Lars Jakobsson

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Articles

Article: ANGIOGENESIS. 2025;28(1):6
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Queiro-Palou A; Jin Y; Jakobsson L
Article: BIOMEDICINE & PHARMACOTHERAPY. 2025;182:117740
Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencing.
Kohl F; Laufkötter O; Firth M; Krimpenfort L; Mangla P; Ansarizadeh M; Geylan G; Eklund L; De Maria L; Jakobsson L; Wiseman J
Journal article: ANGIOGENESIS. 2024;28(1):6
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT.
Queiro-Palou A; Jin Y; Jakobsson L
Article: ANGIOGENESIS. 2024;27(3):523-542
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2^L914F mutation in endothelial cells
Lazovic B; Nguyen H-T; Ansarizadeh M; Wigge L; Kohl F; Li S; Carracedo M; Kettunen J; Krimpenfort L; Elgendy R; Richter K; De Silva L; Bilican B; Singh P; Saxena P; Hong X; Eklund L; Hicks R
Article: FLUIDS AND BARRIERS OF THE CNS. 2024;21(1):35
Analysis of ischemic stroke-mediated effects on blood-brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Protzmann J; Jung F; Jakobsson L; Fredriksson L
Article: SCIENCE. 2024;383(6683):eade8064
Corpora cavernosa fibroblasts mediate penile erection
Guimaraes EL; Dias DO; Hau WF; Julien A; Holl D; Garcia-Collado M; Savant S; Vagesjo E; Phillipson M; Jakobsson L; Goritz C
Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674
Anatomy of the complete mouse eye vasculature explored by light-sheet fluorescence microscopy exposes subvascular-specific remodeling in development and pathology
Krimpenfort LT; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; Andre H; Uhlen P; Jakobsson L
Article: MATRIX BIOLOGY. 2023;121:56-73
Endothelial basement membrane laminins- new players in mouse and human myoendothelial junctions and shear stress communication
Luik A-L; Hannocks M-J; Loismann S; Kapupara K; Cerina M; Stoel MVD; Tsytsyura Y; Glyvuk N; Nordenvall C; Klingauf J; Huveneers S; Meuth S; Jakobsson L; Sorokin L
Article: CIRCULATION RESEARCH. 2020;126(2):243-257
Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Park C; Lin H; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Article: SCIENTIFIC REPORTS. 2018;8(1):10672
Characterization of multi-cellular dynamics of angiogenesis and vascular remodelling by intravital imaging of the wounded mouse cornea
Wang Y; Jin Y; Lavina B; Jakobsson L
Article: DEVELOPMENT. 2017;144(19):3590-3601
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
Wang Y; Jin Y; Mae MA; Zhang Y; Ortsater H; Betsholtz C; Makinen T; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):639-652
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y; Muhl L; Burmakin M; Wang Y; Duchez A-C; Betsholtz C; Arthur HM; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):653-665
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW; Meissner R; Aegerter-Wilmsen T; Tsaryk R; Leonard EV; Bussmann J; Hamm MJ; Herzog W; Jin Y; Jakobsson L; Denz C; Siekmann AF
Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378
Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling
Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
Article: SCIENCE SIGNALING. 2016;9(438):ra76
RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms
Yang J; Wu C; Stefanescu I; Jakobsson L; Chervoneva I; Horowitz A
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2014;42(6):1576-1583
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning
Jin Y; Kaluza D; Jakobsson L
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2014;90(9):778-789
The hippocampal neurovascular niche during normal development and after irradiation to the juvenile mouse brain
Bostrom M; Erkenstam NH; Kaluza D; Jakobsson L; Kalm M; Blomgren K
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2012;32(5):1255-1263
Functional Overlap Between Chondroitin and Heparan Sulfate Proteoglycans During VEGF-Induced Sprouting Angiogenesis
Le Jan S; Hayashi M; Kasza Z; Eriksson I; Bishop JR; Weibrecht I; Heldin J; Holmborn K; Jakobsson L; Soderberg O; Spillmann D; Esko JD; Claesson-Welsh L; Kjellen L; Kreuger J
Article: CANCERS. 2012;4(2):400-419
The dynamics of developmental and tumor angiogenesis-a comparison.
Jin Y; Jakobsson L
Article: NATURE CELL BIOLOGY. 2011;13(10):1202-1213
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Tammela T; Zarkada G; Nurmi H; Jakobsson L; Heinolainen K; Tvorogov D; Zheng W; Franco CA; Murtomaki A; Aranda E; Miura N; Yla-Herttuala S; Fruttiger M; Makinen T; Eichmann A; Pollard JW; Gerhardt H; Alitalo K
Article: NATURE CELL BIOLOGY. 2010;12(10):943-953
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson L; Franco CA; Bentley K; Collins RT; Ponsioen B; Aspalter IM; Rosewell I; Busse M; Thurston G; Medvinsky A; Schulte-Merker S; Gerhardt H
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2009;37(Pt 6):1233-1236
VEGFRs and Notch: a dynamic collaboration in vascular patterning
Jakobsson L; Bentley K; Gerhardt H
Article: THE SCIENTIFIC WORLD JOURNAL. 2008;8:1246-1249
Vascular Basement Membrane Components in Angiogenesis - An Act of Balance
Jakobsson L; Claesson-Welsh L
Article: BLOOD. 2008;112(9):3638-3649
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
Kawamura H; Li X; Goishi K; van Meeteren LA; Jakobsson L; Cebe-Suarez S; Shimizu A; Edholm D; Ballmer-Hofer K; Kjellen L; Klagsbrun M; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(20):13905-13912
Endothelial cell migration in stable gradients of vascular endothelial growth factor a and fibroblast growth factor 2 - Effects on chemotaxis and chemokinesis
Barkefors I; Le Jan S; Jakobsson L; Hejll E; Carlson G; Johansson H; Jarvius J; Park JW; Jeon NL; Kreuger J
Article: FASEB JOURNAL. 2008;22(5):1530-1539
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
Jakobsson L; Domogatskaya A; Tryggvason K; Edgar D; Claesson-Welsh L
Article: GENES & DEVELOPMENT. 2007;21(16):2055-2068
Angiomotin regulates endothelial cell migration during embryonic angiogenesis
Aase K; Ernkvist M; Ebarasi L; Jakobsson L; Majumdar A; Yi C; Birot O; Ming Y; Kvanta A; Edholm D; Aspenstrom P; Kissil J; Claesson-Welsh L; Shimono A; Holmgren L
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(6):i17
Building blood vessels—stem cell models in vascular biology
Jakobsson L; Kreuger J; Claesson-Welsh L
Article: BLOOD. 2006;108(6):1877-1886
Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation
Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
Article: DEVELOPMENTAL CELL. 2006;10(5):625-634
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis
Jakobsson L; Kreuger J; Holmborn K; Lundin L; Eriksson I; Kjellén L; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(51):42397-42404
Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis
Bohman S; Matsumoto T; Suh K; Dimberg A; Jakobsson L; Yuspa S; Welsh LC
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(5):944-949
Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development
Magnusson PU; Ronca R; Dell'Era P; Carlstedt P; Jakobsson L; Partanen J; Dimberg A; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(22):23766-23772
Laminin-1 promotes angiogenesis in synergy with fibroblast growth factor by distinct regulation of the gene and protein expression profile in endothelial cells
Dixelius J; Jakobsson L; Genersch E; Bohman S; Ekblom P; Claesson-Welsh L
Article: JOURNAL OF CELL SCIENCE. 2004;117(8):1513-1523
Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development
Magnusson P; Rolny C; Jakobsson L; Wikner C; Wu Y; Hicklin DJ; Claesson-Welsh L
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All other publications

Preprint: BIORXIV. 2022
Anatomy of the complete mouse eye vasculature in development and pathology explored by light-sheet fluorescence microscopy
Krimpenfort L; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; André H; Uhlén P; Jakobsson L
Editorial comment: CIRCULATION RESEARCH. 2020;127(6):744-746
Oncogenes in Brain Arteriovenous Malformations
Jakobsson L; Arthur HM
Conference publication: EUROPEAN HEART JOURNAL. 2015;36:497-498
Endoglin is required to maintain normal cardiac function in adult life
Tual-Chalot S; Davison BJ; Jin Y; Redgrave RE; Jakobsson L; Taggart MJ; Arthur HM
Conference publication: ANGIOGENESIS. 2015;18(4):571-572
Endoglin is required to maintain normal cardiac function in adult life
Tual-Chalot S; Davison BJ; Yin Y; Redgrave RE; Jakobsson L; Arthur HM
Review: EXPERIMENTAL CELL RESEARCH. 2013;319(9):1264-1270
Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts
Jakobsson L; van Meeteren LA
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)
Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Conference publication: FASEB JOURNAL. 2010;24:9.1
Endothelial Tip Cell Guidance and Mechanisms
Franco CA; Jakobsson L; Rosewell I; Bentley K; Busse M; Gerhardt H
Review: JOURNAL OF CELL BIOLOGY. 2007;177(5):751-755
Building blood vessels - stem cell models in vascular biology
Jakobsson L; Kreuger J; Claesson-Welsh L

Grants

Jakobsson, Lars Gustav – Mechanisms of oncogenic transformation of vascular malformation into angiosarcomas
Swedish Cancer Society
1 January 2023
The interface of signalling and flow in regulation of vascular architecture and function in genetic disease
Swedish Research Council
1 January 2022 - 31 December 2025
Vaskulära malformationer i Morbus Osler och dess koppling till hjärtpatologi - identifiering och utvärdering av behandling
Swedish Heart-Lung Foundation
1 January 2020 - 31 December 2022
Signalling in regulation of vascular matrix composition and its role in fibrosis and oncogenic transformation
Swedish Cancer Society
1 January 2020

Employments

Principal Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2022-
Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2016-2022
Assistant Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2012-2016
Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2010-2012

Degrees and Education

Docent, Karolinska Institutet, 2017
PhD in Molecular Medicine, IGP, Uppsala University, 2007

Visiting research fellowships

Postdoc, Long term EMBO fellowship, Cancer Research UK, London Research Institute, 2007-2009

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