Michael Sachs

About me
Publications
CV
Public outreach and news

About me

Michael Sachs is a biostatistical researcher at the Karolinska Institute. He
has a PhD degree in biostatistics from the University of Washington, Seattle,
WA. He is a member of the Applied Biostatistics Group [1] at MEB [2] where he
collaborates with researchers from around the institute.
His research interests are the development and evaluation of risk prediction
models and biomarkers, assay development and validation, statistical
computing, causal inference in observational studies, and tools for
reproducible research.
[1] https://ki.se/en/meb/meb-biostatistics-group
[2] https://ki.se/en/meb/

Articles

Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2024;39(3):313-322
Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case-control study in Sweden
Dehara M; Kullberg S; Bixo M; Sachs MC; Grunewald J; Arkema EV
Article: STATISTICS IN MEDICINE. 2024;43(3):534-547
Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation
Gabriel EE; Sachs MC; Martinussen T; Waernbaum I; Goetghebeur E; Vansteelandt S; Sjolander A
Article: BIOSTATISTICS. 2023;25(1):220-236
Flexible evaluation of surrogacy in platform studies
Sachs MC; Gabriel EE; Crippa A; Daniels MJ
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2023;21(12):3132-3142
Increasing Risk of Lymphoma Over Time in Crohn's Disease but Not in Ulcerative Colitis: A Scandinavian Cohort Study
Olen O; Smedby KE; Erichsen R; Pedersen L; Halfvarson J; Hallqvist-Everhov A; Askling J; Ekbom A; Sachs MC; Sorensen HT; Ludvigsson JF
Article: BIOSTATISTICS. 2023;24(4):1017-1030
Cross-direct effects in settings with two mediators
Gabriel EE; Sjolander A; Follmann D; Sachs MC
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(544):2446-2453
Sharp Nonparametric Bounds for Decomposition Effects with Two Binary Mediators
Gabriel EE; Sachs MC; Sjolander A
Article: DIGESTIVE DISEASES AND SCIENCES. 2023;68(9):3596-3604
Suboptimal Guideline Adherence and Biomarker Underutilization in Monitoring of Post-operative Crohn's Disease
Li T; Click B; Bachour S; Sachs M; Barnes EL; Cohen BL; Contreras S; Axelrad J
Article: INFLAMMATORY BOWEL DISEASES. 2023;29(6):888-897
Early Initiation of Antitumor Necrosis Factor Therapy Reduces Postoperative Recurrence of Crohn's Disease Following Ileocecal Resection
Axelrad JE; Li T; Bachour SP; Nakamura TI; Shah R; Sachs MC; Chang S; Hudesman DP; Holubar SD; Lightner AL; Barnes EL; Cohen BL; Rieder F; Esen E; Remzi F; Regueiro M; Click B
Article: JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS (JCGS). 2023;32(2):567-576
A General Method for Deriving Tight Symbolic Bounds on Causal Effects
Sachs MC; Jonzon G; Sjolander A; Gabriel EE
Article: BRITISH JOURNAL OF CANCER. 2023;128(7):1278-1285
Confirmatory prediction-driven RCTs in comparative effectiveness settings for cancer treatment
Brand A; Sachs MC; Sjoelander A; Gabriel EEE
Article: ERJ OPEN RESEARCH. 2023;9(2):492-2022
Modifiable lifestyle risk factors for sarcoidosis: a nested case-control study
Dehara M; Sachs MC; Grunewald J; Blomberg A; Arkema EV
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(541):684-692
Nonparametric Bounds for Causal Effects in Imperfect Randomized Experiments
Gabriel EE; Sjolander A; Sachs MC
Article: JOURNAL OF BIOPHARMACEUTICAL STATISTICS. 2022;32(6):858-870
Survival stacking with multiple data types using pseudo-observation-based-AUC loss
Ginestet PG; Gabriel EE; Sachs MC
Article: BRITISH JOURNAL OF CANCER. 2022;127(9):1636-1641
Confidence bands in survival analysis
Sachs MC; Brand A; Gabriel EE
Article: NUTRITION & DIABETES. 2022;12(1):43
The association of serum vitamin D with incident diabetes in an African American population
Joseph JJ; Langan S; Lunyera J; Kluwe B; Williams A; Chen H; Sachs MC; Hairston KG; Bertoni AG; Hsueh WA; Golden SH
Journal article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2022;117(10S):e567
S796 Monitoring in Post-Operative Crohn’s Disease: Describing Approaches and the Impact of Guidelines
Li T; Click B; Bachour S; Sachs M; Axelrad J
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2022;56(3):491-500
Age determines the risk of familial inflammatory bowel disease-A nationwide study
Halfvarson JF; Ludvigsson JF; Bresso F; Askling J; Sachs MC; Olen O
Journal article: GASTROENTEROLOGY. 2022;162(7):s-853
Tu1029: UNDERSTANDING SURVEILLANCE AND GUIDELINE ADHERENCE IN POST-OPERATIVE CROHN’S PATIENTS
Li T; Click B; Bachour SP; Sachs M; Axelrad JE
Journal article: GASTROENTEROLOGY. 2022;162(7):s-183-s-184
720: EARLY INITIATION OF ANTI-TUMOR NECROSIS FACTOR THERAPY REDUCES POSTOPERATIVE RECURRENCE OF CROHN'S DISEASE FOLLOWING ILEOCECAL RESECTION
Axelrad JE; Li T; Nakamura T; Bachour SP; Shah RS; Sachs M; Chang S; Hudesman D; Holubar SD; Cohen BL; Rieder F; Lightner AL; Esen E; Barnes EL; Remzi FH; Regueiro MD; Click B
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2022;117(538):939-950
Causal Bounds for Outcome-Dependent Sampling in Observational Studies
Gabriel EE; Sachs MC; Sjolander A
Article: ANNALS OF EPIDEMIOLOGY. 2022;66:1-4
Direct modeling of relative and absolute risks in register data: Mortality risk in sarcoidosis
Gabriel EE; Arkema EV; Sachs MC
Article: BMC PULMONARY MEDICINE. 2022;22(1):43
Reproductive and hormonal risk factors for sarcoidosis: a nested case-control study
Dehara M; Sachs MC; Kullberg S; Grunewald J; Blomberg A; Arkema EV
Article: JOURNAL OF STATISTICAL SOFTWARE. 2022;102(9):1-34
Event History Regression with Pseudo-Observations: Computational Approaches and an Implementation in R
Sachs MC; Gabriel EE
Article: JOURNAL OF PEDIATRICS. 2021;238:66-73.e1
Serious Infections in Pediatric Inflammatory Bowel Disease 2002-2017-A Nationwide Cohort Study
Ludvigsson JF; Sachs MC; Jaras J; Malmborg P; Olen O
Article: MICROBIOLOGY SPECTRUM. 2021;9(2):e0054921-e00521
Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy
Saccon E; Bandera A; Sciume M; Mikaeloff F; Lashari AA; Aliberti S; Sachs MC; Billi F; Blasi F; Gabriel EE; Costantino G; De Roberto P; Krishnan S; Gori A; Peyvandi F; Scudeller L; Canetta C; Lorson CL; Valenti L; Singh K; Baldini L; Fracchiolla NS; Neogi U
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021;56(10):1152-1162
Adult-onset inflammatory bowel disease and rate of serious infections compared to the general population: a nationwide register-based cohort study 2002-2017
Ludvigsson JF; Holmgren J; Grip O; Halfvarson J; Askling J; Sachs MC; Olen O
Journal article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2021;116(1):s462
S966 Surveillance Rates and Modalities in Post-Op Crohn's Disease
Li T; Axelrad J; Click B; Sachs M; Bachour SP
Article: JOURNAL OF CROHN'S AND COLITIS. 2021;15(5):757-765
Association Between Statin Use and Inflammatory Bowel Diseases: Results from a Swedish, Nationwide, Population-based Case-control Study
Lochhead P; Khalili H; Sachs MC; Chan AT; Olen O; Ludvigsson JF
Journal article: GASTROENTEROLOGY. 2021;160(6):s-698-s-699
Su455 SIMILAR RATES OF POSTOPERATIVE OBJECTIVE RECURRENCE IN ADULT CROHN'S DISEASE PATIENTS ON DIFFERENT POSTOPERATIVE BIOLOGIC THERAPIES
Nakamura TI; Shah RS; Bachour SP; Sachs MC; Chang S; Hudesman D; Regueiro MD; Click BH; Axelrad JE
Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2021;30(5):886-894
Hepatobiliary Cancer Risk in Patients with Inflammatory Bowel Disease: A Scandinavian Population-Based Cohort Study
Erichsen R; Olen O; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Ludvigsson JF; Sorensen HT
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021;56(4):410-421
Capturing biologic treatment for IBD in the Swedish Prescribed Drug Register and the Swedish National Patient Register - a validation study
Broms G; Soderling J; Sachs MC; Halfvarson J; Myrelid P; Ludvigsson JF; Everhov AH; Olen O
Article: GUT. 2021;70(2):297-308
Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden
Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2021;53(4):471-483
Drug survival of anti-TNF agents compared with vedolizumab as a second-line biological treatment in inflammatory bowel disease: results from nationwide Swedish registers
Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Article: BIOMETRICS. 2020;76(4):1053-1063
A unified evaluation of differential vaccine efficacy
Gabriel EE; Sachs MC; Follmann DA; Andersson TM-L
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2020;18(11):2491-2499.e3
Mortality of Patients With Microscopic Colitis in Sweden
Khalili H; Bergman D; Roelstraete B; Burke KE; Sachs MC; Olen O; Ludvigsson JF
Article: BRITISH JOURNAL OF SURGERY. 2020;107(11):1529-1538
Decrease in primary but not in secondary abdominal surgery for Crohn's disease: nationwide cohort study, 1990-2014
Kalman TD; Everhov AH; Nordenvall C; Sachs MC; Halfvarson J; Ekbom A; Ludvigsson JE; Myrelid P; Olen O
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2020;52(1):143-154
Inflammatory bowel disease and pancreatic cancer: a Scandinavian register-based cohort study 1969-2017
Everhov AH; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Ludvigsson JF; Sorensen HT; Olen O
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2020;51(11):1022-1030
Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study
Liu B; Wanders A; Wirdefeldt K; Sjolander A; Sachs MC; Eberhardson M; Ye W; Ekbom A; Olen O; Ludvigsson JF
Journal article: GASTROENTEROLOGY. 2020;158(6):s-408-s-409
Sa1752 POSTOPERATIVE CROHN'S DISEASE RECURRENCE BASED ON GUIDELINE CONCORDANT RISK STRATIFICATION
Shah RS; Nakamura TI; Sachs M; Hudesman D; Regueiro MD; Axelrad JE; Click BH
Journal article: GASTROENTEROLOGY. 2020;158(6):s-698-s-699
Su1911 CORRELATION BETWEEN HISTOLOGIC AND ENDOSCOPIC SCORING INDICES FOR EVALUATION OF POSTOPERATIVE DISEASE ACTIVITY IN CROHN'S DISEASE
Nakamura TI; Chauhan K; Sachs MC; Chang S; Hudesman D; Axelrad JE
Journal article: GASTROENTEROLOGY. 2020;158(6):s-924-s-926
Mo1796 TUMOR NECROSIS FACTOR ANTAGONISTS ARE SUPERIOR TO ANTI-INTEGRIN AND ANTI-IL-12/23 THERAPIES FOR PREVENTING POSTOPERATIVE RECURRENCE IN ADULT CROHN'S DISEASE PATIENTS REQUIRING POSTOPERATIVE THERAPY
Nakamura TI; Shah RS; Chauhan K; Sachs M; Chang S; Hudesman D; Click BH; Regueiro MD; Axelrad JE
Article: GASTROENTEROLOGY. 2020;158(6):1574-1583.e2
Microscopic Colitis and Risk of In flammatory Bowel Disease in a Nationwide Cohort Study
Khalili H; Burke KE; Roelstraete B; Sachs MC; Olen O; Ludvigsson JF
Article: EPIDEMIOLOGY. 2020;31(3):359-364
Aim for Clinical Utility, Not Just Predictive Accuracy
Sachs MC; Sjolander A; Gabriel EE
Article: THE LANCET GASTROENTEROLOGY AND HEPATOLOGY. 2020;5(5):475-484
Colorectal cancer in Crohn's disease: a Scandinavian population-based cohort study
Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2020;55(4):430-435
The use of ICD codes to identify IBD subtypes and phenotypes of the Montreal classification in the Swedish National Patient Register
Shrestha S; Olen O; Eriksson C; Everhov AH; Myrelid P; Visuri I; Ludvigsson JF; Schoultz I; Montgomery S; Sachs MC; Halfvarson J; Olsson M; Hjortswang H; Bengtsson J; Strid H; Andersson M; Jaghult S; Eberhardson M; Nordenvall C; Bjork J; Fagerberg UL; Rejler M; Grip O; Karling P; Block M; Angenete E; Hellstrom PM; Gustaysson A
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2020;51(8):789-800
Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study
Mouratidou N; Malmborg P; Sachs MC; Askling J; Ekbom A; Neovius M; Smedby KE; Savendahl L; Ludvigsson JF; Olen O
Article: GUT. 2020;69(3):453-461
Mortality in adult-onset and elderly-onset IBD: a nationwide register-based cohort study 1964-2014
Olen O; Askling J; Sachs MC; Neovius M; Smedby KE; Ekbom A; Ludvigsson JF
Journal article: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s436-s437
P502 Tumour necrosis factor antagonists are superior to anti-integrin and anti-IL-12/23 therapies for preventing postoperative recurrence in adult Crohn’s disease patients requiring postoperative therapy
Nakamura T; Shah R; Sachs M; Chang S; Hudesman D; Click B; Axelrad J
Article: THE LANCET. 2020;395(10218):123-131
Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study
Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Article: CLINICAL EPIDEMIOLOGY. 2020;12:1059-1072
A Novel Method for Quantifying Intestinal Inflammatory Burden in Inflammatory Bowel Disease Using Register Data
Axelrad JE; Sachs MC; Ludvigsson JF; Olen O
Article: CLINICAL EPIDEMIOLOGY. 2020;12:273-285
Work Loss in Relation to Pharmacological and Surgical Treatment for Crohn's Disease: A Population-Based Cohort Study
Everhov A; Sachs M; Ludvigsson J; Khalili H; Askling J; Neovius M; Myrelid P; Halfvarson J; Nordenvall C; Soderling J; Olen O
Article: THE JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES C (APPLIED STATISTICS). 2019;68(5):1431-1446
Ensemble prediction of time-to-event outcomes with competing risks: a case-study of surgical complications in Crohn's disease
Sachs MC; Discacciati A; Everhov AH; Olen O; Gabriel EE
Article: INFLAMMATORY BOWEL DISEASES. 2019;25(10):1663-1673
Effects of Childhood-onset Inflammatory Bowel Disease on School Performance: A Nationwide Population-based Cohort Study Using Swedish Health and Educational Registers
Malmborg P; Mouratidou N; Sachs MC; Hammar U; Khalili H; Neovius M; Hjern A; Smedby KE; Ekbom A; Askling J; Ludvigsson JF; Olen O
Article: ARCHIVES OF PATHOLOGY AND LABORATORY MEDICINE. 2019;143(9):1106-1118
The Biospecimen Preanalytical Variables Program A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality
Carithers LJ; Agarwal R; Guan P; Odeh H; Sachs MC; Engel KB; Greytak SR; Barcus M; Soria C; Lih C-JJ; Williams PM; Branton PA; Sobin L; Fombonne B; Bocklage T; Andry C; Duffy ER; Sica G; Dhir R; Jewell S; Roche N; Moore HM; Das B; Camalier C; Burges R; Smith A; Elbum KM; Krubit T; Vatanian N; Matose T; Bradbury D; Seleski J; Shive C; Qi L; Hariharan P; Hunter S; McLean J; Robinson K; Gover E; Bavarva J; Tabor D; Rohrer D; Valley D; Hostetter G; Dosunmu-Dorincy E; Butler C; Burnes B; Yu K; Higgins K; Martinez C; Schultz F; Spencer C; Lurie-Marino M; Chavlovich A; Green A
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2019;17(7):1311-1322.e7
Gastrointestinal Infection Increases Odds of Inflammatory Bowel Disease in a Nationwide Case-Control Study
Axelrad JE; Olen O; Askling J; Lebwohl B; Khalili H; Sachs MC; Ludvigsson JF
Article: STATISTICS IN MEDICINE. 2019;38(7):1135-1146
Optimizing and evaluating biomarker combinations as trial-level general surrogates
Gabriel EE; Sachs MC; Daniels MJ; Halloran ME
Article: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2019;114(2):291-304
Fracture Risk in Patients With Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study From 1964 to 2014
Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Article: GASTROENTEROLOGY. 2019;156(3):614-622
Increased Mortality of Patients With Childhood- Onset Inflammatory Bowel Diseases, Compared With the General Population
Olen O; Askling J; Sachs MC; Frumento P; Neovius M; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Article: BMC MEDICINE. 2019;17(1):14
From high to low malaria transmission in Zanzibar-challenges and opportunities to achieve elimination
Bjorkman A; Shakely D; Ali AS; Morris U; Mkali H; Abbas AK; Al-Mafazy A-W; Haji KA; Mcha J; Omar R; Cook J; Elfving K; Petzold M; Sachs MC; Aydin-Schmidt B; Drakeley C; Msellem M; Martensson A
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2019;54(1):55-63
Changes in inflammatory bowel disease subtype during follow-up and over time in 44,302 patients
Everhov AH; Sachs MC; Malmborg P; Nordenvall C; Myrelid P; Khalili H; Elmberg M; Ekbom A; Askling J; Jakobsson G; Halfvarson J; Ludvigsson JF; Olen O
Article: INFLAMMATORY BOWEL DISEASES. 2019;25(1):111-123
Inflammatory Bowel Disease and Parkinson's Disease: A Nationwide Swedish Cohort Study
Weimers P; Halfvarson J; Sachs MC; Saunders-Pullman R; Ludvigsson JF; Peter I; Burisch J; Olen O
Article: BMC MEDICINE. 2018;16(1):215
A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination settinghigh coverage and safety, but no significant impact on transmission
Morris U; Msellem MI; Mkali H; Islam A; Aydin-Schmidt B; Jovel I; Shija SJ; Khamis M; Ali SM; Hodzic L; Magnusson E; Poirot E; Bennett A; Sachs MC; Tarning J; Martensson A; Ali AS; Bjorkman A
Article: BIOPRESERVATION AND BIOBANKING. 2018;16(6):467-476
Small Nucleolar RNA Score: An Assay to Detect Formalin-Overfixed Tissue
Ammerlaan W; Trouet J; Sachs MC; Guan P; Carithers L; Lambert P; Frasquilho S; Antunes L; Kofanova O; Rohrer D; Valley DR; Blanski A; Jewell S; Moore H; Betsou F
Article: BIOSTATISTICS. 2018;19(3):307-324
Evaluation and comparison of predictive individual-level general surrogates
Gabriel EE; Sachs MC; Halloran ME
Article: STATISTICS IN MEDICINE. 2018;37(4):519-529
Measuring precision in bioassays: Rethinking assay validation
Fay MP; Sachs MC; Miura K
Article: GASTROENTEROLOGY. 2018;154(3):518-528.e15
Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden
Everhov AH; Halfvarson J; Myrelid P; Sachs MC; Nordenvall C; Soderling J; Ekbom A; Neovius M; Ludvigsson JF; Askling J; Olen O
Article: THE BMJ. 2017;358:j3951
Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
Olen O; Askling J; Sachs MC; Frumento P; Neovius M; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Article: JOURNAL OF STATISTICAL SOFTWARE. 2017;79(CN2):2
plotROC: A Tool for Plotting ROC Curves
Sachs MC
Article: PLOS ONE. 2017;12(8):e0182739
Development and validation of a Luminex assay for detection of a predictive biomarker for PROSTVAC-VF therapy
Lucas JL; Tacheny EA; Ferris A; Galusha M; Srivastava AK; Ganguly A; Williams PM; Sachs MC; Thurin M; Tricoli JV; Ricker W; Gildersleeve JC
Journal article: CANCER RESEARCH. 2016;76(14_Supplement):1377
Abstract 1377: Impact of biospecimen pre-analytical factors on molecular analysis
Agarwal R; Guan P; Barcus M; Bavarva J; Burges R; Branton P; Carithers L; Camalier C; Das B; Lih J; Odeh H; Roche N; Rohrer D; Sachs M; Sobin L; Scott J; Smith A; Soria C; Valentino K; Valley D; Williams M; Moore H
Article: JOURNAL OF BIOPHARMACEUTICAL STATISTICS. 2016;26(6):1098-1110
Issues in developing multivariable molecular signatures for guiding clinical care decisions
Sachs MC; McShane LM
Article: ANNALS OF ONCOLOGY. 2016;27(1):10-15
Statistical controversies in clinical research: assessing pathologic complete response as a trial-level surrogate end point for early-stage breast cancer
Korn EL; Sachs MC; McShane LM
Journal article: CIRCULATION. 2015;131(suppl_1)
Abstract P157: Serum Vitamin D is Not Associated With Risk of Incident Diabetes in African Americans: The Jackson Heart Study
Harman JL; Chen H; Sachs MC; Hairston KG; Golden SH; Joseph JJ; Bertoni AG
Article: STATISTICS IN MEDICINE. 2015;34(3):381-395
Comparing and combining biomarkers as principle surrogates for time-to-event clinical endpoints
Gabriel EE; Sachs MC; Gilbert PB
Article: PLOS ONE. 2015;10(7):e0127353
Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue
Carrick DM; Mehaffey MG; Sachs MC; Altekruse S; Camalier C; Chuaqui R; Cozen W; Das B; Hernandez BY; Lih C-J; Lynch CF; Makhlouf H; McGregor P; McShane LM; Rohan JP; Walsh WD; Williams PM; Gillanders EM; Mechanic LE; Schully SD
Article: AMERICAN JOURNAL OF KIDNEY DISEASES. 2014;64(2):187-197
Estimated GFR and Circulating 24,25-Dihydroxyvitamin D₃ Concentration: A Participant-Level Analysis of 5 Cohort Studies and Clinical Trials
de Boer IH; Sachs MC; Chonchol M; Himmelfarb J; Hoofnagle AN; Ix JH; Kremsdorf RA; Lin YS; Mehrotra R; Robinson-Cohen C; Siscovick DS; Steffes MW; Thummel KE; Tracy RP; Wang Z; Kestenbaum B
Article: CIRCULATION. 2014;130(4):298-307
Fibroblast Growth Factor-23 and Incident Atrial Fibrillation The Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS)
Mathew JS; Sachs MC; Katz R; Patton KK; Heckbert SR; Hoofnagle AN; Alonso A; Chonchol M; Deo R; Ix JH; Siscovick DS; Kestenbaum B; de Boer IH
Article: JAMA NEUROLOGY. 2014;71(7):878-883
Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence of APOE Genotype in Persons With Pathologically Verified Alzheimer Disease
Ringman JM; Sachs MC; Zhou Y; Monsell SE; Saver JL; Vinters HV
Article: CIRCULATION: HEART FAILURE. 2014;7(3):409-417
Fibroblast Growth Factor-23 and Cardiovascular Disease in the General Population The Multi-Ethnic Study of Atherosclerosis
Kestenbaum B; Sachs MC; Hoofnagle AN; Siscovick DS; Ix JH; Robinson-Cohen C; Lima JAC; Polak JF; Blondon M; Ruzinski J; Rock D; de Boer IH
Article: ATHEROSCLEROSIS. 2014;233(2):331-337
Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA)
Linefsky JP; O'Brien KD; Sachs M; Katz R; Eng J; Michos ED; Budoff MJ; de Boer I; Kestenbaum B
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2014;63(12):1214-1222
Association of 25-Hydroxyvitamin D and Parathyroid Hormone With Incident Hypertension MESA (Multi-Ethnic Study of Atherosclerosis)
van Ballegooijen AJ; Kestenbaum B; Sachs MC; de Boer IH; Siscovick DS; Hoofnagle AN; Ix JH; Visser M; Brouwer IA
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(2):399-406
Physical Activity and Change in Estimated GFR among Persons with CKD
Robinson-Cohen C; Littman AJ; Duncan GE; Weiss NS; Sachs MC; Ruzinski J; Kundzins J; Rock D; de Boer IH; Ikizler TA; Himmelfarb J; Kestenbaum BR
Article: KIDNEY INTERNATIONAL. 2013;84(5):989-997
No independent association of serum phosphorus with risk for death or progression to end-stage renal disease in a large screen for chronic kidney disease
Mehrotra R; Peralta CA; Chen S-C; Li S; Sachs M; Shah A; Norris K; Saab G; Whaley-Connell A; Kestenbaum B; McCullough PA
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(11):2639-2645
25-Hydroxyvitamin D and Parathyroid Hormone Are Not Associated With Carotid Intima-Media Thickness or Plaque in the Multi-Ethnic Study of Atherosclerosis
Blondon M; Sachs M; Hoofnagle AN; Ix JH; Michos ED; Korcarz C; Gepner AD; Siscovick DS; Kaufman JD; Stein JH; Kestenbaum B; de Boer IH
Article: CLINICAL ENDOCRINOLOGY. 2013;79(3):429-436
Parathyroid hormone and arterial dysfunction in the multi-ethnic study of atherosclerosis
Bosworth C; Sachs MC; Duprez D; Hoofnagle AN; Ix JH; Jacobs DRJ; Peralta CA; Siscovick DS; Kestenbaum B; de Boer IH
Article: DIABETES CARE. 2013;36(8):2423-2429
Circulating Vitamin D Metabolites and Subclinical Atherosclerosis in Type 1 Diabetes
Sachs MC; Brunzell JD; Cleary PA; Hoofnagle AN; Lachin JM; Molitch ME; Steffes MW; Zinman B; de Boer IH
Article: JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA). 2013;310(2):179-188
Racial Differences in the Association of Serum 25-Hydroxyvitamin D Concentration With Coronary Heart Disease Events
Robinson-Cohen C; Hoofnagle AN; Ix JH; Sachs MC; Tracy RP; Siscovick DS; Kestenbaum BR; de Boer IH
Article: BIOMETRICAL JOURNAL. 2013;55(4):589-602
Partial summary measures of the predictiveness curve
Sachs MC; Zhou X-H
Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;97(6):1243-1251
Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis
Sachs MC; Shoben A; Levin GP; Robinson-Cohen C; Hoofnagle AN; Swords-Jenny N; Ix JH; Budoff M; Lutsey PL; Siscovick DS; Kestenbaum B; de Boer IH
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2013;24(2):302-308
Kidney Disease and Increased Mortality Risk in Type 2 Diabetes
Afkarian M; Sachs MC; Kestenbaum B; Hirsch IB; Tuttle KR; Hinnmelfarb J; de Boer IH
Article: KIDNEY INTERNATIONAL. 2013;83(2):323-330
Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease
de Boer IH; Sachs M; Hoofnagle AN; Utzschneider KM; Kahn SE; Kestenbaum B; Himmelfarb J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2012;97(12):4780-4788
Circulating Vitamin D Metabolites and Kidney Disease in Type 1 Diabetes
de Boer IH; Sachs MC; Cleary PA; Hoofnagle AN; Lachin JM; Molitch ME; Steffes MW; Sun W; Zinman B; Brunzell JD
Journal article: ALZHEIMER'S AND DEMENTIA. 2010;6(4S_Part_15):s460-s461
P3‐040: Factors associated with brain autopsy in a large sample of decedents
Sachs M
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2010;19(2):665-672
Pharmacological treatment of Alzheimer's disease: effect of race and demographic variables.
Hernandez S; McClendon MJ; Zhou X-HA; Sachs M; Lerner AJ
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2009;64(12):1251-1261
Total and Cause-Specific Mortality in the Cardiovascular Health Study
Newman AB; Sachs MC; Arnold AM; Fried LP; Kronmal R; Cushman M; Psaty BM; Harris TB; Robbins JA; Burke GL; Kuller LH; Lumley T
Article: RESPIRATORY CARE. 2009;54(10):1321-1328
Performance of Maximum Inspiratory Pressure Tests and Maximum Inspiratory Pressure Reference Equations for 4 Race/Ethnic Groups
Sachs MC; Enright PL; Stukovsky KDH; Jiang R; Barr RG
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2009;57(3):432-440
Long-Term Function in an Older Cohort-The Cardiovascular Health Study All Stars Study
Newman AB; Arnold AM; Sachs MC; Ives DG; Cushman M; Strotmeyer ES; Ding J; Kritchevsky SB; Chaves PHM; Fried LP; Robbins J
Journal article: ALZHEIMER'S AND DEMENTIA. 2008;4(4S_Part_22):t712
P4‐144: Factors associated with brain autopsy in a large multicenter sample of decedents: A multivariate analysis
Sachs M; Koepsell T
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All other publications

Preprint: ARXIV. 2023
Inverse probability of treatment weighting with generalized linear outcome models for doubly robust estimation
Gabriel EE; Sachs MC; Martinussen T; Waernbaum I; Goetghebeur E; Vansteelandt S; Sjölander A
Preprint: 2023
Sharp symbolic nonparametric bounds for measures of benefit in observational and imperfect randomized studies with ordinal outcomes
Gabriel EE; Sachs MC; Jensen AK
Preprint: ARXIV. 2022
Accessible Computation of Tight Symbolic Bounds on Causal Effects using an Intuitive Graphical Interface
Jonzon G; Sachs MC; Gabriel EE
Preprint: 2022
Flexible evaluation of surrogacy in Bayesian adaptive platform studies
Sachs MC; Gabriel EE; Crippa A; Daniels MJ
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2022;117(10):S567
Monitoring in Post-Operative Crohn's Disease: Describing Approaches and the Impact of Guidelines
Li T; Click B; Bachour S; Sachs M; Axelrad J
Preprint: ARXIV. 2021
Sharp nonparametric bounds for decomposition effects with two binary mediators
Gabriel EE; Sachs MC; Sjölander A
Letter: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2021;190(10):2231-2232
ON THE USE OF NONPARAMETRIC BOUNDS FOR CAUSAL EFFECTS IN NULL RANDOMIZED TRIALS
Gabriel EE; Sachs MC
Letter: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION. 2021;120(9):1788-1789
No evidence of substantial underreporting of COVID-19 deaths in Taiwan during 2020
Chen EY-T; Sachs MC; Dickman PW
Letter: JOURNAL OF CROHN'S AND COLITIS. 2021;15(8):1403-1404
Statin Use and Risk of Inflammatory Bowel Diseases: Authors' Reply
Lochhead P; Khalili H; Sachs MC; Chan AT; Olen O; Ludvigsson JF
Letter: GUT. 2021;70(5):998
Reply: Survival in Crohn's disease-associated small bowel adenocarcinoma
Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Letter: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2021;53(9):1046-1047
Letter: vedolizumab or a second anti-TNF-no difference in efficacy for primary biologic failures with IBD. Authors' reply
Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Preprint: MEDRXIV. 2021
A distinct metabolic profile associated with a fatal outcome in COVID-19 patients during early epidemic in Italy
Saccon E; Bandera A; Sciumè M; Mikeloff F; Lashari AA; Aliberti S; Sachs M; Billi F; Blasi F; Gabriel E; Costantino G; De Roberto P; Krishnan S; Gori A; Peyvandi F; Scudeller L; Lorson CL; Valenti L; Singh K; Baldini L; Fracchiolla NS; Neogi U
Editorial comment: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2021;53(5):642-643
Editorial: anti-TNF agents against vedolizumab as a second-line treatment? Not surprising tie game-authors' reply
Rundquist S; Sachs MC; Eriksson C; Olen O; Montgomery S; Halfvarson J
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2021;116:S462
Surveillance Rates and Modalities in Post-Op Crohn's Disease
Li T; Axelrad J; Click B; Sachs M; Bachour SP
Preprint: ARXIV. 2020
Nonparametric bounds for causal effects in imperfect randomized experiments
Gabriel EE; Sjölander A; Sachs MC
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115(1):s324-s325
S0647 Endoscopic and Histologic Activity Predict Inflammatory Bowel Disease-Related Hospitalization: A Nationwide Study
Axelrad JE; Sachs M; Ludvigsson JF; Olén O
Conference publication: GASTROENTEROLOGY. 2020;158(6):s-171-s-172
848 ASSOCIATION BETWEEN STATIN USE AND RISK OF INFLAMMATORY BOWEL DISEASES
Lochhead P; Khalili H; Sachs MC; Olen O; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2020;158(6):s-157-s-158
762 INCREASED RISK OF SMALL BOWEL CANCER AND SMALL BOWEL CANCER DEATH IN INFLAMMATORY BOWEL DISEASE: A BINATIONAL POPULATION-BASED STUDY
Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson JF
Preprint: ARXIV. 2020
A General Method for Deriving Tight Symbolic Bounds on Causal Effects
Sachs MC; Jonzon G; Sjölander A; Gabriel EE
Preprint: ARXIV. 2020
Causal bounds for outcome-dependent sampling in observational studies
Gabriel EE; Sachs MC; Sjölander A
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s013-s014
OP14 Risk of colorectal cancer diagnosis and colorectal cancer mortality in Crohn’s disease: A Scandinavian population-based cohort study
Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson JF
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s007-s010
OP08 Inflammatory bowel disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden
Axelrad J; Olen O; Sachs M; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sørensen HT; Ludvigsson J
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s317
P327 Effectiveness of anti-TNF vs. vedolizumab as a second biologic in IBD: results from national Swedish registers
Rundquist S; Sachs M; Eriksson C; Olén O; Montgomery S; Halfvarson J
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s592-s593
P740 Age determines the risk of familial IBD: A nationwide case–control study
Halfvarson J; Ludvigsson J; Sachs M; Askling J; Olén O
Conference publication: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2020;115:S325
Endoscopic and Histologic Activity Predict Inflammatory Bowel Disease-Related Hospitalization: A Nationwide Study
Axelrad JE; Sachs M; Ludvigsson JF; Olen O
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14:S436-S437
Tumour necrosis factor antagonists are superior to anti-integrin and anti-IL-12/23 therapies for preventing postoperative recurrence in adult Crohn's disease patients requiring postoperative therapy
Nakamura T; Shah R; Sachs M; Chang S; Hudesman D; Click B; Axelrad J
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14:S317-S318
Effectiveness of anti-TNF vs. vedolizumab as a second biologic in IBD: results from national Swedish registers
Rundquist S; Sachs M; Eriksson C; Olen O; Montgomery S; Halfvarson J
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14:S013-S014
Risk of colorectal cancer diagnosis and colorectal cancer mortality in Crohn's disease: A Scandinavian population-based cohort study
Olen O; Erichsen R; Sachs MC; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14:S592-S593
Age determines the risk of familial IBD: A nationwide case-control study
Halfvarson J; Ludvigsson J; Sachs M; Askling J; Olen O
Conference publication: GASTROENTEROLOGY. 2020;158(6):S171-S172
ASSOCIATION BETWEEN STATIN USE AND RISK OF INFLAMMATORY BOWEL DISEASES
Lochhead P; Khalili H; Sachs MC; Olen O; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2020;158(6):S157-S158
INCREASED RISK OF SMALL BOWEL CANCER AND SMALL BOWEL CANCER DEATH IN INFLAMMATORY BOWEL DISEASE: A BINATIONAL POPULATION-BASED STUDY
Axelrad JE; Olen O; Sachs MC; Erichsen R; Pedersen L; Halfvarson J; Askling J; Ekbom A; Sorensen HT; Ludvigsson JF
Preprint: 2019
Aim for clinical utility, not just predictive accuracy
Sachs MC; Sjölander A; Gabriel EE
Conference publication: GASTROENTEROLOGY. 2019;156(6):s-101
513 – Mortality in Microscopic Colitis - Results from a Nationwide Cohort Study
Khalili H; Roelstraete B; Burke KE; Bergman D; Sachs MC; Olen O; Ludvigsson JF
Letter: AMERICAN JOURNAL OF GASTROENTEROLOGY. 2019;114(5):830-831
The Problem of Incomplete Validation in Reporting Prediction Models
Sachs MC
Preprint: ARXIV. 2019
Ensemble Prediction of Time to Event Outcomes with Competing Risks: A Case Study of Surgical Complications in Crohn's Disease
Sachs MC; Discacciati A; Everhov Å; Olén O; Gabriel EE
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Mortality in Microscopic Colitis - A Nationwide Cohort Study in Sweden
Khalili H; Bergman D; Roelstraete B; Burke KE; Sachs MC; Olén O; Ludvigsson JF
Letter: GUT. 2019;68(1):175-176
Association between inflammatory bowel disease and Parkinson's disease: seek and you shall find?
Weimers P; Halfvarson J; Sachs MC; Ludvigsson JF; Peter I; Olen O; Burisch J
Conference publication: GASTROENTEROLOGY. 2019;156(6):S101
MORTALITY IN MICROSCOPIC COLITIS - RESULTS FROM A NATIONWIDE COHORT STUDY
Khalili H; Roelstraete B; Burke KE; Bergman D; Sachs MC; Olen O; Ludvigsson JF
Conference publication: GASTROENTEROLOGY. 2018;154(6):s-603
Su1841 - Fracture Risk in Patients with Inflammatory Bowel Disease - A Nationwide Cohort Study 1964-2014
Ludvigsson JF; Mahl M; Sachs MC; Björk J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2018;12(supplement_1):s60-s61
DOP042 Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990–2014
Kalman D; Nordenvall C; Everhov AH; Sachs MC; Ludvigsson JF; Ekbom A; Myrelid P; Olén O
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2018;12(suppl_1):s11-s12
OP016 Need for primary abdominal surgery, but not repeated surgery, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990–2014
Kalman D; Nordenvall C; Everhov AH; Ludvigsson JF; Sachs MC; Ekbom A; Olén O; Myrelid P
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2018;12:S60-S61
Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-2014
Kalman D; Nordenvall C; Everhov AH; Sachs MC; Ludvigsson JF; Ekbom A; Myrelid P; Olen O
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2018;12:S11-S12
Need for primary abdominal surgery, but not repeated surgery, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-2014
Kalman D; Nordenvall C; Everhov AH; Ludvigsson JF; Sachs MC; Ekbom A; Olen O; Myrelid P
Conference publication: GASTROENTEROLOGY. 2018;154(6):S603
FRACTURE RISK IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE A NATIONWIDE COHORT STUDY 1964-2014
Ludvigsson JF; Mahl M; Sachs MC; Bjork J; Michaelsson K; Ekbom A; Askling J; Backman A-S; Olen O
Corrigendum: STATISTICS IN MEDICINE. 2017;36(21):3440
Comparing and combining biomarkers as principal surrogates for time-to-event clinical endpoints (vol 34, pg 381, 2015)
Gabriel EE; Sachs MC; Gilbert PB
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2017;11(suppl_1):s14-s15
OP024 Childhood-onset inflammatory bowel disease and risk of cancer – a Swedish nationwide cohort study 1964–2014
Olén O; Askling J; Frumento P; Sachs MC; Neovius M; Eriksson J; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2017;11:S14-S15
Childhood-onset inflammatory bowel disease and risk of cancer - a Swedish nationwide cohort study 1964-2014
Olen O; Askling J; Frumento P; Sachs MC; Neovius M; Eriksson J; Smedby KE; Ekbom A; Malmborg P; Ludvigsson JF
Editorial comment: R JOURNAL. 2016;8(2):277-292
An Introduction to Principal Surrogate Evaluation with the pseval Package
Sachs MC; Gabriel EE
Review: CHINESE CLINICAL ONCOLOGY. 2015;4(3):29
Statistical principles for omics-based clinical trials.
Sachs MC
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Employments

Statistician, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020-

Degrees and Education

Docent, Karolinska Institutet, 2022

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