Mats Ulfendahl
Affiliated to Research | Docent
E-mail: mats.ulfendahl@ki.se
Visiting address: Solnavägen 9 - kvarter B8, 17165 Solna
Postal address: C4 Neurovetenskap, C4 Forskning Experimentell Traumatologi, 171 77 Stockholm
About me
- I started Medical School at KI in 1981, got my PhD (Dept. of Physiology) in
1989, and was appointed Associate Professor (physiology) in 1991. In 1997 the
ENT Clinic at the Karolinska Hospital recruited me as Lab Director to build
up their research laboratory. During 2002-2010 I was also Director of the
Center for Hearing and Communication Research at KI. Was appointed Professor
of Experimental Audiology and Otology in 2004. Initiated and was until 2009
Director of a “FAS Center” running a 10-year research program focusing on
hearing impairment in working life. During three years (2007-2009) I was
member of the Scientific Council for Medicine at the Swedish Research Council
(VR). Was appointed Secretary-General for Medicine and Health at VR 2010 (a
six-year term ending in 2015). Was among many other assignments responsible
for a trans-European cooperation structure for research and policy issues
related to antibiotic resistance, the Joint Programming Initiative on
Antimicrobial Resistance (chair 2010-2016). Been a member of the National
Priority Board for Highly Specialized Health Care (Rikssjukvårdsnämnden),
the Board of the Swedish Agency for Health Technology Assessment and
Assessment of Social Services (SBU), the Decision-Making Board for the
National Quality Registers, the National Steering group for the ALF Agreement
etc. Around the time I was appointed Secretary-General I moved my research
group back to the KI Campus and joined the Department of Neuroscience. During
2016-2017 I chaired an international expert panel appointed by the European
Commission to evaluate the European & Developing Countries Clinical Trials
Partnership (EDCTP). Member of international expert panels evaluating the
Canadian Institutes for Health Research (CIHR; 2016-2017), and the Human
Frontier Science Program (HFSP; ongoing). In 2016 I was elected chairman of
the board of the Swedish Society for Medical Research (SSMF), and chairman of
the Delegation for research of the Swedish Society for Medicine (Svenska
Läkaresällskapet). In 2017, I was appointed chairman of the board of
Forskningsinstitutet Hörselbron AB, a non-profit organisation that among
other things has established a unique national quality register for hearing
aids. Co-author of a Swedish textbook in physiology (the 6th edition
published in 2017).
The Swedish Dental Society's Honorary Award 2016; Honorary Doctor (Dr h.c.)
of Odontology, Malmö University College 2016; The Petrus and Augusta Hedlund
40-year anniversary award (4 MSEK) 2001; Guest Professor, Anhui Medical
School (Hefei, Kina) 2000.
Research
- My research is focused on the auditory system, and especially the function of
the hearing organ and how it is affected by trauma. My PhD thesis was about
the inner ear sensory cells and the structural and functional basis for their
motile properties. During my PhD work I initiated a long-term and very
fruitful collaboration with a research group a Columbia University (New York)
investigating the motion pattern of the intact hearing organ (was Associate
Research Scientist at Columbia Univ. 1989-90). We established an in vitro
model of the guinea pig inner ear and made unique measurements of extremely
small sound-evoked vibration using laser interferometry (a method we some
years later set up at the ENT Research Laboratory at the Karolinska
Hospital). We could demonstrate that the inner ear sensory cells (the outer
hair cells) have a key role in the motion pattern of the hearing organ and
thus for the sensitivity of the peripheral auditory system. My group also
studied mechanical properties at the cellular level using isolated sensory
cells, e.g. using atomic force microscopy. We have, for example, shown that
the mechanical characteristics of the sensory cells are affected by acoustic
overstimulation, a finding that may explain the temporary hearing impairment
caused by noise exposure. We also used confocal microscopy and advanced image
analysis tools to directly visualise the hearing organ and how it is affected
by sound. Among other things, we published the first confocal microscopy
images of the inner ear in the living quinea-pig. After moving to the
Karolinska Hospital the focus of my research gradually changed to the
mechanisms underlying hearing disorder and how to treat hearing impairment.
We have primarily worked with an animal model, in which we can directly
(using sound- or electrically evoked auditory brainstem responses) monitor
how the auditory function is affected by different intervention strategies.
Several studies (e.g. two recently completed EU projects) have investigated
structural and functional effects of neurotrophic factors but we have also
explored antioxidants, cell therapy approaches, and entirely novel
substances.
Articles
- Article: TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2014;11(3):187-194Khalifa SAM; Ulfendahl M; Bjork P; Schonberg T; Vieider C; Scarfone E
- Article: EXPERIMENTAL GERONTOLOGY. 2013;48(11):1173-1179Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the ratMannstrom P; Ulfhake B; Kirkegaard M; Ulfendahl M
- Article: TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2013;10(5):266-272Khalifa SAM; Bjork P; Vieider C; Ulfendahl M; Scarfone E
- Journal article: LANCET GLOBAL HEALTH. 2013;1(2):e64-e65Collins F; Beaudet A; Draghia-Akli R; Gruss P; Savill J; Syrota A; Dautry A; Ulfendahl M; Walport M; Onken J; Glass RI
- Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2012;1(12):e61Dash-Wagh S; Jacob S; Lindberg S; Fridberger A; Langel U; Ulfendahl M
- Article: EXPERIMENTAL NEUROLOGY. 2012;233(1):172-181Jorgensen JR; Fransson A; Fjord-Larsen L; Thompson LH; Houchins JP; Andrade N; Torp M; Kalkkinen N; Andersson E; Lindvall O; Ulfendahl M; Brunak S; Johansen TE; Wahlberg LU
- Article: NOISE & HEALTH. 2011;13(55):432-443Le Prell CG; Johnson AC; Lindblad AC; Skjonsberg A; Ulfendahl M; Guire K; Green GE; Campbell KCM; Miller JM
- Article: PLOS GENETICS. 2011;7(9):e1002285Hellstrom AR; Watt B; Fard SS; Tenza D; Mannstrom P; Narfstroem K; Ekesten B; Ito S; Wakamatsu K; Larsson J; Ulfendahl M; Kullander K; Raposo G; Kerje S; Hallbook F; Marks MS; Andersson L
- Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2011;39(5):501-507Gustafsson K; Backenroth-Ohsako G; Rosenhall U; Ternevall-Kjerulf E; Ulfendahl M; Alexanderson K
- Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2011;461(6):677-686Brownell WE; Jacob S; Hakizimana P; Ulfendahl M; Fridberger A
- Article: JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY. 2011;22(2):104-112Pienkowski M; Ulfendahl M
- Article: JOURNAL OF BIOMEDICAL OPTICS. 2010;15(5):056012von Tiedemann M; Fridberger A; Ulfendahl M; de Monvel JB
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2010;32(5):717-724Watanabe F; Kirkegaard M; Matsumoto S; Gont C; Mannstrom P; Ulfendahl M; Fridberger A
- Article: JOURNAL OF NEUROTRAUMA. 2010;27(9):1745-1751Fransson A; Maruyama J; Miller JM; Ulfendahl M
- Article: JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. 2010;39(2):115-121Kawaguchi S; Hultcrantz M; Jin Z; Ulfendahl M; Suzuki M
- Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010;39(1-3):110-115Saber A; Strand SP; Ulfendahl M
- Article: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY. 2010;6(3):307-315Saber A; Gont C; Dash-Wagh S; Kirkegaard M; Strand SP; Ulfendahl M
- Article: OTOLOGY & NEUROTOLOGY. 2009;30(4):551-558Hu Z; Ulfendahl M; Prieskorn DM; Olivius P; Miller JM
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2009;87(7):1712-1717Fransson A; Jaerlebark LE; Ulfendahl M
- Article: JOURNAL OF NEUROSCIENCE METHODS. 2009;179(2):271-277Jacob S; Johansson C; Ulfendahl M; Fridberger A
- Article: EAR AND HEARING. 2009;30(1):81-89Saber A; Laurell G; Bramer T; Edsman K; Engmer C; Ulfendahl M
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2008;86(11):2363-2375Magnusson AK; Linderholm P; Vieider C; Ulfendahl M; Erlandsson A
- Article: HEARING RESEARCH. 2008;236(1-2):33-41Severinsen SA; Raarup MK; Ulfendahl M; Wogensen L; Nyengaard JR; Kirkegaard M
- Article: JOURNAL OF NEUROTRAUMA. 2008;25(1):72-77Murai N; Kirkegaard M; Jarlebark L; Risling M; Suneson A; Ulfendahl M
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2008;27(1):145-154Jin Z; Ulfendahl M; Jarlebark L
- Article: AUDIOLOGY AND NEUROTOLOGY. 2008;13(2):97-104Skjoensberg A; Bucinskaite V; Laurell G; Ulfendahl M
- Article: NEUROBIOLOGY OF DISEASE. 2008;29(1):14-21Maruyama J; Miller JM; Ulfendahl M
- Article: LAB ON A CHIP. 2007;7(11):1603-1606Pesen D; Erlandsson A; Ulfendahl M; Haviland DB
- Article: BRAIN RESEARCH. 2007;1170:48-58Thonabulsombat C; Johansson S; Spenger C; Ulfendahl M; Olivius P
- Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):75-79Ulfendahl M; Hu Z; Olivius P; Duan M; Wei D
- Article: NEUROIMAGE. 2007;35(4):1393-1400Tomo I; Le Calvez S; Maier H; de Monvel JB; Fridberger A; Ulfendahl M
- Article: CELL AND TISSUE RESEARCH. 2007;328(2):257-270Jin Z; Mannstrom P; Jarlebark L; Ulfendahl M
- Article: JOURNAL OF BIOMEDICAL OPTICS. 2007;12(2):021005Jacob S; Tomo I; Fridberger A; de Monvel JB; Ulfendahl M
- Article: HEARING RESEARCH. 2007;224(1-2):27-33Skjonsberg A; Halsey K; Ulfendahl M; Dolan DF
- Article: NEUROBIOLOGY OF DISEASE. 2007;25(2):309-318Maruyama J; Yamagata T; Ulfendahl M; Bredberg G; Altschuler RA; Miller JM
- Article: DEVELOPMENTAL NEUROBIOLOGY. 2007;67(1):108-122Wei D; Jin Z; Jarlebark L; Scarfone E; Ulfendahl M
- Article: ACTA OTO-LARYNGOLOGICA. 2006;126(11):1140-1147Duan M; Chen Z; Qiu J; Ulfendahl M; Laurell G; Borg E; Ruan R
- Article: NEUROSCIENCE. 2006;142(2):425-435Kirkegaard M; Murai N; Risling M; Suneson A; Jarlebark L; Ulfendahl M
- Article: HEARING RESEARCH. 2006;219(1-2):74-84Jin Z; Mannstrom P; Skjonsberg A; Jarlebark L; Ulfendahl M
- Article: BIOPHYSICAL JOURNAL. 2006;91(1):364-381de Monvel JB; Brownell WE; Ulfendahl M
- Article: STEM CELLS AND DEVELOPMENT. 2006;15(3):449-459Hu Z; Ulfendahl M
- Article: ACTA OTO-LARYNGOLOGICA. 2006;126(4):346-352Liang GH; Jin Z; Ulfendahl M; Järlebark L
- Article: MICROSCOPY RESEARCH AND TECHNIQUE. 2006;69(1):10-20Von Tiedemann M; Fridberger A; Ulfendahl M; De Monvel JB
- Article: AUDIOLOGY AND NEUROTOLOGY. 2005;10(6):323-330Skjönsberg Å; Herrlin P; Duan ML; Johnson AC; Ulfendahl M
- Article: BRAIN RESEARCH. 2005;1051(1-2):137-144Hu ZQ; Andäng M; Ni DF; Ulfendahl M
- Article: BIOPHYSICAL JOURNAL. 2005;88(4):2982-2993Zelenskaya A; de Monvel JB; Pesen D; Radmacher M; Hoh JH; Ulfendahl M
- Article: HEARING RESEARCH. 2005;201(1-2):99-108Halsey K; Skjönsberg Å; Ulfendahl M; Dolan DF
- Article: NEUROBIOLOGY OF DISEASE. 2005;18(1):184-192Hu ZQ; Ulfendahl M; Olivius NP
- Article: EXPERIMENTAL CELL RESEARCH. 2005;302(1):40-47Hu ZQ; Wei DG; Johansson CB; Holmström N; Duan ML; Frisén J; Ulfendahl M
- Article: ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY. 2005;67(2):75-82Liang GH; Moore EJ; Ulfendahl M; Rydqvist B; Järlebark L
- Article: BRAIN RESEARCH. 2004;1026(1):68-73Hu ZQ; Ulfendahl M; Olivius NP
- Article: HEARING RESEARCH. 2004;197(1-2):131-136Chen ZQ; Ulfendahl M; Ruan RS; Tan L; Duan ML
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;78(1):75-86Yamagata T; Miller JM; Ulfendahl M; Olivius NP; Altschuler RA; Pyykkö I; Bredberg G
- Article: JOURNAL OF MICROSCOPY. 2004;215(Pt 2):203-212Johansson GA; Khanna SM; Nair A; Mannström P; Denbeaux G; Ulfendahl M
- Article: NEUROTOXICOLOGY AND TERATOLOGY. 2004;26(2):253-260Liang GH; Järlebark L; Ulfendahl M; Bian JT; Moore EJ
- Article: BRAIN RESEARCH. 2004;12(3):152-156Olivius P; Alexandrov L; Miller JM; Ulfendahl M; Bagger-Sjöbäck D; Kozlova EN
- Article: EXPERIMENTAL NEUROLOGY. 2004;185(1):7-14Hu ZQ; Ulfendahl M; Olivius NP
- Article: BIOPHYSICAL JOURNAL. 2003;85(6):3991-4001de Monvel JB; Scarfone E; Le Calvez S; Ulfendahl M
- Article: ACTA OTO-LARYNGOLOGICA. 2003;123(8):905-909Chen ZQ; Ulfendahl M; Ruan RS; Tan L; Duan ML
- Article: BRAIN RESEARCH. 2003;979(1-2):1-6Olivius P; Alexandrov L; Miller J; Ulfendahl M; Bagger-Sjöbäck D; Kozlova EN
- Article: NEUROTOXICOLOGY AND TERATOLOGY. 2003;25(3):349-359Liang GH; Järlebark L; Ulfendahl M; Moore EJ
- Article: AUDIOLOGY AND NEUROTOLOGY. 2003;8(1):49-56Chen ZQ; Duan ML; Lee H; Ruan RS; Ulfendahl M
- Article: JOURNAL OF NEUROSCIENCE. 2002;22(22):9850-9857Fridberger A; de Monvel JB; Ulfendahl M
- Article: NEUROREPORT. 2002;13(10):1295-1299Duan ML; Bordet T; Mezzina M; Kahn A; Ulfendahl M
- Article: LAKARTIDNINGEN. 2002;99(16):1848Ulfendahl M
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(3):1657-1660Shinohara T; Bredberg G; Ulfendahl M; Pyykkö I; Olivius NP; Kaksonen R; Lindström B; Altschuler R; Miller JM
- Article: NEUROSCIENCE. 2002;111(3):625-634Magnusson AK; Ulfendahl M; Tham R
- Article: BIOPHYSICAL JOURNAL. 2001;80(5):2455-2470de Monvel JB; Le Calvez S; Ulfendahl M
- Article: HEARING RESEARCH. 2001;151(1-2):41-47Ulfendahl M; Flock Å; Scarfone E
- Article: NEUROIMAGE. 2000;12(3):307-313Ulfendahl M; Scarfone E; Flock Å; Le Calvez S; Conradi P
- Article: BRAIN CELL BIOLOGY. 2000;29(9):645-652Le Calvez S; Ulfendahl M
- Article: JOURNAL OF NEUROSCIENCE. 1999;19(11):4498-4507Flock Å; Flock B; Fridberger A; Scarfone E; Ulfendahl M
- Article: ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY. 1999;61(2):57-62Conradi P; Ulfendahl M
- Article: HEARING RESEARCH. 1999;128(1-2):166-174Chan E; Ulfendahl M
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(12):7127-7132Fridberger A; Flock Å; Ulfendahl M; Flock B
- Article: PHYSIOLOGY. 1998;13:107-111Ulfendahl M; Flock Å
- Article: ACTA OTO-LARYNGOLOGICA. 1998;118(3):352-361Fridberger A; Van Maarseveen JTPW; Ulfendahl M
- Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1998;436(1):9-15Ulfendahl M; Chan E; McConnaughey WB; Prost-Domasky S; Elson EL
- Article: NEUROSCIENCE. 1998;83(3):961-968Chan E; Suneson A; Ulfendahl M
- Article: NEUROSCIENCE. 1998;83(1):215-228Flock Å; Scarfone E; Ulfendahl M
- Article: HEARING RESEARCH. 1998;116(1-2):71-85Khanna SM; Ulfendahl M; Steele CR
- Article: ACTA PHYSIOLOGICA. 1997;161(4):533-539Chan E; Ulfendahl M
- Article: ACTA PHYSIOLOGICA. 1997;161(2):239-252Fridberger A; vanMaarseveen JTPW; Scarfone E; Ulfendahl M; Flock B; Flock A
- Article: NEURAL PLASTICITY. 1997;6(2):105-113Andersson L; Ulfendahl M; Tham R
- Article: JOURNAL OF NEUROPHYSIOLOGY. 1996;76(6):3850-3862Mechanical response characteristics of the hearing organ in the low-frequency regions of the cochleaUlfendahl M; Khanna SM; Fridberger A; Flock A; Flock B; Jager W
- Article: ACTA PHYSIOLOGICA. 1996;158(3):275-285Ulfendahl M; Khanna SM; Decraemer WF
- Article: NEUROSCIENCE. 1996;75(2):587-600Scarfone E; Ulfendahl M; Lundeberg T
- Article: NEUROSCIENCE. 1996;72(1):199-212Ulfendahl M; Khanna SM; Flock A
- Article: ACTA OTO-LARYNGOLOGICA. 1996;116(1):17-24Fridberger A; Ulfendahl M
- Article: ANNALS OF BIOMEDICAL ENGINEERING. 1995;23(5):583-607TEICH MC; HENEGHAN C; KHANNA SM; FLOCK A; ULFENDAHL M; BRUNDIN L
- Article: NEUROREPORT. 1995;6(8):1157-1160ULFENDAHL M; KHANNA SM; HENEGHAN C
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All other publications
- Review: REGENERATIVE MEDICINE. 2013;8(3):309-318Hu Z; Ulfendahl M
- Other: LAKARTIDNINGEN. 2010;107(19-20):1281Ulfendahl M; Adami J
- Letter: OTOLOGY & NEUROTOLOGY. 2010;31(1):179-180Hu Z; Ulfendahl M
- Corrigendum: HEARING RESEARCH. 2010;259(1-2):118Duan ML; Ulfendahl M; Laurell G; Counter SA; Pyykko I; Borg E; Rosenhall U
- Editorial comment: JOURNAL OF BIOMEDICAL OPTICS. 2007;12(2):021001-021001-1-021001Anvari B; Brownell WE; Freeman DM; Ulfendahl M
- Review: HEARING RESEARCH. 2002;169(1-2):169-178Duan ML; Ulfendahl M; Laurell G; Counter AS; Pyykkö I; Borg E; Rosenhall U
- Published conference paper: AUDIOLOGY AND NEUROTOLOGY. 2002;7(1):27-30Ulfendahl M; de Monvel JB; Le Calvez S
- Review: LAKARTIDNINGEN. 2000;97(10):1106-1112Duan ML; Ulfendahl M; Ahlberg A; Pyykkö I; Borg E
- Review: CURRENT OPINION IN NEUROBIOLOGY. 1998;8(4):475-479Ulfendahl M; Flock Å
- Review: LAKARTIDNINGEN. 1997;94(45):4077-4080Ulfendahl M
- Review: PROGRESS IN NEUROBIOLOGY. 1997;53(3):331-380Ulfendahl M
Employments
- Affiliated to Research, Department of Neuroscience, Karolinska Institutet, 2024-2026
Degrees and Education
- Docent, Karolinska Institutet, 1991