curves

Sachs MC
Article: PLOS ONE. 2017;12(8):e0182739

Development and validation of a Luminex assay for detection of a predictive biomarker for PROSTVAC-VF therapy

Lucas JL; Tacheny EA; Ferris A; Galusha M; Srivastava AK; Ganguly A; Williams PM; Sachs MC; Thurin M; Tricoli JV; Ricker W; Gildersleeve JC
Journal article: CANCER RESEARCH. 2016;76(14_Supplement):1377

Abstract 1377: Impact of biospecimen pre-analytical factors on molecular analysis

Agarwal R; Guan P; Barcus M; Bavarva J; Burges R; Branton P; Carithers L; Camalier C; Das B; Lih J; Odeh H; Roche N; Rohrer D; Sachs M; Sobin L; Scott J; Smith A; Soria C; Valentino K; Valley D; Williams M; Moore H
Article: JOURNAL OF BIOPHARMACEUTICAL STATISTICS. 2016;26(6):1098-1110

Issues in developing multivariable molecular signatures for guiding clinical care decisions

Sachs MC; McShane LM
Article: ANNALS OF ONCOLOGY. 2016;27(1):10-15

Statistical controversies in clinical research: assessing pathologic complete response as a trial-level surrogate end point for early-stage breast cancer

Korn EL; Sachs MC; McShane LM
Journal article: CIRCULATION. 2015;131(suppl_1)

Abstract P157: Serum Vitamin D is Not Associated With Risk of Incident Diabetes in African Americans: The Jackson Heart Study

Harman JL; Chen H; Sachs MC; Hairston KG; Golden SH; Joseph JJ; Bertoni AG
Article: STATISTICS IN MEDICINE. 2015;34(3):381-395

Comparing and combining biomarkers as principle surrogates for time-to-event clinical endpoints

Gabriel EE; Sachs MC; Gilbert PB
Article: PLOS ONE. 2015;10(7):e0127353

Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue

Carrick DM; Mehaffey MG; Sachs MC; Altekruse S; Camalier C; Chuaqui R; Cozen W; Das B; Hernandez BY; Lih C-J; Lynch CF; Makhlouf H; McGregor P; McShane LM; Rohan JP; Walsh WD; Williams PM; Gillanders EM; Mechanic LE; Schully SD
Article: AMERICAN JOURNAL OF KIDNEY DISEASES. 2014;64(2):187-197

Estimated GFR and Circulating 24,25-Dihydroxyvitamin D₃ Concentration: A Participant-Level Analysis of 5 Cohort Studies and Clinical Trials

de Boer IH; Sachs MC; Chonchol M; Himmelfarb J; Hoofnagle AN; Ix JH; Kremsdorf RA; Lin YS; Mehrotra R; Robinson-Cohen C; Siscovick DS; Steffes MW; Thummel KE; Tracy RP; Wang Z; Kestenbaum B
Article: CIRCULATION. 2014;130(4):298-307

Fibroblast Growth Factor-23 and Incident Atrial Fibrillation The Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS)

Mathew JS; Sachs MC; Katz R; Patton KK; Heckbert SR; Hoofnagle AN; Alonso A; Chonchol M; Deo R; Ix JH; Siscovick DS; Kestenbaum B; de Boer IH
Article: JAMA NEUROLOGY. 2014;71(7):878-883

Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence of APOE Genotype in Persons With Pathologically Verified Alzheimer Disease

Ringman JM; Sachs MC; Zhou Y; Monsell SE; Saver JL; Vinters HV
Article: CIRCULATION-HEART FAILURE. 2014;7(3):409-417

Fibroblast Growth Factor-23 and Cardiovascular Disease in the General Population The Multi-Ethnic Study of Atherosclerosis

Kestenbaum B; Sachs MC; Hoofnagle AN; Siscovick DS; Ix JH; Robinson-Cohen C; Lima JAC; Polak JF; Blondon M; Ruzinski J; Rock D; de Boer IH
Article: ATHEROSCLEROSIS. 2014;233(2):331-337

Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA)

Linefsky JP; O'Brien KD; Sachs M; Katz R; Eng J; Michos ED; Budoff MJ; de Boer I; Kestenbaum B
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2014;63(12):1214-1222

Association of 25-Hydroxyvitamin D and Parathyroid Hormone With Incident Hypertension MESA (Multi-Ethnic Study of Atherosclerosis)

van Ballegooijen AJ; Kestenbaum B; Sachs MC; de Boer IH; Siscovick DS; Hoofnagle AN; Ix JH; Visser M; Brouwer IA
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(2):399-406

Physical Activity and Change in Estimated GFR among Persons with CKD

Robinson-Cohen C; Littman AJ; Duncan GE; Weiss NS; Sachs MC; Ruzinski J; Kundzins J; Rock D; de Boer IH; Ikizler TA; Himmelfarb J; Kestenbaum BR
Article: KIDNEY INTERNATIONAL. 2013;84(5):989-997

No independent association of serum phosphorus with risk for death or progression to end-stage renal disease in a large screen for chronic kidney disease

Mehrotra R; Peralta CA; Chen S-C; Li S; Sachs M; Shah A; Norris K; Saab G; Whaley-Connell A; Kestenbaum B; McCullough PA
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(11):2639-2645

25-Hydroxyvitamin D and Parathyroid Hormone Are Not Associated With Carotid Intima-Media Thickness or Plaque in the Multi-Ethnic Study of Atherosclerosis

Blondon M; Sachs M; Hoofnagle AN; Ix JH; Michos ED; Korcarz C; Gepner AD; Siscovick DS; Kaufman JD; Stein JH; Kestenbaum B; de Boer IH
Article: CLINICAL ENDOCRINOLOGY. 2013;79(3):429-436

Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis

Bosworth C; Sachs MC; Duprez D; Hoofnagle AN; Ix JH; Jacobs DRJ; Peralta CA; Siscovick DS; Kestenbaum B; de Boer IH
Article: DIABETES CARE. 2013;36(8):2423-2429

Circulating Vitamin D Metabolites and Subclinical Atherosclerosis in Type 1 Diabetes

Sachs MC; Brunzell JD; Cleary PA; Hoofnagle AN; Lachin JM; Molitch ME; Steffes MW; Zinman B; de Boer IH
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2013;310(2):179-188

Racial Differences in the Association of Serum 25-Hydroxyvitamin D Concentration With Coronary Heart Disease Events

Robinson-Cohen C; Hoofnagle AN; Ix JH; Sachs MC; Tracy RP; Siscovick DS; Kestenbaum BR; de Boer IH
Article: BIOMETRICAL JOURNAL. 2013;55(4):589-602

Partial summary measures of the predictiveness curve

Sachs MC; Zhou X-H
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;97(6):1243-1251

Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis

Sachs MC; Shoben A; Levin GP; Robinson-Cohen C; Hoofnagle AN; Swords-Jenny N; Ix JH; Budoff M; Lutsey PL; Siscovick DS; Kestenbaum B; de Boer IH
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2013;24(2):302-308

Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

Afkarian M; Sachs MC; Kestenbaum B; Hirsch IB; Tuttle KR; Hinnmelfarb J; de Boer IH
Article: KIDNEY INTERNATIONAL. 2013;83(2):323-330

Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease

de Boer IH; Sachs M; Hoofnagle AN; Utzschneider KM; Kahn SE; Kestenbaum B; Himmelfarb J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2012;97(12):4780-4788

Circulating Vitamin D Metabolites and Kidney Disease in Type 1 Diabetes

de Boer IH; Sachs MC; Cleary PA; Hoofnagle AN; Lachin JM; Molitch ME; Steffes MW; Sun W; Zinman B; Brunzell JD
Journal article: ALZHEIMERS & DEMENTIA. 2010;6(4S_Part_15):s460-s461

P3‐040: Factors associated with brain autopsy in a large sample of decedents

Sachs M
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;19(2):665-672

Pharmacological treatment of Alzheimer's disease: effect of race and demographic variables.

Hernandez S; McClendon MJ; Zhou X-HA; Sachs M; Lerner AJ
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2009;64(12):1251-1261

Total and Cause-Specific Mortality in the Cardiovascular Health Study

Newman AB; Sachs MC; Arnold AM; Fried LP; Kronmal R; Cushman M; Psaty BM; Harris TB; Robbins JA; Burke GL; Kuller LH; Lumley T
Article: RESPIRATORY CARE. 2009;54(10):1321-1328

Performance of Maximum Inspiratory Pressure Tests and Maximum Inspiratory Pressure Reference Equations for 4 Race/Ethnic Groups

Sachs MC; Enright PL; Stukovsky KDH; Jiang R; Barr RG
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(3):432-440

Long-Term Function in an Older Cohort-The Cardiovascular Health Study All Stars Study

Newman AB; Arnold AM; Sachs MC; Ives DG; Cushman M; Strotmeyer ES; Ding J; Kritchevsky SB; Chaves PHM; Fried LP; Robbins J
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_22):t712

P4‐144: Factors associated with brain autopsy in a large multicenter sample of decedents: A multivariate analysis

Sachs M; Koepsell T
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All other publications

Preprint: ARXIV. 2023

Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation

Gabriel EE; Sachs MC; Martinussen T; Waernbaum I; Goetghebeur E; Vansteelandt S; Sjölander A
Preprint: 2023

Sharp symbolic nonparametric bounds for measures of benefit in observational and imperfect randomized studies with ordinal outcomes

Gabriel EE; Sachs MC; Jensen AK
Preprint: ARXIV. 2022

Accessible Computation of Tight Symbolic Bounds on Causal Effects using an Intuitive Graphical Interface

Jonzon G; Sachs MC; Gabriel EE
Preprint: 2022

Flexible evaluation of surrogacy in Bayesian adaptive platform studies

Sachs MC; Gabriel EE; Crippa A; Daniels MJ
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2022;117(10):S567

Monitoring in Post-Operative Crohn's Disease: Describing Approaches and the Impact of Guidelines

Li T; Click B; Bachour S; Sachs M; Axelrad J
Preprint: ARXIV. 2021

Sharp nonparametric bounds for decomposition effects with two binary mediators

Gabriel EE; Sachs MC; Sjölander A
Letter: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2021;190(10):2231-2232

ON THE USE OF NONPARAMETRIC BOUNDS FOR CAUSAL EFFECTS IN NULL RANDOMIZED TRIALS

Gabriel EE; Sachs MC
Letter: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION. 2021;120(9):1788-1789

No evidence of substantial underreporting of COVID-19 deaths in Taiwan during 2020

Chen EY-T; Sachs MC; Dickman PW
Letter: JOURNAL OF CROHNS & COLITIS. 2021;15(8):1403-1404

Statin Use and Risk of Inflammatory Bowel Diseases: Authors' Reply

Lochhead P; Khalili H; Sachs MC; Chan AT; Olen O; Ludvigsson JF
Letter: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(9):1046-1047

Letter: vedolizumab or a second anti-TNF-no difference in efficacy for primary biologic failures with IBD. Authors' reply

Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Letter: GUT. 2021;70(5):998

Reply: Survival in Crohn's disease-associated small bowel adenocarcinoma

Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Preprint: MEDRXIV. 2021

A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy

Saccon E; Bandera A; Sciumè M; Mikeloff F; Lashari AA; Aliberti S; Sachs M; Billi F; Blasi F; Gabriel E; Costantino G; De Roberto P; Krishnan S; Gori A; Peyvandi F; Scudeller L; Lorson CL; Valenti L; Singh K; Baldini L; Fracchiolla NS; Neogi U
Editorial comment: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(5):642-643

Editorial: anti-TNF agents against vedolizumab as a second-line treatment? Not surprising tie game-authors' reply

Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2021;116:S462

Surveillance Rates and Modalities in Post-Op Crohn's Disease

Li T; Axelrad J; Click B; Sachs M; Bachour SP
Preprint: ARXIV. 2020

Nonparametric bounds for causal effects in imperfect randomized experiments

Gabriel EE; Sjölander A; Sachs MC
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115(1):s324-s325

S0647 Endoscopic and Histologic Activity Predict Inflammatory Bowel Disease-Related Hospitalization: A Nationwide Study

Axelrad JE; Sachs M; Ludvigsson JF; Olén O
Conference publication: GASTROENTEROLOGY. 2020;158(6):s-171-s-172

848 ASSOCIATION BETWEEN STATIN USE AND RISK OF INFLAMMATORY BOWEL DISEASES

Lochhead P; Khalili H; Sachs MC; Olen O; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2020;158(6):s-157-s-158

762 INCREASED RISK OF SMALL BOWEL CANCER AND SMALL BOWEL CANCER DEATH IN INFLAMMATORY BOWEL DISEASE: A BINATIONAL POPULATION-BASED STUDY

Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson JF
Preprint: ARXIV. 2020

A General Method for Deriving Tight Symbolic Bounds on Causal Effects

Sachs MC; Jonzon G; Sjölander A; Gabriel EE
Preprint: ARXIV. 2020

Causal bounds for outcome-dependent sampling in observational studies

Gabriel EE; Sachs MC; Sjölander A
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14(Supplement_1):s592-s593

P740 Age determines the risk of familial IBD: A nationwide case–control study

Halfvarson J; Ludvigsson J; Sachs M; Askling J; Olén O
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14(Supplement_1):s317

P327 Effectiveness of anti-TNF vs. vedolizumab as a second biologic in IBD: results from national Swedish registers

Rundquist S; Sachs M; Eriksson C; Olén O; Montgomery S; Halfvarson J
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14(Supplement_1):s013-s014

OP14 Risk of colorectal cancer diagnosis and colorectal cancer mortality in Crohn’s disease: A Scandinavian population-based cohort study

Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson JF
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14(Supplement_1):s007-s010

OP08 Inflammatory bowel disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden

Axelrad J; Olen O; Sachs M; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson J
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14:S436-S437

Tumour necrosis factor antagonists are superior to anti-integrin and anti-IL-12/23 therapies for preventing postoperative recurrence in adult Crohn's disease patients requiring postoperative therapy

Nakamura T; Shah R; Sachs M; Chang S; Hudesman D; Click B; Axelrad J
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14:S317-S318

Effectiveness of anti-TNF vs. vedolizumab as a second biologic in IBD: results from national Swedish registers

Rundquist S; Sachs M; Eriksson C; Olen O; Montgomery S; Halfvarson J
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14:S592-S593

Age determines the risk of familial IBD: A nationwide case-control study

Halfvarson J; Ludvigsson J; Sachs M; Askling J; Olen O
Conference publication: JOURNAL OF CROHNS & COLITIS. 2020;14:S013-S014

Risk of colorectal cancer diagnosis and colorectal cancer mortality in Crohn's disease: A Scandinavian population-based cohort study

Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2020;158(6):S157-S158

INCREASED RISK OF SMALL BOWEL CANCER AND SMALL BOWEL CANCER DEATH IN INFLAMMATORY BOWEL DISEASE: A BINATIONAL POPULATION-BASED STUDY

Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2020;158(6):S171-S172

ASSOCIATION BETWEEN STATIN USE AND RISK OF INFLAMMATORY BOWEL DISEASES

Lochhead P; Khalili H; Sachs MC; Olen O; Ludvigsson JF
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115:S325

Endoscopic and Histologic Activity Predict Inflammatory Bowel Disease-Related Hospitalization: A Nationwide Study

Axelrad JE; Sachs M; Ludvigsson JF; Olen O
Preprint: 2019

Aim for clinical utility, not just predictive accuracy

Sachs MC; Sjölander A; Gabriel EE
Conference publication: GASTROENTEROLOGY. 2019;156(6):s-101

513 – Mortality in Microscopic Colitis - Results from a Nationwide Cohort Study

Khalili H; Roelstraete B; Burke KE; Bergman D; Sachs MC; Olen O; Ludvigsson JF
Letter: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2019;114(5):830-831

The Problem of Incomplete Validation in Reporting Prediction Models

Sachs MC
Preprint: ARXIV. 2019

Ensemble Prediction of Time to Event Outcomes with Competing Risks: A Case Study of Surgical Complications in Crohn's Disease

Sachs MC; Discacciati A; Everhov Å; Olén O; Gabriel EE
Preprint: SSRN ELECTRONIC JOURNAL. 2019

Mortality in Microscopic Colitis - A Nationwide Cohort Study in Sweden

Khalili H; Bergman D; Roelstraete B; Burke KE; Sachs MC; Olén O; Ludvigsson JF
Letter: GUT. 2019;68(1):175-176

Association between inflammatory bowel disease and Parkinson's disease: seek and you shall find?

Weimers P; Halfvarson J; Sachs MC; Ludvigsson JF; Peter I; Olen O; Burisch J
Conference publication: GASTROENTEROLOGY. 2019;156(6):S101

MORTALITY IN MICROSCOPIC COLITIS - RESULTS FROM A NATIONWIDE COHORT STUDY

Khalili H; Roelstraete B; Burke KE; Bergman D; Sachs MC; Olen O; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2018;154(6):s-603

Su1841 - Fracture Risk in Patients with Inflammatory Bowel Disease - A Nationwide Cohort Study 1964-2014

Ludvigsson JF; Mahl M; Sachs MC; Björk J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12(supplement_1):s60-s61

DOP042 Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990–2014

Kalman D; Nordenvall C; Everhov AH; Sachs MC; Ludvigsson JF; Ekbom A; Myrelid P; Olén O
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12(suppl_1):s11-s12

OP016 Need for primary abdominal surgery, but not repeated surgery, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990–2014

Kalman D; Nordenvall C; Everhov AH; Ludvigsson JF; Sachs MC; Ekbom A; Olén O; Myrelid P
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12:S60-S61

Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-2014

Kalman D; Nordenvall C; Everhov AH; Sachs MC; Ludvigsson JF; Ekbom A; Myrelid P; Olen O
Conference publication: JOURNAL OF CROHNS & COLITIS. 2018;12:S11-S12

Need for primary abdominal surgery, but not repeated surgery, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-2014

Kalman D; Nordenvall C; Everhov AH; Ludvigsson JF; Sachs MC; Ekbom A; Olen O; Myrelid P
Conference publication: GASTROENTEROLOGY. 2018;154(6):S603

FRACTURE RISK IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE A NATIONWIDE COHORT STUDY 1964-2014

Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Corrigendum: STATISTICS IN MEDICINE. 2017;36(21):3440

Comparing and combining biomarkers as principal surrogates for time-to-event clinical endpoints (vol 34, pg 381, 2015)

Gabriel EE; Sachs MC; Gilbert PB
Conference publication: JOURNAL OF CROHNS & COLITIS. 2017;11(suppl_1):s14-s15

OP024 Childhood-onset inflammatory bowel disease and risk of cancer – a Swedish nationwide cohort study 1964–2014

Olén O; Askling J; Frumento P; Sachs MC; Neovius M; Eriksson J; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Conference publication: JOURNAL OF CROHNS & COLITIS. 2017;11:S14-S15

Childhood-onset inflammatory bowel disease and risk of cancer - a Swedish nationwide cohort study 1964-2014

Olen O; Askling J; Frumento P; Sachs MC; Neovius M; Eriksson J; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Editorial comment: R JOURNAL. 2016;8(2):277-292

An Introduction to Principal Surrogate Evaluation with the pseval Package

Sachs MC; Gabriel EE
Review: CHINESE CLINICAL ONCOLOGY. 2015;4(3):29

Statistical principles for omics-based clinical trials.

Sachs MC
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Employments

Statistician, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020-

Degrees and Education

Docent, Karolinska Institutet, 2022

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