Experienced Immunologist working on translational projects with the basis in pre-clinical science.
Current position: Research Group Leader, Associate Professor.
Particular interest in: Infection and Immunology; Innate Immune Responses; Tissue Inflammation and Pathology; Acute and Chronic Inflammation; Tissue Engineering.
Currently leading and managing several pre-clinical research projects. In addition, from 1st of January 2013 this includes the project leadership and management of the EU-FP7 INFECT project, which is a consortium composed of 14 partners, focusing on systems medicine in acute severe soft tissue infections.
1995, MSc in Biology (Immunology), Lund University.
2000, Doctoral Degree (PhD), Immunology, Lunds Universitet.
2010, Associate professor (Docent), Immunology, Karolinska Institutet.
Although much of my previous research have focused on experimental models of infectious diseases, the current focus of my research has shifted towards research projects based on basic pre-clinical immunology and infection with patient oriented studies. Currently we are developing 3D-tissue models, composed of a stroma (fibroblasts) matrix layer, a stratified epithelium and hematopoietic phagocyte cells. The research now principally concentrates on unraveling pathways controlling differentiation and function of human monocytes, macrophages and dendritic cells, in specific models, that resemble living tissue. The research aim at advancing our insight into the mechanisms regulating immune responses at steady state and during infection and inflammation. This includes exploring host pathogen interaction in lung, skin and oral tissue, as well as mechanisms of chronic inflammation in granulomatous diseases. The 3D tissue organisation are likely to have strong impact on cellular function and allow studies on human phagocyte cell activation and trafficking, in addition to interactions with pathogens in living tissue. We also anticipate that a more complete understanding of phagocyte cell regulation has the potential to generate new strategies of modulating tissue inflammation, by allowing therapeutic targeting of the immunological basis of disease.
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Journal of visualized experiments : JoVE 2015;(104):-
Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections
Scientific reports 2015;5():16945-
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
Disease models & mechanisms 2015;8(11):1413-25
Modulatory effects on dendritic cells by human herpesvirus 6
Frontiers in microbiology 2015;6():388-
Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells
Clinical immunology (Orlando, Fla.) 2015;156(2):85-97
Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients
Clinical immunology (Orlando, Fla.) 2014;153(1):112-22
Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates
PloS one 2014;9(8):e106107-
Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue
Disease models & mechanisms 2014;7(2):281-8
Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3
Clinical immunology (Orlando, Fla.) 2014;151(2):84-99
Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung
Journal of leukocyte biology 2014;96(3):481-9
Human herpesvirus 6A partially suppresses functional properties of DC without viral replication
PloS one 2013;8(3):e58122-
Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2012;302(2):L226-37
Prime-boost vaccination with rBCG/rAd35 enhances CD8⁺ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis-infected primates
Molecular medicine (Cambridge, Mass.) 2012;18():647-58
Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2(-/-)gc(-/-) Mice
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2010;71(2):83-90
Dendritic Cell Regulation by Cannabinoid-Based Drugs
Pharmaceuticals (Basel, Switzerland) 2010;3(8):2733-2750
Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7
PLOS PATHOGENS 2010;6(3):e1000813-
Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation
EUROPEAN JOURNAL OF IMMUNOLOGY 2010;40(1):117-23
Stromal Cell-Derived CXCL12 and CCL8 Cooperate To Support Increased Development of Regulatory Dendritic Cells Following Leishmania Infection
JOURNAL OF IMMUNOLOGY 2010;185(4):2360-71
Compartmentalization of Immune Responses in Human Tuberculosis Few CD8 + Effector T Cells but Elevated Levels of FbxP3 + Regulatory T Cells in the Granulomatous Lesions
AMERICAN JOURNAL OF PATHOLOGY 2009;174(6):2211-24
Isolation and culture of human hematopoietic progenitors for studies of dendritic cell biology
Methods in molecular biology (Clifton, N.J.) 2009;531():187-202
Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity
JOURNAL OF IMMUNOLOGY 2008;181(5):3057-66
Co-transplantation of Stromal Cells Interferes with the Rejection of Allogeneic Islet Grafts
IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE 2008;:213-6
Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination
CELLULAR MICROBIOLOGY 2006;8(10):1611-23
Strornal-cell regulation of dendritic-cell differentiation and function
TRENDS IN IMMUNOLOGY 2006;27(12):580-7
Invariant NKT cells are essential for the regulation of hepatic CXCL10 gene expression during Leishmania donovani infection
INFECTION AND IMMUNITY 2005;73(11):7541-7
Stromal cells direct local differentiation of regulatory dendritic cells
The immunopathology of experimental visceral leishmaniasis
IMMUNOLOGICAL REVIEWS 2004;:239-53
Leishmania-induced inhibition of macrophage antigen presentation analyzed at the single-cell level
JOURNAL OF IMMUNOLOGY 2003;171(12):6706-13
Antigen-presenting cells and anti-Salmonella immunity
MICROBES AND INFECTION 2001;3(14-15):1239-48
Differential involvement of dendritic cell subsets during acute Salmonella infection
JOURNAL OF IMMUNOLOGY 2001;166(11):6802-11
In vivo activation of dendritic cells and T cells during Salmonella enterica serovar typhimurium infection
INFECTION AND IMMUNITY 2001;69(9):5726-35
Salmonella typhimurium-induced cytokine production and surface molecule expression by murine macrophages
MICROBIAL PATHOGENESIS 2001;31(2):91-102
Salmonella enterica serovar Typhimurium-induced maturation of bone marrow-derived dendritic cells
INFECTION AND IMMUNITY 2000;68(11):6311-20
Salmonella infection of bone marrow-derived macrophages and dendritic cells: influence on antigen presentation and initiating an immune response
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 2000;27(4):313-20
Classical MHC class I peptide presentation of a bacterial fusion protein by bone marrow-derived dendritic cells
EUROPEAN JOURNAL OF IMMUNOLOGY 1999;29(1):180-8
Bacterial antigen delivery systems: phagocytic processing of bacterial antigens for MHC-I and MHC-II presentation to T cells
Behring Institute Mitteilungen 1997;(98):197-211
Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells
JOURNAL OF IMMUNOLOGY 1997;158(9):4229-36
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.
Gut 2016 10;65(10):1632-41Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
J. Leukoc. Biol. 2014 Sep;96(3):481-9Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.
Clin. Immunol. 2014 Jul;153(1):112-22Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.
PLoS ONE 2014 ;9(8):e106107