Martin Köhler

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Articles

Article: DIABETES. 2021;70(1):111-118
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
Barker CJ; Tessaro FHG; Ferreira SDS; Simas R; Ayala TS; Kohler M; Rajasekaran SS; Martins JO; Dare E; Berggren P-O
Article: SCIENTIFIC REPORTS. 2020;10(1):20145
Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells
Moede T; Leibiger B; Sanchez PV; Dare E; Kohler M; Muhandiramlage TP; Leibiger IB; Berggren P-O
Article: CELL TRANSPLANTATION. 2020;29:963689720913256-096368972091325
Islet Transplantation to the Anterior Chamber of the Eye-A Future Treatment Option for Insulin-Deficient Type-2 Diabetics? A Case Report from a Nonhuman Type-2 Diabetic Primate
Tun SBB; Chua M; Hasan R; Kohler M; Zheng X; Ali Y; Abdulreda MH; Juntti-Berggren L; Barathi VA; Berggren P-O
Article: THE FASEB JOURNAL. 2020;34(1):945-959
In vivo Ca²⁺ dynamics in single pancreatic β cells
Jacob S; Kohler M; Troster P; Visa M; Garcia-Prieto CF; Alanentalo T; Moede T; Leibiger B; Leibiger IB; Berggren P-O
Article: JOURNAL OF BIOPHOTONICS. 2018;11(12):e201800206
Integrative microendoscopic system combined with conventional microscope for live animal tissue imaging
Kohler M; Paulson B; Kim Y; Lee S; Dicker A; van Krieken P; Kim JY; Pack C-G; Joo J; Berggren P-O; Kim JK
Article: CELL REPORTS. 2018;24(4):922-934
Blocking Ca²⁺ Channel β₃ Subunit Reverses Diabetes
Lee K; Kim J; Kohler M; Yu J; Shi Y; Yang S-N; Ryu SH; Berggren P-O
Article: CELLULAR SIGNALLING. 2018;46:120-128
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Article: CELL REPORTS. 2017;20(6):1490-1501
Pancreatic Islet Blood Flow Dynamics in Primates
Diez JA; Arrojo e Drigo R; Zheng X; Stelmashenko OV; Chua M; Rodriguez-Diaz R; Fukuda M; Kohler M; Leibiger I; Tun SBB; Ali Y; Augustine GJ; Barathi VA; Berggren P-O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(20):E2611-E2619
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
Avall K; Ali Y; Leibiger IB; Leibiger B; Moede T; Paschen M; Dicker A; Dare E; Kohler M; Ilegems E; Abdulreda MH; Graham M; Crooke RM; Tay VSY; Refai E; Nilsson SK; Jacob S; Selander L; Berggren P-O; Juntti-Berggren L
Article: NATURE MEDICINE. 2015;21(4):363-372
Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment
Marquard J; Otter S; Welters A; Stirban A; Fischer A; Eglinger J; Herebian D; Kletke O; Klemen MS; Stozer A; Wnendt S; Piemonti L; Kohler M; Ferrer J; Thorens B; Schliess F; Rupnik MS; Heise T; Berggren P-O; Kloecker N; Meissner T; Mayatepek E; Eberhard D; Kragl M; Lammert E
Article: DIABETES. 2014;63(12):4100-4114
Defects in β-Cell Ca²⁺ Dynamics in Age-Induced Diabetes
Li L; Trifunovic A; Kohler M; Wang Y; Berglund JP; Illies C; Juntti-Berggren L; Larsson N-G; Berggren P-O
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(8):1229-1238
Evidence for Ca²⁺-regulated ATP release in gastrointestinal stromal tumors
Berglund E; Berglund D; Akcakaya P; Ghaderi M; Dare E; Berggren P-O; Kohler M; Aspinwall CA; Lui W-O; Zedenius J; Larsson C; Branstrom R
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2012;69(10):1733-1743
Transthyretin binds to glucose-regulated proteins and is subjected to endocytosis by the pancreatic β-cell
Dekki N; Refai E; Holmberg R; Kohler M; Jornvall H; Berggren P-O; Juntti-Berggren L
Article: DIABETES. 2012;61(3):665-673
Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver Disruption of Islet Integrity Necessary for Islet Revascularization
Henriksnas J; Lau J; Zang G; Berggren P-O; Kohler M; Carlsson P-O
Article: INTEGRATIVE BIOLOGY (UNITED KINGDOM). 2012;4(2):209-219
One-step purification of functional human and rat pancreatic alpha cells
Koehler M; Dare E; Ali MY; Rajasekaran SS; Moede T; Leibiger B; Leibiger IB; Tibell A; Juntti-Berggren L; Berggren P-O
Article: SCIENCE SIGNALING. 2010;3(113):ra19
Cholinergic Augmentation of Insulin Release Requires Ankyrin-B
Healy JA; Nilsson KR; Hohmeier HE; Berglund J; Davis J; Hoffman J; Kohler M; Li L-S; Berggren P-O; Newgard CB; Bennett V
Article: CELL TRANSPLANTATION. 2009;18(1):23-30
Beneficial Role of Pancreatic Microenvironment for Angiogenesis in Transplanted Pancreatic Islets
Lau J; Kampf C; Mattsson G; Nyqvist D; Kohler M; Berggren P-O; Carlsson P-O
Article: CELL METABOLISM. 2008;7(6):545-554
Glutamate is a positive autocrine signal for glucagon release
Cabrera O; Jacques-Silva MC; Speier S; Yang S-N; Kohler M; Fachado A; Vieira E; Zierath JR; Kibbey R; Berman DM; Kenyon NS; Ricordi C; Caicedo A; Berggren P-O
Article: NATURE MEDICINE. 2008;14(5):574-578
Noninvasive in vivo imaging of pancreatic islet cell biology
Speier S; Nyqvist D; Cabrera O; Yu J; Molano RD; Pileggi A; Moede T; Kohler M; Wilbertz J; Leibiger B; Ricordi C; Leibiger IB; Caicedo A; Berggren P-O
Article: NATURE PROTOCOLS. 2008;3(8):1278-1286
Noninvasive high-resolution in vivo imaging of cell biology in the anterior chamber of the mouse eye
Speier S; Nyqvist D; Koehler M; Caicedo A; Leibiger IB; Berggren P-O
Article: EXPERIMENTAL DIABETES RESEARCH. 2008;2008:865850
Real-Time Monitoring of Apoptosis by Caspase-3-Like Protease Induced FRET Reduction Triggered by Amyloid Aggregation
Paulsson JF; Schultz S; Kohler M; Leibiger I; Berggren P-O; Westermark GT
Article: CELL METABOLISM. 2007;6(3):217-228
Glucose recruits K_ATP channels via non-insulin-containing dense-core granules
Yang S-N; Wenna ND; Yu J; Yang G; Qiu H; Yu L; Juntti-Berggren L; Koher M; Berggren P-O
Article: DIABETES. 2007;56(6):1544-1550
Implantation site-dependent dysfunction of transplanted pancreatic islets
Lau J; Mattsson G; Carlsson C; Nyqvist D; Kohler M; Berggren P-O; Jansson L; Carlsson P-O
Article: CELL TRANSPLANTATION. 2007;16(6):621-627
Distribution of intraportally implanted microspheres and fluorescent islets in mice
von Seth E; Nyqvist D; Andersson A; Carlsson P-O; Koehler M; Mattsson G; Nordin A; Berggrenj P-O; Jansson L
Article: DIABETES. 2005;54(8):2287-2293
Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts
Nyqvist D; Köhler M; Wahlstedt H; Berggren PO
Article: JOURNAL OF ENDOCRINOLOGY. 2005;186(2):333-341
Pancreatic islet function in a transgenic mouse expressing fluorescent protein
Nyqvist D; Mattsson G; Köhler M; Lev-Ram V; Andersson A; Carlsson PO; Nordin A; Berggren PO; Jansson L
Article: CELL. 2004;119(2):273-284
Removal of Ca²⁺ channel β₃ Subunit enhances Ca²⁺ oscillation frequency and insulin exocytosis
Berggren PO; Yang SN; Murakami M; Efanov AM; Uhles S; Köhler M; Moede T; Fernström A; Appelskog LB; Aspinwall CA; Zaitsev SV; Larsson O; de Vargas LM; Fecher-Trost C; Weissgerber P; Ludwig A; Leibiger B; Juntti-Berggren L; Barker CJ; Gromada J; Freichel M; Leibiger IB; Flockerzi V
Article: MOLECULAR ENDOCRINOLOGY. 2004;18(7):1658-1669
Growth hormone promotes Ca²⁺-induced Ca²⁺ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation
Zhang QM; Köhler M; Yang SN; Zhang F; Larsson O; Berggren PO
Article: DIABETES. 2003;52(12):2943-2950
On-line monitoring of apoptosis in insulin-secreting cells
Köhler M; Zaitsev SV; Zaitseva II; Leibiger B; Leibiger IB; Turunen M; Kapelioukh IL; Bakkman L; Appelskog IB; de Monvel JB; Imreh G; Berggren PO
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2002;59(7):1185-1189
Proinsulin C-peptide and its analogues induce intracellular Ca²⁺ increases in human renal tubular cells
Shafqat J; Juntti-Berggren L; Zhong Z; Ekberg K; Köhler M; Berggren PO; Johansson J; Wahren J; Jörnvall H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):36946-36950
Glucose-induced metabolic oscillations parallel those of Ca²⁺ and insulin release in clonal insulin-secreting cells -: A multiwell approach to oscillatory cell behavior
Deeney JT; Köhler M; Kubik K; Brown G; Schultz V; Tornheim K; Corkey BE; Berggren PO
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(37):34530-34536
Glucose-induced oscillations in cytoplasmic free Ca²⁺ concentration precede oscillations in mitochondrial membrane potential in the pancreatic β-cell
Kindmark H; Köhler M; Brown G; Bränström R; Larsson O; Berggren PO
Article: NATURE GENETICS. 2000;26(3):336-340
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
Silva JP; Köhler M; Graff C; Oldfors A; Magnuson MA; Berggren PO; Larsson NG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3242-3247
G protein-coupled receptors regulate Na⁺,K⁺-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin
Ogimoto G; Yudowski GA; Barker CJ; Köhler M; Katz AI; Féraille E; Pedemonte CH; Berggren PO; Bertorello AM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(18):10164-10169
Syntaxin 1 interacts with the L_D subtype of voltage-gated Ca²⁺ channels in pancreatic β cells
Yang SN; Larsson O; Bränström R; Bertorello AM; Leibiger B; Leibiger IB; Moede T; Köhler M; Meister B; Berggren PO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(10):5539-5544
The stimulatory action of tolbutamide on Ca²⁺-dependent exocytosis in pancreatic β cells is mediated by a 65-kDa mdr-like P-glycoprotein
Barg S; Renström E; Berggren PO; Bertorello A; Bokvist K; Braun M; Eliasson L; Holmes WE; Köhler M; Rorsman P; Thévenod F
Article: FEBS LETTERS. 1998;441(1):97-102
Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K⁺-channel activity in insulin-secreting cells
Köhler M; Norgren S; Berggren PO; Fredholm BB; Larsson O; Rhodes CJ; Herbert TP; Luthman H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(50):33501-33507
Glucose and tolbutamide induce apoptosis in pancreatic β-cells -: A process dependent on intracellular Ca²⁺ concentration
Efanova IB; Zaitsev SV; Zhivotovsky B; Köhler M; Efendic S; Orrenius S; Berggren PO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(16):9307-9312
Short-term regulation of insulin gene transcription by glucose
Leibiger B; Moede T; Schwarz T; Brown GR; Köhler M; Leibiger IB; Berggren PO
Article: BIOCHEMICAL JOURNAL. 1997;325(Pt 3):771-778
Parallel changes in nuclear and cytosolic calcium in mouse pancreatic beta-cells
Brown GR; Kohler M; Berggren PO
Article: HEARING RESEARCH. 1996;102(1-2):155-166
Morphological and functional characteristics of the different cell types in the stria vascularis: A comparison between cells obtained from fresh tissue preparations and cells cultured in vitro
Agrup C; Berggren PO; Kohler M; Spangberg ML; BaggerSjoback D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(32):19074-19079
Insulin exocytosis and glucose-mediated increase in cytoplasmic free Ca2+ concentration in the pancreatic beta-cell are independent of cyclic ADP-ribose
Webb DL; Islam MS; Efanov AM; Brown G; Kohler M; Larsson O; Berggren PO
Article: FEBS LETTERS. 1995;369(2-3):315-320
DISSOCIATION BETWEEN EXOCYTOSIS AND CA2+-CHANNEL ACTIVITY IN MOUSE PANCREATIC BETA-CELLS STIMULATED WITH CALMIDAZOLIUM (COMPOUND R24571)
KINDMARK H; KOHLER M; LARSSON O; KHAN A; BERGGREN PO
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Corrigendum: CELLULAR SIGNALLING. 2019;53:415
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells (vol 46, pg 120, 2018)
Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Thesis / dissertation: 2015
Assessment of pancreatic islet cell function and survival
Köhler, Martin
Review: ADVANCES IN BIOLOGICAL REGULATION. 2015;57:112-119
β-Cell Ca(2+) dynamics and function are compromised in aging.
Barker CJ; Li L; Köhler M; Berggren P-O
Published conference paper: DIABETES. 2001;50:S77-S81
Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells
Chandra J; Yang SN; Köhler M; Zaitsev S; Juntti-Berggren L; Berggren PO; Zhivotovsky B; Orrenius S
Published conference paper: DIABETES. 2001;50:S70-S76
Imidazoline compounds protect against interleukin 1β-induced β-cell apoptosis
Zaitsev SV; Appelskog IB; Kapelioukh IL; Yang SN; Köhler M; Efendic S; Berggren PO
Published conference paper: ZOOLOGICAL STUDIES. 1995;34:191-194
A SENSITIVE METHOD FOR MEASUREMENTS OF LUMINESCENCE IN SINGLE CELLS
KOHLER M; NORGREN S; FREDHOLM BB; LARSSON O; LUTHMAN H; BERGGREN PO

Employments

Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2015

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