Margaret Sällberg Chen
Professor
E-mail: margaret.chen@ki.se
Telephone: +46852488125
Visiting address: Institutionen för Labmed / ANA Futura, Alfred Nobels Allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Patologi Sällberg Chen, 171 77 Stockholm
About me
- Professor of Clinical Oral Immunology. Research Group Leader. Faculty Representative Research Education Committee at Karolinska Institutet.
Margaret Sällberg Chen received her D.D.S. and Ph.D. degrees from Karolinska Institutet. Following postdoctoral trainings at The Scripps Research Institute, La Jolla, USA, where she developed T cell receptor transgene models for immunological studies of infection and cancer, she was recruited to the former Swedish Institute for Infectious Disease Control to study experimental vaccines and infection immunology. She became full professor 2020 at KI. She has published over 90 scientific articles which have been cited more than 4000 times. She has active commitments on numerous scientific and editorial board.
Research
- The lab is broadly interested in immunological mechanisms effective in eliminating microbial pathogens associated with chronic diseases and tumors. The research pursues several lines investigating cellular functions capable of sensing and killing intracellular pathogens and tumors, and the target identification. The models are exclusively human infectious diseases and the methodologies employed include synthetic genetics, genetically modified cells and animals, viral and non-viral vectors, and next generation sequencing.
Major research area: infection and cancer immunity, redirection of lymphocytes, T cell receptors, viral and neo-antigens, human microbiome and immune cell interactions, therapeutic targets in oral diseases including tumors and endodontic infections.
Group members
Dr. Michal Sobkowiak, Research specialist, Dr Sobkowiak holds a PhD in mucosal immunology
Dr. Pooja Tajpara, Postdoc, Dr. Tajpara holds a Master in Biotechnology and a PhD in human tissue immunology.
Dr. Mahin Ghorbani, Postdoc, Dr Ghorbani has a PhD in metatranscriptome analysis of gut microbiome and biomarker discovery.
Dr. Zara Ahmad Khan, Postdoc, Dr Naud holds a PhD in human microbiota and microbial proteomics.
PhD students: Liyan Lu (DDS), Rahul Harshad Nagadia (DDS, MD, Specialist in Oral and Maxillofacial Surgery), Khaled Al-Manei (DDS, MSc Specialist in Endodontics). Affiliated research students: Agne Kvedaraite (DDS, FTV Regio Stockholm), Choon Boon Too (Singapore NTU).
Co-supervisor to PhD students Asif Halimi (MD, Specialist in Surgery)
Alumni
Tanja Näslund PhD degree 2009, Anna Pasetto PhD degree 2012, Haleh Davanian PhD degree 2014, Michal Sobkowiak PhD degree 2019. Hassan Alkharaan PhD degree 2021. Katie Healy PhD degree 2022, Zeeshan Ateeb PhD degree 2023.
Dr. Anila Yasmeen, Postdoc. Dr. Balasiddaiah Anangi, Postdoc. Dr Rogier Gaiser, Dr Haleh Davanian, Dr Giorgio Garbarini.
Research awards
Cancerfonden, Vetenskapsrådet, KI KID faculty funds, CIMED, Johnson & - Johnson Innovation Award, KI/SLL SOF, ALF Stockholm, Radiumhemmets Forskningsfond, NBIS/SciLifeLab Bioinformatics Long-term Support
Teaching
- Formal courses taught at university level
- Course director “General Pathology”, Dentistry Programme KI, 2023 – present
- Course director “Exam Work in Oral Sciences”, Dentistry Programme KI, 2015 – 2023
- Course director “Medical Microbiology, Medical Programme KI, 2002
- Curriculum Director, Year 2, Dentistry Programme KI, 2014- present
- Clinical instructor for Dentistry Students (Year 3-5), Dentistry Programme KI, 2008-2017
Selected publications
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Article: CELL HOST & MICROBE. 2024;32(2):156-161.e3
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Article: NPJ BIOFILMS AND MICROBIOMES. 2023;9(1):104
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Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
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Article: IMMUNITY. 2022;55(9):1732-1746.e5
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Article: MED. 2022;3(2):137-153.e3
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Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1079995
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Article: JCI INSIGHT. 2021;6(5):140074
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Article: GUT MICROBES. 2021;13(1):1983101
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Article: GUT. 2019;68(12):2186-2194
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Article: JOURNAL OF HEPATOLOGY. 2019;71(4):673-684
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Article: INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2019;11(2):16
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Article: GASTROENTEROLOGY. 2018;155(1):180-193.e6
Articles
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Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1346749
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Article: ORAL ONCOLOGY. 2023;146:106556
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Article: JOURNAL OF HEMATOLOGY. 2023;12(4):170-175
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Article: MICROBIOLOGY SPECTRUM. 2022;10(6):e0248722-e02422
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Article: BRITISH JOURNAL OF CANCER. 2022;127(12):2133-2140
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Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
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Article: JOURNAL OF VIRAL HEPATITIS. 2022;29(9):835-839
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Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2022;31(7):1418-1425
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Article: MOLECULAR MEDICINE. 2022;28(1):54
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):462-471
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Article: MOLECULAR MEDICINE. 2022;28(1):20
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Article: LEUKEMIA. 2022;36(2):476-481
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Article: FRONTIERS IN IMMUNOLOGY. 2022;13:896242
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Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(3):407-414
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Article: JHEP REPORTS. 2021;3(4):100318
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Article: JOURNAL OF PROTEOME RESEARCH. 2021;20(5):2725-2738
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Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
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Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s83-s84
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Article: FRONTIERS IN IMMUNOLOGY. 2020;11:2003
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Article: SCIENTIFIC REPORTS. 2019;9(1):10208
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Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2076
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(1):133-143
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Journal article: ANNALS OF PANCREATIC CANCER. 2018;1(4):ab100
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Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):149.8
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Article: JOURNAL OF VIROLOGY. 2017;91(9):e00010-e00017
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Article: ONCOTARGET. 2017;8(3):4530-4542
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Article: SCIENTIFIC REPORTS. 2016;6:24991
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Article: ACTA ODONTOLOGICA SCANDINAVICA. 2014;72(7):557-560
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Article: JOURNAL OF IMMUNOLOGY. 2013;190(3):1113-1124
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Article: JOURNAL OF IMMUNOLOGY. 2012;189(9):4510-4519
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Article: CYTOKINE. 2012;57(3):406-416
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Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 2):247-258
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Article: JOURNAL OF IMMUNOLOGY. 2011;186(9):5107-5118
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Article: VIROLOGY JOURNAL. 2011;8:36
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Article: DRUG NEWS AND PERSPECTIVES. 2010;23(10):647-653
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Article: VACCINE. 2009;27(5):701-707
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Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;96(3):403-409
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Article: VACCINE. 2007;25(11):1969-1992
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Article: JOURNAL OF VIROLOGY. 2005;79(5):3016-3027
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Article: JOURNAL OF VIROLOGY. 2005;79(5):2964-2972
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Article: NATURE. 2005;433(7028):887-892
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Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2005;43(2):269-276
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(41):14913-14918
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Article: JOURNAL OF IMMUNOLOGY. 2002;169(6):3208-3216
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Article: INTERNATIONAL JOURNAL OF CANCER. 2002;98(4):554-560
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Article: JOURNAL OF GENERAL VIROLOGY. 2002;83(Pt 2):369-381
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Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2001;31(2):105-112
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Article: JOURNAL OF GENERAL VIROLOGY. 2001;82(Pt 6):1299-1308
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Article: JOURNAL OF INFECTIOUS DISEASES. 2001;183(9):1395-1398
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Article: JOURNAL OF MEDICAL VIROLOGY. 2000;62(3):334-344
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Article: JOURNAL OF VIROLOGY. 2000;74(16):7587-7599
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Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2000;32(4):445-446
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Article: CLINICAL AND VACCINE IMMUNOLOGY. 2000;7(1):58-63
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Article: JOURNAL OF CLINICAL MICROBIOLOGY. 1999;37(12):4153-4155
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Article: GASTROENTEROLOGY. 1999;116(1):135-143
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Article: HEPATOLOGY. 1998;28(1):219-224
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Journal article: OBSTETRICAL & GYNECOLOGICAL SURVEY. 1998;53(4):208-209.
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Article: JOURNAL OF IMMUNOLOGY. 1998;160(4):2013-2021
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(26):14648-14653
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Article: JOURNAL OF GENERAL VIROLOGY. 1997;78 ( Pt 11):2735-2746
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Article: JOURNAL OF INFECTIOUS DISEASES. 1997;176(1):281-285
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Article: JOURNAL OF VIROLOGY. 1997;71(7):5295-5303
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Article: JOURNAL OF CLINICAL MICROBIOLOGY. 1997;35(4):973-975
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Journal article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 1997;24(4):488
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Article: JOURNAL OF GENERAL VIROLOGY. 1996;77 ( Pt 11):2721-2728
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Article: JOURNAL OF MEDICAL VIROLOGY. 1995;45(2):223-226
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Article: JOURNAL OF MEDICAL VIROLOGY. 1995;45(1):50-55
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Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1995;27(4):319-324
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Journal article: CLINICAL AND VACCINE IMMUNOLOGY. 1994;1(3):290-294
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Journal article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1994;26(3):263-270
- Show more
All other publications
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Preprint: RESEARCH SQUARE. 2024
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Letter: HAEMATOLOGICA. 2024;109(2):646-651
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Letter: BLOOD. 2022;140(22):2403-2407
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Corrigendum: SCIENTIFIC REPORTS. 2022;12(1):5281
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Review: CELLS. 2020;9(6):E1471-1471
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Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S83-S84
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Meeting abstract: JOURNAL OF HEPATOLOGY. 2018;68:S798-S799
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Conference publication: JOURNAL OF VIRAL HEPATITIS. 2018;25:123
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Review: EXPERT REVIEW OF VACCINES. 2016;15(5):629-640
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Review: MEDICAL MICROBIOLOGY AND IMMUNOLOGY. 2015;204(1):131-135
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Review: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2014;62(1):23-30
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Review: DRUG RESISTANCE UPDATES. 2013;16(3-5):60-67
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Meeting abstract: JOURNAL OF HEPATOLOGY. 2011;54:S476-S477
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Published conference paper: ANTIVIRAL RESEARCH. 2001;52(2):99-111
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Other: JOURNAL OF INFECTIOUS DISEASES. 1995;171(5):1356-1359
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Other: JOURNAL OF CLINICAL MICROBIOLOGY. 1995;33(3):778-780
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Addendum: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1995;27(5):319-324
Grants
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Radiumhemmets Forskningsfonder1 January 2024 - 31 December 2025
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Swedish Cancer Society1 January 2023 - 31 December 2025
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CIMED1 January 2022 - 31 December 2024
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Swedish Research Council1 June 2021 - 31 May 2025
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Swedish Research Council1 January 2021 - 31 December 2023
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RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2018
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RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2017
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RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2016
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T cell Receptor Transfer: Translationella Studier för Förbättrad Behandling av Virushepatit and LevercancerSwedish Cancer Society1 January 2015
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T cell Receptor Transfer: Translationella Studier för Förbättrad Behandling av Virushepatit and LevercancerSwedish Cancer Society1 January 2014
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Swedish Research Council1 January 2009 - 31 December 2010
Employments
- Professor, Department of Laboratory Medicine, Karolinska Institutet, 2023-
- Professor, Department of Dental Medicine, Karolinska Institutet, 2023-2026
Degrees and Education
- Doctor Of Medical Science, Department of Dental Medicine, Karolinska Institutet, 1998
- Doctor Of Medical Science, Department of Laboratory Medicine, Karolinska Institute, 1998
Committee work
- Member, Committee for Doctoral Education of Karolinska Instititet
- Chair, Steering group for KID-funding