Lars Björndahl
Affiliated to Research | Docent
E-mail: lars.bjorndahl@ki.se
Visiting address: C2:94, Karolinska Universitetssjukhuset Huddinge, 14186 Stockholm
Postal address: H7 Medicin, Huddinge, H7 Endokrinologi och diabetes Rydén&Mejhert, 171 77 Stockholm
About me
- Associate Professor in Andrology, Specialist in laboratory medicine (Clinical Chemistry). Worked with
standardization, training and quality control concerning human ejaculate
examination since 1994.
Ph.D: in reproductive physiology with a thesis 1986: /On sperm nuclear zinc
and chromatin decondensation : an in vitro study on the physiology of the
ejaculated human spermatozoon/. Stockholm, Karolinska Institutet.
Active in the build of a new andrology laboratory at Karolinska University
Hospital since 1987. Head of this laboratory as part of ANOVA since 2013.
Consultant Advisor in Laboratory Andrology since 1995.
/Research Fellow/ and /honorary Senior Lecturer/ in Human Reproductive
Biology, University of Birmingham and the Assisted Conception Unit, ,
Birmingham Women's Health Care Trust, 2001-2005
Senior Consultant Physician at the Andrology Laboratory, Centre for Andrology
and Sexual Medicine (later ANOVA), from 2010.
Organizer of the ESHRE Campus Course on Sperm Chromatin Stability (Stockholm
2009)
Chairman of the Organizing Committee and Host of the XIIIth International
Symposium on Spermatology (Stockholm 2018).
*Earlier Scientific Commissions:*
* 2004-08: Co-ordinator of the ESHRE Special Interest Group in Andrology.
* 2010-14: Associate Editor of Human Reproduction.
* 2005-2010: Member of Editorial Board of WHO manual on human semen
examination, 5th edition
*Present Scientific Commissions:*
* Associate Editor of Human Reproduction Update
* Associate Editor of Andrology
* Editorial Board Member Asian Journal of Andrology
* Project Leader: ISO Technical Standard for human semen examination
* Editor in Chief - Editorial Board of WHO manual on human semen
examination, 6th edition
* Expert (Laboratory Andrology) in WHO Infertility Global Guidelines and
Research Group
* Chairman Technical Committe 331, Swedish Institute for Standards
(www.sis.se)
Hon Senior Lecturer in Reproductive Medicine, University of Birmingham,
2003-2005.
Associate Editor, Human Reproduction 2010-14 - twice awarded "top-ten"
reviewer of manuscripts for Human Reproduction,
Member of editorial committees of Andrology and Asian Journal of Androloy.
Conference Grant (Swedish Research Council): Sperm Chromatin structure and
stability (2009)
Conference Grant (Swedish Research Council): XIIIth International Symposium
on Spermatology (2018)
M.D. 1982 - Ph.D. 1986 (Karolinska Institutet). Swedish Licence as Physician
1990, Specialist in Clinical Chemistry 1992
Research
- Starting out with investigations on the zinc dependence of human sperm
head-tail connection my Ph.D. project focused on the zinc dependent chromatin
stabilization, concluding that the environment spermatozoa were expelled in
determined the status of the sperm chromatin stability. Early loss of zinc
(to binders originating from the seminal vesicular fluid) induced an
initially decreased stability that was rapidly exchanged for an extreme
stability, that would jeopardize the rapid unravelling of the chromaitn in
the oocyte potentially causing failure of zygote development after
fertilization. The relation between zinc rich prostatic fluid and potential
negative influence of seminal vesicular fluid has been further investigated.
Co-supervisor of Dr Emma Holmes has shown the huge increase in semen
osmolality in ejaculates kept in vitro and the relation to rapid
deterioration of sperm motility during clinical relevant preparation for
Assisted Reproductive Technologies.
Supervisor of Dr Petr Houska whos project focuses on sperm DNA abnormalities
as (sperm DNA fragmentation) measured by Flow Cytometry of sperm DNA stained
with Acridine Orange in order to distinguish between single stranded and
double stranded DNA. This test is widely used in commercial IVF centres, but
the clinical value for the individual patient is very limited since many
unknown factors influence the result of individual patients. The Ph.D.
project includes experimental studies to evaluate factors besides actual DNA
damages that can have significant effect on the final result of the sperm DNA
fragmentation test.
My own studies in recent years have focused on the establishment of modern
laboratory medicine techniques for reliable results from ejaculate
examinations.
Teaching
- Extensive experience from teaching physiology and most aspects of basic
medicine to different categories of students. Since 1995 involved in
development of standardized training courses on WHO and ESHRE recommended
techniques for reliable analysis of human semen.
Course-leader and teacher SVK Andrologi och Sexualmedicin (KI 2020-) and
teacher SVK Sexualmedicin (KI 2020)
Articles
- Journal article: REPRODUCTIVE BIOMEDICINE ONLINE. 2024;48:104060
- Article: ASIAN JOURNAL OF ANDROLOGY. 2024;26(3):229-232
- Article: BIOLOGY OF REPRODUCTION. 2024;110(1):63-77
- Article: ANDROLOGY. 2023;11(7):1225-1231
- Article: SCIENTIFIC REPORTS. 2023;13(1):14777
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(673):eabm2417
- Article: FERTILITY AND STERILITY. 2022;117(2):237-245
- Article: FERTILITY AND STERILITY. 2022;117(2):246-251
- Journal article: HUMAN REPRODUCTION. 2021;36(Supplement_1):deab130.122
- Journal article: HUMAN REPRODUCTION. 2021;36(Supplement_1):deab130.104
- Journal article: HUMAN REPRODUCTION. 2021;36(Supplement_1):deab130.103
- Article: ANDROLOGY. 2021;9(3):817-822
- Article: ANDROLOGY. 2021;9(1):10-18
- Article: ANDROLOGIA. 2020;52(11):e13859
- Article: BIOCHEMICAL PHARMACOLOGY. 2020;182:114212
- Article: ACS APPLIED MATERIALS & INTERFACES. 2019;11(50):46572-46584
- Article: ANDROLOGIA. 2019;51(11):e13443
- Article: ANDROLOGIA. 2019;51(7):e13311
- Article: HUMAN REPRODUCTION UPDATE. 2017;23(6):660-680
- Article: ANDROLOGY. 2016;4(5):771-772
- Article: HUMAN REPRODUCTION. 2016;31(2):227-232
- Journal article: EUROPEAN UROLOGY OPEN SCIENCE. 2014;13(1):e157
- Journal article: EUROPEAN UROLOGY OPEN SCIENCE. 2014;13(1):e255
- Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2014;791:1-11
- Article: HUMAN REPRODUCTION UPDATE. 2013;19:i1-45
- Article: METHODS IN MOLECULAR BIOLOGY. 2013;927:3-12
- Article: HUMAN REPRODUCTION. 2013;28(1):10-21
- Article: HUMAN REPRODUCTION. 2012;27(2):314-322
- Article: LAKARTIDNINGEN. 2011;108(50):2665-2666
- Article: HUMAN REPRODUCTION. 2011;26(12):3207-3212
- Article: LAKARTIDNINGEN. 2011;108(48):2514
- Article: HUMAN FERTILITY. 2011;14(3):179-186
- Journal article: REVISTA DEL LABORATORIO CLINICO. 2011;4(3):134-144
- Article: HUMAN REPRODUCTION. 2010;25(4):824-838
- Article: ASIAN JOURNAL OF ANDROLOGY. 2010;12(1):33-35
- Article: JOURNAL OF CHIROPRACTIC MEDICINE. 2008;7(2):39-47
- Article: HUMAN REPRODUCTION. 2006;21(1):145-149
- Article: MOLECULAR HUMAN REPRODUCTION. 2005;11(7):523-529
- Article: JOURNAL OF ANDROLOGY. 2005;26(2):170-173
- Article: JOURNAL OF ANDROLOGY. 2005;26(1):11
- Article: JOURNAL OF ANDROLOGY. 2004;25(6):862-863
- Article: JOURNAL OF ANDROLOGY. 2004;25(5):671-678
- Article: HUMAN REPRODUCTION. 2004;19(6):1438-1447
- Article: REPRODUCTIVE BIOMEDICINE ONLINE. 2003;7(4):440-448
- Article: HUMAN REPRODUCTION. 2003;18(4):813-816
- Article: INTERNATIONAL JOURNAL OF ANDROLOGY. 2002;25(5):306-311
- Article: HUMAN REPRODUCTION. 2002;17(5):1299-1305
- Article: ANDROLOGIA. 1995;27(2):71-79
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1992;15(2):103-113
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1991;14(3):174-178
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1990;13(4):245-252
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1990;13(4):287-296
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1990;13(3):232-237
- Journal article: NORDISK MEDICIN. 1988;103(11):312-315
- Journal article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 1988;22(1):1-6
- Journal article: JOURNAL OF TRACE ELEMENTS AND ELECTROLYTES IN HEALTH AND DISEASE. 1987;1(2):85-87
- Journal article: SCANNING MICROSCOPY. 1987;1(3):1241-1247
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1986;9(1):77-80
- Journal article: ACTA PHYSIOLOGICA. 1985;125(2):297-303
- Journal article: ACTA PHYSIOLOGICA. 1985;124(2):195-200
- Journal article: ACTA PHYSIOLOGICA. 1985;124(2):189-194
- Journal article: INTERNATIONAL JOURNAL OF ANDROLOGY. 1982;5(5):478-486
- Journal article: ACTA PHYSIOLOGICA. 1982;116(1):51-55
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All other publications
- Book chapter: MEN'S REPRODUCTIVE AND SEXUAL HEALTH THROUGHOUT THE LIFESPAN. 2023;p. 159-164
- Conference publication: HUMAN REPRODUCTION. 2023;38
- Preprint: RESEARCH SQUARE. 2022
- Review: HUMAN REPRODUCTION. 2022;37(11):2497-2502
- Review: REPRODUCTIVE BIOMEDICINE ONLINE. 2022;45(4):731-736
- Review: HUMAN REPRODUCTION OPEN. 2022;2022(2):hoac014
- Book chapter: MANUAL OF SPERM FUNCTION TESTING IN HUMAN ASSISTED REPRODUCTION. 2021;p. 6-10
- Conference publication: HUMAN REPRODUCTION. 2021;36:183-184
- Conference publication: HUMAN REPRODUCTION. 2021;36:184
- Conference publication: HUMAN REPRODUCTION. 2021;36:192
- Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 323-330
- Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 39-45
- Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 3-8
- Other: ANDROLOGY. 2020;8(3):530-531
- Editorial comment: BASIC AND CLINICAL ANDROLOGY. 2018;28:13
- Book chapter: ENDOCRINOLOGY OF THE TESTIS AND MALE REPRODUCTION: ENDOCRINOLOGY (SWITZERLAND). 2017;p. 535-554
- Review: REPRODUCTIVE BIOMEDICINE ONLINE. 2015;30(6):568-580
- Book chapter: GENETIC DAMAGE IN HUMAN SPERMATOZOA: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2014;p. e1
- Book chapter: PATERNAL INFLUENCES ON HUMAN REPRODUCTIVE SUCCESS. 2013;p. 183-190
- Review: SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE. 2011;57(1-2):86-92
- Conference publication: HUMAN REPRODUCTION. 2011;26:I145-I146
- Conference publication: HUMAN REPRODUCTION. 2011;26:I139
- Conference publication: JOURNAL OF ANDROLOGY. 2011;:87-88
- Conference publication: HUMAN REPRODUCTION. 2011;26:I141-I142
- Conference publication: HUMAN REPRODUCTION. 2011;26:I137-I138
- Book chapter: REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY. 2010;p. 379-388
- Review: REPRODUCTIVE BIOMEDICINE ONLINE. 2010;20(1):114-124
- Review: MOLECULAR HUMAN REPRODUCTION. 2010;16(1):23-29
- Published conference paper: FERTILITY AND STERILITY. 2009;91(2):627-631
- Conference publication: JOURNAL OF ANDROLOGY. 2009;:42
- Conference publication: JOURNAL OF ANDROLOGY. 2009;:40-41
- Conference publication: JOURNAL OF ANDROLOGY. 2009;30:108-109
- Review: TIDSSKRIFT FOR DEN NORSKE LEGEFORENING. 2008;128(3):320-323
- Letter: HUMAN REPRODUCTION. 2006;21(11):3030-3031
- Letter: HUMAN REPRODUCTION. 2006;21(11):3028-3029
- Review: HUMAN REPRODUCTION. 2003;18(5):1037-1046
- Conference publication: HUMAN REPRODUCTION. 1998;13:143-144
- Conference publication: TRACE ELEMENTS IN MEDICINE. 1986;3(3):136-137
- Conference publication: TRACE ELEMENTS IN MEDICINE. 1986;3(3):128-129
- Conference publication: TRACE ELEMENTS IN MEDICINE. 1986;3(3):135-136
- Conference publication: DEVELOPMENT GROWTH AND DIFFERENTIATION. 1986;28:57
- Conference publication: ACTA PHYSIOLOGICA. 1985;124:389
- Conference publication: ACTA PHYSIOLOGICA. 1984;120(2):A52
- Conference publication: ACTA PHYSIOLOGICA. 1983;118(2):A24
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Grants
- Swedish Research Council1 November 2017 - 30 November 2017
- Swedish Research Council1 January 2009 - 31 December 2009
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2023-2024
Degrees and Education
- Docent, Andrology, Karolinska Institutet, 2024