Michael Alvarsson

About me
Publications
CV
Public outreach and news

Research

Michael Alvarsson is responsible for clinical studies on β-cell rest and the
HPA-axis on metabolic control in diabetics and clinical studies on the
effects of training on patients with type 2-diabetes.
Research group Growth and metabolism [1]
[1] http://default/node/2970

Articles

Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes
Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne GT; Alvarsson M; Lundberg JO; Zhou Z; Yang J; Pernow J
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2022;86(1):245-257
Glucose-Lowering Medications and Post-Dementia Survival in Patients with Diabetes and Dementia
Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: DIABETES. 2022;71(2):285-297
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:772801
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin
Trouva A; Alvarsson M; Calissendorff J; asvold BO; Vanky E; Hirschberg AL
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2021;13(1):197
The association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia
Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: PRIMARY CARE DIABETES. 2021;15(2):262-268
Risk factor management of type 2 diabetic patients in primary care in the Scandinavian countries between 2003 and 2015
Knudsen ST; Bodegard J; Birkeland KI; Furuseth K; Thuresson M; Lindh A; Nilsson PM; Alvarsson M; Jorgensen ME; Sondergaard J; Persson F
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2020;76(4):1581-1594
Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years
Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: DIABETES CARE. 2020;43(8):1851-1858
The Association of Lipoprotein(a) Plasma Levels With Prevalence of Cardiovascular Disease and Metabolic Control Status in Patients With Type 1 Diabetes
Littmann K; Wodaje T; Alvarsson M; Bottai M; Eriksson M; Parini P; Brinck J
Article: CELLS. 2020;9(7):E1712-1712
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase
Mahdi A; Tengbom J; Alvarsson M; Wernly B; Zhou Z; Pernow J
Article: BMJ OPEN DIABETES RESEARCH & CARE. 2020;8(1):e000833
Cholinesterase inhibitors in patients with diabetes mellitus and dementia: an open-cohort study of ∼23 000 patients from the Swedish Dementia Registry
Secnik J; Schwertner E; Alvarsson M; Hammar N; Fastbom J; Winblad B; Garcia-Ptacek S; Religa D; Eriksdotter M
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226
Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling
Mahdi A; Tratsiakovich Y; Tengbom J; Jiao T; Garib L; Alvarsson M; Yang J; Pernow J; Zhou Z
Article: ENDOCRINOLOGY, DIABETES & METABOLISM. 2019;2(1):e00053
Progression of glucose-lowering diabetes therapy in TECOS
Bethel MA; Engel SS; Stevens SR; Lokhnygina Y; Ding J; Josse RG; Alvarsson M; Hramiak I; Green JB; Peterson ED; Holman RR
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861
The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes
Mahdi A; Jiao T; Yang J; Kovamees O; Alvarsson M; von Heijne M; Zhou Z; Pernow J
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy
Mahdi A; Kovamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780
Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I
Zhou Z; Mahdi A; Tratsiakovich Y; Zahoran S; Kovamees O; Nordin F; Gonzalez AEU; Alvarsson M; Ostenson C-G; Andersson DC; Hedin U; Hermesz E; Lundberg JO; Yang J; Pernow J
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463
Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species
Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kovamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
Article: LAKARTIDNINGEN. 2018;115:EX4W
Stora framsteg inom diabetes typ 2.
Alvarsson M
Article: LAKARTIDNINGEN. 2018;115:EY3P
Ny era inom terapin för typ 2-diabetes – men vad är nytt? - Metformin fortfarande förstahandsval, men därefter rekommenderas att behandlingen individualiseras.
Alvarsson M; Östgren C-J
Article: DIABETES CARE. 2016;39(12):2304-2310
Effect of Sitagliptin on Kidney Function and Respective Cardiovascular Outcomes in Type 2 Diabetes: Outcomes From TECOS
Cornel JH; Bakris GL; Stevens SR; Alvarsson M; Bax WA; Chuang L-M; Engel SS; Lopes RD; McGuire DK; Riefflin A; Rodbard HW; Sinay I; Tankova T; Wainstein J; Peterson ED; Holman RR
Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2016;13(5):361-366
Improvement of insulin sensitivity in response to exercise training in type 2 diabetes mellitus is associated with vascular endothelial growth factor A expression
Wagner H; Fischer H; Degerblad M; Alvarsson M; Gustafsson T
Article: DIABETES CARE. 2016;39(3):345-352
No Effect of High-Dose Vitamin D Treatment on -Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial
Wagner H; Alvarsson M; Mannheimer B; Degerblad M; Ostenson C-G
Article: DIABETES, OBESITY AND METABOLISM. 2016;18(2):186-190
Frequency of cancer events with saxagliptin in the SAVOR-TIMI 53 trial
Leiter LA; Teoh H; Mosenzon O; Cahn A; Hirshberg B; Stahre CAM; Hoekstra JBL; Alvarsson M; Im K; Scirica BM; Bhatt DL; Raz I
Article: GROWTH HORMONE AND IGF RESEARCH. 2015;25(6):298-303
Improved glycemic control due to sitagliptin is not related to cortisol or the surrogate marker IGFBP-1 for hepatic insulin sensitivity
Arnetz L; Hage C; Ekberg NR; Alvarsson M; Brismar K; Norhammar A; Mellbin L
Article: JOURNAL OF RENAL CARE. 2015;41(3):187-194
A MULTI-DIMENSIONAL SUPPORT PROGRAMME FOR PATIENTS WITH DIABETIC KIDNEY DISEASE.
Pagels AA; Hylander B; Alvarsson M
Article: ENDOCRINE CONNECTIONS. 2015;4(2):92-99
Gender difference in adrenal sensitivity to ACTH is abolished in type 2 diabetes
Arnetz L; Ekberg NR; Brismar K; Alvarsson M
Article: LAKARTIDNINGEN. 2013;110(49-50):2246-2248
[HbA1c will complement other methods in the diagnosis of diabetes. Coordinated introduction in Sweden in January 2014].
Lilja M; Jansson S; Alvarsson M; Aldrimer M; Nordin G; Attvall S
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2013;369(14):1317-1326
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
Scirica BM; Bhatt DL; Braunwald E; Steg PG; Davidson J; Hirshberg B; Ohman P; Frederich R; Wiviott SD; Hoffman EB; Cavender MA; Udell JA; Desai NR; Mosenzon O; McGuire DK; Ray KK; Leiter LA; Raz I; SAVOR-TIMI 53 Steering Committee and Investigators
Article: ISRN ENDOCRINOLOGY. 2013;2013:148497-9
Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance.
Arnetz L; Rajamand Ekberg N; Höybye C; Brismar K; Alvarsson M
Article: LAKARTIDNINGEN. 2012;109(45):2031-2032
[Measuring blood ketones--when, where and how].
Jendle J; Alvarsson M; Hanås R; Attvall S
Article: CARDIOVASCULAR DIABETOLOGY. 2012;11:18
A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?
Alvarsson A; Sandgren B; Wendel C; Alvarsson M; Brismar K
Article: DIABETOLOGIA. 2011;54(6):1298-1303
Exposure to candesartan during the first trimester of pregnancy in type 1 diabetes: experience from the placebo-controlled DIabetic REtinopathy Candesartan Trials.
Porta M; Hainer JW; Jansson S-O; Malm A; Bilous R; Chaturvedi N; Fuller JH; Klein R; Orchard T; Parving H-H; Sjølie A-K; DIRECT Study Group
Article: REVIEW OF DIABETIC STUDIES. 2010;7(3):225-232
Effects of insulin versus sulphonylurea on beta-cell secretion in recently diagnosed type 2 diabetes patients: a 6-year follow-up study.
Alvarsson M; Berntorp K; Fernqvist-Forbes E; Lager I; Steen L; Orn T; Grill V
Article: THE LANCET. 2009;374(9683):39-47
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).
Buse JB; Rosenstock J; Sesti G; Schmidt WE; Montanya E; Brett JH; Zychma M; Blonde L; LEAD-6 Study Group
Article: DIABETIC MEDICINE. 2009;26(4):345-353
Factors determining normalization of glucose intolerance in middle-aged Swedish men and women: a 8-10-year follow-up
Alvarsson M; Hilding A; Ostenson C-G
Article: THE LANCET. 2008;372(9647):1385-1393
Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial.
Sjølie AK; Klein R; Porta M; Orchard T; Fuller J; Parving HH; Bilous R; Chaturvedi N; DIRECT Programme Study Group
Article: THE LANCET. 2008;372(9647):1394-1402
Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials.
Chaturvedi N; Porta M; Klein R; Orchard T; Fuller J; Parving HH; Bilous R; Sjølie AK; DIRECT Programme Study Group
Article: DIABETES, OBESITY AND METABOLISM. 2008;10(5):421-429
Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes:: a 4-year follow-up
Alvarsson M; Sundkvist G; Lager I; Berntorp K; Fernqvist-Forbes E; Steen L; Orn T; Holberg MA; Kirksaether N; Grill V
Article: DIABETES CARE. 2007;30(6):1364-1369
Initiate insulin by aggressive titration and education (INITIATE) -: A randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups
Yki-Jarvinen H; Juurinen L; Alvarsson M; Bystedt T; Caldwell I; Davies M; Lahdenpera S; Nijpels G; Vahatalo M
Article: DIABETOLOGIA. 2005;48(11):2262-2268
K-value and low insulin secretion in a non-obese white population:: predicted glucose tolerance after 25 years
Alvarsson M; Wajngot A; Cerasi E; Efendic S
Article: DIABETES CARE. 2005;28(6):1495-1497
Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes
Jörneskog G; Kalani M; Kuhl J; Båvenholm P; Katz A; Allerstrand G; Alvarsson M; Efendic S; Östenson CG; Pernow J; Wahren J; Brismar K
Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464
Special pre-manufactured footwear with insoles can prevent ulceration in diabetic patients with diabetic foot syndrome by pressure reduction. A prospective randomised study
Veitenhansl M; Stegner K; Hierl FX; Dieterle C; Feldmeier H; Gutt B; Landgraf R
Article: DIABETES CARE. 2003;26(8):2231-2237
Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients
Alvarsson M; Sundkvist G; Lager I; Henricsson M; Berntorp K; Fernqvist-Forbes E; Steen L; Westermark G; Westermark P; Örn T; Grill V
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2002;283(1):E20-E28
Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients
Blomqvist G; Alvarsson M; Grill V; Von Heijne G; Ingvar M; Thorell JO; Ston-Elander S; Widén L; Ekberg K
Article: DIABETES CARE. 1999;22(7):1043-1047
Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men
Carlsson S; Persson PG; Alvarsson M; Efendic S; Norman A; Svanström L; Östenson CG; Grill V
Article: DIABETOLOGIA. 1999;42(1):15-23
Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects
Grill V; Persson G; Carlsson S; Norman A; Alvarsson M; Östensson CG; Svanström L; Efendic S
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 1998;148(6):539-545
Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men
Carlsson S; Persson PG; Alvarsson M; Efendic S; Norman A; Svanström L; Östenson CG; Grill V
Article: JOURNAL OF INTERNAL MEDICINE. 1997;241(6):493-500
Enhancement of B-cell secretion by blood glucose normalization in type 2 diabetes is associated with fasting C-peptide levels
Clauson P; Alvarsson M; Grill V
Article: HEALTH PROMOTION INTERNATIONAL. 1997;12(2):151-160
Strategies and methods for implementing a community-based diabetes primary prevention program in Sweden
Bjaras G; Ahlbom A; Alvarsson M; Burstrom B; Diderichsen F; Efendic S; Grill V; Haglund BJ; Norman A; Persson PG; Svanstrom L; Tillgren P; Ullen H; Ostenson CG
Article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 1996;56(6):563-570
Impact of nicotinic acid treatment on insulin secretion and insulin sensitivity in low and high insulin responders
Alvarsson M; Grill V
Article: ACTA DIABETOLOGICA. 1995;32(2):86-91
RELATIONSHIP BETWEEN INSULIN RESPONSES TO D-GLUCOSE AND TO L-ARGININE IN WOMEN WITH A HISTORY OF GESTATIONAL DIABETES
ALVARSSON M; WAJNGOT A; EFENDIC S; GRILL V
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All other publications

Review: ACTA DIABETOLOGICA. 2014;51(2):185-192
Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes
Arnetz L; Dorkhan M; Alvarsson M; Brismar K; Ekberg NR
Review: DIABETES, METABOLIC SYNDROME AND OBESITY. 2014;7:409-420
Sex differences in type 2 diabetes: focus on disease course and outcomes.
Arnetz L; Ekberg NR; Alvarsson M
Published conference paper: ACTA PHYSIOLOGICA. 2008;192(1):117-125
Pathophysiology and treatment of patients with type 2 diabetes exhibiting failure to oral drugs
Efendic S; Alvarsson M; Brismar K; Wagner H
Published conference paper: DIABETIC MEDICINE. 1996;13(9):S37-S39
Characteristics of insulin release in healthy subjects and in subjects with a glucokinase (Glu 256 Lys) mutation
Grill V; Alvarsson M

Employments

Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, karolinska institutet, 2009

Research

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