Lisha Wang

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About me

2023-present: independent line of research
Development of proteolysis-targeting chimeras (PROTACs) to promote degradation of toxic tau variants for Alzheimer disease
2019-2023: Postdoc
Investigation of protein-protein interactions between chaperone (Hsp90) and co-chaperone (FKBP51), and development of small molecules inhibiting this target
2014-2019: PhD
Pharmacokinetics, bioanalysis, and pharmacodynamics of active natural products on cognition

Research

Development of small molecules targeting protein-protein interactions to bring novel treatment for Alzheimer disease

Teaching

PhD course “Protein Metabolism in Health and Disease” (#2332) at Karolinska Institutet

Articles

Article: ALZHEIMERS & DEMENTIA. 2025;21(3):e70091
Intraneuronal Aβ accumulation causes tau hyperphosphorylation via endolysosomal leakage
Gao Y; Wang L; Doeswijk T; Winblad B; Schedin-Weiss S; Tjernberg LO
Journal article: BEHAVIOURAL BRAIN RESEARCH. 2024;471:115142
Cajaninstilbene acid ameliorates depression-like behaviors in mice by suppressing TLR4/NF-κB κ B mediated neuroinflammation and promoting autophagy
Tao X; Zhou Y; Wang Z; Wang L; Xia T; Yan M; Chang Q
Article: SCIENCE. 2024;384(6696):660-665
Spike timing-based coding in neuromimetic tactile system enables dynamic object classification
Chen L; Karilanova S; Chaki S; Wen C; Wang L; Winblad B; Zhang S-L; Ozcelikkale A; Zhang Z-B
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2024;270:116356
Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction
Wang L; Kumar R; Winblad B; Pavlov PF
Article: MOLECULAR NEUROBIOLOGY. 2024;61(3):1479-1494
FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet
Wang L; Wojcieszak J; Kumar R; Zhao Z; Sun X; Xie S; Winblad B; Pavlov PF
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:824138
Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
Yan M; Jin S; Liu Y; Wang L; Wang Z; Xia T; Chang Q
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(173)
Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Wang L; Bergkvist L; Kumar R; Winblad B; Pavlov PF
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2021;69(7):2129-2137
Absorption, Metabolism, and Excretion of Cajaninstilbene Acid
Wang L; Wang Z; Xia T; Cao F; Ye L; Pan R; Jin S; Yan M; Chang Q
Journal article: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(6):356
Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice
Tao X; Yan M; Wang L; Zhou Y; Wang Z; Xia T; Liu X; Pan R; Chang Q
Journal article: FITOTERAPIA. 2020;141:104450
Antidepressant-like effects of cajaninstilbene acid and its related mechanisms in mice
Zhang M-D; Tao X; Pan R-L; Wang L-S; Li C-C; Zhou Y-F; Liao Y-H; Chen S-G; Chang Q; Liu X-M
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2019;1112:24-32
LC-MS/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice
Wang L-S; Zhang M-D; Tao X; Zhou Y-F; Liu X-M; Pan R-L; Liao Y-H; Chang Q
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:1084
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β_1-42 Oligomers
Wang L-S; Tao X; Liu X-M; Zhou Y-F; Zhang M-D; Liao Y-H; Pan R-L; Chang Q
Journal article: BIOMEDICAL CHROMATOGRAPHY. 2018;32(8):e4250
Inhibitory effects of Danhong Injection and its major constituents on human cytochrome P450 enzymes in vitro
Ye L-H; Zhao X-Q; Kong L-T; Wang L-S; Tao X; Wu H; He M; Chang Q
Journal article: FRONTIERS IN PHARMACOLOGY. 2018;9:902
Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain
Ye L-H; He X-X; You C; Tao X; Wang L-S; Zhang M-D; Zhou Y-F; Chang Q
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2017;65(20):4066-4073
Pharmacokinetics of Cajaninstilbene Acid and Its Main Glucuronide Metabolite in Rats
Wang L-S; Tao X; Pan R-L; Cao F-R; Feng L; Liao Y-H; Liu X-M; Chang Q
Journal article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2017;1052:19-26
Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method
Cao F-R; Xiao B-X; Wang L-S; Tao X; Yan M-Z; Pan R-L; Liao Y-H; Liu X-M; Chang Q
Journal article: FRONTIERS IN PHARMACOLOGY. 2017;8:599
Brain Pharmacokinetics and the Pharmacological Effects on Striatal Neurotransmitter Levels of Pueraria lobata Isoflavonoids in Rat
Xiao B; Sun Z; Cao F; Wang L; Liao Y; Liu X; Pan R; Chang Q
Journal article: FRONTIERS IN PHARMACOLOGY. 2017;8:101
Ganoderic Acid A Metabolites and Their Metabolic Kinetics
Cao F-R; Feng L; Ye L-H; Wang L-S; Xiao B-X; Tao X; Chang Q
Journal article: JOURNAL OF ETHNOPHARMACOLOGY. 2016;194:913-917
Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity
Ye L-H; Kong L-T; Yan M-Z; Cao F-R; Wang L-S; Liao Y-H; Pan R-L; Chang Q
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2016;497(1-2):239-247
Formulation of 20(S)-protopanaxadiol nanocrystals to improve oral bioavailability and brain delivery
Chen C; Wang L; Cao F; Miao X; Chen T; Chang Q; Zheng Y
Journal article: MARINE DRUGS. 2013;11(5):1492-1505
A Shark Liver Gene-Derived Active Peptide Expressed in the Silkworm, Bombyx mori: Preliminary Studies for Oral Administration of the Recombinant Protein
Liu Y; Chen Y; Chen J; Zhang W; Sheng Q; Chen J; Yu W; Nie Z; Zhang Y; Wu W; Wang L; Indran IR; Li J; Qian L; Lv Z
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All other publications

Review: ALZHEIMERS & DEMENTIA. 2025;21(3):e70048
Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities
Wang L; Sooram B; Kumar R; Schedin-Weiss S; Tjernberg LO; Winblad B
Review: CELLS. 2021;10(10):2596
Targeting Chaperone/Co-Chaperone Interactions with Small Molecules: A Novel Approach to Tackle Neurodegenerative Diseases
Wang L; Bergkvist L; Kumar R; Winblad B; Pavlov PF
Review: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2021;209:112915
Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance
Wang L; Bharti; Kumar R; Pavlov PF; Winblad B

Grants

PROTACs: A novel strategy for the treatment of Alzheimer disease
StratNeuro Funding for postdoctoral researchers
New treatments and diagnostics for Alzheimer´s disease
Private initiative "Innovative ways to fight Alzheimer´s disease - Leif Lundblad Family and others"
Tore Nilsons Stiftelse För Medicinsk Forskning
Åhlén stiftelsen
Gun & Bertil Stohnes Stiftelse
Stiftelsen för Gamla Tjänarinnor
Karolinska Institutet Geriatrics Foundation
Karolinska Institutet Research Foundation Grants
Karolinska Institutet Loo och Hans Ostermans Stifelse
A novel treatment strategy for Alzheimer disease by inducing protein-protein interactions
Petrus och Augusta Hedlunds Stiftelse

Employments

Assistant Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2025-2031
Postdoctoral Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2019-2021
Postdoctoral Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2019-2021

Degrees and Education

PhD, Cognitive Enhancing Effects and Pharmacokinetics of Cajaninstilbene Acid, Chinese Academy of Medical Sciences & Peking Union Medical College, 2019

About me

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