Mark Clements
About me
I am a docent and associate professor in biostatistics. I have worked as a biostatistician in Sweden, Australia, New Zealand and the United Kingdom, including positions in academia and in government.
I am currently a member of the Management Group for the Swedish eScience Research Centre and co-leader for
- eScience Methods for Precision Health (eMPHasis) project. I am also a member of the Steering Group for the KI Epidemiology Doctoral Program.
My research group includes a mix of biostatistics (x4), health economists (x3) and epidemiologists (x3).
Education
- 1991, BSc (Hons) in Mathematics and Statistics, University of Auckland
- 2001, PhD in Biostatistics and Cancer Epidemiology, University of Sydney
- 2021, Docent in Biostatistics, Karolinska Institutet.
Grants
I have received generous financial support as the principal investigator from Cancerfonden, the Swedish Research Council, Prostatacancerförbundet, ALF and KI.
Current primary PhD supervision
- Birzhan Akynkozhayev
- Xiaoyang Du
- Balram Rai
Previous primary PhD supervision
- Andreas Karlsson
- Xingrong Liu
- Shuang Hao
I have also co-supervised 13 other PhDs.
Research
My main interests are in statistical modelling and simulation, with applications to cancer epidemiology and health economics. This includes:
- Methods for survival analysis, including generalised survival models, smooth accelerated failure time models and parametric multi-state Markov models (http://CRAN.R-project.org/package=rstpm2
- Liu et al, 2016
- Liu et al, 2017
- Crowther et al, 2023).
- Modelling software for cost-effectiveness analysis (https://CRAN.R-project.org/package=microsimulation
- https://CRAN.R-project.org/package=hesim).
- Microsimulation for cost-effectiveness analysis of prostate cancer testing (https://github.com/mclements/prostata
- Karlsson et al, 2019
- Hao et al, 2021
- Hao et al, 2022
- Hao et al, 2023
- Du et al, 2024).
- Natural history modelling for cervical cancer screening (https://github.com/mclements/nkcx_analysis
- Clements, 2023).
I am also interested in computational methods in a variety of programming languages&
- amp
- see my GitHub repos.
Teaching
I am the course director for Biostatistics III: Survival analysis for epidemiologists in R, which has an accompanying R package biostat3 on CRAN and an accompanying web-site.
I will be the course director for a new masters course in
- Survival Analysis with Applications in Medicine.
Articles
- Article: EUROPEAN UROLOGY ONCOLOGY. 2024;:S2588-9311(24)00133-0
- Article: MEDICAL DECISION MAKING. 2024;44(3):269-282
- Article: JAMA NETWORK OPEN. 2024;7(2):e2354577
- Article: PLOS ONE. 2024;19(8):e0308254
- Journal article: VALUE IN HEALTH. 2023;26(12):s202
- Article: TRANSFUSION. 2023;63(11):2040-2051
- Article: JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS (JCGS). 2023;32(4):1393-1401
- Article: BIOSTATISTICS. 2023;24(3):811-831
- Article: EUROPEAN UROLOGY OPEN SCIENCE. 2023;51:89-94
- Journal article: INVESTIGATIVE UROLOGY. 2023;209(Supplement 4):e997
- Journal article: EUROPEAN UROLOGY. 2023;83:s1266-s1267
- Article: DIGESTIVE DISEASES AND SCIENCES. 2023;68(1):65-76
- Article: PHARMACOECONOMICS (AUCKLAND). 2022;40(12):1207-1220
- Article: JAMA ONCOLOGY. 2022;9(1):88-94
- Article: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 2022;226:107125
- Article: ESOPHAGUS. 2022;19(4):535-541
- Article: EUROPEAN UROLOGY. 2022;82(1):12-19
- Article: VACCINE. 2022;40(27):3797-3801
- Article: GUT. 2022;71(6):1088-1094
- Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2022;55(6):691-699
- Article: PLOS ONE. 2022;17(8):e0273003
- Article: ENVIRONMENTAL EPIDEMIOLOGY. 2021;5(6):e182
- Article: VALUE IN HEALTH. 2021;24(12):1763-1772
- Article: COMMUNICATIONS IN STATISTICS PART B: SIMULATION AND COMPUTATION. 2021;50(11):3777-3793
- Article: THE LANCET ONCOLOGY. 2021;22(9):1240-1249
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2021;56(6):680-686
- Article: ELIFE. 2021;10:e65658
- Article: PLOS ONE. 2021;16(2):e0246674
- Article: VIRCHOWS ARCHIV. 2020;477(6):777-786
- Article: EUROPEAN UROLOGY ONCOLOGY. 2020;3(5):640-647
- Article: BIOMETRICAL JOURNAL. 2020;62(4):989-1011
- Article: BMC HEALTH SERVICES RESEARCH. 2020;20(1):448
- Article: SCIENTIFIC REPORTS. 2020;10(1):7736
- Journal article: GASTROENTEROLOGY. 2020;158(6):s-826
- Article: BMJ OPEN. 2020;10(3):e032914
- Article: PLOS ONE. 2020;15(9):e0239611
- Article: STATISTICS IN MEDICINE. 2019;38(23):4477-4502
- Article: EUROPEAN UROLOGY ONCOLOGY. 2019;2(5):490-496
- Article: EUROPEAN UROLOGY FOCUS. 2019;5(5):842-848
- Article: APMIS. 2019;127(8):554-560
- Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2019;49(11):1395-1400
- Article: VIRCHOWS ARCHIV. 2019;474(5):577-584
- Article: PLOS ONE. 2019;14(2):e0211918
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2018;187(10):2186-2191
- Article: NEUROBIOLOGY OF AGING. 2018;69:111-116
- Article: EUROPEAN UROLOGY FOCUS. 2018;4(5):707-710
- Article: HISTOPATHOLOGY. 2018;73(1):8-18
- Journal article: 2018The Association between Post-Treatment Plasma 1,25-Dihydroxy Vitamin D Levels and Survival of Men with Clinically Significant Prostate Cancer
- Article: STATISTICAL METHODS IN MEDICAL RESEARCH. 2018;27(5):1531-1546
- Article: HISTOPATHOLOGY. 2018;72(3):481-489
- Article: STATISTICS IN MEDICINE. 2017;36(29):4743-4762
- Article: HISTOPATHOLOGY. 2017;71(5):677-685
- Article: THE LANCET PUBLIC HEALTH. 2017;2(11):e522-e528
- Article: JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA. 2017;24(5):950-957
- Article: PROSTATE. 2017;77(8):900-907
- Article: SAFETY SCIENCE. 2017;93:143-151
- Article: PLOS ONE. 2017;12(2):e0171013
- Article: BRITISH JOURNAL OF CANCER. 2016;115(11):1400-1407
- Article: PUBLIC HEALTH RESEARCH & PRACTICE. 2016;26(4):2641646
- Article: JOURNAL OF INFECTION. 2016;72(6):650-658
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(15):5050
- Article: APMIS. 2016;124(4):263-270
- Journal article: EUROPEAN UROLOGY OPEN SCIENCE. 2016;15(3):e86
- Article: THE LANCET ONCOLOGY. 2015;16(16):1667-1676
- Article: EUROPEAN JOURNAL OF CANCER. 2015;51(6):725-733
- Article: CANCER EPIDEMIOLOGY. 2015;39(1):29-36
- Article: WORLD JOURNAL OF UROLOGY. 2014;32(5):1251-1257
- Article: MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2014;765:6-10
- Article: BMC CANCER. 2014;14:445
- Journal article: EUROPEAN UROLOGY OPEN SCIENCE. 2014;13(1):e860
- Article: BRITISH JOURNAL OF CANCER. 2014;110(5):1378-1384
- Article: EUROPEAN UROLOGY. 2014;65(1):169-176
- Article: JOURNAL OF CANCER SURVIVORSHIP. 2013;7(4):641-651
- Article: CANCER CAUSES AND CONTROL. 2013;24(11):2005-2011
- Article: BMC CANCER. 2013;13:458
- Article: CANCER CAUSES AND CONTROL. 2013;24(7):1323-1330
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2013;37(6):790-799
- Article: WORLD JOURNAL OF UROLOGY. 2013;31(3):673-682
- Article: PHOTOCHEMISTRY AND PHOTOBIOLOGY. 2013;89(1):208-214
- Article: BMC HEALTH SERVICES RESEARCH. 2012;12:446
- Article: CANCER CAUSES AND CONTROL. 2012;23(10):1625-1634
- Article: MUTAGENESIS. 2012;27(5):609-614
- Article: INTERNATIONAL JOURNAL OF CANCER. 2012;131(5):E726-E732
- Article: CLINICAL INFECTIOUS DISEASES. 2011;53(12):1237-1244
- Article: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH. 2011;35(6):557-563
- Article: JOURNAL OF WATER AND HEALTH. 2011;9(3):507-514
- Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2011;65(6):529-534
- Article: BMJ OPEN. 2011;1(1):e000104
- Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2011;30(2):161-163
- Article: PUBLIC HEALTH NUTRITION. 2011;14(1):34-43
- Article: SOCIAL SCIENCE AND MEDICINE. 2011;72(2):224-229
- Article: BMC PUBLIC HEALTH. 2010;10:734
- Article: CANCER CAUSES AND CONTROL. 2010;21(10):1701-1709
- Article: PEDIATRIC DIABETES. 2010;11(6):394-402
- Article: EUROSURVEILLANCE. 2010;15(26):19603
- Article: SOCIAL SCIENCE AND MEDICINE. 2010;70(12):2052-2060
- Article: BMC MEDICAL RESEARCH METHODOLOGY. 2010;10:26
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2010;118(3):382-386
- Article: ARTHRITIS & RHEUMATOLOGY. 2009;61(10):1417-1424
- Article: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH. 2009;33(5):458-465
- Article: EMERGING INFECTIOUS DISEASES. 2009;15(9):1359-1365
- Article: GEOARCHAEOLOGY. 2008;23(2):243-273
- Article: JOURNAL OF MEDICAL SCREENING. 2008;15(4):188-198
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2007;64(11):747-752
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2007;36(1):157-165
- Article: STATISTICS IN MEDICINE. 2007;26(1):171-183
- Article: JOURNAL OF MARRIAGE AND FAMILY. 2006;68(2):394-410
- Article: THE LANCET. 2006;367(9504):44-51
- Article: BIOSTATISTICS. 2005;6(4):576-589
- Article: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH. 2005;29(3):222-228
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2005;14(5):1171-1181
- Article: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH. 2005;29(1):53-57
- Article: HIV CLINICAL TRIALS. 2004;5(4):192-200
- Article: JOURNAL OF SCIENCE AND MEDICINE IN SPORT. 2004;7(2):232-236
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2004;35(4):401-406
- Article: HIV MEDICINE. 2003;4(4):332-337
- Article: BJU INTERNATIONAL. 2003;92(3):267-270
- Article: NEW ZEALAND MEDICAL JOURNAL. 2000;113(1112):245-247
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH. 1999;9(2):97-107
- Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 1999;88(3):253-258
- Article: NEW ZEALAND MEDICAL JOURNAL. 1998;111(1074):364-366
- Article: NEW ZEALAND MEDICAL JOURNAL. 1998;111(1058):14-16
- Article: PEDIATRICS. 1997;100(5):835-840
- Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 1997;86(1):51-56
- Article: NEW ZEALAND MEDICAL JOURNAL. 1996;109(1030):352-355
- Article: EUROPEAN JOURNAL OF PEDIATRICS. 1996;155(8):712-716
- Article: NEW ZEALAND MEDICAL JOURNAL. 1996;109(1023):206-207
- Article: ARCHIVES OF DISEASE IN CHILDHOOD. 1995;73(6):498-501
- Journal article: JOURNAL OF THEORETICAL BIOLOGY. 1994;170(3):273-281
- Journal article: NEW ZEALAND MEDICAL JOURNAL. 1994;107(973):71-73
- Journal article: ARCHIVES OF DISEASE IN CHILDHOOD. 1994;70(3):187-191
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All other publications
- Letter: JAMA ONCOLOGY. 2023;9(6):868-869
- Conference publication: JOURNAL OF UROLOGY. 2023;209:E997-E998
- Conference publication: VALUE IN HEALTH. 2023;26(12):S202
- Corrigendum: EUROPEAN UROLOGY. 2022;82(1):e21
- Preprint: MEDRXIV. 2022
- Letter: STATISTICS IN MEDICINE. 2022;41(7):1314-1315
- Conference publication: VALUE IN HEALTH. 2022;25(12):S67
- Conference publication: VALUE IN HEALTH. 2022;25(12):S375-S376
- Preprint: ARXIV. 2021
- Preprint: ARXIV. 2021
- Preprint: BIORXIV. 2021
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Conference publication: GASTROENTEROLOGY. 2020;158(6):S826
- Editorial comment: TRANSFUSION. 2019;59(6):1945-1952
- Review: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2018;27(11):1159-1165
- Preprint: ARXIV. 2018
- Review: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2018;97(7):795-807
- Conference publication: BJU INTERNATIONAL. 2018;122:24
- Conference publication: BJU INTERNATIONAL. 2018;122:30-31
- Other: UROLOGIC ONCOLOGY: SEMINARS AND ORIGINAL INVESTIGATIONS. 2017;35(3):120
- Conference publication: 2016;:323-330
- Conference publication: CANCER RESEARCH. 2016;76:p1-07-22-p1-07-22
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2016;34(2):36
- Conference publication: CANCER RESEARCH. 2013;73(8):2514
- Editorial comment: EUROPEAN UROLOGY. 2013;63(3):427
- Conference publication: BJU INTERNATIONAL. 2013;112:9-10
- Letter: INTERNATIONAL JOURNAL OF CANCER. 2012;131(9):2206-2207
- Conference publication: CANCER RESEARCH. 2012;72:5482
- Conference publication: ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. 2012;8:32
- Conference publication: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2011;65:A172
- Conference publication: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2011;65:A84
- Conference publication: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2011;65:A260-A261
- Conference publication: EPIDEMIOLOGY. 2011;22(1):S155
- Review: MOLECULAR NUTRITION AND FOOD RESEARCH. 2010;54(8):1062-1071
- Letter: MEDICAL JOURNAL OF AUSTRALIA. 2010;192(2):110
- Letter: MEDICAL JOURNAL OF AUSTRALIA. 2009;191(10):574-575
- Letter: BREAST CANCER RESEARCH AND TREATMENT. 2009;117(3):671-673
- Editorial comment: MEDICAL JOURNAL OF AUSTRALIA. 2009;191(4):199-200
- Letter: MEDICAL JOURNAL OF AUSTRALIA. 2009;190(3):164-165
- Conference publication: APMIS. 2009;117:157
- Conference publication: LUNG CANCER. 2006;54:S33
- Letter: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2006;164(3):292-293
- Conference publication: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2001;153(11):S135
- Conference publication: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2001;153(11):S130
- Letter: NEW ZEALAND MEDICAL JOURNAL. 1997;110(1056):445
- Letter: THE LANCET. 1995;345(8956):1045-1046
- Other: AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE. 1995;25(2):155-156
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Grants
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2023 - 31 December 2025
- Clements, Mark Sheldon – Cost-effectiveness of prostate cancer testing and cervical cancer screeningSwedish Cancer Society1 January 2022
- Swedish Research Council1 January 2019 - 31 December 2022
- Swedish Research Council1 January 2018 - 31 December 2021
- Cost-effectiveness in screening for limo neck and prostate cancer.Swedish Cancer Society1 January 2018
- Swedish Research Council for Health Working Life and Welfare1 January 2016 - 31 December 2018
- Statistical and mathematical modeling of efficacy in prostate cancer screening.Swedish Cancer Society1 January 2014
Employments
- Senior Lecturer, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2012-
Degrees and Education
- Docent, Karolinska Institutet, 2019
Supervisor
- Enoch Chen, Extrapolating survival with applications in health technology assessment, 2021
- Linda Abrahamsson, Statistical models of breast cancer tumour progression for mammography screening data, 2012
- Andreas Karlsson, Microsimulation modelling of prostate cancer screening in Sweden.