Marie Wahren-Herlenius | Karolinska Institutet

About me
Publications
CV
Public outreach and news

About me

- Professor of Experimental Rheumatology, Karolinska Institutet
- Head, Department of Medicine, Karolinska Institutet (prefekt@meds.ki.se)
- International experience as postdoc/visiting scientist/visiting professor from University of Bergen, Norway, University of Tokyo, Japan and Harvard Medical School, USA
- Recieved the Göran Gustafssons prize in Medicine, the Nanna Svartz prize for Rheumatologic research, Scandinavian Journal of Rheumatology's prize for rheumatologic research, the IMID-prise for research on immune-mediated inflammatory disease from the Swedish societies of dermatology, rheumatology and gastroenterology
- Awarded Best abstract of the year by the Swedish Rheumatology Association (three times)
- Theses from my group awarded Best PhD thesis of the year by the Swedish Rheumatology Association (three times)
- President, The Scandinavian Society for Immunology 2010-2015
- President, Junior Faculty, Karolinska Institutet 2002-2005
- President, PhD student's association, Karolinska Institutet 1991

Education
- PhD, Department of Cell and Molecular Biology, Karolinska Institutet 1994
- Medical Degree, Karolinska Institutet 1995
- Docent of Molecular Immunologi 1999
- Licensed physician 2000

Research

Our research is focused on autoimmune rheumatic diseases, and aims at understanding the pathogenesis and disease mechanisms for development of novel diagnostics and treatment. Our projects include basic cell and molecular biology, studies in experimental models as well as clinical and epidemiological patient-based investigations. The research group includes around 15 scientists from basic and clinicial disciplines.

Articles

Article: ARTHRITIS & RHEUMATOLOGY. 2025;77(2):212-225
Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases
Bianchi M; Kozyrev SV; Notarnicola A; Sandling JK; Pettersson M; Leonard D; Sjowall C; Gunnarsson I; Rantapaa-Dahlqvist S; Bengtsson AA; Jonsen A; Svenungsson E; Enocsson H; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Baecklund E; Jonsson R; Hammenfors D; Eriksson P; Mandl T; Omdal R; Padyukov L; Andersson H; Molberg O; Diederichsen LP; Syvanen A-C; Wahren-Herlenius M; Nordmark G; Lundberg IE; Ronnblom L; Lindblad-Toh K
Journal article: RMD OPEN. 2025;11(1):e005160
Associations of infection burden with Kawasaki disease in a population-based setting during 30 years
Mofors J; Rudolph A; Schiller B; Elinder G; Sonesson S-E; Eliasson H; Bergman G; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2024;:keae693
A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren's disease
Fugmann C; Reid S; Pucholt P; Kvarnstrom M; Bjork A; Mofors J; Sjowall C; Eriksson P; Olsson P; Mandl T; Forsblad-d'Elia H; Magnusson Bucher S; Johnsen SJ; Norheim KB; Appel S; Hammenfors D; Jensen JL; Palm O; Omdal R; Jonsson R; Baecklund E; Wahren-Herlenius M; Leonard D; Imgenberg-Kreuz J; Nordmark G
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2024;103(12):2433-2441
Impact of early detection and steroid treatment on fetal ventricular heart rate and pacemaker implantation in anti-Ro/SSA positive congenital heart block
Sonesson S-E; Ambrosi A; Nordenstam F; Eliasson H; Wahren-Herlenius M
Article: ADVANCED SCIENCE. 2024;11(31):e2400260
A Non-Coding Oligonucleotide Recruits Cutaneous CD11b⁺ Cells that Inhibit Thelper Responses and Promote Tregs
Kamal K; Richardsdotter-Andersson E; Dondalska A; Wahren-Herlenius M; Spetz A-L
Article: RHEUMATOLOGY. 2024;:keae317
Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis
Galindo-Feria AS; Lodin K; Horuluoglu B; Sarrafzadeh-Zargar S; Wigren E; Graslund S; Danielsson O; Wahren-Herlenius M; Dastmalchi M; Lundberg IE
Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2024;65:152378
The Sjogren's Working Group: The 2023 OMERACT meeting and provisional domain generation
Gordon RA; Nguyen Y; Foulquier N; Beydon M; Gheita TA; Hajji R; Sahbudin I; Hoi A; Ng W-F; Mendonca JA; Wallace DJ; Shea B; Bruyn GAW; Goodman SM; Fisher BA; Baldini C; Torralbat KD; Bootsma H; Akpek E; Karakus S; Baer AN; Chakravarty S; Terslev L; D'Agostino M-A; Mariette X; Direnzo D; Rasmussen A; Papas A; Montoya C; Arends S; Yusof MYM; Pintilie I; Warnerjj BM; Hammitt KM; Strand V; Bouillot C; Tugwell P; Inanc N; Andreu JL; Wahren-Herlenius M; Devauchelle-Pensec V; Shiboski CH; Benyoussef A; Masli S; Lee AYS; Cornec D; Bowman S; Rischmueller M; McCoy S; Seror R
Article: EBIOMEDICINE. 2023;96:104804
Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
Leclair V; Galindo-Feria AS; Rothwell S; Krystufkova O; Zargar SS; Mann H; Diederichsen LP; Andersson H; Klein M; Tansley S; Ronnblom L; Lindblad-Toh K; Syvanen A-C; Wahren-Herlenius M; Sandling JK; McHugh N; Lamb JA; Vencovsky J; Chinoy H; Holmqvist M; Bianchi M; Padyukov L; Lundberg IE; Diaz-Galloc L-M
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023;189(2):235-241
Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease
Lundtoft C; Eriksson D; Bianchi M; Aranda-Guillen M; Landegren N; Rantapaa-Dahlqvist S; Soderkvist P; Meadows JRS; Bensing S; Pielberg GR; Lindblad-Toh K; Ronnblom L; Kampe O
Article: AUTOIMMUNITY REVIEWS. 2023;22(3):103259
Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases
Andreoli L; Chighizola CB; Iaccarino L; Botta A; Gerosa M; Ramoni V; Tani C; Bermas B; Brucato A; Buyon J; Cetin I; Chambers CD; Clowse MEB; Costedoat-Chalumeau N; Cutolo M; De Carolis S; Dolhain R; Fazzi EM; Foerger F; Giles I; Haase I; Khamashta M; Levy RA; Meroni PL; Mosca M; Nelson-Piercy C; Raio L; Salmon J; Villiger P; Wahren-Herlenius M; Wallenius M; Zanardini C; Shoenfeld Y; Tincani A
Article: JOURNAL OF AUTOIMMUNITY. 2023;134:102951
Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies
Preger C; Notarnicola A; Hellstrom C; Wigren E; Fernandes-Cerqueira C; Kvarnstrom M; Wahren-Herlenius M; Idborg H; Lundberg IE; Persson H; Graslund S; Jakobsson P-J
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1168684
Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor
Scheffschick A; Nenonen J; Xiang M; Winther AH; Ehrstrom M; Wahren-Herlenius M; Eidsmo L; Brauner H
Article: RHEUMATOLOGY. 2022;62(1):243-255
Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies
Hernandez-Molina G; Kostov B; Brito-Zeron P; Vissink A; Mandl T; Hinrichs AC; Quartuccio L; Baldini C; Seror R; Szanto A; Isenberg D; Gerli R; Nordmark G; Rasmussen A; Solans-Laque R; Hofauer B; Sene D; Pasoto SG; Rischmueller M; Praprotnik S; Gheita TA; Danda D; Armagan B; Suzuki Y; Valim V; Devauchelle-Pensec V; Retamozo S; Kvarnstrom M; Sebastian A; Atzeni F; Giacomelli R; Carsons SE; Kwok S-K; Nakamura H; Moca Trevisani VF; Flores-Chavez A; Mariette X; Ramos-Casals M
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(11):1842-1850
Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjogren's Syndrome
Lundtoft C; Sjowall C; Rantapaa-Dahlqvist S; Bengtsson AA; Jonsen A; Pucholt P; Wu YL; Lundstrom E; Eloranta M-L; Gunnarsson I; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Bucher S; Norheim KB; Johnsen SJA; Omdal R; Kvarnstrom M; Wahren-Herlenius M; Truedsson L; Nilsson B; Kozyrev SV; Bianchi M; Lindblad-Toh K; Yu C-Y; Nordmark G; Sandling JK; Svenungsson E; Leonard D; Ronnblom L
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
Lundtoft C; Pucholt P; Martin M; Bianchi M; Lundstrom E; Eloranta M-L; Sandling JK; Sjowall C; Jonsen A; Gunnarsson I; Rantapaa-Dahlqvist S; Bengtsson AA; Leonard D; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Bucher SM; Norheim KB; Johnsen SJA; Omdal R; Kvarnstrom M; Wahren-Herlenius M; Notarnicola A; Andersson H; Molberg O; Diederichsen LP; Almlof J; Syvanen A-C; Kozyrev SV; Lindblad-Toh K; Nilsson B; Blom AM; Lundberg IE; Nordmark G; Diaz-Gallo LM; Svenungsson E; Ronnblom L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: NATURE COMMUNICATIONS. 2022;13(1):4287
Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
Khatri B; Tessneer KL; Rasmussen A; Aghakhanian F; Reksten TR; Adler A; Alevizos I; Anaya J-M; Aqrawi LA; Baecklund E; Brun JG; Bucher SM; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Glenn SB; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kvarnstrom M; Kelly JA; Li H; Mandl T; Martin J; Nocturne G; Norheim KB; Palm O; Skarstein K; Stolarczyk AM; Taylor KE; Teruel M; Theander E; Venuturupalli S; Wallace DJ; Grundahl KM; Hefner KS; Radfar L; Lewis DM; Stone DU; Kaufman CE; Brennan MT; Guthridge JM; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Eriksson P; Bowman SJ; Omdal R; Ronnblom L; Warner B; Rischmueller M; Witte T; Farris AD; Mariette X; Alarcon-Riquelme ME; Shiboski CH; Wahren-Herlenius M; Ng W-F; Sivils KL; Adrianto I; Nordmark G; Lessard CJ
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39(6):166-174
Influence of the age at diagnosis in the disease expression of primary Sjogren's syndrome. Analysis of 12,753 patients from the Sjogren Big Data Consortium
Retamozo S; Acar-Denizli N; Horvath IF; Ng W-F; Rasmussen A; Dong X; Li X; Baldini C; Olsson P; Priori R; Seror R; Gottenberg J-E; Kruize AA; Hernandez-Molina G; Vissink A; Sandhya P; Armagan B; Quartuccio L; Sebastian A; Praprotnik S; Bartoloni E; Kwok S-K; Kvarnstrom M; Rischmueller M; Solans-Laque R; Sene D; Pasoto SG; Suzuki Y; Isenberg DA; Valim V; Nordmark G; Nakamura H; Fernandes Moca Trevisani V; Hofauer B; Siso-Almirall A; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Atzeni F; Hammenfors D; Maure B; Carsons SE; Gheita T; Sanchez-Berna I; Lopez-Dupla M; Morel J; Inanc N; Fonseca-Aizpuru E; Morcillo C; Vollenweider C; Melchor S; Vazquez M; Diaz-Cuiza E; Consani-Fernandez S; de-Miguel-Campo B; Szanto A; Bombardieri S; Gattamelata A; Hinrichs A; Sanchez-Guerrero J; Danda D; Kilic L; de Vita S; Wiland P; Gerli R; Park S-H; Wahren-Herlenius M; Bootsma H; Mariette X; Ramos-Casals M; Brito-Zeron P
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):132
Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE
Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Hayry A; Soderlund-Matell T; Charlesworth CM; Madden B; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
Article: RHEUMATOLOGY. 2021;60(3):1445-1455
Interferon activation status underlies higher antibody response to viral antigens in patients with systemic lupus erythematosus receiving no or light treatment
Bjork A; Rodrigues RDS; Andersson ER; Sepulveda JIR; Mofors J; Kvarnstrom M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(2):194-202
Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block
Ivanchenko M; Thorlacius GE; Hedlund M; Ottosson V; Meneghel L; Bjorkander S; Ossoinak A; Tingstrom J; Bremme K; Sverremark-Ekstrom E; Gemzell-Danielsson K; Sonesson S-E; Chemin K; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2021;60(2):837-848
Genetic and clinical basis for two distinct subtypes of primary Sjogren's syndrome
Thorlacius GE; Hultin-Rosenberg L; Sandling JK; Bianchi M; Imgenberg-Kreuz J; Pucholt P; Theander E; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Johnsen SJA; Hammenfors D; Skarstein K; Jonsson MV; Baecklund E; Aqrawi LA; Jensen JL; Palm O; Morris AP; Meadows JRS; Rantapaa-Dahlqvist S; Mandl T; Eriksson P; Lind L; Omdal R; Jonsson R; Lindblad-Toh K; Ronnblom L; Wahren-Herlenius M; Nordmark G
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173
SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development
Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;93(1):e12995
Interferons and innate immune activation in autoimmune congenital heart block
Ambrosi A; Thorlacius GE; Sonesson S-E; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2020;59(9):2350-2359
Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjogren's syndrome
Brito-Zeron P; Acar-Denizli N; Ng W-F; Horvath IF; Rasmussen A; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnstrom M; Praprotnik S; Sene D; Gerli R; Solans R; Rischmueller M; Mandl T; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura H; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Trevisani VFM; Hammenfors D; Pasoto SG; Retamozo S; Gheita TA; Atzeni F; Morel J; Vollenweider C; Zeher M; Sivils K; Xu B; Bombardieri S; Sandhya P; De Vita S; Minniti A; Sanchez-Guerrero J; Kilic L; van der Heijden E; Park S-H; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Article: RMD OPEN. 2020;6(3):e001402
Cigarette smoking patterns preceding primary Sjogren's syndrome
Mofors J; Bjork A; Richardsdotter Andersson E; Kvarnstrom M; Forsblad D'Elia H; Magnusson-Bucher S; Padyukov L; Kockum I; Hillert J; Eriksson P; Mandl T; Nordmark G; Alfredsson L; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2020;59(7):1651-1661
Viral antigens elicit augmented immune responses in primary Sjogren's syndrome
Bjork A; Thorlacius GE; Mofors J; Andersson ER; Ivanchenko M; Tingstrom J; James T; Brokstad KA; Cox RJ; Jonsson R; Kvarnstrom M; Wahren-Herlenius M
Article: RMD OPEN. 2020;6(1):e000995
Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjogren's syndrome
Bjork A; Andersson ER; Imgenberg-Kreuz J; Thorlacius GE; Mofors J; Syvanen A-C; Kvarnstrom M; Nordmark G; Wahren-Herlenius M
Article: RMD OPEN. 2020;6(1):e000989
Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
Hedlund M; Thorlacius GE; Ivanchenko M; Ottosson V; Kyriakidis N; Lagnefeldt L; Tingstrom J; Sirsjo A; Bengtsson AA; Aronsson E; Gemzell-Danielsson K; Ronnblom L; Bergman G; Espinosa A; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:580547
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Palsson SA; Dondalska A; Bergenstrahle J; Rolfes C; Bjork A; Sedano L; Power UF; Rameix-Welti M-A; Lundeberg J; Wahren-Herlenius M; Mastrangelo P; Eleouet J-F; Le Goffic R; Galloux M; Spetz A-L
Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60
Sex differences in clinical presentation of systemic lupus erythematosus
Sepulveda JIR; Bolin K; Mofors J; Leonard D; Svenungsson E; Jonsen A; Bengtsson C; Nordmark G; Dahlqvist SR; Bengtsson AA; Ronnblom L; Sjowall C; Gunnarsson I; Wahren-Herlenius M; Zickert A; Bjork A; Jonsen A; Sjowali C; Enocsson H; Wettero J; Eriksson P; Thorlacius GE; Lundberg IE; Sanding JK; SeNiveda JIR; Lindblad-Toh K; Ronnblom L; Padyukov L; Hultin-Rosenberg L; Eloranta M-L; Dahiqvist SR
Article: EUROPACE. 2019;21(11):1717-1724
Pacing therapy in children with isolated complete atrioventricular block: a retrospective study of pacing system survival and pacing-related complications in a national cohort
Eliasson H; Sonesson S-E; Salomonsson S; Andreasson AS; Wahren-Herlenius M; Gadler F
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(4):458-468
Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjogren's syndrome
Mofors J; Holmqvist M; Westermark L; Bjork A; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Eriksson P; Theander E; Mandl T; Wahren-Herlenius M; Nordmark G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(30):11404-11419
E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2
Anandapadamanaban M; Kyriakidis NC; Csizmok V; Wallenhammar A; Espinosa AC; Ahlner A; Round AR; Trewhella J; Moche M; Wahren-Herlenius M; Sunnerhagen M
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2019;54(1):87-95
Benefits of fetal echocardiographic surveillance in pregnancies at risk of congenital heart block: single-center study of 212 anti-Ro52-positive pregnancies
Sonesson S-E; Ambrosi A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2019;37(3):97-106
Systemic manifestations of primary Sjogren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients
Retamozo S; Acar-Denizli N; Rasmussen A; Horvath IF; Baldini C; Priori R; Sandhya P; Hernandez-Molina G; Armagan B; Praprotnik S; Kvarnstrom M; Gerli R; Sebastian A; Solans R; Rischmueller M; Pasoto SG; Valim V; Nordmark G; Kruize AA; Nakamura H; Hofauer B; Giacomelli R; Fernandes Moca Trevisani V; Devauchelle-Pensec V; Atzeni F; Gheita TA; Consani-Fernandez S; Szanto A; Sivils K; Gattamelata A; Danda D; Kilic L; Bartoloni E; Bombardieri S; Sanchez-Guerrero J; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zeron P
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(5):696-703
Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero
Mofors J; Eliasson H; Ambrosi A; Salomonsson S; Skog A; Fored M; Ekbom A; Bergman G; Sonesson S-E; Wahren-Herlenius M
Article: ELIFE. 2019;8:e41608
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta
Pernemalm M; Sandberg A; Zhu Y; Boekel J; Tamburro D; Schwenk JM; Bjork A; Wahren-Herlenius M; Amark H; Ostenson C-G; Westgren M; Lehtio J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;194(3):315-326
The Sjogren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production
Brauner S; Ivanchenko M; Thorlacius GE; Ambrosi A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;193(2):167-177
The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages
Mentlein L; Thorlacius GE; Meneghel L; Aqrawi LA; Sepulveda JIR; Grunewald J; Espinosa A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;192(3):259-270
Diminished CXCR5 expression in peripheral blood of patients with Sjogren's syndrome may relate to both genotype and salivary gland homing
Aqrawi LA; Ivanchenko M; Bjork A; Sepulveda JIR; Imgenberg-Kreuz J; Kvarnstrom M; Haselmayer P; Jensen JL; Nordmark G; Chemin K; Skarstein K; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):102-112
How immunological profile drives clinical phenotype of primary Sjogren's syndrome at diagnosis: analysis of 10,500 patients (Sjogren Big Data Project)
Brito-Zeron P; Acar-Denizli N; Ng WF; Zeher M; Rasmussen A; Mandl T; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnstrom M; Praprotnik S; Sene D; Bartoloni E; Solans R; Rischmueller M; Suzuki Y; Isenberg DA; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Knopf A; Bombardieri M; Trevisani V-F; Hammenfors D; Pasoto SG; Retamozo S; Gheita TA; Atzeni F; Morel J; Vollenveider C; Horvath I-F; Sivils KL; Olsson P; De Vita S; Sanchez-Guerrero J; Kilic L; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;87(5):e12662
Transcription profiling of peripheral B cells in antibody-positive primary Sjogren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature
Imgenberg-Kreuz J; Sandling JK; Bjork A; Nordlund J; Kvarnstrom M; Eloranta M-L; Ronnblom L; Wahren-Herlenius M; Syvanen A-C; Nordmark G
Article: CARDIOVASCULAR RESEARCH. 2018;114(1):158-167
Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content
Brauner S; Jiang X; Thorlacius GE; Lundberg AM; Ostberg T; Yan Z-Q; Kuchroo VK; Hansson GK; Wahren-Herlenius M
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1939
Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp
Adam L; Lopez-Gonzalez M; Bjork A; Palsson S; Poux C; Wahren-Herlenius M; Fernandez C; Spetz A-L
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(11):2187-2192
Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjogren's Syndrome
Sharma R; Harris VM; Cavett J; Kurien BT; Liu K; Koelsch KA; Fayaaz A; Chaudhari KS; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Alarcon-Riquelme M; Mariette X; Lessard CJ; Harley JB; Ng W-F; Rasmussen A; Sivils KL; Scofield RH
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8(1):34
Sex influences eQTL effects of SLE and Sjogren's syndrome-associated genetic polymorphisms
Linden M; Sepulveda JIR; James T; Thorlacius GE; Brauner S; Gomez-Cabrero D; Olsson T; Kockum I; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(10):1755-1763
H1N1 vaccination in Sjogren's syndrome triggers polyclonal B cell activation and promotes autoantibody production
Brauner S; Folkersen L; Kvarnstrom M; Meisgen S; Petersen S; Franzen-Malmros M; Mofors J; Brokstad KA; Klareskog L; Jonsson R; Westerberg LS; Trollmo C; Malmstrom V; Ambrosi A; Kuchroo VK; Nordmark G; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2017;56(10):1755-1762
Factors influencing fetal cardiac conduction in anti-Ro/SSA-positive pregnancies
Sonesson S-E; Hedlund M; Ambrosi A; Wahren-Herlenius M
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8(1):25
Long-term follow-up in primary Sjogren's syndrome reveals differences in clinical presentation between female and male patients
Sepulveda JIR; Kvarnstrom M; Eriksson P; Mandl T; Norheim KB; Johnsen SJ; Hammenfors D; Jonsson MV; Skarstein K; Brun JG; Ronnblom L; Forsblad-d'Elia H; Bucher SM; Baecklund E; Theander E; Omdal R; Jonsson R; Nordmark G; Wahren-Herlenius M
Article: EXPERIMENTAL DERMATOLOGY. 2017;26(8):713-720
TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model
Vinter H; Langkilde A; Ottosson V; Espinosa A; Wahren-Herlenius M; Raaby L; Johansen C; Iversen L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(6):1042-1050
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Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita TA; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath IF; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Moca Trevisani VF; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Article: PLOS GENETICS. 2017;13(6):e1006820
Identification of a Sjogren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons
Li H; Reksten TR; Ice JA; Kelly JA; Adrianto I; Rasmussen A; Wang S; He B; Grundahl KM; Glenn SB; Miceli-Richard C; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Goransson LG; Harboe E; Guthridge JM; Kaufman KM; Kvarnstrom M; Graham DSC; Patel K; Adler AJ; Farris AD; Brennan MT; Chodosh J; Gopalakrishnan R; Weisman MH; Venuturupalli S; Wallace DJ; Hefner KS; Houston GD; Huang AJW; Hughes PJ; Lewis DM; Radfar L; Vista ES; Edgar CE; Rohrer MD; Stone DU; Vyse TJ; Harley JB; Gaffney PM; James JA; Turner S; Alevizos I; Anaya J-M; Rhodus NL; Segal BM; Montgomery CG; Scofield RH; Kovats S; Mariette X; Ronnblom L; Witte T; Rischmueller M; Wahren-Herlenius M; Omdal R; Jonsson R; Ng W-F; Nordmark G; Lessard CJ; Sivils KL
Article: RMD OPEN. 2017;3(2):e000520
Environmental and lifestyle factors influencing risk of congenital heart block during pregnancy in anti-Ro/SSA-positive women
Meisgen S; Tingstrom J; Andreasson AS; Sonesson S-E; Kockum I; Wahren-Herlenius M
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8:16
Difference in clinical presentation between women and men in incident primary Sjogren's syndrome
Sepulveda JIR; Kvarnstrom M; Brauner S; Baldini C; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(3):284-291
Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model
Hoxha A; Ruffatti A; Ambrosi A; Ottosson V; Hedlund M; Ottosson L; Anandapadamanaban M; Sunnerhagen M; Sonesson S-E; Wahren-Herlenius M
Article: CLINICAL IMMUNOLOGY. 2016;168:25-29
Klinefelter's syndrome (47,XXY) is in excess among men with Sjogren's syndrome
Harris VM; Sharma R; Cavett J; Kurien BT; Liu K; Koelsch KA; Rasmussen A; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Alarcon-Riquelme ME; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Scofield RH
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(5):1290-1300
X Chromosome Dose and Sex Bias in Autoimmune Diseases
Liu K; Kurien BT; Zimmerman SL; Kaufman KM; Taft DH; Kottyan LC; Lazaro S; Weaver CA; Ice JA; Adler AJ; Chodosh J; Radfar L; Rasmussen A; Stone DU; Lewis DM; Li S; Koelsch KA; Igoe A; Talsania M; Kumar J; Maier-Moore JS; Harris VM; Gopalakrishnan R; Jonsson R; Lessard JA; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Mei GG; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omda R; Rhodus NL; Rischmueller M; Rohrer M; Sega BM; Vvse TJ; Wahren-Herlenius M; Witte T; Pons-Este B; Alarcon-Riquelme ME; Guthridge JM; James JA; Lessard CJ; Kelly JA; Thompson SD; Gaffney PM; Montgomery CG; Edberg JC; Kimberly RP; Alarcon GS; Langefeld CL; Gilkeson GS; Kamen DL; Tsao BP; McCune WJ; Salmon JE; Merrill JT; Weisman MH; Wallace DJ; Utset T; Bottinger EP; Amos CI; Siminovitch KA; Mariette X; Sivils KL; Harley JB; Scofield RH
Article: LUPUS. 2016;25(5):536-542
Anti-Ro/SSA autoantibody-positive women's experience of information given on the risk of congenital heart block
Tingstrom J; Hjelmstedt A; Henriksson EW; Ambrosi A; Sonesson S-E; Wahren-Herlenius M
Article: JOURNAL OF IMMUNOLOGY. 2016;196(1):91-96
The Expression of BAFF Is Controlled by IRF Transcription Factors
Sjostrand M; Johansson A; Aqrawi L; Olsson T; Wahren-Herlenius M; Espinosa A
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2016;95(1):98-105
Outcome in 212 anti-Ro/SSA-positive pregnancies and population-based incidence of congenital heart block
Skog A; Lagnefeldt L; Conner P; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(12):4612-4624
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies
Albrecht I; Wick C; Hallgren A; Tjarnlund A; Nagaraju K; Andrade F; Thompson K; Coley W; Phadke A; Diaz-Gallo L-M; Bottai M; Nennesmo I; Chemin K; Herrath J; Johansson K; Wikberg A; Ytterberg AJ; Zubarev RA; Danielsson O; Krystufkova O; Vencovsky J; Landegren N; Wahren-Herlenius M; Padyukov L; Kampe O; Lundberg IE
Article: LUPUS. 2015;24(14):1540-1545
Ro/SSA autoantibody-positive pregnancy: reactions to serial fetal Doppler echocardiographic surveillance
Tingstrom J; Hjelmstedt A; Henriksson EW; Sonesson S-E; Wahren-Herlenius M
Article: HEART RHYTHM. 2015;12(11):2278-2284
Outcome in young patients with isolated complete atrioventricular block and permanent pacemaker treatment: A nationwide study of 127 patients
Eliasson H; Sonesson S-E; Salomonsson S; Skog A; Wahren-Herlenius M; Gadler F
Article: JOURNAL OF INTERNAL MEDICINE. 2015;278(3):323-332
Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease
Brauner S; Zhou W; Backlin C; Green TM; Folkersen L; Ivanchenko M; Lofstrom B; Xu-Monette ZY; Young KH; Pedersen LM; Moller MB; Sundstrom C; Enblad G; Baecklund E; Wahren-Herlenius M
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Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome
Yue Y; Castrichini M; Srivastava U; Fabris F; Shah K; Li Z; Qu Y; El-Sherif N; Zhou Z; January C; Hussain MM; Jiang X-C; Sobie EA; Wahren-Herlenius M; Chahine M; Capecchi P-L; Laghi-Pasini F; Lazzerini P-E; Boutjdir M
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Incident cases of primary Sjogren's syndrome during a 5-year period in Stockholm County: a descriptive study of the patients and their characteristics
Kvarnstrom M; Ottosson V; Nordmark B; Wahren-Herlenius M
Article: HUMAN MOLECULAR GENETICS. 2015;24(2):582-596
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share
Kottyan LC; Zoller EE; Bene J; Lu X; Kelly JA; Rupert AM; Lessard CJ; Vaughn SE; Marion M; Weirauch MT; Namjou B; Adler A; Rasmussen A; Glenn S; Montgomery CG; Hirschfield GM; Xie G; Coltescu C; Amos C; Li H; Ice JA; Nath SK; Mariette X; Bowman S; Rischmueller M; Lester S; Brun JG; Goransson LG; Harboe E; Omdal R; Cunninghame-Graham DS; Vyse T; Miceli-Richard C; Brennan MT; Lessard JA; Wahren-Herlenius M; Kvarnstrom M; Illei GG; Witte T; Jonsson R; Eriksson P; Nordmark G; Ng W-F; Anaya J-M; Rhodus NL; Sega BM; Merrill JT; James JA; Guthridge JM; Scofield RH; Alarcon-Riquelme M; Bae S-C; Boackle SA; Criswell LA; Gilkeson G; Kamen DL; Jacob CO; Kimberly R; Brown E; Edberg J; Alarcon GS; Reveille JD; Vila LM; Petri M; Ramsey-Goldman R; Freedman BI; Niewold T; Stevens AM; Tsao BP; Ying J; Mayes MD; Gorlova OY; Wakeland W; Radstake T; Martin E; Martin J; Siminovitch K; Sivils KLM; Gaffney PM; Langefeld CD; Harley JB; Kaufman KM
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Interferon beta treatment of multiple sclerosis increases serum interleukin-7
Lundstrom W; Hermanrud C; Sjostrand M; Brauner S; Wahren-Herlenius M; Olsson T; Karrenbauer V; Hillert J; Fogdell-Hahn A
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2014;44(2):171-175
Doppler echocardiographic isovolumetric time intervals in diagnosis of fetal blocked atrial bigeminy and 2:1 atrioventricular block
Sonesson S-E; Eliasson H; Conner P; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(1):244-252
Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjogren's syndrome
Aqrawi LA; Kvarnstrom M; Brokstad KA; Jonsson R; Skarstein K; Wahren-Herlenius M
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(6):640-651
The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence
Meisgen S; Ostberg T; Salomonsson S; Ding B; Eliasson H; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(6):1253-1258
Genetic associations to germinal centre formation in primary Sjogren's syndrome
Reksten TR; Johnsen SJA; Jonsson MV; Omdal R; Brun JG; Theander E; Eriksson P; Wahren-Herlenius M; Jonsson R; Nordmark G
Article: ACTA PAEDIATRICA. 2014;103(3):275-281
Late development of complete atrioventricular block may be immune mediated and congenital in origin
Bergman G; Skog A; Tingstrom J; Ottosson V; Hoxha A; Ambrosi A; Salomonsson S; Wahren-Herlenius M
Article: RHEUMATOLOGY INTERNATIONAL. 2014;34(2):191-197
A possible genetic association with chronic fatigue in primary Sjogren's syndrome: a candidate gene study
Norheim KB; Le Hellard S; Nordmark G; Harboe E; Goransson L; Brun JG; Wahren-Herlenius M; Jonsson R; Omdal R
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;78(5):447-454
Association of Genes in the NF-κB Pathway with Antibody-Positive Primary Sjogren's Syndrome
Nordmark G; Wang C; Vasaitis L; Eriksson P; Theander E; Kvarnstrom M; Forsblad-d'Elia H; Jazebi H; Sjowall C; Reksten TR; Brun JG; Jonsson MV; Johnsen SJ; Wahren-Herlenius M; Omdal R; Jonsson R; Bowman S; Ng W-F; Eloranta M-L; Syvanen A-C
Article: NATURE GENETICS. 2013;45(11):1284-1292
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome
Lessard CJ; Li H; Adrianto I; Ice JA; Rasmussen A; Grundahl KM; Kelly JA; Dozmorov MG; Miceli-Richard C; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Goransson LG; Harboe E; Guthridge JM; Kaufman KM; Kvarnstrom M; Jazebi H; Graham DSC; Grandits ME; Nazmul-Hossain ANM; Patel K; Adler AJ; Maier-Moore JS; Farris AD; Brennan MT; Lessard JA; Chodosh J; Gopalakrishnan R; Hefner KS; Houston GD; Huang AJW; Hughes PJ; Lewis DM; Radfar L; Rohrer MD; Stone DU; Wren JD; Vyse TJ; Gaffney PM; James JA; Omdal R; Wahren-Herlenius M; Illei GG; Witte T; Jonsson R; Rischmueller M; Ronnblom L; Nordmark G; Wan-Fai N; Mariette X; Anaya J-M; Rhodus NL; Segal BM; Scofield RH; Montgomery CG; Harley JB; Sivils KL
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3753-3763
Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors
Sjostrand M; Ambrosi A; Brauner S; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Article: LANCET. 2013;382(9894):819-831
Autoimmune Rheumatic Diseases 3 Immunopathogenic mechanisms of systemic autoimmune disease
Wahren-Herlenius M; Doener T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2013;5(195):195ra96
NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome
Rusakiewicz S; Nocturne G; Lazure T; Semeraro M; Flament C; Caillat-Zucman S; Sene D; Delahaye N; Vivier E; Chaba K; Poirier-Colame V; Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Ronnblom L; Nititham J; Taylor KE; Lessard CJ; Sivils KLM; Gottenberg J-E; Criswell LA; Miceli-Richard C; Zitvogel L; Mariette X
Article: ACTA PAEDIATRICA. 2013;102(7):718-726
Long-term growth of children with autoantibody-mediated congenital heart block
Skog A; Eliasson H; Tingstrom J; Kallberg H; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Article: GENES AND IMMUNITY. 2013;14(4):234-237
No association of primary Sjogren's syndrome with Fcγ receptor gene variants
Haldorsen K; Appel S; Le Hellard S; Bruland O; Brun JG; Omdal R; Kristjansdottir G; Theander E; Fernandes CPD; Kvarnstrom M; Eriksson P; Ronnblom L; Herlenius MW; Nordmark G; Jonsson R; Bolstad AI
Article: LUPUS. 2013;22(5):477-485
Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus
Kvarnstrom M; Dzikaite-Ottosson V; Ottosson L; Gustafsson JT; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Article: ACTA PAEDIATRICA. 2013;102(1):40-46
Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA-positive mothers
Skog A; Tingstrom J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Article: MIDWIFERY. 2013;29(1):18-23
Ro52 autoantibody-positive women's experience of being pregnant and giving birth to a child with congenital heart block
Tingstrom J; Henriksson EW; Sonesson S-E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(6):981-988
Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples
Bolstad AI; Le Hellard S; Kristjansdottir G; Vasaitis L; Kvarnstrom M; Sjowall C; Johnsen SJA; Eriksson P; Omdal R; Brun JG; Wahren-Herlenius M; Theander E; Syvanen A-C; Ronnblom L; Nordmark G; Jonsson R
Article: ACTA PAEDIATRICA. 2012;101(5):488-493
Progression to first-degree heart block in preschool children exposed in utero to maternal anti-SSA/Ro52 autoantibodies
Bergman G; Eliasson H; Mohlkert L-A; Wahren-Herlenius M; Sonesson S-E
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(5):1601-1609
Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus
Smith S; Gabhann JN; Higgs R; Stacey K; Wahren-Herlenius M; Espinosa A; Totaro MG; Sica A; Ball E; Bell A; Johnston J; Browne P; O'Neill L; Kearns G; Jefferies CA
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):448-454
Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model
Ambrosi A; Dzikaite V; Park J; Strandberg L; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):334-340
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Skog A; Dzikaite V; Bergman G; Fernlund E; Tingstrom J; Theander E; Rydberg A; Skogh T; Ohman A; Lundstrom U; Mellander M; Winqvist O; Fored M; Ekbom A; Alfredsson L; Kallberg H; Olsson T; Gadler F; Jonzon A; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;74(5):511-517
A Population-based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block
Salomonsson S; Dzikaite V; Zeffer E; Eliasson H; Ambrosi A; Bergman G; Fernlund E; Theander E; Ohman A; Rydberg A; Skogh T; Wallberg-Jonsson S; Elfving A; Fored M; Ekbom A; Lundstrom U; Mellander M; Winqvist O; Sonesson S-E; Gadler F; Jonzon A; Wahren-Herlenius M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(42):36478-36491
Anti-Ro52 Autoantibodies from Patients with Sjogren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface
Espinosa A; Hennig J; Ambrosi A; Anandapadmanaban M; Abelius MS; Sheng Y; Nyberg F; Arrowsmith CH; Sunnerhagen M; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(7):1327-1329
Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome
Appel S; Le Hellard S; Bruland O; Brun JG; Omdal R; Kristjansdottir G; Theander E; Nordmark G; Kvarnstrom M; Eriksson P; Ronnblom L; Wahren-Herlenius M; Jonsson R
Article: AMERICAN JOURNAL OF CARDIOLOGY. 2011;107(5):761-766
Spontaneous Rupture of Atrioventricular Valve Tensor Apparatus as Late Manifestation of Anti-Ro/SSA Antibody-Mediated Cardiac Disease
Cuneo BF; Fruitman D; Benson DW; Ngan B-Y; Liske MR; Wahren-Herlineus M; Ho SY; Jaeggi E
Article: GENES AND IMMUNITY. 2011;12(2):100-109
Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren's syndrome
Nordmark G; Kristjansdottir G; Theander E; Appel S; Eriksson P; Vasaitis L; Kvarnstrom M; Delaleu N; Lundmark P; Lundmark A; Sjowall C; Brun JG; Jonsson MV; Harboe E; Goransson LG; Johnsen SJ; Soderkvist P; Eloranta M-L; Alm G; Baecklund E; Wahren-Herlenius M; Omdal R; Ronnblom L; Jonsson R; Syvanen A-C
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2011;37(2):172-178
Mechanisms in fetal bradyarrhythmia: 65 cases in a single center analyzed by Doppler flow echocardiographic techniques
Eliasson H; Wahren-Herlenius M; Sonesson S-E
Article: PLOS ONE. 2010;5(12):e14212
Polymorphisms of the ITGAM Gene Confer Higher Risk of Discoid Cutaneous Than of Systemic Lupus Erythematosus
Jarvinen TM; Hellquist A; Koskenmies S; Einarsdottir E; Panelius J; Hasan T; Julkunen H; Padyukov L; Kvarnstrom M; Wahren-Herlenius M; Nyberg F; D'Amato M; Kere J; Saarialho-Kere U
Article: MUSCULOSKELETAL CARE. 2010;8(4):215-223
The Experiences of Pregnancy in Women with SSA/Ro52 Autoantibodies
Tingstroem J; Barimani M; Sonesson S-E; Wahren-Herlenius M; Henriksson EW
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2010;36(5):561-566
Diagnostic precision of Doppler flow echocardiography in fetuses at risk for atrioventricular block
Bergman G; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block
Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: PLOS ONE. 2010;5(7):e11776
Self Protection from Anti-Viral Responses-Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors
Higgs R; Lazzari E; Wynne C; Gabhann JN; Espinosa A; Wahren-Herlenius M; Jefferies CA
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2009;34(5):543-549
Anti-Ro52/SSA antibody-exposed fetuses with prolonged atrioventricular time intervals show signs of decreased cardiac performance
Bergman G; Eliasson H; Bremme K; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2009;206(8):1661-1671
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway
Espinosa A; Dardalhon V; Brauner S; Ambrosi A; Higgs R; Quintana FJ; Sjostrand M; Eloranta M-L; Gabhann JN; Winqvist O; Sundelin B; Jefferies CA; Rozell B; Kuchroo VK; Wahren-Herlenius M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(8):2000-2010
High Ro52 Expression in Spontaneous and UV-Induced Cutaneous Inflammation
Oke V; Vassilaki I; Espinosa A; Strandberg L; Kuchroo VK; Nyberg F; Wahren-Herlenius M
Article: LUPUS. 2009;18(9):792-798
Serologic follow-up of children born to mothers with Ro/SSA autoantibodies
Klauninger R; Skog A; Horvath L; Winqvist O; Edner A; Bremme K; Sonesson SE; Wahren-Herlenius M
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2009;38(3):282-288
Minor salivary gland immunohistology in the diagnosis of primary Sjogren's syndrome
Salomonsson S; Rozell BL; Heimburger M; Wahren-Herlenius M
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(20):3605-3613
The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide
Espinosa A; Oke V; Elfving A; Nyberg F; Covacu R; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;154(1):30-37
Antibodies to amino acid 200-239 (p200) of Ro52 as serological markers for the risk of developing congenital heart block
Strandberg L; Winqvist O; Sonesson S-E; Mohseni S; Salomonsson S; Bremme K; Buyon JP; Julkunen H; Wahren-Herlenius M
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2008;28(3):220-231
Interferon-α induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies
Strandberg L; Arnbrosi A; Espinosa A; Ottosson L; Eloranta M-L; Zhou W; Elfving A; Greenfield E; Kuchroo VK; Wahren-Herlenius M
Article: PEDIATRICS. 2008;121(4):e803-e809
Outcome and growth of infants fetally exposed to heart block-associated maternal anti-Ro52/SSA Autoantibodies
Skog A; Wahren-Herlenius M; Sundstrom B; Bremme K; Sonesson S-E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;377(2):431-449
The fellowship of the RING: The RING-B-box linker region interacts with the RING in TRIM21/Ro52, contains a native autoantigenic epitope in Sjogren syndrome, conserved region and is an integral and in TRIM proteins
Hennig J; Bresell A; Sandberg M; Hennig KDM; Wahren-Herlenius M; Persson B; Sunnerhagen M
Article: ACTA DERMATO-VENEREOLOGICA. 2008;88(4):370-375
Clinical follow-up of 102 anti-Ro/SSA-positive patients with dermatological manifestations
Popovic K; Wahren-Herlenius M; Nyberg F
Article: METHODS IN MOLECULAR MEDICINE. 2007;136:19-24
Detection of antigen specific B-cells in tissues.
Wahren-Herlenius M; Salomonsson S
Article: LUPUS. 2007;16(10):794-802
Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus
Barkauskaite V; Ek M; Popovic K; Harris HE; Wahren-Herlenius M; Nyberg F
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(1):255-264
A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus
Popovic K; Nyberg F; Wahren-Herlenius M; Nyberg F
Article: LUPUS. 2007;16(1):10-17
Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun
Popovic K; Brauner S; Ek M; Wahren-Herlenius M; Nyberg F
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(7):2289-2294
Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjogren's syndrome
Ek M; Popovic K; Harris HE; Naucler CS; Wahren-Herlenius M
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2006;28(1):57-62
Doppler echocardiographic and electrocardiographic atrioventricular time intervals in newborn infants: evaluation of techniques for surveillance of fetuses at risk for congenital heart block
Bergman G; Jacobsson L-A; Wahren-Herlenius M; Sonesson S-E
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(6):1917-1927
Induction of interferon-α by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjogren's syndrome autoantigen-associated RNA
Lovgren T; Eloranta M-L; Kastner B; Wahren-Herlenius M; Alm GV; Ronnblom L
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):6277-6285
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A; Zhou W; Ek M; Hedlund M; Brauner S; Popovic K; Horvath L; Wallerskog T; Oukka M; Nyberg F; Kuchroo VK; Wahren-Herlenius M
Article: MOLECULAR IMMUNOLOGY. 2006;43(6):588-598
Structural, functional and immunologic characterization of folded subdomains in the Ro52, protein targeted in Sjogren's syndrome
Ottosson L; Hennig J; Espinosa A; Brauner S; Wahren-Herlenius M; Sunnerhagen M
Article: LUPUS. 2006;15(6):346-353
Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies
Strandberg L; Salomonsson S; Bremme K; Sonesson S-E; Wahren-Herlenius M
Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(6):R167
Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis
Vallerskog T; Heimburger M; Gunnarsson I; Zhou W; Wahren-Herlenius M; Trollmo C; Malmstrom V
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3639-3645
Increased-expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
Popovic K; Ek M; Espinosa A; Padyukov L; Harris HE; Wahren-Herlenius M; Nyberg F
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(39):33250-33261
Structural organization and Zn²⁺-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52
Hennig J; Ottosson L; Andrésen C; Horvath L; Kuchroo VK; Broo K; Wahren-Herlenius M; Sunnerhagen M
Article: NATURE GENETICS. 2005;37(2):125-127
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands
Entesarian M; Matsson H; Klar J; Bergendal B; Olson L; Arakaki R; Hayashi Y; Ohuchi H; Falahat B; Bolstad AI; Jonsson R; Wahren-Herlenius M; Dahl N
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(2):109-118
Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein
Ottosson L; Salomonsson S; Hennig J; Sonesson SE; Dörner T; Raats J; Kuchroo VK; Sunnerhagen M; Wahren-Herlenius M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):11-17
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
Salomonsson S; Sonesson SE; Ottosson L; Muhallab S; Olsson T; Sunnerhagen M; Kuchroo VK; Thorén P; Herlenius E; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(4):1253-1261
Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies
Sonesson SE; Salomonsson S; Jacobsson LA; Bremme K; Wahren-Herlenius M
Article: JOURNAL OF AUTOIMMUNITY. 2004;22(2):167-177
Cloning and characterization of two human Ro52-specific monoclonal autoantibodies directed towards a domain associated with congenital heart block
Salomonsson S; Ottosson L; Säfsten P; Hof D; Brauner H; Sunnerhagen M; Raats J; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(11):3187-3201
Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome
Salomonsson S; Jonsson MV; Skarstein K; Brokstad KA; Hjelmström P; Wahren-Herlenius M; Jonsson R
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2003;32(2):79-82
Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjogren's syndrome
Salomonsson S; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2002;31(3):133-139
Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus
Hassan AB; Lundberg IE; Isenberg D; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2002;46(5):1233-1241
A serologic marker for fetal risk of congenital heart block
Salomonsson S; Dörner T; Theander E; Bremme K; Larsson P; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(4):336-342
Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjogren's syndrome
Salomonsson S; Larsson P; Tengnér P; Mellquist E; Hjelmström P; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(1):208-213
Ro/SS-A- and La/SS-B-reactive B lymphocytes in peripheral blood of patients with Sjogren's syndrome
Halse AK; Wahren-Herlenius M; Jonsson R
Article: JOURNAL OF RHEUMATOLOGY. 2001;28(2):373-376
Primary Sjogren's syndrome - Treatment of fetal incomplete atrioventricular block with dexamethasone
Theander E; Brucato A; Gudmundsson S; Salomonsson S; Wahren-Herlenius M; Manthorpe R
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2000;29(2):116-123
Ro 52kD autoantibodies are detected in a subset of ANA-negative sera
Pourmand N; Blomberg S; Rönnblom L; Karlsson-Parra A; Pettersson I; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2000;29(1):13-19
Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjogren's syndrome
Halse AK; Marthinussen MC; Wahren-Herlenius M; Jonsson R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(25):14487-14492
Key residues revealed in a major conformational epitope of the U1-70K protein
Henriksson EW; Wahren-Herlenius M; Lundberg I; Mellquist E; Pettersson I
Article: ARTHRITIS & RHEUMATOLOGY. 1999;42(11):2471-2481
Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjogren's syndrome
Elagib KEE; Tengnér P; Levi M; Jonsson R; Thompson KM; Natvig JB; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 1999;58(10):623-629
Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with Sjogren's syndrome and systemic lupus erythematosus
Pourmand N; Wahren-Herlenius M; Gunnarsson I; Svenungsson E; Löfström B; Ioannou Y; Isenberg DA; Magnusson CGM
Article: JOURNAL OF HUMAN VIROLOGY. 1999;2(5):296-307
The La protein from human liver cells interacts specifically with the u-rich region in the hepatitis C virus 3′ untranslated region
Spångberg K; Goobar-Larsson L; Wahren-Herlenius M; Schwartz S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;49(5):533-538
Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjogren's syndrome
Halse AK; Tengnér P; Wahren-Herlenius M; Haga HJ; Jonsson R
Article: ARTHRITIS & RHEUMATOLOGY. 1998;41(12):2238-2248
Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjogren's syndrome
Tengnér P; Halse AK; Haga HJ; Jonsson R; Wahren-Herlenius M
Article: JOURNAL OF AUTOIMMUNITY. 1998;11(1):29-38
Ro/SS-A and La/SS-B antibody level variation in patients with Sjogren's syndrome and systemic lupus erythematosus
Wahren M; Tengner P; Gunnarsson I; Lundberg I; Hedfors E; Ringertz NR; Pettersson I
Article: RHEUMATOLOGY INTERNATIONAL. 1997;17(4):133-135
Anti-Ro (SSA) antibodies in rheumatoid arthritis patients with gold-induced side effects
Tishler M; Nyman J; Wahren M; Yaron M
Article: JOURNAL OF AUTOIMMUNITY. 1996;9(4):537-544
Autoantibody repertoire to Ro/SSA and La/SSB antigens in patients with primary and secondary Sjogren's syndrome
Wahren M; Solomin L; Pettersson I; Isenberg D
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 1996;70(3):189-197
Nuclear colocalization of the Ro 60kDa autoantigen and a subset of U snRNP domains
Wahren M; Mellqvist E; Vene S; Ringertz NR; Petterson I
Article: AUTOIMMUNITY. 1996;23(1):25-34
Peripheral blood in Sjogren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-R 48 kD autoantigens
Halse AK; Wahren M; Jonsson R
Article: AUTOIMMUNITY. 1995;22(1):9-16
Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice
Skarstein K; Wahren M; Zaura E; Hattori M; Jonsson R
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All other publications

Preprint: BIORXIV. 2023;BIORXIV
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland.
Wiley MM; Khatri B; Joachims ML; Tessneer KL; Stolarczyk AM; Rasmussen A; Anaya J-M; Aqrawi LA; Bae S-C; Baecklund E; Björk A; Brun JG; Bucher SM; Dand N; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Fugmann C; Glenn SB; Gong C; Gottenberg J-E; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kelly JA; Khanam S; Kim K; Kvarnström M; Mandl T; Martín J; Morris DL; Nocturne G; Norheim KB; Olsson P; Palm Ø; Pers J-O; Rhodus NL; Sjöwall C; Skarstein K; Taylor KE; Tombleson P; Thorlacius GE; Venuturupalli S; Vital EM; Wallace DJ; Grundahl KM; Radfar L; Brennan MT; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Appel S; Eriksson P; Bowman SJ; Omdal R; Rönnblom L; Warner BM; Rischmueller M; Witte T; Farris AD; Mariette X; Shiboski CH; Sjögren’s International Collaborative Clinical All; Wahren-Herlenius M; Alarcón-Riquelme ME; PRECISESADS Clinical Consortium; Ng W-F; UK Primary Sjögren’s Syndrome Registry; Sivils KL; Guthridge JM; Adrianto I; Vyse TJ; Tsao BP; Nordmark G; Lessard CJ
Conference publication: EUROPEAN JOURNAL OF CANCER. 2023;190:S4-S5
Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor
Brauner H; Scheffschick A; Nenonen J; Xiang M; Winther A; Ehrstrom M; Wahren-Herlenius M; Eidsmo L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1069.2-101070
IMMUNE CELLS AND THEIR EFFECTOR FUNCTIONS IN NEONATES BORN TO ANTI-RO/LA POSITIVE WOMEN
Gerstner C; Rudolph L; Thorlacius GE; Ottosson V; Meneghel L; Nordenstam F; Bergman G; Sonesson SE; Hedlund M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:705
SEX-EQTL ANALYSIS REVEALS A SIGNIFICANT SEXBIAS IN THE EFFECTS OF SJOGREN'S SYNDROME ASSOCIATED ALLELES ON GENE TRANSCRIPTION
Thorlacius GE; Bjork A; Wahren-Herlenius M
Review: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(6):754-762
2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice
Rodriguez-Carrio J; Burska A; Conaghan PG; Dik WA; Biesen R; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Fremond M-L; Crow MK; Ronnblom L; Versnel MA; Vital EM
Review: NATURE REVIEWS RHEUMATOLOGY. 2023;19(5):288-306
Genetics and epigenetics of primary Sjogren syndrome: implications for future therapies
Thorlacius GE; Bjork A; Wahren-Herlenius M
Review: RMD OPEN. 2023;9(1):e002864
Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Rodriguez-Carrio J; Burska A; Conaghan PG; Dik WA; Biesen R; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Fremond M-L; Crow MK; Ronnblom L; Vital E; Versnel M
Review: RMD OPEN. 2023;9(1):e002876
Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Burska A; Rodriguez-Carrio J; Biesen R; Dik WA; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Fremond M-L; Crow MK; Ronnblom L; Conaghan PG; Versnel M; Vital E
Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):598
Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells (vol 13, 4287, 2022)
Khatri B; Tessneer K; Rasmussen A; Aghakhanian F; Reksten TR; Adler AA; Alevizos I; Anaya J-MG; Aqrawi L; Baecklund E; Brun J; Bucher SM; Eloranta M-LB; Engelke F; Forsblad-d'Elia H; Glenn S; Hammenfors D; Imgenberg-Kreuz JV; Jensen JL; Johnsen SJAA; Jonsson M; Kvarnstroem M; Kelly J; Li H; Mandl T; Martin J; Nocturne G; Norheim KBM; Palm OE; Skarstein K; Stolarczyk A; Taylor K; Teruel MJ; Theander EM; Venuturupalli SS; Wallace D; Grundahl KM; Hefner KU; Radfar L; Lewis DT; Stone DM; Kaufman CEA; Brennan M; Guthridge JM; James JA; Scofield RH; Gaffney P; Criswell LJ; Jonsson R; Eriksson P; Bowman S; Omdal R; Roennblom L; Warner B; Rischmueller M; Witte TE; Farris ADH; Mariette X; Alarcon-Riquelme M; Shiboski CL; Wahren-Herlenius M; Ng W-F; Sivils KJ; Adrianto I; Nordmark G; Lessard C
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):418
ANTI-FHL1 AUTOANTIBODIES IN ADULT MYOSITIS PATIENTS: BASELINE AND LONGITUDINAL FOLLOW-UP ANALYSIS
Galindo-Feria AS; Lodin K; Horuluoglu B; Sarrafzadeh-Zargar S; Wigren E; Graslund S; Danielsson O; Mohammad AJ; Leonard D; Sjowall C; Husmark T; Hemberg M; Puksic S; Lappas T; Hanna B; Wahren-Herlenius M; Dastmalchi M; Lundberg IE
Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6519
Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells (vol 13, 4287, 2022)
Khatri B; Tessneer KL; Rasmussen A; Aghakhanian F; Reksten TR; Adler A; Alevizos I; Anaya J-M; Aqrawi LA; Baecklund E; Brun JG; Bucher SM; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Glenn SB; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kvarnstrom M; Kelly JA; Li H; Mandl T; Martin J; Nocturne G; Norheim KB; Palm O; Skarstein K; Stolarczyk AM; Taylor KE; Teruel M; Theander E; Venuturupalli S; Wallace DJ; Grundahl KM; Hefner KS; Radfar L; Lewis DM; Stone DU; Kaufman CE; Brennan MT; Guthridge JM; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Eriksson P; Bowman SJ; Omdal R; Ronnblom L; Warner B; Rischmueller M; Witte T; Farris AD; Mariette X; Alarcon-Riquelme ME; Shiboski CH; Wahren-Herlenius M; Ng W-F; Sivils KL; Adrianto I; Nordmark G; Lessard CJ
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:269-270
SJOGREN'S DISEASE AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVALS REVEAL COMMON SNPS WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE AND SALIVARY GLAND CELLS
Wiley MM; Khatri B; Tessneer KL; Joachims ML; Stolarczyk AM; Nagel A; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils K; Nordmark G; Tsao B; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:72-73
INTEGRATION OF GWAS AND EPIGENETIC STUDIES IDENTIFIES NOVEL GENES THAT ALTER EXPRESSION IN THE MINOR SALIVARY GLAND IN SJOGREN'S DISEASE
Aghakhanian F; Wiley MM; Khatri B; Tessneer KL; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme M; Ng WF; Sivils K; Nordmark G; Deshmukh U; Farris AD; Lessard C
Conference publication: ACTA DERMATO-VENEREOLOGICA. 2022;102:43-44
SKIN INFILTRATING NK CELLS IN PRIMARY CUTANEOUS T-CELL LYMPHOMA ARE INCREASED IN NUMBER AND HAVE AN ALTERED PHENOTYPE PARTLY INDUCED BY THE LYMPHOMA
Scheffschick A; Nenonen J; Winther A; Ehrstrom M; Wahren-Herlenius M; Eidsmo L; Brauner H
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3982-3983
Autophagy-related Risk Loci in Systemic Lupus Erythematous and Sjogren's Disease
Nagel A; Khatri B; Radziszewski M; Wiley M; Stolarczyk A; Joachims M; Tessneer K; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield H; Mariette X; Alarcon-Riquelme M; Ng F; Nordmark G; Sun Q; Kim K; Bae S-C; Tsao B; Farris AD; Lessard C
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):17
TRANSCRIPTOME-WIDE ASSOCIATION STUDY OF SJOGREN'S DISEASE RISK ALLELES IDENTIFIES NOVEL GENES WITH ALTERED EXPRESSION IN MINOR SALIVARY GLAND AND OTHER TISSUES
Radziszewski M; Wiley M; Khatri B; Tessneer K; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme ME; Ng WF; Sivils K; Nordmark G; Deshmukh U; Farris AD; Lessard CJ
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):14
FINE MAPPING OF THE DDX6-CXCR5 RISK INTERVAL REVEALS SNPS IN SJOGREN'S DISEASE WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE CELLS AND SALIVARY GLAND
Wiley M; Khatri B; Tessneer K; Joachims M; Stolarczyk A; Nagel A; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils K; Nordmark G; Tsao B; Lessard CJ
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):26
AUTOPHAGY-RELATED PRDM1-ATG5 RISK LOCUS IN SJOGREN'S DISEASE
Nagel A; Khatri B; Radziszewski M; Wiley M; Stolarczyk A; Joachims M; Tessneer K; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Roennblom L; Scofield RH; Mariette X; Alarcon-Riquelme ME; Ng WF; Nordmark G; Farris AD; Lessard CJ
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3981-3982
Fine Mapping of the Sjogren's Disease and Systemic Lupus Erythematosus DDX6-CXCR5 Risk Interval Reveals Common SNPs with Functional Significance in Immune and Salivary Gland Cells
Wiley M; Khatri B; Tessneer K; Joachims M; Stolarczyk A; Nagel A; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield H; Mariette X; Ng F; Nordmark G; Tsao B; Lessard C
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:4557-4560
Fetal Cardiac Targets Identify the Autoantibodies Associated with Congenital Heart Block
Benjamin S; Vi L; Chatterjee D; Jaeggi E; Wahren-Herlenius M; Ruffatti A; Hiraki L; Lohbihler M; Sepiashvili L; Laskin C; Fatah M; Dominguez D; Ng L; Gramolini A; Christoffels V; Protze S; Hamilton R
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:2223-2225
Transcriptome-Wide Association Study of Sjogren's Disease Risk Alleles Identifies Novel Genes with Altered Expression in Minor Salivary Gland and Other Tissues
Radziszewski M; Wiley M; Khatri B; Tessneer K; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme M; Ng F; Nordmark G; Deshmukh U; Farris AD; Lessard C
Review: RHEUMATOLOGY. 2021;60(6):2561-2573
Innate immunity and interferons in the pathogenesis of Sjogren's syndrome
Bodewes ILA; Bjork A; Versnel MA; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:415
TYPE I INTERFERON PATHWAY ASSAYS IN PATIENTS WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - SYSTEMATIC LITERATURE REVIEW (SLR) AND DEVELOPMENT OF CONSENSUS TERMINOLOGY FROM A EULAR TASKFORCE
Burska A; Rodriguez Carrio J; Conaghan PG; Dik WA; Biesen R; Eloranta ML; Cavalli G; Visser M; Boumpas D; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Fremond ML; Crow MK; Ronnblom L; Vital E; Versnel M
Corrigendum: RHEUMATOLOGY. 2021;60(3):1575
Interferon activation status underlies higher antibody response to viral antigens in patients with systemic lupus erythematosus receiving no or light treatment (vol 60, pg 1445, 2021)
Bjork A; Rodrigues RDS; Andersson ER; Sepulveda JIR; Mofors J; Kvarnstrom M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
Letter: LANCET RHEUMATOLOGY. 2020;2(10):E588-E589
Mortality in congenital heart block
Sonesson S-E; Wahren-Herlenius M
Editorial comment: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(8):e95
Effects of maternal medication on long-term outcome in congenital heart block remain to be established. Response to: 'Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero' by Satis et al
Mofors J; Sonesson S-E; Wahren-Herlenius M
Editorial comment: NATURE REVIEWS RHEUMATOLOGY. 2020;16(7):355-356
Learning from similarities between vaccine responses and SLE
Wahren-Herlenius M; Ronnblom L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:335
SKIN PROTEOME INVESTIGATION IN CUTANEOUS LUPUS ERYTHEMATOSUS (CLE) REVEALS NOVEL UNIQUE DISEASE PATHWAYS
Niewold T; Popovic-Silwerfeldt K; Lehman J; Meves A; Charlesworth C; Madden B; Hayry A; Antovic A; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:30-31
GENOME-WIDE ASSOCIATION STUDY OF SJOGREN'S SYNDROME IDENTIFIES TEN NEW RISK LOCI
Khatri B; Reksten TR; Tessneer KL; Rasmussen A; Scofield RH; Bowman SJ; Guthridge J; James JA; Ronnblom L; Warner BM; Mariette X; Omdal R; Martin Ibanez J; Teruel M; Jensen JL; Aqrawi A; Palm O; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Farris AD; Alarcon-Riquelme M; Ng WF; Sivils KL; Nordmark G; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:89-90
FUNCTIONAL EVALUATION OF THE SJOGREN'S SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVAL
Wiley MM; Khatri B; Tessneer KL; Joachims ML; Stolarczyk AM; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils KL; Nordmark G; Tsao B; Lessard C
Review: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):475-492
Environmental factors in the pathogenesis of primary Sjogren's syndrome
Bjork A; Mofors J; Wahren-Herlenius M
Letter: LANCET RHEUMATOLOGY. 2020;2(4):E203-E204
Surveillance of congenital heart block in highly specialised care
Sonesson S-E; Wahren-Herlenius M
Letter: EUROPACE. 2020;22(2):330-331
Pacing therapy in children with isolated complete atrioventricular block: a retrospective study of pacing system survival and pacing-related complications in a national cohort-Authors' reply
Eliasson H; Sonesson S-E; Salomonsson S; Andreasson AS; Wahren-Herlenius M; Gadler F
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):307-308
Increased risk of multiple myeloma in primary Sjogren's syndrome is limited to individuals with Ro/SSA and La/SSB autoantibodies
Mofors J; Bjoerk A; Smedby KE; Kvarnstrom M; Forsblad-d'Elia H; Magnusson-Bucher S; Eriksson P; Mandl T; Baecklund E; Nordmark G; Wahren-Herlenius M
Letter: JOURNAL OF INTERNAL MEDICINE. 2020;287(2):216-217
Response to Letter to the Editor by Bartoloni et al: 'Interplay of anti-SSA/SSB status and hypertension in determining cardiovascular risk in primary Sjogren's syndrome'
Mofors J; Wahren-Herlenius M; Nordmark G
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72
Genome-wide Association Study of Sjogren's Syndrome Identifies Ten New Risk Loci
Khatri B; Reksten TR; Tessneer K; Rasmussen A; Scofield R; Bowman S; Guthridge J; James J; Ronnblom L; Warner B; Mariette X; Omdal R; Martin J; Teruel M; Jensen JL; Aqrawi L; Palm O; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Farris AD; Alarcon-Riquelme M; Ng W-F; Sivils K; Nordmark G; Lessard C
Letter: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2019;195(3):305-309
FoxP3⁺CXCR5⁺CD4⁺ T cell frequencies are increased in peripheral blood of patients with primary Sjogren's syndrome
Ivanchenko M; Aqrawi LA; Bjork A; Wahren-Herlenius M; Chemin K
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2019;71
Systemic Manifestations of Primary Sjogren Syndrome out of the ESSDAI Classification: Prevalence and Clinical Relevance in a Large International, Multi-ethnic Cohort of Patients
Retamozo S; Acar-Denizli N; Rasmussen A; Horvath IF; Baldini C; Priori R; Sandhya P; Hernandez-Molina G; Armagan B; Praprotnik S; Kvarnstrom M; Gerli R; Sebastian A; Solans-Laque R; Rischmueller M; Pasoto SG; Valim V; Nordmark G; Kruize A; Nakamura T; Hofauer B; Giacomelli R; Trevisani VFM; Pensec VD; Atzeni F; Gheita TA; Consani-Fernandez S; Szanto A; Sivils K; Gattamelata A; Danda D; Kilic L; Bartoloni E; Bombardieri S; Sanchez-Guerrero J; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zeron P
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(12):1840-1842
Clinical associations and expression pattern of the autoimmunity susceptibility factor DIORA-1 in patients with primary Sjogren's syndrome
Aqrawi LA; Mentlein L; Meneghel L; Bjork A; Thorlacius GE; Ivanchenko M; Sepulveda JIR; Skarstein K; Kvarnstrom M; Brauner S; Espinosa A; Wahren-Herlenius M
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(9):1381-1382
European families reveal MHC class I and II associations with autoimmune-mediated congenital heart block
Kyriakidis NC; Kockum I; Julkunen H; Hoxha A; Salomonsson S; Meneghel L; Ebbing C; Dilthey A; Eronen M; De Carolis S; Kiserud T; Ruffatti A; Kere J; Meisgen S; Wahren-Herlenius M
Review: CURRENT OPINION IN RHEUMATOLOGY. 2018;30(5):471-481
An update on the role of type I interferons in systemic lupus erythematosus and Sjogren's syndrome
Thorlacius GE; Wahren-Herlenius M; Ronnblom L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:1190
A NORTH-SOUTH WORLDWIDE GRADIENT IN SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: INCREASED SEVERE DISEASE IN PATIENTS FROM SOUTHERN COUNTRIES
Retamozo S; Acar-Denizli N; Ng WF; Zeher M; Rasmussen A; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Solans R; Rischmueller M; Mandi T; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Fernandes Moca Trevisani V; Hammenfors D; Pasoto SG; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:1267
FUNCTIONAL CHARACTERIZATION OF THE SJOGREN'S SYNDROME-ASSOCIATED LOCUS DDX6-CXCR5
Khanam S; Joachims ML; Means N; Omdal R; Wahren-Herlenius M; Alevizos I; Witte T; Jonsson R; Rischmueller M; Rhodus NL; Montgomery C; Ng W-F; Nordmark G; Adrianto I; Sivils K; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:A19
FAM167A/BLK IS A SUSCEPTIBILITY LOCUS IN AUTOIMMUNE DISEASES: CHARACTERISATION OF THE FAM167 GENE FAMILY
Mentlein L; Thorlacius GE; Meneghel L; Sepulveda JIR; Brauner S; Espinosa A; Wahren-Herlenius M
Corrigendum: CLINICAL IMMUNOLOGY. 2018;187:137-138
Klinefelter's syndrome (47,XXY) is in excess among men with Sjogren's syndrome (vol 168, pg 25, 2016)
Harris VM; Sharma R; Cavett J; Kurien BT; Liu K; Koelsch KA; Rasmussen A; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Alarcon-Riquelme ME; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Siminovitch KA; Ng W-F; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Scofield RH
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70
NRo52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production
Ivanchenko M; Brauner S; Thorlacius GE; Ambrosi A; Wahren-Herlenius M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S270
How ethnicity modifies systemic activity of primary Sjogren syndrome: analysis of baseline ESSDAI scores in a multi-ethnic international cohort
Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70
Comparative Analysis of the Total Proteome of the Skin Lesions from Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis (DM)
Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Charlesworth C; Wahren-Herlenius M; Svenungsson E; Oke V
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S268-S269
Systemic Sjogren presenting without sicca syndrome: characterization of 240 patients according to the new 2017 ACR/EULAR Classification Criteria
Retamozo S; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S269-S270
Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis
Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S316-S317
How the different systemic organ involvements are overlapped in patients with primary Sjogren syndrome: analysis using a mathematical model
Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheite TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S31-S32
HOW ETHNICITY MODIFIES SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: ANALYSIS OF BASELINE ESSDAI SCORES IN A MULTI-ETHNIC INTERNATIONAL COHORT
Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S32-S33
HOW DIFFERENT SYSTEMIC ORGAN INVOLVEMENTS OVERLAP IN PATIENTS WITH PRIMARY SJOGREN SYNDROME: ANALYSIS USING A MATHEMATICAL MODEL
Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S29-S30
SYSTEMIC SJOGREN PRESENTING WITHOUT SICCA SYNDROME: CHARACTERIZATION OF 240 PATIENTS ACCORDING TO THE NEW 2017 ACR/EULAR CLASSIFICATION CRITERIA
Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S30-S31
CLINICAL AND IMMUNOLOGICAL PRIMARY SJOGREN SYNDROME' DISEASE PATTERNS ARE DRIVEN BY GENDER AND AGE AT DIAGNOSIS
Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Meeting abstract: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S246-S247
Genetic basis and clinical evidence for two variants of primary Sjogren's syndrome with distinct outcomes
Thorlacius GE; Hultin-Rosenberg L; Sandling JK; Imgenberg-Kreuz J; Theander E; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Johnsen SJ; Hammenfors D; Skarstein K; Jonsson MV; Baecklund E; Mandl T; Eriksson P; Omdal R; Jonsson R; Lindbladh-Toh K; Ronnblom L; Wahren-Herlenius M; Nordmark G
Meeting abstract: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S289
Immune activation following seasonal influenza vaccination in patients with primary Sjogren's syndrome
Bjork A; Thorlacius GE; Mofors J; Kvarnstrom M; Wahren-Herlenius M
Meeting abstract: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S330
Cigarette smoking is a risk factor for developing primary Sjogren's syndrome with Ro/SSA and La/SSB autoantibodies
Bjork A; Mofors J; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Hillert J; Eriksson P; Mandl T; Nordmark G; Alfredsson L; Wahren-Herlenius M
Meeting abstract: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S331-S332
Primary Sjogren's syndrome increases the risk of cardiovascular events, with the highest risk in SSA/SSB autoantibody positive patients
Mofors J; Westermark L; Bjork A; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Eriksson P; Mandl T; Wahren-Herlenius M; Nordmark G
Meeting abstract: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S248-S249
Infections predispose to developing primary Sjogren's syndrome
Mofors J; Arkema EV; Westermark L; Bjorki A; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Eriksson P; Mandl T; Nordmark G; Wahren-Herlenius M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2018;70
How Immunological Profile Drives Clinical Phenotype of Primary Sjogren's Syndrome at Diagnosis: Analysis of 10.500 Patients (Sjogren Big Data Project)
Retamozo S; Acar-Denizli N; Ng W-F; Zeher M; Rasmussen A; Mandl T; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnstrom M; Praprotnik S; Sene D; Bartoloni E; Solans R; Rischmueller M; Suzuki Y; Isenberg DA; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Knopf A; Bombardieri M; Trevisani VF; Hammenfors DS; Pasoto SG; Gheita TA; Atzeni F; Morel J; Vollenveider C; Horvath I-F; Sivils KL; Olsson P; De Vita S; Sanchez-Guerrero J; Kilic L; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zeron P
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2018;70
Clinical Correlations and Expression Pattern of the Autoimmunity Susceptibility Factor Diora-1 in Primary Sjogren's Syndrome
Meneghel L; Aqrawi L; Mentlein L; Bjork A; Thorlacius GE; Ivanchenko M; Ramirez J; Skarstein K; Kvarnstrom M; Brauner S; Espinosa A; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:309-310
COMPARISON OF CLASSIFICATION CRITERIA FOR SJOGREN'S SYNDROME FROM 2002 AND 2016 IN AN INCIDENT COHORT DIAGNOSED 2007 TO 2011 FROM STOCKHOLM COUNTY SWEDEN
Kvarnstrom M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:A7
TYPE I IFN SYSTEM ACTIVATION IN NEWBORNS EXPOSED TO ANTI-RO/SSA AUTOANTIBODIES IN UTERO
Hedlund M; Thorlacius GE; Ivanchenko M; Kyriakidis N; Ronnblom L; Eloranta M-L; Espinosa A; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69
Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero
Thorlacius GE; Hedlund M; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Ronnblom L; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69
Ro/SSA Autoantibody Exposed Neonates Have an Expansion of NK Cells and a Discernible Type II IFN Signature with High IFNγ in Peripheral Blood
Ivanchenko M; Hedlund M; Thorlacius GE; Ottosson V; Chemin K; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):320
Characterization of the FAM167 gene family
Mentlein L; Meneghel L; Thorlacius G-E; Ramirez J; Brauner S; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):321
Identification of cross-reactive targets of anti-Ro52 antibodies in congenital heart block
Meneghel L; Mattsson C; Meisgen S; Nilsson P; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69
Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjogren Syndrome: Analysis of 9302 Patients from the Big Data International Sjogren Cohort
Retamozo S; Brito-Zeron P; Zeher M; Sivils KL; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Gerli R; Solans R; Suzuki Y; Isenberg DA; Rischmueller M; Nordmark G; Fraile G; Wiland P; Bootsma H; Nakamura T; Valim V; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors DS; Carsons SE; Pasoto SG; Morel J; Gheita T; Atzeni F; Vollenweider CF; Kostov B; Mariette X; Ramos-Casals M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2017;69
Immune Response to Seasonal Flu Vaccination in Patients with Primary Sjogren's Syndrome
Bjork A; Kvarnstrom M; Thorlacius GE; Wahren-Herlenius M
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):327
Immune response to seasonal flu vaccination in patients with primary Sjogren's syndrome
Bjork A; Kvarnstrom M; Thorlacius G-E; Wahren-Herlenius M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2017;69
Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren's Syndrome at Diagnosis and in Long-Term Follow-up
Ramirez J; Kvarnstrom M; Brauner S; Baldini C; Eriksson P; Mandl T; Norheim KB; Johnsen SJ; Hammenfors DS; Jonsson MV; Skarstein K; Brun JG; Ronnblom L; D'Elia HF; Bucher SM; Theander E; Omdal R; Jonsson R; Nordmark G; Wahren-Herlenius M
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):324
Expression of CXCR5 is decreased in the periphery of patients with primary Sjogren's syndrome
Aqrawi LA; Ivanchenko M; Bjork A; Ramirez J; Kvarnstrom M; Jensen JL; Skarstein K; Wahren-Herlenius M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2017;69
Comparison of Classification Criteria for Sjogren's Syndrome from 2002 and 2016 in an Incident Cohort Diagnosed 2007 to 2011 from Stockholm County Sweden
Kvarnstrom M; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:772
ETHNIC DIFFERENCES STRONGLY INFLUENCE THE PHENOTYPIC EXPRESSION OF PRIMARY SJOGREN: STUDY OF 7887 PATIENTS FROM 20 COUNTRIES ON 5 CONTINENTS (EULAR-SS TASK FORCE BIG DATA SJOGREN PROJECT)
Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize A; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Park S-H; Nordmark G; Suzuki Y; Giacomelli R; Saraux A; Bombardieri M; Hofauer B; Bootsma H; Hammenfors D; Fraile G; Carsons S; Gheita T; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Theander E; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Moca-Trevisano V; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:314-315
WORLDWIDE HETEROGENEOUS DIAGNOSTIC APPROACH TO PRIMARY SJOGREN SYNDROME IN 8315 PATIENTS (EULAR-SS TASK FORCE BIG DATA SJOGREN PROJECT)
Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize A; Valim V; Kvarnstrom M; Sene D; Bartoloni E; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Hammenfors D; Fraile G; Carsons S; Gheita T; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Theander E; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Moca-Trevisano V; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68
Expression of IFN-Regulated Genes in Autoantibody Exposed Babies in Utero
Hedlund M; Thorlacius G-E; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Tingstrom J; Espinosa A; Ronnblom L; Eloranta M-L; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68
Identification and Characterization of Sjogren's Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci
Joachims ML; Adrianto I; Johnston A; Ice J; Rasmussen A; Bowman S; Lewis DM; Radfar L; Omdal R; Wahren-Herlenius M; Alevizos I; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Theander E; Rhodus NL; Segal BM; Scofield RH; Montgomery CG; Mariette X; Ng W-F; Nordmark G; Sivils KL; Lessard CJ
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68
Very Rare X Chromosome Abnormalities in SLE and SjoGren's May Localize X Gene Dose Effect
Sharma R; Harris VM; Cavett J; Kurien BT; Liu K; Koelsch KA; Radfar L; Lewis DM; Stone DU; Kaufman CE; Li S; Segal BM; Wallace DJ; Weisman M; Kelly JA; Pons-Estel B; Jonsson R; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer MD; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Rasmussen A; Scofield RH; Venturopalli S; Lu X; Hughes P; Huang AJW; Miceli-Richard C
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2016;68
Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)
Brito-Zeron P; Retamozo S; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; Morel J; Vollenweider CF; Atzeni F; Acar-Denizli N; Horvath I-F; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; Van der Heijden E; Trevisano VM; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2016;68
Expression of the Chemokine Receptor CXCR5 Is Decreased in the Periphery of Patients with Primary Sjogren's Syndrome
Wahren-Herlenius M; Aqrawi LA; Ivanchenko M; Bjork A; Ramirez J; Kvarnstrom M; Jensen JCL; Skarstein K
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2016;68
Genome-Wide Association Study Identifies Novel Sjogren's Syndrome Risk Loci in the Regions of NAB1, TYK2, and PTTG1-mir146a
Lessard CJ; Adrianto I; Ice J; Rasmussen A; Grundahl K; Kelly JA; Scofield RH; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Goransson LG; Harboe E; Kvarnstrom M; Brernnan MT; Chodosh J; Gopalakrishnan R; Huang AJW; Hughes P; Lewis DM; Rohrer MD; Stone DU; Rhodus NL; Segal BM; Radfar L; Farris AD; Guthridge JM; Gaffney PM; James JA; Harley JB; Ronnblom L; Anaya J-M; Cunninghame-Graham DS; Vyse TJ; Alevizos I; Mariette X; Omdal R; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Criswell LA; Montgomery CG; Ng W-F; Nordmark G; Sivils KL
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2016;68
How Does Primary Sjogren Syndrome Present in Biopsy-Proven Patients without Circulating Ro/La Autoantibodies? Characteristics at Diagnosis of 2073 Patients from the SjoGren Big Data Project
Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; More J; Vollenweider CF; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Mand T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Trevisano VM; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2016;68
Isolated Anti-La/SS-B Positivity in Patients Diagnosed with Primary Sjogren Syndrome: Analysis of 222 Patients from the Sjogren Big Data Cohort
Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; Morel J; Vollenweider CF; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Trevisano VM; Wahren-Herlenius M; Ramos-Casals M
Review: CURRENT OPINION IN RHEUMATOLOGY. 2015;27(5):468-475
Update on the immunobiology of Sjogren's syndrome
Ambrosi A; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:578
BIG DATA SJOGREN PROJECT (EULAR-SS TASK FORCE INTERNATIONAL NETWORK): SYSTEMIC INVOLVEMENT AT DIAGNOSIS EVALUATED BY THE ESSDAI IN 3314 PATIENTS WITH PRIMARY SJOGREN SYNDROME
Zeron PB; Kostov BA; Seror R; Baldini C; Quartuccio L; Kvarnstrom M; Kruize A; Molina GH; Praprotnik S; Bartoloni E; Solans R; Theander E; Valim V; Priori R; Zeher M; Isenberg D; Rasmussen A; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Review: AUTOIMMUNITY REVIEWS. 2015;14(5):376-386
State of the art: Reproduction and pregnancy in rheumatic diseases
Ostensen M; Andreoli L; Brucato A; Cetin I; Chambers C; Clowse MEB; Costedoat-Chalumeau N; Cutolo M; Dolhain R; Fenstad MH; Foerger F; Wahren-Herlenius M; Ruiz-Irastorza G; Koksvik H; Nelson-Piercy C; Shoenfeld Y; Tincani A; Villiger PM; Wallenius M; von Wolff M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
Auxilin Is a Novel Susceptibility Gene for Congenital Heart Block Modulating Cardiac Function
Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Dzikaite-Ottosson V; Ding B; Strandberg L; Biavati L; Ramskold D; Forsberg D; Bergin L; Ruhrmann S; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
Klinefelter's Syndrome (47,XXY) Among Men with Sjogren's Syndrome
Harris VM; Cavett J; Kurien B; Liu K; Koelsch KA; Radfar L; Lewis DM; Stone DU; Li S; Segal B; Wallace DJ; Weisman MH; Kelly JA; Alarcon-Riquelme M; Pons-Estel B; Jonsson R; Lu X; Gottenberg J; Anaya J-M; Cunninghame-Graham DS; Keystone EC; Huang AJW; Brennan MT; Hughes P; Illei G; Miceli C; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer MD; Wahren-Herlenius M; Witte T; Mariette X; Lessard C; Harley JB; Sivils KL; Scofield RH
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):416
Early B Cell Factor 1 is Associated to Clinical Manifestations in Primary Sjogren's Syndrome and SLE
Bolin K; Leonard D; Gunnarsson I; Sjowall C; Eriksson P; Forsblad-d'Elia H; Jonsen A; Theander E; Omdal R; Jonsson R; Sivils K; Wahren-Herlenius M; Ronnblom L; Nordmark G
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2015;67
Sjogren's Syndrome in Male Patients Presents with Higher Autoantibody Levels and More Extraglandular Manifestations
Ramirez J; Kvarnstrom M; Wahren-Herlenius M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2015;67
Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1
Lessard CJ; Li H; Ice J; Adrianto I; Rasmussen A; Grundahl K; Kelly JA; Miceli C; Bowman S; Lester S; Brun JG; Goransson LG; Harboe E; Guthridge JM; Kaufman KM; Eriksson P; Eloranta M-L; Kvarnstrom M; Cunninghame-Graham DS; Farris AD; Brennan MT; Chodosh J; Gopalakrishnan R; Huang AJW; Hughes P; Lewis DM; Radfar L; Rohrer MD; Stone DU; Vyse TJ; Gaffney PM; James JA; Harley JB; Omdal R; Wahren-Herlenius M; Illei GG; Witte T; Jonsson R; Rischmueller M; Ronnblom L; Mariette X; Anaya J-M; Ng W-F; Nordmark G; Montgomery CG; Rhodus NL; Segal BM; Scofield RH; Sivils KL
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):397
Comparison between Multiplex and Routine Clinical Immunology Analysis of Antibodies Against SSA and SSB
Signer L; Brokstad K; Vasaitis L; Kvarnstrom M; Sjowall C; Eriksson P; Theander E; Jonsson R; Wahren-Herlenius M; Nordmark G
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2015;67
Big Data International Primary Sjogren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria
Brito-Zeron P; Retamozo S; Zeher M; Rasmussen A; Theander E; Gottenberg J; Baldini C; Quartuccio L; Priori R; Valim V; Kvarnstrom M; Kruize A; Hernandez-Molina G; Bartoloni-Bocci E; Praprotnik S; Isenberg DA; Nordmark G; Bombardieri M; Suzuki Y; Solans R; Giacomelli R; Hammenfors DS; Carsons SE; Boostma H; Vollenweider CF; Atzeni F; Sivils K; Mandl T; De Vita S; Wahren-Herlenius M; Kawano M; Gerli R; Vissink A; Brun JG; Trevisani V; Sanchez-Guerrero J; Mariette X; Ramos-Casals M
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):444
Characterization of Baseline Systemic Activity Using the New ClinESSDAI in the Big Data Sjogren Project Cohort: Analysis in 3316 Patients
Brito-Zeron P; Kostov BA; Seror R; Baldini C; Quartuccio L; Kvarnstrom M; Kruize A; Hernandez-Molina G; Praprotnik S; Bartoloni E; Solans R; Theander E; Valim V; Priori R; Zeher M; Isenberg D; Rasmussen A; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):441-442
Clinical and Immunological Characterization at Diagnosis of 5041 Patients with Primary Sjogren Syndrome Fulfilling the 2002 AE Classification Criteria: The Big Data International Sjogren Project
Brito-Zeron P; Kostov BA; Zeher M; Theander E; Gottenberg JE; Baldini C; Quartuccio L; Priori R; Kvarnstrom M; Kruize A; Hernandez-Molina G; Praprotnik S; Isenberg D; Bartoloni E; Rasmussen A; Solans R; Valim V; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
Identification of Four-and-a-Half-LIM Domain 1 (FHL1) As a New Autoantibody Target in Idiopathic Inflammatory Myopathies
Albrecht I; Wick C; Hallgren A; Tjarnlund A; Nagaraju K; Andrade F; Thompson K; Coley W; Phadke A; Diaz-Gallo L-M; Bottai M; Nennesmo I; Chemin K; Herrath J; Johansson K; Wikberg A; Ytterberg J; Zubarev R; Danielsson O; Krystufkova O; Vencovsky J; Landegren N; Wahren-Herlenius M; Padyukov L; Kampe O; Lundberg IE
Review: EXPERIMENTAL CELL RESEARCH. 2014;325(1):2-9
Molecular mechanisms of congenital heart block
Ambrosi A; Sonesson S-E; Wahren-Herlenius M
Conference publication: JOURNAL OF IMMUNOLOGY. 2014;192:46.2
X chromosome dose and sex bias in autoimmune diseases: increased 47,XXX in systemic lupus erythematosus and Sjogren's syndrome
Liu K; Kurien B; Zimmerman S; Kaufman K; Mariette X; Kottyan L; Jonsson R; Ng W-F; Omdal R; Rischmueller M; Wahren-herlenius M; James J; Lessard C; Thompson S; Gaffney P; Montgomery C; Siminovitch K; Edberg J; Kimberly R; Tsao B; McCune W; Salmon J; Sivils K; Harley J; Scofield R
Letter: AUTOIMMUNITY REVIEWS. 2014;13(1):70-72
Letter to the Editor in response to the article "Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: A review of published literature and registered clinical trials." by Gleicher N, Elkayam U, Autoimmun Rev. 2013 Sep;12(11):1039-45
Costedoat-Chalumeau N; Lzmirly P; Clancy R; Saxena A; Wahren-Herlenius M; Silverman E; Brucato A; Boutjdir M; Khamashta M; Llanos C; Pisoni CN; Friedman DM; Phoon CKL; Buyon JP
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):461
Sex-Biased Expression of Sjogren's Syndrome Susceptibility Genes
Ramirez J; Thorlacius GE; Bergman T; Brauner S; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):454-455
Characterization of the Sjogren's Syndrome Susceptibility Genes Fam167/Blk
Thorlacius GE; Bergman T; Brauner S; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):461-462
Identification of Molecules Targeted by Ro52 Autoantibodies in the Development of Congenital Heart Block
Tworus K; Meisgen S; Mattson C; Nilsson P; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):453-454
Ro52/TRIM21 Expression is Decreased in Malignant B Cells
Ivanchenko M; Brauner S; Enblad G; Sundstrom C; Backlin C; Baecklund E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):455
Cardiopathogenic Role of Human RO/SSA and LA/SSA Antibodies in a Novel Animal Model of Congenital Heart Block
Ottosson V; Hoxha A; Ruffatti A; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Meeting abstract: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:87-88
An NFKB1 gene promoter polymorphism is associated with primary Sjogren's syndrome
Nordmark G; Vasaitis L; Theander E; Kvarnstrom M; Johnsen SJ; Brun JG; Jonsson MV; Sjowall C; Forsblad-d'Elia H; Wahren-Herlenius M; Omdal R; Jonsson R; Eloranta M-L; Eriksson P
Review: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):544-554
Cutaneous lupus erythematosus: clinical aspects and molecular pathogenesis
Oke V; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A40
Ro52 EXPRESSION IS A PROGNOSTIC FACTOR FOR SURVIVAL IN B CELL LYMPHOMA
Brauner S; Zhou W; Backlin C; Green TM; Young KH; Lofstrom B; Lundberg I; Pedersen LM; Moller MB; Sundstrom C; Enblad G; Baecklund E; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A56
The HLA Locus Contains Novel Foetal Susceptibility Alleles For Congenital Heart Block with Significant Paternal Influence
Gorgen S; Ostberg T; Salomonsson S; Ding B; Eliasson H; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(4):316
Elevated Plasma IL-7 Levels in Multiple Sclerosis Patients Treated with Interferon Beta are Caused by Decreased Cell Consumption
Hermanrud C; Lundstrom W; Sjostrand M; Brauner S; Wahren-Herlenius M; Olsson T; Karrenbauer VD; Hillert J; Fogdell-Hahn A
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S1184-S1185
Complex Functional Effects Within The HLA Contribute To Sjogren's Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding.
Lessard CJ; Li H; Adrianto I; Ice JA; Dozmorov MG; Jonsson R; Rischmueller M; Nordmark G; Mariette X; Miceli-Richard C; Wahren-Herlenius M; Witte T; Brennan MT; Omdal R; Ronnblom L; Gaffney PM; Ng W-F; Rhodus NL; Segal BM; Wren JD; Scofield RH; Anaya J-M; Harley JB; Montgomery CG; Sivils KL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:462-463
DEFINING THE PATHOGENETIC AUTOANTIBODIES IN CONGENITAL HEART BLOCK
Hoxha A; Ruffatti A; Ottosson V; Anandapadmanaban M; Tonello M; Punzi L; Sunnerhagen M; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S379
Sex Bias In Autoimmune Diseases: Increased Risk Of 47,XXX In Systemic Lupus Erythematosus (SLE) and Sjogren's Syndrome (SS) Supports The Gene Dose Hypothesis
Liu K; Kaufman KM; James JA; Jonsson R; Kurien BT; Mariette X; Merrill JT; Omdal R; Rischmueller M; Vyse TJ; Wahren-Herlenius M; Witte T; Lessard CJ; Zimmerman SL; Thompson SD; Hirschfield G; Xie G; Montgomery CG; Ng W-F; Nordmark G; Gaffney PM; Siminovitch KA; Sivils KL; Scofield RH
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S1185
The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjogren's Syndrome.
Nocturne G; Rusakiewicz S; Sene D; Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Ronnblom L; Nititham J; Taylor KE; Lessard CJ; Moser KL; Gottenberg J-E; Criswell LA; Miceli-Richard C; Zitvogel L; Mariette X
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:256
EFFICACY AND SAFETY OF A COMBINED TREATMENT PROTOCOL FOR 2ND DEGREE CONGENITAL HEART BLOCK
Hoxha A; Ottosson V; Brauner S; Wahren-Herlenius M; Favaro M; Calligaro A; Facchinetti M; Ruffatti A; Punzi L
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2013;65:S634-S635
Endosomal TLR Triggering Of B Cells In Sjogren's Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production
Wahren-Herlenius M; Brauner S; Kvarnstrom M; Folkersen L; Gorgen S; Trollmo C; Malmstrom V; Nordmark G
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:78-79
CARDIOPATHOGENIC ROLE OF HUMAN RO/SSA AND LA/SSA ANTIBODIES DEMONSTRATED IN A NOVEL ANIMAL MODEL OF CONGENITAL HEART BLOCK
Hoxha A; Ruffatti A; Ottosson V; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(9):2274-2284
IL-17: A new actor in IFN-driven systemic autoimmune diseases
Ambrosi A; Espinosa A; Wahren-Herlenius M
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):75-76
3rd Nordic Meeting on Genetics and Pathogenesis of Inflammatory Diseases
Wahren-Herlenius M; Fogdell-Hahn A
Review: JOURNAL OF AUTOIMMUNITY. 2012;39(1-2):77-82
The immunobiology of Ro52 (TRIM21) in autoimmunity: A critical review
Oke V; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:481
ANTI-R052 AUTOANTIBODY EPITOPE MAPPING IN EUROPEAN COHORT OF MYOSITIS PATIENTS
Krystufkova O; Dzikatite V; Charles PJ; Mann HF; Ekholm L; Vincze M; Putova I; Kasprikova N; Padyukov L; Danko K; Novota P; Vencovsky J; Wahren-Herlenius M; Lundberg IE
Review: ARTHRITIS RESEARCH & THERAPY. 2012;14(2):208
Congenital heart block: evidence for a pathogenic role of maternal autoantibodies
Ambrosi A; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A50
ANTI-RO52 EPITOPE MAPPING IN INFLAMMATORY MYOPATHIES
Krystufkova O; Dzikatite V; Charles P; Mann HF; Ekholm L; Vincze M; Putova I; Kasprikova N; Novota P; Padyukov L; Danko K; Vencovsky J; Wahren-Herlenius M; Lundberg IE
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a54-a55
MHC GENES DETERMINE FETAL SUSCEPTIBILITY IN A RAT MODEL OF CONGENITAL HEART BLOCK
Dzikaite V; Jagodic M; Kuchroo VK; Olsson T; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A81
TRIM GENES ARE PART OF THE INTERFERON SIGNATURE OBSERVED IN PATIENTS WITH PRIMARY SJOGREN'S SYNDROME
Sjostrand M; Brauner S; Kvarnstrom M; Wahren-Herlenius M; Espinosa A
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A40
AUTOANTIBODIES TO THE FUNCTIONALLY ACTIVE RING-DOMAIN OF RO52/SSA ASSOCIATE WITH CLINICAL ACTIVITY IN A SUBSET OF PATIENTS WITH LUPUS
Kvarnstrom M; Dzikaite V; Ottosson L; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a60
IDENTIFICATION OF NOVEL GENETIC RISK LOCI DETERMINE FETAL OUTCOME IN CONGENITAL HEART BLOCK
Gorgen S; Ding B; Salomonsson S; Klareskog L; Hamsten A; Hillert J; Alfredsson L; Olsson T; Kockum I; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a86
NEUROPSYCHIATRIC DEVELOPMENT AND HEALTH IN CHILDREN WITH AND WITHOUT CONGENITAL HEART BLOCK BORN TO MOTHERS WITH RO/SSA AUTOANTIBODIES - A RETROSPECTIVE FOLLOW-UP
Skog A; Tingstrom J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):208
Identification of Novel Genetic Risk Loci Associated with Fetal Outcome in Congenital Heart Block
Gorgen S; Ding B; Salomonsson S; Klareskog L; Hamsten A; Hillert J; Alfredsson L; Olsson T; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):196
Neuropsychiatric Development in Children with and without CHB Born to Mothers with Anti-Ro52/SSA Autoantibodies
Skog A; Tingstrom J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S1133
A Genome-Wide Association Study Establishes Muliple Susceptibility Loci for Sjogren's Syndrome
Lessard CJ; Li H; Adrianto I; Ice JA; Jonsson R; Illei GG; Rischmueller M; Nordmark G; Mariette X; Miceli-Richard C; Wahren-Herlenius M; Witte T; Brennan MT; Omdal R; Gaffney PM; Lessard JA; Ng W-F; Rhodus NL; Segal BM; Scofield RH; James JA; Anaya J-M; Harley JB; Montgomery CG; Sivils KM
Conference publication: IMMUNOLOGY. 2012;137:31-32
Expression of the immune regulator TRIM21 is controlled by interferon regulatory factors
Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):210
Expression of the Immune Regulator TRIM21 is Controlled by Interferon Regulatory Factors
Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Conference publication: IMMUNOLOGY. 2012;137:45
Enhanced interferon regulatory factor 3 binding to the IL-23p19 promoter correlates with enhanced IL-23 expression in Systemic Lupus Erythematosus
Smith S; Gabhann JN; Stacey K; Espinosa A; Wahren-Herlenius M; Kearns G; O'Neill L; Ball E; Johnston JA; Bell A; Grazia-Totaro M; Sica A; Jefferies CA
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S228
Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA/SSB Positive Primary Sjogren's Syndrome in Scandinavian Samples
Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Ronnblom L
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):199-200
Hyperreactive B Cells Upon Endosomal TLR Triggering Underlying Primary Sjogren's Syndrome
Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Folkersen L; Klareskog CTL; Jonsson R; Nordmark G; Malmstrom V; Wahren-Herlenius M
Meeting abstract: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S758
Hyperammaglobulinemia in Primary Sjogren's Syndrome Is Induced by Triggering of TLR7 and 9
Brauner S; Kvarnstrom M; Nordmark G; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):200
Ro/SSA Autoantibody Mediated Congenital Heart Block Indicate Need for Increased Information, Support and Highly Specialized Medical Care - A Questionnaire Study
Tingstrom J; Hjelmstedt A; Henriksson EW; Sonesson S-E; Wahren-Herlenius M
Review: IMMUNOLOGY LETTERS. 2011;141(1):1-9
The complexity of Sjogren's syndrome: Novel aspects on pathogenesis
Jonsson R; Vogelsang P; Volchenkov R; Espinosa A; Wahren-Herlenius M; Appel S
Editorial comment: SEMINARS IN IMMUNOLOGY. 2011;23(2):65-66
Gene-environment interaction in induction of autoimmunity
Wahren-Herlenius M; Kuchroo VK
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a87-a88
DEVELOPMENT OF HEART BLOCK IN SSA/SSB AUTOANTIBODY-POSITIVE PREGNANCIES IS ASSOCIATED WITH MATERNAL AGE AND DISPLAY A SEASON-OF-BIRTH PATTERN
Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Dzikaite V; Bergman G; Fernlund E; Theander E; Rydberg A; Skogh T; Wallberg-Jonsson S; Ohman A; Lundstrom U; Mellander M; Winqvist O; Fored M; Ekbom A; Alfredsson L; Kallberg H; Gadler F; Jonzon A; Sonesson S-E; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A67
VACCINATION OF PATIENTS WITH PRIMARY SJOGREN'S SYNDROME REVEALS HYPERREACTIVE B CELL COMPARTMENT WITH A SKEWED MATURATION PATTERN
Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Folkersen L; Trollmo C; Klareskog L; Jonsson R; Malmstrom V; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):349-350
Transfer of Ro52-p200 Monoclonals, but not Other Ro52-Specificities, Induce Congenital Heart Block (CHB) in a Rat Model
Dzikaite V; Ambrosi A; Park J; Ottosson L; Sonesson S-E; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):350
MHC Genes Determine Fetal Susceptibility in a Rat Model of Congenital Heart Block
Dzikaite V; Jagodic M; Kuchroo VK; Olsson T; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):369
Vaccination of Patients with Primary Sjogren's Syndrome Reveals Hyperreactive B Cell Compartment
Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Trollmo C; Klareskog L; Jonsson R; Malmstrom V; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):364-365
The Expression of the Autoantigen Ro52 is Regulated by Interferon Regulatory Factors
Sjostrand M; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):370
HLA-DRB1*04 is a Novel Fetal Susceptibility Allele in Congenital Heart Block
Ostberg T; Gorgen S; Salomonsson S; Ding B; Eliasson H; Elfving A; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Padukov L; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):171-172
Immunological Contribution to the Pathogenesis of Congenital Heart Block
Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):271
Emotional Response to Serial Doppler Echocardiography Examinations as a Screening Method to Detect Developing Congential Heart Block In SSA/Ro Positive Pregnancy
Tingstrom J; Barimani M; Sonesson S-E; Wahren-Herlenius M; Henriksson EW
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):263
Fetal Doppler Echocardiography Predicts Cardiac Conduction Abnormalities Developing in Preschool Children Fetally Exposed to Ro52 Autoantibodies
Bergman G; Eliasson H; Mohlkert L-A; Wahren-Herlenius M; Sonesson S-E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274-275
A Population-Based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block
Zeffer E; Salomonsson S; Dzikaite V; Eliasson H; Ambrosi A; Bergman G; Fernlund E; Theander E; Ohman A; Rydberg A; Skogh T; Rantapaa-Dahlqvist S; Elfving A; Fored M; Blomqvist P; Ekbom A; Lindstrom U; Melander M; Winqvist O; Sonesson S-E; Gadler F; Jonzon A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):265
Influence of Season of Birth and Maternal Age in the Development of Congenital Heart Block in Anti-Ro-SSA/La-SSB Positive Pregnancies
Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Dzikaite V; Bergman G; Fernlund E; Theander E; Ryberg A; Ohman A; Skogh T; Rantapaa S; Fored M; Blomqvist P; Ekbom A; Lindsrtom U; Melander M; Winqvist O; Gadler F; Jonzon A; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274
Ro52 Autoantibodies Specific for Amino Acid 200-239 Mediate Calcium Dysregulation in Cardiomyocytes
Herlenius E; Park J; Ambrosi A; Dzikate V; Strandberg L; Kuchroo V; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):264-265
Anti-Ro52/p200 Antibodies Induce Heart Block in Rodents Upon Transfer During Gestation in a Time- and Dose-Dependent Manner
Ambrosi A; Dzikaite V; Strandberg L; Kuchroo VK; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):272-273
The Expression of the CHB Autoantigen Ro52 is Regulated by Interferon Regulatory Factors
Espinosa A; Sjostrand M; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39:36
Fcγ receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fcγ receptor IIIB copy number variation: No association with primary Sjogren's syndrome
Haldorsen K; Appel S; Bruland O; Le Hellard S; Brun JG; Omdal R; Kristjansdottir G; Theander E; Nordmark G; Kvamstrom M; Eriksson P; Ronnblom L; Wahren-Herlenius M; Jonsson R; Bolstad AI
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39:32
GENE VARIANTS IN FAM167A-BLK AND TNFSF4 ARE ASSOCIATED WITH PRIMARY SJOGREN'S SYNDROME
Nordmark G; Kristjansdotti G; Theander E; Appel S; Eriksson P; Vasaitis L; Wahren-Herlenius M; Omdal R; Ronnblom L; Jonsson R; Syvanen A-C
Meeting abstract: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):273-274
Ring and B-Box Autoantibody Titers in SLE Patients with Ro52 Autoantibodies
Kvarnstrom M; Dzikaite V; Ottosson L; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):269-270
HLA-DRB1*04 is a Novel Fetal Susceptibility Gene Variant in Congenital Heart Block
Ostberg T; Salomonsson S; Ding B; Eliasson H; Elfving A; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Padukov L; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):269
MHC Genes Determine Fetal Susceptibility in a Rat Model of Congenital Heart Block
Dzikaite V; Strandberg LS; Ambrosi A; Jagodic M; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):271-272
Ro52 Autoantibody-Positive Women's Experience of Being Pregnant and Giving Birth to a Child with Congenital Heart Block
Tingstrom J; Sonesson S-E; Henriksson EW; Wahren-Herlenius M
Letter: JOURNAL OF IMMUNOLOGY. 2009;183(12):7620-7621
Comment on "Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-κB-Dependent Cytokine Expression in Fibroblasts Response
Espinosa A; Brauner S; Ambrosi A; Kuchroo V; Wahren-Herlenius M
Conference publication: SWISS MEDICAL WEEKLY. 2009;139(31-32):13S
Women with anti-Ro/SSA autoantibodies: Experiences during pregnancy and after childbirth
Tingstrom J; Wahren-Herlenius M; Sonesson S-E; Henriksson EW
Conference publication: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2009;301(1):47
High Expression of Ro52 in Skin Lesions in Cutaneous Lupus Erythematosus
Oke V; Strandberg L; Nyberg F; Wahren-Herlenius M
Conference publication: SWISS MEDICAL WEEKLY. 2009;139(31-32):12S-13S
Outcome and Growth of Infants Fetally Exposed to Heart Block-Associated Maternal Anti-Ro52/SSA Autoantibodies
Skog A; Wahren-Herlenius M; Sundstrom B; Bremme K; Sonesson S-E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):193
Anti-Ro52 antibodies inducing heart block cross-react with alpha-enolase
Ambrosi A; Strandberg L; Dzikaite V; Ottosson L; Kampe O; Wahren-Herlenius M
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:s94
Identification of the specific Sjogren-syndrome related maternal Ro52 autoantibodies that induce heart block in the fetus during pregnancy
Dzikaite V; Strandberg L; Ambrosi A; Ottosson L; Salomonsson S; Sonesson S-E; Kuchroo V; Wahren-Herlenius M
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S24
Anti-Ro/SSA autoantibodies specific for the RING-domain of ro52 inhibit E3 ligase activity and polyubiquitination
Espinosa A; Hennig J; Ambrosi A; Nyberg F; Sunnerhaqen M; Wahren-Herlenius M
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127:S73
High expression of Ro52 in cutaneous Lupus Erythematosus
Barkauskaite V; Nyberg M; Strandberg L; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:A12
Genetic dissection of congenital heart block in a rat model
Strandberg L; Salomonsson S; Jagodic M; Bechanovic K; Sonesson S-E; Olsson T; Wahren-Herlenius M
Review: CURRENT OPINION IN IMMUNOLOGY. 2006;18(6):690-696
Specificity and effector mechanisms of autoantibodies in congenital heart block
Wahren-Herlenius M; Sonesson S-E
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:460
Induction of interferon-alpha by immune complexes or liposomes containing autoantigen-associated RNA
Lovgren T; Eloranta ML; Kastner B; Wahren-Herlenius M; Alm GV; Ronnblom L
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S25
The Sjogren's syndrome associated autoantigen Ro52 is a ring-dependent E3 ligase that regulates cell death.
Espinosa A; Zhou W; Oukka M; Kuchroo V; Wahren-Herlenius M
Conference publication: CLINICAL IMMUNOLOGY. 2005;115:S129
Genetic dissection of congenital heart block in a rat model.
Horvath LS; Salomonsson S; Jagodic M; Becanovic K; Sonesson SE; Olsson T; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S370
The Sjogren's syndrome associated autoantigen Ro52 is an E3 ligase with proliferation suppressive and proapoptotic properties.
Espinosa A; Zhou W; Ek M; Nyberg F; Kuchroo V; Wahren-Herlenius M
Conference publication: CLINICAL IMMUNOLOGY. 2005;115:S12
The Sjogren's syndrome associated autoantigen Ro52 is a RING-dependent E3 ligase that suppresses cellular proliferation.
Espinosa A; Hedlund M; Brauner S; Kuchroo VK; Wahren-Herlenius M
Letter: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):366-368
Fetal first-degree heart block, or where to set the confidence limit: comment on the article by Sonesson et al - Reply
Wahren-Herlenius M; Sonesson SE
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(2)
Increased expression of the novel proinflammatory cytokine HMGB1 is detected in cutaneous lupus erythematosus lesions
Popovic K; Ek M; Erlandsson-Harris H; Wahren-Herlenius M; Nyberg F
Letter: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):2697-2698
Development of systemic lupus erythematosus in a patient with congenital heart block
Feist E; Keitzer R; Gerhold K; Horvath L; Wahren-Herlenius M; Dörner T
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S64
Ro52 monoclonal antibodies bind the cell surface of cardiomyocytes
Salomonsson S; Ottosson L; RAats J; Herlenius E; Wahren-Herlenius M
Editorial comment: NATURE BIOTECHNOLOGY. 2002;20(12):1205-1206
Killers come to the rescue
Wahren-Herlenius M; Kuchroo VK
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2002;46(9):S127
Conformation-dependent autoantibodies to the leucine zipper of Ro52 are associated with congenital heart block
Salornosson S; Ottosson L; Sunnerhagen M; Wahren-Herlenius M
Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B351
Autoantibodies in autoimmune diseases.
Wahren-Herlenius M
Review: TRENDS IN IMMUNOLOGY. 1999;20(5):234-240
Analysis of B-cell epitopes of the Ro/SS-A autoantigen
Wahren-Herlenius M; Muller S; Isenberg D
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1999;42(9):S61
In vitro mutagenesis reveals key residues in a major conformational epitope of the U1-70K protein
Wahren-Herlenius M; Henriksson EW; Lundberg I; Mellquist E; Pettersson I
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1999;42(9):S114
In vitro mutagenesis reveals key residues in a major conformational epitope the U1-70K protein.
Wahren-Herlenius M; Henriksson EW; Lundberg I; Mellquist E; Pertersson I
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1998;41(9):S298
Increased number of IL-6 and IL-10 secreting cells in peripheral blood from patients with primary Sjogren's syndrome
Tengnér P; Halse AK; Wahren-Herlenius M; Haga HJ; Jonsson R
Letter: LUPUS. 1995;4(6):498
Autoantibodies to calprotectin are not found in patients with systemic lupus erythematosus or other inflammatory rheumatic diseases
Wahren M; Brun JG; Jonsson R; Haga HJ
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Employments

Professor, Department of Medicine, Karolinska Institutet, 2006-

Degrees and Education

Docent, Karolinska Institutet, 1999
University Medical Degree, Karolinska Institutet, 1996

Leadership and responsibility assignments

Head of department, Department of Medicine, Karolinska Institutet, 2021-

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