Marlene Rietz

Marlene Rietz

Affiliated to Research
Visiting address: Alfred Nobels allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Fysiologi, 141 52 Huddinge

About me

  • Between 2019 and 2024, I obtained a bachelor's degree in Biomedicine and a master's in Translational Physiology and Pharmacology at Karolinska Institutet. In addition to my main education, I collected approximately 80 ECTS in data science and machine learning. Next to this, I have been involved in various research projects at the intersection of physiology, data science, and physical activity or exercise.

    My previous supervisors/collaborators include Sabrina Schlesinger at the German Diabetes Center, Düsseldorf, Anders Grøntved and Jan C. Brønd at the University of Southern Denmark, Katrine H. Rubin at Odense University Hospital, and Helene Rundqvist and Tommy Lundberg at Karolinska Institutet. These collaborations have resulted in several lead-author publications. My first publication "Physical Activity and Risk of Major Diabetes-Related Complications in Individuals with Diabetes: A Systematic Review and Meta-analysis of Observational Studies" was published in Diabetes Care at the start of my master's education. I am a committee member of Sports Medicine Stockholm, a regional committee of the Swedish Association for Physical Activity and Sports Medicine. 

    In 2024, I was able to obtain several grants including two travel grants by Radiumhemmets Forskningsfonder of approx. 47, 000 SEK (246340, 246890), the international student award by American College of Sports Medicine of $1000, as well as the Pernille Højman Travel Grant of 10, 000 DK for a conference visit in 2025. In 2022, I received a grant by the International Diabetes Epidemiology Group to attend the 2022 IDEG Conference in Porto, and a visit grant by the Danish Data Science Academy (approx 10, 000 DK) to visit Professor A. Grøntved at the University of Southern Denmark.   

Research

  • In the future, I plan to pursue an academic career using artificial intelligence to uncover physiological links between exercise or environmental exposures and non-communicable pathologies. I recently obtained PhD funding for my project: "Integrative Analysis of Multi-dimensional Data to Unveil Risk Dynamics in Major Diabetes-Related Complications: Insights from the Danish Centre for Strategic Research in Type 2 Diabetes Cohort" from the Danish Diabetes and Endocrine Academy. 

Teaching

  • I have been involved in teaching the course Scientific Methodology 2 (1BA174) in the Biomedical Laboratory Science bachelor's programme for two years now. 

Articles

All other publications

Grants

  • Integrative Analysis of Multi-dimensional Data to Unveil Risk Dynamics in Major Diabetes-Related Complications: Insights from the Danish Centre for Strategic Research in Type 2 Diabetes Cohort
    Danish Diabetes and Endocrine Academy
    1 May 2025 - 1 May 2028
    Background: Type 2 diabetes (T2D) may cause major diabetes-related complications including cardiovascular disease (CVD), nephropathy, retinopathy, and neuropathies. Evidence profiling the interactions of risk factors in these complications is scarce. Objectives and hypotheses: We aim to investigate the interactions between multidimensional risk factors, including genomics, molecular biomarkers, medication, comorbidities, and objectively measured physical activity (PA), in association with the development of and mortality from diabetes-related complications in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. This integration will support complex risk prediction models advancing personalised diabetology. Methods: Until 2024, approximately 12,700 newly diagnosed individuals with T2D were enrolled in the DD2 cohort. Core data collection included anthropometrics, accelerometry, plasma and urine samples, self-reported lifestyle and T2D heritability, and health registry data. Data describing complication outcomes will be obtained from Danish national registries. Polygenic risk scores for T2D, complications, comorbidities, and adverse lifestyle habits will be calculated from plasma-based genome-wide sequencing (GWS). Unsupervised machine learning will be used to group clinical biomarkers into patterns associated with increased risk of complications. For a subset of the DD2, prospective trajectories of PA and sedentary time (ST) will be computed. Registry data describing T2D pharmacological treatment and comorbidities will be integrated with individualised risk profiles. Cox-proportional hazards models will be created for each risk factor and interactions. Lastly, all risk factors extracted from the DD2 study will be combined using a gradient boosting model (GBM) to predict personalised risk scores for T2D complications independently of interactions. Potential Impact: Analysing risk factor dynamics in T2D complications will allow for effective personalised medicine.

Employments

  • Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2025-2026
  • Research Assistant, Artificial Intelligence for Fracture Prediction, Open Patient Data Exploratory Network (OPEN) Research Unit, Odense University Hospital, 2024-2024

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