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A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes
Stone Vm, Hankaniemi Mm, Svedin E, Sioofy-khojine A, Oikarinen S, Hyöty H, et al
Diabetologia 2018;61(2):476-481

A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses
Saarinen Nvv, Laiho Je, Richardson Sj, Zeissler M, Stone Vm, Marjomäki V, et al
Scientific reports 2018;8(1):33-

New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms
Laitinen Oh, Svedin E, Kapell S, Hankaniemi Mm, Larsson Pg, Domsgen E, et al
Journal of virological methods 2018;255():29-37

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense
Svedin E, Utorova R, Hühn Mh, Larsson Pg, Stone Vm, Garimella M, et al
The Journal of infectious diseases 2017;216(10):1308-1317

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
Edlund A, Pedersen Mg, Lindqvist A, Wierup N, Flodström-tullberg M, Eliasson L
Scientific reports 2017;7(1):90-

Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial
Pincikova T, Paquin-proulx D, Sandberg Jk, Flodström-tullberg M, Hjelte L
European journal of clinical nutrition 2017;71(2):203-205

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, et al
European journal of immunology 2017;47(8):1280-1294

Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model
Hankaniemi Mm, Laitinen Oh, Stone Vm, Sioofy-khojine A, Määttä Jae, Larsson Pg, et al
Vaccine 2017;35(30):3718-3725

Vitamin D treatment modulates immune activation in cystic fibrosis
Pincikova T, Paquin-proulx D, Sandberg Jk, Flodström-tullberg M, Hjelte L
Clinical and experimental immunology 2017;189(3):359-371

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets
Domsgen E, Lind K, Kong Lj, Huhn Mh, Rasool O, Van Kuppeveld F, et al
SCIENTIFIC REPORTS 2016;:39378-

Coxsackievirus counters the host innate immune response by blocking type III interferon expression
Lind K, Svedin E, Domsgen E, Kapell S, Laitinen O, Moll M, et al
The Journal of general virology 2016;97(6):1-12

Cystic fibrosis bronchial epithelial cells have impaired ability to activate vitamin D
Pincikova T, Svedin E, Domsgen E, Flodström-tullberg M, Hjelte L
Acta paediatrica (Oslo, Norway : 1992) 2016;105(7):851-3

Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice
Brauner H, Hall Ht, Flodström-tullberg M, Kärre K, Höglund P, Johansson S
Immunology and cell biology 2016;94(2):177-84

Enteroviral proteases: structure, host interactions and pathogenicity
Laitinen Oh, Svedin E, Kapell S, Nurminen A, Hytönen Vp, Flodström-tullberg M
Reviews in medical virology 2016;26(4):251-67

Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype
Schulte Bm, Gielen Pr, Kers-rebel Ed, Prosser Ac, Lind K, Flodström-tullberg M, et al
Viral immunology 2016;29(7):389-97

Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology
Laiho Je, Oikarinen S, Oikarinen M, Larsson Pg, Stone Vm, Hober D, et al
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2015;69():165-71

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models
Larsson Pg, Lakshmikanth T, Laitinen Oh, Utorova R, Jacobson S, Oikarinen M, et al
Diabetologia 2015;58(2):346-54

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
Edlund A, Esguerra Jl, Wendt A, Flodström-tullberg M, Eliasson L
BMC medicine 2014;12():87-

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Ponten F et al [letter]
Richardson Sj, Leete P, Dhayal S, Russell Ma, Oikarinen M, Laiho Je, et al
DIABETOLOGIA 2014;57(3):647-9

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas
Npod-v Consortium, Richardson Sj, Leete P, Dhayal S, Russell Ma, Oikarinen M, et al
DIABETOLOGIA 2014;57(2):392-401

Novel role for matricellular proteins in the regulation of islet β cell survival: the effect of SPARC on survival, proliferation, and signaling
Ryall Cl, Viloria K, Lhaf F, Walker Aj, King A, Jones P, et al
The Journal of biological chemistry 2014;289(44):30614-24

Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection
Lind K, Svedin E, Utorova R, Stone Vm, Flodström-tullberg M
Clinical and experimental immunology 2014;177(3):687-95

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets
Lind K, Richardson Sj, Leete P, Morgan Ng, Korsgren O, Flodström-tullberg M
Journal of virology 2013;87(13):7646-54

Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice
Larsson Pg, Lakshmikanth T, Svedin E, King C, Flodström-tullberg M
Diabetologia 2013;56(4):867-74

Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell Stimulation
Ghazarian Ln, Diana J, Beaudoin L, Larsson Pg, Puri Rk, Van Rooijen N, et al
DIABETES 2013;62(11):3785-96

The TheraCyte™ device protects against islet allograft rejection in immunized hosts
Kumagai-braesch M, Jacobson S, Mori H, Jia X, Takahashi T, Wernerson A, et al
Cell transplantation 2013;22(7):1137-46

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes
Lind K, Huhn Mh, Flodstrom-tullberg M
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2012;168(1):30-8

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
Zadjali F, Santana-farre R, Vesterlund M, Carow B, Mirecki-garrido M, Hernandez-hernandez I, et al
FASEB JOURNAL 2012;26(8):3282-91

Active CFTR channels are important for insulin- and glucagon secretion
Edlund A, Huhn M, Flodstrom-tullberg M, Eliasson L
DIABETOLOGIA 2010;:S225-S225

Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2(-/-)gc(-/-) Mice
Jacobson S, Heuts F, Juarez J, Hultcrantz M, Korsgren O, Svensson M, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2010;71(2):83-90

Coxsackievirus B3 induces the mRNA expression of IFNbeta and viral recognition receptors in human pancreatic islets
Lind K, Larsson Pg, Huhn M, Korsgren O, Flodstrom-tullberg M
DIABETOLOGIA 2010;:S186-S187

Depletion of IL-2/15 receptor beta-positive cells protects from diabetes in non-obese diabetic mice: role of natural killer cells and a subset of CD8+T cells
Brauner H, Johansson S, Hall H, Flodstrom-tullberg M, Karre K, Hoglund P
DIABETOLOGIA 2010;:S176-S176

Distinct Phenotype and Function of NK Cells in the Pancreas of Nonobese Diabetic Mice
Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodstrom-tullberg M, et al
JOURNAL OF IMMUNOLOGY 2010;184(5):2272-80

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56(dim) NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom Nk, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson Ma, et al
BLOOD 2010;116(19):3853-64

Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection
Huhn Mh, Mccartney Sa, Lind K, Syedin E, Colonna M, Flodstrom-tullberg M
VIROLOGY 2010;401(1):42-8

Previous Coxsackievirus B3 infection in mothers protect offspring from virus-induced type 1 diabetes
Larsson Pg, Flodstrom-tullberg M
DIABETOLOGIA 2010;:S174-S174

Distinct phenotype and function of natural killer cells in the pancreas of non obese diabetic mice
Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodstrom-tullberg M, et al
DIABETOLOGIA 2009;:S194-S194

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
Mcguire Hm, Vogelzang A, Hill N, Flodstrom-tullberg M, Sprent J, King C
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(46):19438-43

Natural killer cells in human autoimmunity
Flodstrom-tullberg M, Bryceson Yt, Shi Fd, Hoglund P, Ljunggren Hg
CURRENT OPINION IN IMMUNOLOGY 2009;21(6):634-40

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death
Zaitseva Ii, Hultcrantz M, Sharoyko V, Flodstrom-tullberg M, Zaitsev Sv, Berggren Po
CELLULAR AND MOLECULAR LIFE SCIENCES 2009;66(23):3787-95

The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice
Hultcrantz M, Jacobson S, Hill Nj, Santamaria P, Flodstrom-tullberg M
DIABETOLOGIA 2009;52(2):299-305

Co-transplantation of Stromal Cells Interferes with the Rejection of Allogeneic Islet Grafts
Jacobson S, Kumagai-braesch M, Tibell A, Svensson M, Flodstrom-tullberg M
IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE 2008;:213-6

Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice
Ohlsson L, Hjelte L, Huhn M, Scholte Bj, Wilke M, Flodstrom-tullberg M, et al
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 2008;47(5):547-54

IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
Huhn Mh, Hultcrantz M, Lind K, Ljunggren Hg, Malmberg Kj, Flodstrom-tullberg M
CELLULAR MICROBIOLOGY 2008;10(2):426-36

Recent acquisitions on the genetic basis of autoimmune disease
Hill Nj, King C, Flodstrom-tullberg M
FRONTIERS IN BIOSCIENCE 2008;:4838-51

Interferons induce an antiviral state in human pancreatic islet cells
Hultcrantz M, Huhn Mh, Wolf M, Olsson A, Jacobson S, Williams Br, et al
VIROLOGY 2007;367(1):92-101

Mini-review: The target tissue in autoimmunity - an influential niche
Hill Nj, Hultcrantz M, Sarvetnick N, Flodstrom-tullberg M
EUROPEAN JOURNAL OF IMMUNOLOGY 2007;37(3):589-97

NK cells in type 1 diabetes
Branner H, Wareing M, Flodstrom-tullberg M, Karre K, Hoglund P
DIABETOLOGIA 2007;:S190-S190

Differences in suppressor of cytokine signaling-I (SOCS-1) expressing islet allograft destruction in normal BALB/c and spontaneously-diabetic NOD recipient mice
Solomon M, Flodstrom-tullberg M, Sarvetnick N
TRANSPLANTATION 2005;79(9):1104-9

RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection
Flodstrom-tullberg M, Hultcrantz M, Stotland A, Maday A, Tsai D, Fine C, et al
JOURNAL OF IMMUNOLOGY 2005;174(3):1171-7

Suppressor of cytokine signaling-1 (SOCS-1) renders islets apoptosis resistant and enhances their survival during alloimmune attack
Solomon Mf, Flodstrom-tullberg M, Sarvetnick N
FASEB JOURNAL 2005;19(5):A1438-A1438

B7-2 (CD86) controls the priming of autoreactive CD4 T cell response against pancreatic islets
Yadav D, Judkowski V, Flodstrom-tullberg M, Sterling L, Redmond Wl, Sherman L, et al
JOURNAL OF IMMUNOLOGY 2004;173(6):3631-9

Strong attraction may be dangerous: parameters for the development of long term commitment
Judkowski V, Pinilla C, Alicotti G, Flodstrom M, Sanna P, Sarvetnick N
MOLECULAR IMMUNOLOGY 2004;40(14-15):1109-12

Diabetogenic potential of human pathogens uncovered in experimentally permissive beta-cells
Flodstrom M, Tsai D, Fine C, Maday A, Sarvetnick N
DIABETES 2003;52(8):2025-34

Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse
Flodstrom-tullberg M, Yadav D, Hagerkvist R, Tsai D, Secrest P, Stotland A, et al
DIABETES 2003;52(11):2696-700

The stromal cell-derived factor-1 alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas
Kayali Ag, Van Gunst K, Campbell Il, Stotland A, Kritzik M, Liu Gx, et al
JOURNAL OF CELL BIOLOGY 2003;163(4):859-69

Viral infections: their elusive role in regulating susceptibility to autoimmune disease
Flodstrom-tullberg M
MICROBES AND INFECTION 2003;5(10):911-21

Target cell defense prevents the development of diabetes after viral infection
Flodstrom M, Maday A, Balakrishna D, Cleary Mm, Yoshimura A, Sarvetnick N
NATURE IMMUNOLOGY 2002;3(4):373-82

The natural killer cell - Friend or foe in autoimmune disease?
Flodstrom M, Shi Fd, Sarvetnick N, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2002;55(5):432-41

Control of the autoimmune response by type 2 nitric oxide synthase
Shi Fd, Flodstrom M, Kim Sh, Pakala S, Cleary M, Ljunggren Hg, et al
JOURNAL OF IMMUNOLOGY 2001;167(5):3000-6

Critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection
Flodstrom M, Horwitz Ms, Maday A, Balakrishna D, Rodriguez E, Sarvetnick N
VIROLOGY 2001;281(2):205-15

Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase
Andersson Ak, Flodstrom M, Sandler S
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2001;281(2):396-403

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse
Shi Fd, Flodstrom M, Balasa B, Kim Sh, Van Gunst K, Strominger Jl, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2001;98(12):6777-82

Control B cell-mediated autoimmune response by type 2 nitric oxide synthase (NOS2)
Shi Fd, Flodstrom M, Kim Sh, Cleary Mm, Ljunggren Hg, Sarvetnick N
JOURNAL OF LEUKOCYTE BIOLOGY 2000;:33-33

Cytokine induced inhibition of insulin release from beta-cells deficient in inducible nitric oxide synthase
Andersson Ak, Flodstrom M, Sandler S
DIABETOLOGIA 2000;:A123-A123

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS(-/-))
Liu Db, Pavlovic D, Chen Mc, Flodstrom M, Sandler S, Eizirik Dl
DIABETES 2000;49(7):1116-22

Islet blood flow in multiple low dose streptozotocin-treated wild-type and inducible nitric oxide synthase-deficient mice
Carlsson Po, Flodström M, Sandler S
Endocrinology 2000;141(8):2752-7

Islet blood flow in multiple low dose streptozotocin-treated wild-type and inducible nitric oxide synthase-deficient mice
Carlsson Po, Flodstrom M, Sandler S
ENDOCRINOLOGY 2000;141(8):2752-2757

Novel experimental strategies to prevent the development of type 1 diabetes mellitus
Sandler S, Andersson Ak, Barbu A, Hellerstrom C, Holstad M, Karlsson E, et al
UPSALA JOURNAL OF MEDICAL SCIENCES 2000;105(2):17-34

Decreased immune-mediated pancreatic beta-cell damage in mice lacking the inducible form of nitric oxide synthase (iNOS)
Flodstrom M, Tyrberg B, Eizirik Dl, Sandler S
FASEB JOURNAL 1999;13(4):A486-A486

Interleukin 1 beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells
Flodstrom M, Chen Mc, Smismans A, Schuit F, Pipeleers Dg, Eizirik Dl
CYTOKINE 1999;11(6):400-7

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
Flodstrom M, Tyrberg B, Eizirik Dl, Sandler S
DIABETES 1999;48(4):706-13

iNOS-/- mice have a reduced sensitivity to immune mediated beta-cell damage: In vitro and in vivo studies.
Flodstrom M, Eizirik Dl, Sandler S
DIABETOLOGIA 1998;:A63-A63

Low insulin secretion in diabetic children whose lymphocytes express iNOS mRNA
Karlsson Mge, Flodstrom M, Ludvigsson J
DIABETOLOGIA 1998;:A95-A95

Interferon-gamma-induced interferon regulatory factor-1 (IRF-1) expression in rodent and human islet cells precedes nitric oxide production
Flodstrom M, Eizirik Dl
ENDOCRINOLOGY 1997;138(7):2747-53

Interferon-gamma signal-transduction in RINm5F cells and human pancreatic islets
Flodstrom M, Eizirik Dl
DIABETOLOGIA 1997;:338-338

Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice
Eizirik Dl, Jansson L, Flodstrom M, Hellerstrom C, Andersson A
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1997;82(8):2660-3

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets
Flodstrom M, Welsh N, Eizirik Dl
FEBS LETTERS 1996;385(1-2):4-6

Cytokines induce expression of interferon-regulatory factor-1 (IRF-1) in insulin-producing cells
Flodstrom M, Eizirik Dl
DIABETOLOGIA 1996;:384-384

Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells
Demello Mar, Flodstrom M, Eizirik Dl
BIOCHEMICAL PHARMACOLOGY 1996;52(11):1703-9

Ebselen decreases NF-kB activation and reduces cytokine-induced nitric oxide formation by insulin-producing cells
Eizirik Dl, Flodstrom M, Demello Mar
DIABETOLOGIA 1996;:387-387

Mechanisms involved in human pancreatic islet glucose insensitivity
Andersson A, Eizirik Dl, Flodstrom M, Pipeleers Dg, Hellerstrom C, Jansson L
DIABETOLOGIA 1996;:481-481

Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines
Flodstrom M, Morris Sm, Eizirik Dl
CYTOKINE 1996;8(8):642-50

The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
Eizirik Dl, Flodstrom M, Karlsen Ae, Welsh N
DIABETOLOGIA 1996;39(8):875-90

DIFFERENCES IN THE EXPRESSION OF HEAT-SHOCK PROTEINS AND ANTIOXIDANT ENZYMES BETWEEN HUMAN AND RODENT PANCREATIC-ISLETS - IMPLICATIONS FOR THE PATHOGENESIS OF INSULIN-DEPENDENT DIABETES-MELLITUS
Welsh N, Margulis B, Borg Lah, Wiklund Hj, Saldeen J, Flodstrom M, et al
MOLECULAR MEDICINE 1995;1(7):806-20

EXPRESSION OF THE CITRULLINE NITRIC-OXIDE CYCLE IN RODENT AND HUMAN PANCREATIC BETA-CELLS
Flodstrom M, Niemann A, Bedoya Fj, Morris Sm, Eizirik Dl
DIABETOLOGIA 1995;:A81-A81

EXPRESSION OF THE CITRULLINE-NITRIC OXIDE CYCLE IN RODENT AND HUMAN PANCREATIC BETA-CELLS - INDUCTION OF ARGININOSUCCINATE SYNTHETASE BY CYTOKINES
Flodstrom M, Niemann A, Bedoya Fj, Morris Sm, Eizirik Dl
ENDOCRINOLOGY 1995;136(8):3200-6

PYRROLIDINE DITHIOCARBAMATE PREVENTS IL-1-INDUCED NITRIC-OXIDE SYNTHASE MESSENGER-RNA, BUT NOT SUPEROXIDE-DISMUTASE MESSENGER-RNA, IN INSULIN-PRODUCING CELLS
Bedoya Fj, Flodstrom M, Eizirik Dl
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1995;210(3):816-22

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